ReDisulphID

a tool for identifying redox-active disulphides from structures

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Complement component C7

Intramolecular
Cysteine 128 and cysteine 165
Cysteine 599 and cysteine 626
Cysteine 523 and cysteine 535
Cysteine 702 and cysteine 713
Cysteine 512 and cysteine 545
Cysteine 776 and cysteine 789
Cysteine 773 and cysteine 782
Cysteine 28 and cysteine 63
Cysteine 721 and cysteine 743
Cysteine 659 and cysteine 688
More...
Cysteine 773 and cysteine 776
Cysteine 460 and cysteine 475
Cysteine 571 and cysteine 613
Cysteine 477 and cysteine 486
Cysteine 776 and cysteine 782
Cysteine 39 and cysteine 73
Cysteine 805 and cysteine 838
Cysteine 715 and cysteine 750
Cysteine 797 and cysteine 818
Cysteine 791 and cysteine 825
Cysteine 728 and cysteine 763
Cysteine 337 and cysteine 353
Cysteine 457 and cysteine 473
Cysteine 103 and cysteine 119
Cysteine 631 and cysteine 673
Cysteine 91 and cysteine 109
Cysteine 455 and cysteine 505
Cysteine 789 and cysteine 825
Cysteine 789 and cysteine 791
Cysteine 85 and cysteine 96
Cysteine 42 and cysteine 79
Cysteine 433 and cysteine 560
Cysteine 782 and cysteine 789
Cysteine 773 and cysteine 789
Cysteine 475 and cysteine 486
Cysteine 776 and cysteine 825
Cysteine 713 and cysteine 750
Cysteine 782 and cysteine 825
Cysteine 776 and cysteine 791
Cysteine 773 and cysteine 791
Cysteine 773 and cysteine 825
Cysteine 460 and cysteine 486
Cysteine 713 and cysteine 715
Cysteine 702 and cysteine 715
Cysteine 791 and cysteine 797
Cysteine 789 and cysteine 797
Cysteine 702 and cysteine 750
Cysteine 460 and cysteine 477
Cysteine 721 and cysteine 750
Cysteine 791 and cysteine 818
Cysteine 743 and cysteine 750
Cysteine 776 and cysteine 797
Cysteine 782 and cysteine 791
Cysteine 715 and cysteine 721
Cysteine 475 and cysteine 477
Cysteine 797 and cysteine 825
Cysteine 715 and cysteine 743
Cysteine 457 and cysteine 475
Cysteine 457 and cysteine 460
Cysteine 473 and cysteine 475
Cysteine 818 and cysteine 825
Cysteine 460 and cysteine 473
Cysteine 455 and cysteine 457
Cysteine 457 and cysteine 505
Cysteine 28 and cysteine 473
Cysteine 39 and cysteine 79
Cysteine 85 and cysteine 91
Cysteine 96 and cysteine 109
Cysteine 42 and cysteine 433
Cysteine 39 and cysteine 42
Cysteine 473 and cysteine 505
Cysteine 91 and cysteine 96
Cysteine 85 and cysteine 109
Cysteine 79 and cysteine 433
Cysteine 455 and cysteine 473
A redox-regulated disulphide may form within Complement component C7 at these cysteines.

Relevent regions

MACPF
begin
124
end
456
score
98.9079989079989
distance
2.817979
seq distance
0
chain
D
MACPF
begin
124
end
456
score
98.9079989079989
distance
2.817979
seq distance
0
chain
D
In dbSNP:rs2271708.
original residue
C
variation residue
R
position
128
score
100.0
distance
2.8496788
seq distance
0
chain
D
In dbSNP:rs2271708.
original residue
C
variation residue
R
position
128
score
100.0
distance
2.8496788
seq distance
0
chain
D
Disordered
begin
108
end
143
score
100.0
distance
2.8496788
seq distance
0
chain
D
Disordered
begin
108
end
143
score
100.0
distance
2.8496788
seq distance
0
chain
D
LDL-receptor class A
begin
83
end
121
score
100.0
distance
10.679332
seq distance
7
chain
D
LDL-receptor class A
begin
83
end
121
score
100.0
distance
10.679332
seq distance
7
chain
D
LDL-receptor class A
begin
84
end
92
score
56.56565656565656
distance
25.475805
seq distance
False
chain
C
LDL-receptor class A
begin
84
end
92
score
56.56565656565656
distance
25.475805
seq distance
False
chain
C
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
420
score
100.0
distance
29.487078
seq distance
255
chain
D
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
420
score
100.0
distance
29.487078
seq distance
255
chain
D
Disordered
begin
91
end
92
score
68.18181818181817
distance
31.895489
seq distance
False
chain
C
Disordered
begin
91
end
92
score
68.18181818181817
distance
31.895489
seq distance
False
chain
C
Disordered
begin
138
end
138
score
50.0
distance
38.381577
seq distance
False
chain
E
Disordered
begin
138
end
138
score
50.0
distance
38.381577
seq distance
False
chain
E
TSP type-1 1
begin
27
end
80
score
99.83164983164983
distance
39.28269
seq distance
48
chain
D
TSP type-1 1
begin
27
end
80
score
99.83164983164983
distance
39.28269
seq distance
48
chain
D
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
412
score
63.63636363636363
distance
40.879395
seq distance
False
chain
C
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
412
score
63.63636363636363
distance
40.879395
seq distance
False
chain
C
CCP 1
begin
545
end
615
score
83.48271446862996
distance
41.16804
seq distance
380
chain
D
CCP 1
begin
545
end
615
score
83.48271446862996
distance
41.16804
seq distance
380
chain
D
Confirmed at protein level; dbSNP:rs1063499.
original residue
S
variation residue
T
position
389
score
100.0
distance
41.596752
seq distance
224
chain
D
Confirmed at protein level; dbSNP:rs1063499.
original residue
S
variation residue
T
position
389
score
100.0
distance
41.596752
seq distance
224
chain
D
TSP type-1 2
begin
500
end
549
score
100.0
distance
43.518837
seq distance
335
chain
D
TSP type-1 2
begin
500
end
549
score
100.0
distance
43.518837
seq distance
335
chain
D
In dbSNP:rs75345202.
original residue
R
variation residue
H
position
414
score
54.54545454545454
distance
46.211952
seq distance
False
chain
F
In dbSNP:rs75345202.
original residue
R
variation residue
H
position
414
score
54.54545454545454
distance
46.211952
seq distance
False
chain
F
EGF-like
begin
457
end
487
score
100.0
distance
46.418636
seq distance
292
chain
D
EGF-like
begin
457
end
487
score
100.0
distance
46.418636
seq distance
292
chain
D
LDL-receptor class A
begin
83
end
98
score
52.69886363636363
distance
46.48474
seq distance
False
chain
F
LDL-receptor class A
begin
83
end
98
score
52.69886363636363
distance
46.48474
seq distance
False
chain
F
Disordered
begin
516
end
538
score
100.0
distance
48.57471
seq distance
351
chain
D
Disordered
begin
516
end
538
score
100.0
distance
48.57471
seq distance
351
chain
D
Disordered
begin
585
end
589
score
50.90909090909091
distance
48.939102
seq distance
False
chain
B
Disordered
begin
585
end
589
score
50.90909090909091
distance
48.939102
seq distance
False
chain
B
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
587
score
68.18181818181817
distance
48.98272
seq distance
False
chain
B
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
587
score
68.18181818181817
distance
48.98272
seq distance
False
chain
B
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
521
score
100.0
distance
53.840675
seq distance
356
chain
D
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
521
score
100.0
distance
53.840675
seq distance
356
chain
D
Sushi 1
begin
572
end
628
score
99.04306220095694
distance
55.347923
seq distance
407
chain
D
Sushi 1
begin
572
end
628
score
99.04306220095694
distance
55.347923
seq distance
407
chain
D
Disordered
begin
41
end
41
score
70.45454545454545
distance
57.812813
seq distance
False
chain
B
Disordered
begin
41
end
41
score
70.45454545454545
distance
57.812813
seq distance
False
chain
B
CCP 2
begin
616
end
691
score
99.2822966507177
distance
63.221954
seq distance
451
chain
D
CCP 2
begin
616
end
691
score
99.2822966507177
distance
63.221954
seq distance
451
chain
D
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
65.410324
seq distance
False
chain
X
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
65.410324
seq distance
False
chain
X
EGF-like
begin
451
end
455
score
54.090909090909086
distance
65.98642
seq distance
False
chain
C
EGF-like
begin
451
end
455
score
54.090909090909086
distance
65.98642
seq distance
False
chain
C
Confirmed at protein level; dbSNP:rs13157656.
original residue
T
variation residue
P
position
587
score
100.0
distance
67.09402
seq distance
422
chain
D
Confirmed at protein level; dbSNP:rs13157656.
original residue
T
variation residue
P
position
587
score
100.0
distance
67.09402
seq distance
422
chain
D
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
70.62473
seq distance
False
chain
X
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
70.62473
seq distance
False
chain
X
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
71.22213
seq distance
False
chain
G
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
71.22213
seq distance
False
chain
G
Disordered
begin
504
end
504
score
68.18181818181817
distance
71.680916
seq distance
False
chain
C
Disordered
begin
504
end
504
score
68.18181818181817
distance
71.680916
seq distance
False
chain
C
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
72.47916
seq distance
False
chain
X
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
72.47916
seq distance
False
chain
X
Confirmed at protein level; dbSNP:rs1063499.
original residue
S
variation residue
T
position
1058
score
54.54545454545454
distance
73.554855
seq distance
False
chain
A
Confirmed at protein level; dbSNP:rs1063499.
original residue
S
variation residue
T
position
1058
score
54.54545454545454
distance
73.554855
seq distance
False
chain
A
Sushi 2
begin
629
end
690
score
99.56011730205279
distance
76.25087
seq distance
464
chain
D
Sushi 2
begin
629
end
690
score
99.56011730205279
distance
76.25087
seq distance
464
chain
D
Confirmed at protein level; dbSNP:rs13157656.
original residue
T
variation residue
P
position
714
score
50.0
distance
80.17641
seq distance
False
chain
B
Confirmed at protein level; dbSNP:rs13157656.
original residue
T
variation residue
P
position
714
score
50.0
distance
80.17641
seq distance
False
chain
B
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
82.544876
seq distance
False
chain
W
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
82.544876
seq distance
False
chain
W
TSP type-1 2
begin
512
end
517
score
80.30303030303031
distance
82.7379
seq distance
False
chain
F
TSP type-1 2
begin
512
end
517
score
80.30303030303031
distance
82.7379
seq distance
False
chain
F
Disordered
begin
219
end
240
score
100.0
distance
83.50745
seq distance
54
chain
D
Disordered
begin
219
end
240
score
100.0
distance
83.50745
seq distance
54
chain
D
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
31
score
50.0
distance
86.466805
seq distance
False
chain
F
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
31
score
50.0
distance
86.466805
seq distance
False
chain
F
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
86.56096
seq distance
False
chain
W
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
86.56096
seq distance
False
chain
W
In C7D; dbSNP:rs541873000.
original residue
E
variation residue
Q
position
682
score
100.0
distance
86.976364
seq distance
517
chain
D
In C7D; dbSNP:rs541873000.
original residue
E
variation residue
Q
position
682
score
100.0
distance
86.976364
seq distance
517
chain
D
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
87.07664
seq distance
False
chain
P
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
87.07664
seq distance
False
chain
P
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
87.87133
seq distance
False
chain
W
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
87.87133
seq distance
False
chain
W
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
92.490486
seq distance
False
chain
G
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
92.490486
seq distance
False
chain
G
In C7D; dbSNP:rs113187203.
original residue
R
variation residue
H
position
687
score
100.0
distance
95.54291
seq distance
522
chain
D
In C7D; dbSNP:rs113187203.
original residue
R
variation residue
H
position
687
score
100.0
distance
95.54291
seq distance
522
chain
D
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
100.63592
seq distance
False
chain
V
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
100.63592
seq distance
False
chain
V
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
102.643486
seq distance
False
chain
H
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
102.643486
seq distance
False
chain
H
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
103.54552
seq distance
False
chain
V
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
103.54552
seq distance
False
chain
V
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
104.21684
seq distance
False
chain
V
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
104.21684
seq distance
False
chain
V
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
104.35549
seq distance
False
chain
G
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
104.35549
seq distance
False
chain
G
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
109.39443
seq distance
False
chain
P
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
109.39443
seq distance
False
chain
P
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
116.92076
seq distance
False
chain
I
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
116.92076
seq distance
False
chain
I
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
118.01436
seq distance
False
chain
U
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
118.01436
seq distance
False
chain
U
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
118.15543
seq distance
False
chain
U
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
118.15543
seq distance
False
chain
U
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
121.12586
seq distance
False
chain
P
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
121.12586
seq distance
False
chain
P
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
121.90775
seq distance
False
chain
U
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
121.90775
seq distance
False
chain
U
In C7D; dbSNP:rs369349760.
original residue
R
variation residue
Q
position
220
score
100.0
distance
125.158195
seq distance
55
chain
D
In C7D; dbSNP:rs369349760.
original residue
R
variation residue
Q
position
220
score
100.0
distance
125.158195
seq distance
55
chain
D
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
125.41582
seq distance
False
chain
H
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
125.41582
seq distance
False
chain
H
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
125.52885
seq distance
False
chain
X
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
125.52885
seq distance
False
chain
X
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
129.57428
seq distance
False
chain
J
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
129.57428
seq distance
False
chain
J
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
129.73569
seq distance
False
chain
G
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
129.73569
seq distance
False
chain
G
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
130.6806
seq distance
False
chain
W
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
130.6806
seq distance
False
chain
W
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
130.75005
seq distance
False
chain
T
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
130.75005
seq distance
False
chain
T
In dbSNP:rs75345202.
original residue
R
variation residue
H
position
222
score
100.0
distance
131.87546
seq distance
57
chain
D
In dbSNP:rs75345202.
original residue
R
variation residue
H
position
222
score
100.0
distance
131.87546
seq distance
57
chain
D
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
134.27449
seq distance
False
chain
T
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
134.27449
seq distance
False
chain
T
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
137.05525
seq distance
False
chain
H
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
137.05525
seq distance
False
chain
H
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
137.67792
seq distance
False
chain
V
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
137.67792
seq distance
False
chain
V
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
138.64047
seq distance
False
chain
P
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
138.64047
seq distance
False
chain
P
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
138.9047
seq distance
False
chain
T
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
138.9047
seq distance
False
chain
T
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
139.74065
seq distance
False
chain
I
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
139.74065
seq distance
False
chain
I
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
140.20676
seq distance
False
chain
K
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
140.20676
seq distance
False
chain
K
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
141.3244
seq distance
False
chain
S
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
141.3244
seq distance
False
chain
S
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
145.81712
seq distance
False
chain
U
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
145.81712
seq distance
False
chain
U
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
147.7334
seq distance
False
chain
H
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
147.7334
seq distance
False
chain
H
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
147.83781
seq distance
False
chain
S
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
147.83781
seq distance
False
chain
S
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
148.53607
seq distance
False
chain
L
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
148.53607
seq distance
False
chain
L
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
149.44757
seq distance
False
chain
R
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
149.44757
seq distance
False
chain
R
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
151.20813
seq distance
False
chain
I
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
151.20813
seq distance
False
chain
I
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
152.02219
seq distance
False
chain
J
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
152.02219
seq distance
False
chain
J
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
153.40039
seq distance
False
chain
S
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
153.40039
seq distance
False
chain
S
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
154.00792
seq distance
False
chain
T
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
154.00792
seq distance
False
chain
T
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
154.31218
seq distance
False
chain
M
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
154.31218
seq distance
False
chain
M
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
154.95183
seq distance
False
chain
Q
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
154.95183
seq distance
False
chain
Q
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
156.12198
seq distance
False
chain
I
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
156.12198
seq distance
False
chain
I
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
157.37651
seq distance
False
chain
N
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
157.37651
seq distance
False
chain
N
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
157.6233
seq distance
False
chain
O
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
157.6233
seq distance
False
chain
O
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
158.91971
seq distance
False
chain
R
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
158.91971
seq distance
False
chain
R
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
161.58757
seq distance
False
chain
S
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
161.58757
seq distance
False
chain
S
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
161.8668
seq distance
False
chain
K
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
161.8668
seq distance
False
chain
K
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
163.2617
seq distance
False
chain
J
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
163.2617
seq distance
False
chain
J
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
163.49678
seq distance
False
chain
J
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
163.49678
seq distance
False
chain
J
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
165.45802
seq distance
False
chain
R
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
165.45802
seq distance
False
chain
R
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
167.16544
seq distance
False
chain
Q
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
167.16544
seq distance
False
chain
Q
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
168.06622
seq distance
False
chain
R
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
168.06622
seq distance
False
chain
R
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
169.05336
seq distance
False
chain
L
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
169.05336
seq distance
False
chain
L
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
169.64268
seq distance
False
chain
K
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
169.64268
seq distance
False
chain
K
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
172.37875
seq distance
False
chain
O
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
172.37875
seq distance
False
chain
O
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
172.77956
seq distance
False
chain
K
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
172.77956
seq distance
False
chain
K
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
173.13268
seq distance
False
chain
Q
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
173.13268
seq distance
False
chain
Q
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
173.24277
seq distance
False
chain
M
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
173.24277
seq distance
False
chain
M
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
174.23007
seq distance
False
chain
L
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
174.23007
seq distance
False
chain
L
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
174.37065
seq distance
False
chain
N
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
174.37065
seq distance
False
chain
N
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
174.7516
seq distance
False
chain
Q
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
174.7516
seq distance
False
chain
Q
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
176.44766
seq distance
False
chain
O
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
176.44766
seq distance
False
chain
O
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
176.9375
seq distance
False
chain
M
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
176.9375
seq distance
False
chain
M
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
177.52205
seq distance
False
chain
N
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
177.52205
seq distance
False
chain
N
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
179.55675
seq distance
False
chain
L
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
179.55675
seq distance
False
chain
L
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
180.99883
seq distance
False
chain
O
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
180.99883
seq distance
False
chain
O
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
183.29854
seq distance
False
chain
M
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
183.29854
seq distance
False
chain
M
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
183.8485
seq distance
False
chain
N
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
183.8485
seq distance
False
chain
N

Details

Redox score
84.71
PDB code
6h04
Structure name
closed conformation of the membrane attack complex
Structure deposition date
2018-07-06
Thiol separation (Å)
3.52
Half-sphere exposure sum
74
Minimum pKa
6.22
% buried
54
Peptide accession
P10643
Residue number A
128
Residue number B
165
Peptide name
Complement component C7
A redox-regulated disulphide may form within Complement component C7 at these cysteines.

Relevent regions

CCP 2
begin
616
end
691
score
99.2822966507177
distance
2.8064775
seq distance
0
chain
D
CCP 2
begin
616
end
691
score
99.2822966507177
distance
2.8064775
seq distance
0
chain
D
Sushi 1
begin
572
end
628
score
99.04306220095694
distance
2.8064775
seq distance
0
chain
D
Sushi 1
begin
572
end
628
score
99.04306220095694
distance
2.8064775
seq distance
0
chain
D
CCP 1
begin
545
end
615
score
83.48271446862996
distance
2.8109024
seq distance
0
chain
D
CCP 1
begin
545
end
615
score
83.48271446862996
distance
2.8109024
seq distance
0
chain
D
Sushi 2
begin
629
end
690
score
99.56011730205279
distance
8.722968
seq distance
3
chain
D
Sushi 2
begin
629
end
690
score
99.56011730205279
distance
8.722968
seq distance
3
chain
D
Confirmed at protein level; dbSNP:rs13157656.
original residue
T
variation residue
P
position
587
score
100.0
distance
20.903303
seq distance
12
chain
D
Confirmed at protein level; dbSNP:rs13157656.
original residue
T
variation residue
P
position
587
score
100.0
distance
20.903303
seq distance
12
chain
D
In C7D; dbSNP:rs541873000.
original residue
E
variation residue
Q
position
682
score
100.0
distance
25.255117
seq distance
56
chain
D
In C7D; dbSNP:rs541873000.
original residue
E
variation residue
Q
position
682
score
100.0
distance
25.255117
seq distance
56
chain
D
In C7D; dbSNP:rs113187203.
original residue
R
variation residue
H
position
687
score
100.0
distance
35.78042
seq distance
61
chain
D
In C7D; dbSNP:rs113187203.
original residue
R
variation residue
H
position
687
score
100.0
distance
35.78042
seq distance
61
chain
D
TSP type-1 1
begin
27
end
80
score
99.83164983164983
distance
45.102104
seq distance
519
chain
D
TSP type-1 1
begin
27
end
80
score
99.83164983164983
distance
45.102104
seq distance
519
chain
D
LDL-receptor class A
begin
83
end
121
score
100.0
distance
46.72408
seq distance
478
chain
D
LDL-receptor class A
begin
83
end
121
score
100.0
distance
46.72408
seq distance
478
chain
D
MACPF
begin
124
end
456
score
98.9079989079989
distance
48.68684
seq distance
143
chain
D
MACPF
begin
124
end
456
score
98.9079989079989
distance
48.68684
seq distance
143
chain
D
TSP type-1 2
begin
500
end
549
score
100.0
distance
49.155827
seq distance
50
chain
D
TSP type-1 2
begin
500
end
549
score
100.0
distance
49.155827
seq distance
50
chain
D
Disordered
begin
516
end
538
score
100.0
distance
59.542015
seq distance
61
chain
D
Disordered
begin
516
end
538
score
100.0
distance
59.542015
seq distance
61
chain
D
Disordered
begin
108
end
143
score
100.0
distance
62.056473
seq distance
456
chain
D
Disordered
begin
108
end
143
score
100.0
distance
62.056473
seq distance
456
chain
D
LDL-receptor class A
begin
84
end
92
score
56.56565656565656
distance
67.733536
seq distance
False
chain
C
LDL-receptor class A
begin
84
end
92
score
56.56565656565656
distance
67.733536
seq distance
False
chain
C
Confirmed at protein level; dbSNP:rs1063499.
original residue
S
variation residue
T
position
1058
score
54.54545454545454
distance
71.33849
seq distance
False
chain
A
Confirmed at protein level; dbSNP:rs1063499.
original residue
S
variation residue
T
position
1058
score
54.54545454545454
distance
71.33849
seq distance
False
chain
A
Disordered
begin
585
end
589
score
50.90909090909091
distance
72.121574
seq distance
False
chain
B
Disordered
begin
585
end
589
score
50.90909090909091
distance
72.121574
seq distance
False
chain
B
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
521
score
100.0
distance
73.15508
seq distance
78
chain
D
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
521
score
100.0
distance
73.15508
seq distance
78
chain
D
Disordered
begin
91
end
92
score
68.18181818181817
distance
73.17228
seq distance
False
chain
C
Disordered
begin
91
end
92
score
68.18181818181817
distance
73.17228
seq distance
False
chain
C
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
420
score
100.0
distance
74.254036
seq distance
179
chain
D
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
420
score
100.0
distance
74.254036
seq distance
179
chain
D
In dbSNP:rs2271708.
original residue
C
variation residue
R
position
128
score
100.0
distance
75.25177
seq distance
471
chain
D
In dbSNP:rs2271708.
original residue
C
variation residue
R
position
128
score
100.0
distance
75.25177
seq distance
471
chain
D
EGF-like
begin
457
end
487
score
100.0
distance
76.7436
seq distance
112
chain
D
EGF-like
begin
457
end
487
score
100.0
distance
76.7436
seq distance
112
chain
D
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
587
score
68.18181818181817
distance
77.39779
seq distance
False
chain
B
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
587
score
68.18181818181817
distance
77.39779
seq distance
False
chain
B
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
412
score
63.63636363636363
distance
79.05397
seq distance
False
chain
C
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
412
score
63.63636363636363
distance
79.05397
seq distance
False
chain
C
Disordered
begin
504
end
504
score
68.18181818181817
distance
80.1078
seq distance
False
chain
C
Disordered
begin
504
end
504
score
68.18181818181817
distance
80.1078
seq distance
False
chain
C
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
81.54463
seq distance
False
chain
X
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
81.54463
seq distance
False
chain
X
Confirmed at protein level; dbSNP:rs13157656.
original residue
T
variation residue
P
position
714
score
50.0
distance
82.13848
seq distance
False
chain
B
Confirmed at protein level; dbSNP:rs13157656.
original residue
T
variation residue
P
position
714
score
50.0
distance
82.13848
seq distance
False
chain
B
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
82.81828
seq distance
False
chain
X
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
82.81828
seq distance
False
chain
X
LDL-receptor class A
begin
83
end
98
score
52.69886363636363
distance
85.06752
seq distance
False
chain
F
LDL-receptor class A
begin
83
end
98
score
52.69886363636363
distance
85.06752
seq distance
False
chain
F
Disordered
begin
41
end
41
score
70.45454545454545
distance
93.36184
seq distance
False
chain
B
Disordered
begin
41
end
41
score
70.45454545454545
distance
93.36184
seq distance
False
chain
B
EGF-like
begin
451
end
455
score
54.090909090909086
distance
99.03852
seq distance
False
chain
C
EGF-like
begin
451
end
455
score
54.090909090909086
distance
99.03852
seq distance
False
chain
C
Confirmed at protein level; dbSNP:rs1063499.
original residue
S
variation residue
T
position
389
score
100.0
distance
99.32301
seq distance
210
chain
D
Confirmed at protein level; dbSNP:rs1063499.
original residue
S
variation residue
T
position
389
score
100.0
distance
99.32301
seq distance
210
chain
D
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
101.74372
seq distance
False
chain
W
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
101.74372
seq distance
False
chain
W
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
104.28437
seq distance
False
chain
W
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
104.28437
seq distance
False
chain
W
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
108.66725
seq distance
False
chain
X
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
108.66725
seq distance
False
chain
X
In dbSNP:rs75345202.
original residue
R
variation residue
H
position
414
score
54.54545454545454
distance
108.71385
seq distance
False
chain
F
In dbSNP:rs75345202.
original residue
R
variation residue
H
position
414
score
54.54545454545454
distance
108.71385
seq distance
False
chain
F
Disordered
begin
138
end
138
score
50.0
distance
112.86211
seq distance
False
chain
E
Disordered
begin
138
end
138
score
50.0
distance
112.86211
seq distance
False
chain
E
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
120.09898
seq distance
False
chain
G
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
120.09898
seq distance
False
chain
G
TSP type-1 2
begin
512
end
517
score
80.30303030303031
distance
120.47239
seq distance
False
chain
F
TSP type-1 2
begin
512
end
517
score
80.30303030303031
distance
120.47239
seq distance
False
chain
F
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
31
score
50.0
distance
122.95852
seq distance
False
chain
F
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
31
score
50.0
distance
122.95852
seq distance
False
chain
F
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
126.64966
seq distance
False
chain
W
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
126.64966
seq distance
False
chain
W
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
126.96443
seq distance
False
chain
V
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
126.96443
seq distance
False
chain
V
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
129.2186
seq distance
False
chain
V
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
129.2186
seq distance
False
chain
V
Disordered
begin
219
end
240
score
100.0
distance
133.1303
seq distance
359
chain
D
Disordered
begin
219
end
240
score
100.0
distance
133.1303
seq distance
359
chain
D
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
135.33444
seq distance
False
chain
G
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
135.33444
seq distance
False
chain
G
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
142.0793
seq distance
False
chain
P
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
142.0793
seq distance
False
chain
P
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
146.4222
seq distance
False
chain
G
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
146.4222
seq distance
False
chain
G
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
146.72455
seq distance
False
chain
V
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
146.72455
seq distance
False
chain
V
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
153.19218
seq distance
False
chain
U
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
153.19218
seq distance
False
chain
U
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
154.41042
seq distance
False
chain
U
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
154.41042
seq distance
False
chain
U
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
160.79579
seq distance
False
chain
P
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
160.79579
seq distance
False
chain
P
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
163.22348
seq distance
False
chain
H
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
163.22348
seq distance
False
chain
H
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
166.81729
seq distance
False
chain
U
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
166.81729
seq distance
False
chain
U
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
169.15222
seq distance
False
chain
X
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
169.15222
seq distance
False
chain
X
In C7D; dbSNP:rs369349760.
original residue
R
variation residue
Q
position
220
score
100.0
distance
170.98488
seq distance
379
chain
D
In C7D; dbSNP:rs369349760.
original residue
R
variation residue
Q
position
220
score
100.0
distance
170.98488
seq distance
379
chain
D
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
172.40218
seq distance
False
chain
P
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
172.40218
seq distance
False
chain
P
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
174.18828
seq distance
False
chain
W
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
174.18828
seq distance
False
chain
W
In dbSNP:rs75345202.
original residue
R
variation residue
H
position
222
score
100.0
distance
177.21596
seq distance
377
chain
D
In dbSNP:rs75345202.
original residue
R
variation residue
H
position
222
score
100.0
distance
177.21596
seq distance
377
chain
D
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
178.23154
seq distance
False
chain
T
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
178.23154
seq distance
False
chain
T
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
178.77269
seq distance
False
chain
T
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
178.77269
seq distance
False
chain
T
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
182.26486
seq distance
False
chain
I
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
182.26486
seq distance
False
chain
I
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
182.93321
seq distance
False
chain
V
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
182.93321
seq distance
False
chain
V
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
183.97679
seq distance
False
chain
H
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
183.97679
seq distance
False
chain
H
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
185.1975
seq distance
False
chain
T
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
185.1975
seq distance
False
chain
T
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
186.98813
seq distance
False
chain
G
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
186.98813
seq distance
False
chain
G
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
194.26498
seq distance
False
chain
U
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
194.26498
seq distance
False
chain
U
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
195.92093
seq distance
False
chain
H
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
195.92093
seq distance
False
chain
H
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
198.72224
seq distance
False
chain
J
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
198.72224
seq distance
False
chain
J
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
199.19107
seq distance
False
chain
S
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
199.19107
seq distance
False
chain
S
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
200.35884
seq distance
False
chain
P
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
200.35884
seq distance
False
chain
P
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
201.12344
seq distance
False
chain
S
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
201.12344
seq distance
False
chain
S
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
201.51884
seq distance
False
chain
S
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
201.51884
seq distance
False
chain
S
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
203.99623
seq distance
False
chain
I
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
203.99623
seq distance
False
chain
I
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
206.32503
seq distance
False
chain
T
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
206.32503
seq distance
False
chain
T
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
212.1239
seq distance
False
chain
K
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
212.1239
seq distance
False
chain
K
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
213.47977
seq distance
False
chain
H
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
213.47977
seq distance
False
chain
H
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
214.01135
seq distance
False
chain
R
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
214.01135
seq distance
False
chain
R
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
216.00673
seq distance
False
chain
I
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
216.00673
seq distance
False
chain
I
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
216.87277
seq distance
False
chain
R
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
216.87277
seq distance
False
chain
R
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
218.09776
seq distance
False
chain
S
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
218.09776
seq distance
False
chain
S
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
220.53967
seq distance
False
chain
J
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
220.53967
seq distance
False
chain
J
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
220.96147
seq distance
False
chain
R
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
220.96147
seq distance
False
chain
R
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
222.08858
seq distance
False
chain
L
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
222.08858
seq distance
False
chain
L
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
223.45157
seq distance
False
chain
Q
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
223.45157
seq distance
False
chain
Q
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
225.08829
seq distance
False
chain
I
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
225.08829
seq distance
False
chain
I
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
228.33083
seq distance
False
chain
M
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
228.33083
seq distance
False
chain
M
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
228.835
seq distance
False
chain
R
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
228.835
seq distance
False
chain
R
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
229.07072
seq distance
False
chain
O
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
229.07072
seq distance
False
chain
O
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
230.66916
seq distance
False
chain
Q
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
230.66916
seq distance
False
chain
Q
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
230.689
seq distance
False
chain
N
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
230.689
seq distance
False
chain
N
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
232.40224
seq distance
False
chain
J
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
232.40224
seq distance
False
chain
J
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
233.18166
seq distance
False
chain
K
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
233.18166
seq distance
False
chain
K
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
234.63197
seq distance
False
chain
J
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
234.63197
seq distance
False
chain
J
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
236.53647
seq distance
False
chain
Q
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
236.53647
seq distance
False
chain
Q
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
237.86455
seq distance
False
chain
Q
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
237.86455
seq distance
False
chain
Q
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
240.21333
seq distance
False
chain
O
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
240.21333
seq distance
False
chain
O
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
241.68439
seq distance
False
chain
L
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
241.68439
seq distance
False
chain
L
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
242.06888
seq distance
False
chain
K
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
242.06888
seq distance
False
chain
K
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
244.35374
seq distance
False
chain
O
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
244.35374
seq distance
False
chain
O
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
244.67194
seq distance
False
chain
K
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
244.67194
seq distance
False
chain
K
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
245.23099
seq distance
False
chain
N
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
245.23099
seq distance
False
chain
N
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
245.71199
seq distance
False
chain
M
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
245.71199
seq distance
False
chain
M
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
246.9264
seq distance
False
chain
L
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
246.9264
seq distance
False
chain
L
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
247.78882
seq distance
False
chain
O
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
247.78882
seq distance
False
chain
O
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
247.90807
seq distance
False
chain
N
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
247.90807
seq distance
False
chain
N
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
248.93405
seq distance
False
chain
M
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
248.93405
seq distance
False
chain
M
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
252.58223
seq distance
False
chain
L
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
252.58223
seq distance
False
chain
L
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
254.37256
seq distance
False
chain
N
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
254.37256
seq distance
False
chain
N
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
255.88365
seq distance
False
chain
M
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
255.88365
seq distance
False
chain
M

Details

Redox score
81.73
PDB code
6h04
Structure name
closed conformation of the membrane attack complex
Structure deposition date
2018-07-06
Thiol separation (Å)
3.73
Half-sphere exposure sum
52
Minimum pKa
9.24
% buried
15
Peptide accession
P10643
Residue number A
599
Residue number B
626
Peptide name
Complement component C7
A redox-regulated disulphide may form within Complement component C7 at these cysteines.

Relevent regions

Disordered
begin
516
end
538
score
100.0
distance
2.8086336
seq distance
0
chain
D
Disordered
begin
516
end
538
score
100.0
distance
2.8086336
seq distance
0
chain
D
TSP type-1 2
begin
500
end
549
score
100.0
distance
2.8086336
seq distance
0
chain
D
TSP type-1 2
begin
500
end
549
score
100.0
distance
2.8086336
seq distance
0
chain
D
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
521
score
100.0
distance
7.6063175
seq distance
2
chain
D
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
521
score
100.0
distance
7.6063175
seq distance
2
chain
D
MACPF
begin
124
end
456
score
98.9079989079989
distance
10.66222
seq distance
67
chain
D
MACPF
begin
124
end
456
score
98.9079989079989
distance
10.66222
seq distance
67
chain
D
EGF-like
begin
457
end
487
score
100.0
distance
12.736797
seq distance
36
chain
D
EGF-like
begin
457
end
487
score
100.0
distance
12.736797
seq distance
36
chain
D
Disordered
begin
41
end
41
score
70.45454545454545
distance
18.12384
seq distance
False
chain
B
Disordered
begin
41
end
41
score
70.45454545454545
distance
18.12384
seq distance
False
chain
B
TSP type-1 1
begin
27
end
80
score
99.83164983164983
distance
20.920605
seq distance
443
chain
D
TSP type-1 1
begin
27
end
80
score
99.83164983164983
distance
20.920605
seq distance
443
chain
D
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
420
score
100.0
distance
24.665413
seq distance
103
chain
D
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
420
score
100.0
distance
24.665413
seq distance
103
chain
D
CCP 1
begin
545
end
615
score
83.48271446862996
distance
25.224953
seq distance
10
chain
D
CCP 1
begin
545
end
615
score
83.48271446862996
distance
25.224953
seq distance
10
chain
D
Disordered
begin
108
end
143
score
100.0
distance
29.592888
seq distance
380
chain
D
Disordered
begin
108
end
143
score
100.0
distance
29.592888
seq distance
380
chain
D
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
34.839127
seq distance
False
chain
X
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
34.839127
seq distance
False
chain
X
Disordered
begin
585
end
589
score
50.90909090909091
distance
35.027893
seq distance
False
chain
B
Disordered
begin
585
end
589
score
50.90909090909091
distance
35.027893
seq distance
False
chain
B
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
412
score
63.63636363636363
distance
35.219147
seq distance
False
chain
C
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
412
score
63.63636363636363
distance
35.219147
seq distance
False
chain
C
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
587
score
68.18181818181817
distance
36.248604
seq distance
False
chain
B
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
587
score
68.18181818181817
distance
36.248604
seq distance
False
chain
B
Confirmed at protein level; dbSNP:rs1063499.
original residue
S
variation residue
T
position
389
score
100.0
distance
38.494366
seq distance
134
chain
D
Confirmed at protein level; dbSNP:rs1063499.
original residue
S
variation residue
T
position
389
score
100.0
distance
38.494366
seq distance
134
chain
D
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
42.98583
seq distance
False
chain
X
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
42.98583
seq distance
False
chain
X
Disordered
begin
504
end
504
score
68.18181818181817
distance
44.75364
seq distance
False
chain
C
Disordered
begin
504
end
504
score
68.18181818181817
distance
44.75364
seq distance
False
chain
C
LDL-receptor class A
begin
83
end
121
score
100.0
distance
46.41418
seq distance
402
chain
D
LDL-receptor class A
begin
83
end
121
score
100.0
distance
46.41418
seq distance
402
chain
D
EGF-like
begin
451
end
455
score
54.090909090909086
distance
50.370113
seq distance
False
chain
C
EGF-like
begin
451
end
455
score
54.090909090909086
distance
50.370113
seq distance
False
chain
C
Disordered
begin
219
end
240
score
100.0
distance
55.387974
seq distance
283
chain
D
Disordered
begin
219
end
240
score
100.0
distance
55.387974
seq distance
283
chain
D
Sushi 1
begin
572
end
628
score
99.04306220095694
distance
55.4305
seq distance
37
chain
D
Sushi 1
begin
572
end
628
score
99.04306220095694
distance
55.4305
seq distance
37
chain
D
CCP 2
begin
616
end
691
score
99.2822966507177
distance
56.971138
seq distance
81
chain
D
CCP 2
begin
616
end
691
score
99.2822966507177
distance
56.971138
seq distance
81
chain
D
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
57.063953
seq distance
False
chain
X
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
57.063953
seq distance
False
chain
X
In dbSNP:rs2271708.
original residue
C
variation residue
R
position
128
score
100.0
distance
57.575462
seq distance
395
chain
D
In dbSNP:rs2271708.
original residue
C
variation residue
R
position
128
score
100.0
distance
57.575462
seq distance
395
chain
D
LDL-receptor class A
begin
84
end
92
score
56.56565656565656
distance
59.418713
seq distance
False
chain
C
LDL-receptor class A
begin
84
end
92
score
56.56565656565656
distance
59.418713
seq distance
False
chain
C
Disordered
begin
91
end
92
score
68.18181818181817
distance
59.571465
seq distance
False
chain
C
Disordered
begin
91
end
92
score
68.18181818181817
distance
59.571465
seq distance
False
chain
C
In dbSNP:rs75345202.
original residue
R
variation residue
H
position
414
score
54.54545454545454
distance
60.321342
seq distance
False
chain
F
In dbSNP:rs75345202.
original residue
R
variation residue
H
position
414
score
54.54545454545454
distance
60.321342
seq distance
False
chain
F
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
66.0862
seq distance
False
chain
W
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
66.0862
seq distance
False
chain
W
Confirmed at protein level; dbSNP:rs13157656.
original residue
T
variation residue
P
position
587
score
100.0
distance
66.17656
seq distance
52
chain
D
Confirmed at protein level; dbSNP:rs13157656.
original residue
T
variation residue
P
position
587
score
100.0
distance
66.17656
seq distance
52
chain
D
Confirmed at protein level; dbSNP:rs1063499.
original residue
S
variation residue
T
position
1058
score
54.54545454545454
distance
68.33518
seq distance
False
chain
A
Confirmed at protein level; dbSNP:rs1063499.
original residue
S
variation residue
T
position
1058
score
54.54545454545454
distance
68.33518
seq distance
False
chain
A
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
71.732346
seq distance
False
chain
W
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
71.732346
seq distance
False
chain
W
Disordered
begin
138
end
138
score
50.0
distance
73.93936
seq distance
False
chain
E
Disordered
begin
138
end
138
score
50.0
distance
73.93936
seq distance
False
chain
E
LDL-receptor class A
begin
83
end
98
score
52.69886363636363
distance
74.69612
seq distance
False
chain
F
LDL-receptor class A
begin
83
end
98
score
52.69886363636363
distance
74.69612
seq distance
False
chain
F
TSP type-1 2
begin
512
end
517
score
80.30303030303031
distance
75.8111
seq distance
False
chain
F
TSP type-1 2
begin
512
end
517
score
80.30303030303031
distance
75.8111
seq distance
False
chain
F
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
81.72995
seq distance
False
chain
W
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
81.72995
seq distance
False
chain
W
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
82.84287
seq distance
False
chain
G
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
82.84287
seq distance
False
chain
G
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
88.8355
seq distance
False
chain
X
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
88.8355
seq distance
False
chain
X
Sushi 2
begin
629
end
690
score
99.56011730205279
distance
89.10926
seq distance
94
chain
D
Sushi 2
begin
629
end
690
score
99.56011730205279
distance
89.10926
seq distance
94
chain
D
In C7D; dbSNP:rs369349760.
original residue
R
variation residue
Q
position
220
score
100.0
distance
90.91123
seq distance
303
chain
D
In C7D; dbSNP:rs369349760.
original residue
R
variation residue
Q
position
220
score
100.0
distance
90.91123
seq distance
303
chain
D
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
31
score
50.0
distance
92.127594
seq distance
False
chain
F
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
31
score
50.0
distance
92.127594
seq distance
False
chain
F
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
95.03203
seq distance
False
chain
V
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
95.03203
seq distance
False
chain
V
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
97.1008
seq distance
False
chain
W
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
97.1008
seq distance
False
chain
W
Confirmed at protein level; dbSNP:rs13157656.
original residue
T
variation residue
P
position
714
score
50.0
distance
97.1146
seq distance
False
chain
B
Confirmed at protein level; dbSNP:rs13157656.
original residue
T
variation residue
P
position
714
score
50.0
distance
97.1146
seq distance
False
chain
B
In dbSNP:rs75345202.
original residue
R
variation residue
H
position
222
score
100.0
distance
97.12958
seq distance
301
chain
D
In dbSNP:rs75345202.
original residue
R
variation residue
H
position
222
score
100.0
distance
97.12958
seq distance
301
chain
D
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
98.97335
seq distance
False
chain
V
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
98.97335
seq distance
False
chain
V
In C7D; dbSNP:rs541873000.
original residue
E
variation residue
Q
position
682
score
100.0
distance
100.79375
seq distance
147
chain
D
In C7D; dbSNP:rs541873000.
original residue
E
variation residue
Q
position
682
score
100.0
distance
100.79375
seq distance
147
chain
D
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
104.16421
seq distance
False
chain
P
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
104.16421
seq distance
False
chain
P
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
104.88377
seq distance
False
chain
V
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
104.88377
seq distance
False
chain
V
In C7D; dbSNP:rs113187203.
original residue
R
variation residue
H
position
687
score
100.0
distance
109.22068
seq distance
152
chain
D
In C7D; dbSNP:rs113187203.
original residue
R
variation residue
H
position
687
score
100.0
distance
109.22068
seq distance
152
chain
D
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
109.70282
seq distance
False
chain
V
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
109.70282
seq distance
False
chain
V
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
110.28416
seq distance
False
chain
G
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
110.28416
seq distance
False
chain
G
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
117.64037
seq distance
False
chain
G
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
117.64037
seq distance
False
chain
G
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
119.45797
seq distance
False
chain
G
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
119.45797
seq distance
False
chain
G
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
121.70907
seq distance
False
chain
U
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
121.70907
seq distance
False
chain
U
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
124.01887
seq distance
False
chain
H
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
124.01887
seq distance
False
chain
H
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
124.04295
seq distance
False
chain
U
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
124.04295
seq distance
False
chain
U
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
124.45952
seq distance
False
chain
U
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
124.45952
seq distance
False
chain
U
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
126.01198
seq distance
False
chain
U
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
126.01198
seq distance
False
chain
U
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
132.03253
seq distance
False
chain
P
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
132.03253
seq distance
False
chain
P
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
132.05185
seq distance
False
chain
P
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
132.05185
seq distance
False
chain
P
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
139.05504
seq distance
False
chain
T
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
139.05504
seq distance
False
chain
T
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
141.68408
seq distance
False
chain
I
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
141.68408
seq distance
False
chain
I
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
141.68977
seq distance
False
chain
P
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
141.68977
seq distance
False
chain
P
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
144.54587
seq distance
False
chain
T
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
144.54587
seq distance
False
chain
T
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
145.98341
seq distance
False
chain
H
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
145.98341
seq distance
False
chain
H
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
146.15155
seq distance
False
chain
T
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
146.15155
seq distance
False
chain
T
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
146.70314
seq distance
False
chain
T
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
146.70314
seq distance
False
chain
T
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
151.97101
seq distance
False
chain
H
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
151.97101
seq distance
False
chain
H
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
152.14659
seq distance
False
chain
S
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
152.14659
seq distance
False
chain
S
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
156.89856
seq distance
False
chain
J
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
156.89856
seq distance
False
chain
J
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
158.16371
seq distance
False
chain
I
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
158.16371
seq distance
False
chain
I
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
159.97664
seq distance
False
chain
S
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
159.97664
seq distance
False
chain
S
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
161.93584
seq distance
False
chain
H
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
161.93584
seq distance
False
chain
H
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
163.5048
seq distance
False
chain
R
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
163.5048
seq distance
False
chain
R
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
166.17784
seq distance
False
chain
S
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
166.17784
seq distance
False
chain
S
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
167.40686
seq distance
False
chain
S
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
167.40686
seq distance
False
chain
S
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
168.0235
seq distance
False
chain
J
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
168.0235
seq distance
False
chain
J
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
169.29555
seq distance
False
chain
K
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
169.29555
seq distance
False
chain
K
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
169.38437
seq distance
False
chain
I
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
169.38437
seq distance
False
chain
I
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
172.11131
seq distance
False
chain
R
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
172.11131
seq distance
False
chain
R
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
172.69205
seq distance
False
chain
Q
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
172.69205
seq distance
False
chain
Q
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
175.39357
seq distance
False
chain
K
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
175.39357
seq distance
False
chain
K
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
178.61246
seq distance
False
chain
L
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
178.61246
seq distance
False
chain
L
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
178.68083
seq distance
False
chain
O
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
178.68083
seq distance
False
chain
O
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
179.44481
seq distance
False
chain
I
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
179.44481
seq distance
False
chain
I
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
180.43051
seq distance
False
chain
L
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
180.43051
seq distance
False
chain
L
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
180.787
seq distance
False
chain
Q
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
180.787
seq distance
False
chain
Q
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
182.1845
seq distance
False
chain
R
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
182.1845
seq distance
False
chain
R
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
182.51248
seq distance
False
chain
N
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
182.51248
seq distance
False
chain
N
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
182.68854
seq distance
False
chain
M
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
182.68854
seq distance
False
chain
M
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
183.92274
seq distance
False
chain
J
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
183.92274
seq distance
False
chain
J
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
184.57286
seq distance
False
chain
M
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
184.57286
seq distance
False
chain
M
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
185.10785
seq distance
False
chain
R
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
185.10785
seq distance
False
chain
R
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
185.76346
seq distance
False
chain
O
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
185.76346
seq distance
False
chain
O
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
186.98634
seq distance
False
chain
N
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
186.98634
seq distance
False
chain
N
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
193.91266
seq distance
False
chain
J
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
193.91266
seq distance
False
chain
J
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
194.43164
seq distance
False
chain
Q
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
194.43164
seq distance
False
chain
Q
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
195.21259
seq distance
False
chain
K
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
195.21259
seq distance
False
chain
K
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
199.01056
seq distance
False
chain
Q
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
199.01056
seq distance
False
chain
Q
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
202.68799
seq distance
False
chain
O
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
202.68799
seq distance
False
chain
O
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
202.97496
seq distance
False
chain
L
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
202.97496
seq distance
False
chain
L
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
204.92958
seq distance
False
chain
K
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
204.92958
seq distance
False
chain
K
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
206.78386
seq distance
False
chain
N
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
206.78386
seq distance
False
chain
N
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
206.87149
seq distance
False
chain
M
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
206.87149
seq distance
False
chain
M
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
208.79678
seq distance
False
chain
O
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
208.79678
seq distance
False
chain
O
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
212.24228
seq distance
False
chain
L
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
212.24228
seq distance
False
chain
L
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
214.24893
seq distance
False
chain
N
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
214.24893
seq distance
False
chain
N
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
215.54308
seq distance
False
chain
M
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
215.54308
seq distance
False
chain
M

Details

Redox score
80.6
PDB code
6h04
Structure name
closed conformation of the membrane attack complex
Structure deposition date
2018-07-06
Thiol separation (Å)
4.8
Half-sphere exposure sum
49
Minimum pKa
9.14
% buried
4.5
Peptide accession
P10643
Residue number A
523
Residue number B
535
Peptide name
Complement component C7
A redox-regulated disulphide may form within Complement component C7 at these cysteines.

Relevent regions

Factor I module (FIM) 1
begin
695
end
770
score
99.46172248803828
distance
2.8040588
seq distance
0
chain
A
Factor I module (FIM) 1
begin
695
end
770
score
99.46172248803828
distance
2.8040588
seq distance
0
chain
A
In C7D; dbSNP:rs113187203.
original residue
R
variation residue
H
position
712
score
50.0
distance
4.9483523
seq distance
1
chain
A
In C7D; dbSNP:rs113187203.
original residue
R
variation residue
H
position
712
score
50.0
distance
4.9483523
seq distance
1
chain
A
Factor I module (FIM) 2
begin
771
end
843
score
100.0
distance
14.145845
seq distance
58
chain
A
Factor I module (FIM) 2
begin
771
end
843
score
100.0
distance
14.145845
seq distance
58
chain
A
LDL-receptor class A
begin
795
end
795
score
70.45454545454545
distance
25.312286
seq distance
82
chain
A
LDL-receptor class A
begin
795
end
795
score
70.45454545454545
distance
25.312286
seq distance
82
chain
A

Details

Redox score
77.81
PDB code
2wcy
Structure name
nmr solution structure of factor i-like modules of complement c7.
Structure deposition date
2009-03-17
Thiol separation (Å)
2.03
Half-sphere exposure sum
34
Minimum pKa
nan
% buried
nan
Peptide accession
P10643
Residue number A
702
Residue number B
713
Peptide name
Complement component C7
A redox-regulated disulphide may form within Complement component C7 at these cysteines.

Relevent regions

CCP 1
begin
545
end
615
score
83.48271446862996
distance
2.8087249
seq distance
0
chain
D
CCP 1
begin
545
end
615
score
83.48271446862996
distance
2.8087249
seq distance
0
chain
D
TSP type-1 2
begin
500
end
549
score
100.0
distance
2.8087249
seq distance
0
chain
D
TSP type-1 2
begin
500
end
549
score
100.0
distance
2.8087249
seq distance
0
chain
D
Disordered
begin
516
end
538
score
100.0
distance
5.4316173
seq distance
4
chain
D
Disordered
begin
516
end
538
score
100.0
distance
5.4316173
seq distance
4
chain
D
MACPF
begin
124
end
456
score
98.9079989079989
distance
12.781773
seq distance
56
chain
D
MACPF
begin
124
end
456
score
98.9079989079989
distance
12.781773
seq distance
56
chain
D
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
521
score
100.0
distance
17.290836
seq distance
9
chain
D
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
521
score
100.0
distance
17.290836
seq distance
9
chain
D
TSP type-1 1
begin
27
end
80
score
99.83164983164983
distance
19.24535
seq distance
432
chain
D
TSP type-1 1
begin
27
end
80
score
99.83164983164983
distance
19.24535
seq distance
432
chain
D
EGF-like
begin
457
end
487
score
100.0
distance
28.069197
seq distance
25
chain
D
EGF-like
begin
457
end
487
score
100.0
distance
28.069197
seq distance
25
chain
D
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
420
score
100.0
distance
29.622055
seq distance
92
chain
D
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
420
score
100.0
distance
29.622055
seq distance
92
chain
D
Disordered
begin
108
end
143
score
100.0
distance
30.289007
seq distance
369
chain
D
Disordered
begin
108
end
143
score
100.0
distance
30.289007
seq distance
369
chain
D
Sushi 1
begin
572
end
628
score
99.04306220095694
distance
30.73111
seq distance
27
chain
D
Sushi 1
begin
572
end
628
score
99.04306220095694
distance
30.73111
seq distance
27
chain
D
LDL-receptor class A
begin
83
end
121
score
100.0
distance
31.668531
seq distance
391
chain
D
LDL-receptor class A
begin
83
end
121
score
100.0
distance
31.668531
seq distance
391
chain
D
CCP 2
begin
616
end
691
score
99.2822966507177
distance
32.161724
seq distance
71
chain
D
CCP 2
begin
616
end
691
score
99.2822966507177
distance
32.161724
seq distance
71
chain
D
Disordered
begin
585
end
589
score
50.90909090909091
distance
38.1407
seq distance
False
chain
B
Disordered
begin
585
end
589
score
50.90909090909091
distance
38.1407
seq distance
False
chain
B
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
412
score
63.63636363636363
distance
38.506912
seq distance
False
chain
C
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
412
score
63.63636363636363
distance
38.506912
seq distance
False
chain
C
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
587
score
68.18181818181817
distance
38.695107
seq distance
False
chain
B
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
587
score
68.18181818181817
distance
38.695107
seq distance
False
chain
B
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
39.248695
seq distance
False
chain
X
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
39.248695
seq distance
False
chain
X
Disordered
begin
41
end
41
score
70.45454545454545
distance
39.560215
seq distance
False
chain
B
Disordered
begin
41
end
41
score
70.45454545454545
distance
39.560215
seq distance
False
chain
B
Confirmed at protein level; dbSNP:rs13157656.
original residue
T
variation residue
P
position
587
score
100.0
distance
41.46408
seq distance
42
chain
D
Confirmed at protein level; dbSNP:rs13157656.
original residue
T
variation residue
P
position
587
score
100.0
distance
41.46408
seq distance
42
chain
D
Disordered
begin
504
end
504
score
68.18181818181817
distance
42.07714
seq distance
False
chain
C
Disordered
begin
504
end
504
score
68.18181818181817
distance
42.07714
seq distance
False
chain
C
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
45.51374
seq distance
False
chain
X
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
45.51374
seq distance
False
chain
X
LDL-receptor class A
begin
84
end
92
score
56.56565656565656
distance
52.586304
seq distance
False
chain
C
LDL-receptor class A
begin
84
end
92
score
56.56565656565656
distance
52.586304
seq distance
False
chain
C
Confirmed at protein level; dbSNP:rs1063499.
original residue
S
variation residue
T
position
389
score
100.0
distance
53.381813
seq distance
123
chain
D
Confirmed at protein level; dbSNP:rs1063499.
original residue
S
variation residue
T
position
389
score
100.0
distance
53.381813
seq distance
123
chain
D
Disordered
begin
91
end
92
score
68.18181818181817
distance
54.809444
seq distance
False
chain
C
Disordered
begin
91
end
92
score
68.18181818181817
distance
54.809444
seq distance
False
chain
C
In dbSNP:rs2271708.
original residue
C
variation residue
R
position
128
score
100.0
distance
55.127594
seq distance
384
chain
D
In dbSNP:rs2271708.
original residue
C
variation residue
R
position
128
score
100.0
distance
55.127594
seq distance
384
chain
D
EGF-like
begin
451
end
455
score
54.090909090909086
distance
58.398228
seq distance
False
chain
C
EGF-like
begin
451
end
455
score
54.090909090909086
distance
58.398228
seq distance
False
chain
C
Confirmed at protein level; dbSNP:rs1063499.
original residue
S
variation residue
T
position
1058
score
54.54545454545454
distance
59.49125
seq distance
False
chain
A
Confirmed at protein level; dbSNP:rs1063499.
original residue
S
variation residue
T
position
1058
score
54.54545454545454
distance
59.49125
seq distance
False
chain
A
Sushi 2
begin
629
end
690
score
99.56011730205279
distance
65.06257
seq distance
84
chain
D
Sushi 2
begin
629
end
690
score
99.56011730205279
distance
65.06257
seq distance
84
chain
D
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
68.19607
seq distance
False
chain
X
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
68.19607
seq distance
False
chain
X
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
70.02187
seq distance
False
chain
W
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
70.02187
seq distance
False
chain
W
LDL-receptor class A
begin
83
end
98
score
52.69886363636363
distance
70.292366
seq distance
False
chain
F
LDL-receptor class A
begin
83
end
98
score
52.69886363636363
distance
70.292366
seq distance
False
chain
F
In dbSNP:rs75345202.
original residue
R
variation residue
H
position
414
score
54.54545454545454
distance
71.162834
seq distance
False
chain
F
In dbSNP:rs75345202.
original residue
R
variation residue
H
position
414
score
54.54545454545454
distance
71.162834
seq distance
False
chain
F
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
75.338715
seq distance
False
chain
W
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
75.338715
seq distance
False
chain
W
In C7D; dbSNP:rs541873000.
original residue
E
variation residue
Q
position
682
score
100.0
distance
77.470505
seq distance
137
chain
D
In C7D; dbSNP:rs541873000.
original residue
E
variation residue
Q
position
682
score
100.0
distance
77.470505
seq distance
137
chain
D
Disordered
begin
219
end
240
score
100.0
distance
78.85728
seq distance
272
chain
D
Disordered
begin
219
end
240
score
100.0
distance
78.85728
seq distance
272
chain
D
Disordered
begin
138
end
138
score
50.0
distance
82.595024
seq distance
False
chain
E
Disordered
begin
138
end
138
score
50.0
distance
82.595024
seq distance
False
chain
E
TSP type-1 2
begin
512
end
517
score
80.30303030303031
distance
85.2068
seq distance
False
chain
F
TSP type-1 2
begin
512
end
517
score
80.30303030303031
distance
85.2068
seq distance
False
chain
F
In C7D; dbSNP:rs113187203.
original residue
R
variation residue
H
position
687
score
100.0
distance
86.2333
seq distance
142
chain
D
In C7D; dbSNP:rs113187203.
original residue
R
variation residue
H
position
687
score
100.0
distance
86.2333
seq distance
142
chain
D
Confirmed at protein level; dbSNP:rs13157656.
original residue
T
variation residue
P
position
714
score
50.0
distance
86.89479
seq distance
False
chain
B
Confirmed at protein level; dbSNP:rs13157656.
original residue
T
variation residue
P
position
714
score
50.0
distance
86.89479
seq distance
False
chain
B
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
89.449234
seq distance
False
chain
G
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
89.449234
seq distance
False
chain
G
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
91.71804
seq distance
False
chain
W
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
91.71804
seq distance
False
chain
W
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
31
score
50.0
distance
95.74128
seq distance
False
chain
F
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
31
score
50.0
distance
95.74128
seq distance
False
chain
F
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
100.065796
seq distance
False
chain
V
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
100.065796
seq distance
False
chain
V
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
103.95127
seq distance
False
chain
V
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
103.95127
seq distance
False
chain
V
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
112.60799
seq distance
False
chain
P
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
112.60799
seq distance
False
chain
P
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
113.59734
seq distance
False
chain
G
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
113.59734
seq distance
False
chain
G
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
113.98687
seq distance
False
chain
X
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
113.98687
seq distance
False
chain
X
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
114.89816
seq distance
False
chain
V
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
114.89816
seq distance
False
chain
V
In C7D; dbSNP:rs369349760.
original residue
R
variation residue
Q
position
220
score
100.0
distance
115.7041
seq distance
292
chain
D
In C7D; dbSNP:rs369349760.
original residue
R
variation residue
Q
position
220
score
100.0
distance
115.7041
seq distance
292
chain
D
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
120.89465
seq distance
False
chain
W
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
120.89465
seq distance
False
chain
W
In dbSNP:rs75345202.
original residue
R
variation residue
H
position
222
score
100.0
distance
121.94279
seq distance
290
chain
D
In dbSNP:rs75345202.
original residue
R
variation residue
H
position
222
score
100.0
distance
121.94279
seq distance
290
chain
D
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
123.62128
seq distance
False
chain
G
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
123.62128
seq distance
False
chain
G
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
128.15471
seq distance
False
chain
U
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
128.15471
seq distance
False
chain
U
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
130.44449
seq distance
False
chain
U
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
130.44449
seq distance
False
chain
U
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
131.91356
seq distance
False
chain
V
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
131.91356
seq distance
False
chain
V
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
134.12553
seq distance
False
chain
H
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
134.12553
seq distance
False
chain
H
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
136.53456
seq distance
False
chain
U
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
136.53456
seq distance
False
chain
U
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
137.97028
seq distance
False
chain
G
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
137.97028
seq distance
False
chain
G
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
138.13892
seq distance
False
chain
P
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
138.13892
seq distance
False
chain
P
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
145.33492
seq distance
False
chain
U
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
145.33492
seq distance
False
chain
U
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
148.60239
seq distance
False
chain
P
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
148.60239
seq distance
False
chain
P
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
152.3859
seq distance
False
chain
P
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
152.3859
seq distance
False
chain
P
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
153.07625
seq distance
False
chain
I
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
153.07625
seq distance
False
chain
I
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
154.04749
seq distance
False
chain
T
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
154.04749
seq distance
False
chain
T
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
154.5149
seq distance
False
chain
T
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
154.5149
seq distance
False
chain
T
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
155.7736
seq distance
False
chain
T
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
155.7736
seq distance
False
chain
T
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
159.08394
seq distance
False
chain
T
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
159.08394
seq distance
False
chain
T
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
160.32413
seq distance
False
chain
H
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
160.32413
seq distance
False
chain
H
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
166.42618
seq distance
False
chain
H
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
166.42618
seq distance
False
chain
H
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
169.24643
seq distance
False
chain
J
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
169.24643
seq distance
False
chain
J
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
171.10115
seq distance
False
chain
H
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
171.10115
seq distance
False
chain
H
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
171.9466
seq distance
False
chain
S
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
171.9466
seq distance
False
chain
S
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
171.98615
seq distance
False
chain
S
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
171.98615
seq distance
False
chain
S
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
175.28073
seq distance
False
chain
S
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
175.28073
seq distance
False
chain
S
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
176.66359
seq distance
False
chain
S
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
176.66359
seq distance
False
chain
S
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
178.72331
seq distance
False
chain
I
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
178.72331
seq distance
False
chain
I
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
179.39363
seq distance
False
chain
I
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
179.39363
seq distance
False
chain
I
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
182.36772
seq distance
False
chain
K
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
182.36772
seq distance
False
chain
K
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
183.3767
seq distance
False
chain
R
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
183.3767
seq distance
False
chain
R
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
184.76216
seq distance
False
chain
R
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
184.76216
seq distance
False
chain
R
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
188.7041
seq distance
False
chain
J
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
188.7041
seq distance
False
chain
J
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
190.24025
seq distance
False
chain
I
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
190.24025
seq distance
False
chain
I
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
192.16182
seq distance
False
chain
L
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
192.16182
seq distance
False
chain
L
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
192.43011
seq distance
False
chain
R
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
192.43011
seq distance
False
chain
R
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
192.7128
seq distance
False
chain
Q
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
192.7128
seq distance
False
chain
Q
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
193.99391
seq distance
False
chain
Q
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
193.99391
seq distance
False
chain
Q
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
195.07396
seq distance
False
chain
J
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
195.07396
seq distance
False
chain
J
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
195.60182
seq distance
False
chain
R
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
195.60182
seq distance
False
chain
R
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
196.34119
seq distance
False
chain
K
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
196.34119
seq distance
False
chain
K
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
198.36186
seq distance
False
chain
M
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
198.36186
seq distance
False
chain
M
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
199.1449
seq distance
False
chain
O
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
199.1449
seq distance
False
chain
O
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
199.36702
seq distance
False
chain
O
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
199.36702
seq distance
False
chain
O
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
200.79306
seq distance
False
chain
N
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
200.79306
seq distance
False
chain
N
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
201.34206
seq distance
False
chain
L
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
201.34206
seq distance
False
chain
L
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
202.99014
seq distance
False
chain
N
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
202.99014
seq distance
False
chain
N
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
203.50319
seq distance
False
chain
M
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
203.50319
seq distance
False
chain
M
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
205.61215
seq distance
False
chain
Q
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
205.61215
seq distance
False
chain
Q
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
205.80383
seq distance
False
chain
J
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
205.80383
seq distance
False
chain
J
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
207.14365
seq distance
False
chain
K
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
207.14365
seq distance
False
chain
K
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
210.53906
seq distance
False
chain
Q
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
210.53906
seq distance
False
chain
Q
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
214.5742
seq distance
False
chain
O
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
214.5742
seq distance
False
chain
O
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
215.35469
seq distance
False
chain
L
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
215.35469
seq distance
False
chain
L
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
217.54904
seq distance
False
chain
K
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
217.54904
seq distance
False
chain
K
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
219.12677
seq distance
False
chain
N
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
219.12677
seq distance
False
chain
N
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
219.37834
seq distance
False
chain
M
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
219.37834
seq distance
False
chain
M
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
221.13885
seq distance
False
chain
O
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
221.13885
seq distance
False
chain
O
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
225.24309
seq distance
False
chain
L
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
225.24309
seq distance
False
chain
L
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
227.1588
seq distance
False
chain
N
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
227.1588
seq distance
False
chain
N
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
228.62042
seq distance
False
chain
M
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
228.62042
seq distance
False
chain
M

Details

Redox score
77.21
PDB code
6h04
Structure name
closed conformation of the membrane attack complex
Structure deposition date
2018-07-06
Thiol separation (Å)
2.03
Half-sphere exposure sum
38
Minimum pKa
nan
% buried
nan
Peptide accession
P10643
Residue number A
512
Residue number B
545
Peptide name
Complement component C7
A redox-regulated disulphide may form within Complement component C7 at these cysteines.

Relevent regions

Factor I module (FIM) 2
begin
771
end
843
score
100.0
distance
2.840693
seq distance
0
chain
A
Factor I module (FIM) 2
begin
771
end
843
score
100.0
distance
2.840693
seq distance
0
chain
A
Factor I module (FIM) 1
begin
695
end
770
score
99.46172248803828
distance
7.1713576
seq distance
6
chain
A
Factor I module (FIM) 1
begin
695
end
770
score
99.46172248803828
distance
7.1713576
seq distance
6
chain
A
LDL-receptor class A
begin
795
end
795
score
70.45454545454545
distance
15.969687
seq distance
6
chain
A
LDL-receptor class A
begin
795
end
795
score
70.45454545454545
distance
15.969687
seq distance
6
chain
A
In C7D; dbSNP:rs113187203.
original residue
R
variation residue
H
position
712
score
50.0
distance
36.41227
seq distance
64
chain
A
In C7D; dbSNP:rs113187203.
original residue
R
variation residue
H
position
712
score
50.0
distance
36.41227
seq distance
64
chain
A

Details

Redox score
77.12
PDB code
2wcy
Structure name
nmr solution structure of factor i-like modules of complement c7.
Structure deposition date
2009-03-17
Thiol separation (Å)
2.03
Half-sphere exposure sum
54
Minimum pKa
nan
% buried
nan
Peptide accession
P10643
Residue number A
776
Residue number B
789
Peptide name
Complement component C7
A redox-regulated disulphide may form within Complement component C7 at these cysteines.

Relevent regions

Factor I module (FIM) 2
begin
771
end
843
score
100.0
distance
2.8496232
seq distance
0
chain
A
Factor I module (FIM) 2
begin
771
end
843
score
100.0
distance
2.8496232
seq distance
0
chain
A
Factor I module (FIM) 1
begin
695
end
770
score
99.46172248803828
distance
12.897362
seq distance
3
chain
A
Factor I module (FIM) 1
begin
695
end
770
score
99.46172248803828
distance
12.897362
seq distance
3
chain
A
LDL-receptor class A
begin
795
end
795
score
70.45454545454545
distance
19.274956
seq distance
13
chain
A
LDL-receptor class A
begin
795
end
795
score
70.45454545454545
distance
19.274956
seq distance
13
chain
A
In C7D; dbSNP:rs113187203.
original residue
R
variation residue
H
position
712
score
50.0
distance
40.781
seq distance
61
chain
A
In C7D; dbSNP:rs113187203.
original residue
R
variation residue
H
position
712
score
50.0
distance
40.781
seq distance
61
chain
A

Details

Redox score
77.01
PDB code
2wcy
Structure name
nmr solution structure of factor i-like modules of complement c7.
Structure deposition date
2009-03-17
Thiol separation (Å)
2.03
Half-sphere exposure sum
41
Minimum pKa
nan
% buried
nan
Peptide accession
P10643
Residue number A
773
Residue number B
782
Peptide name
Complement component C7
A redox-regulated disulphide may form within Complement component C7 at these cysteines.

Relevent regions

TSP type-1 1
begin
27
end
80
score
99.83164983164983
distance
2.8261752
seq distance
0
chain
D
TSP type-1 1
begin
27
end
80
score
99.83164983164983
distance
2.8261752
seq distance
0
chain
D
EGF-like
begin
457
end
487
score
100.0
distance
5.1214547
seq distance
394
chain
D
EGF-like
begin
457
end
487
score
100.0
distance
5.1214547
seq distance
394
chain
D
MACPF
begin
124
end
456
score
98.9079989079989
distance
11.949362
seq distance
61
chain
D
MACPF
begin
124
end
456
score
98.9079989079989
distance
11.949362
seq distance
61
chain
D
TSP type-1 2
begin
500
end
549
score
100.0
distance
18.475632
seq distance
437
chain
D
TSP type-1 2
begin
500
end
549
score
100.0
distance
18.475632
seq distance
437
chain
D
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
412
score
63.63636363636363
distance
18.636015
seq distance
False
chain
C
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
412
score
63.63636363636363
distance
18.636015
seq distance
False
chain
C
Disordered
begin
504
end
504
score
68.18181818181817
distance
19.865536
seq distance
False
chain
C
Disordered
begin
504
end
504
score
68.18181818181817
distance
19.865536
seq distance
False
chain
C
Disordered
begin
516
end
538
score
100.0
distance
21.777836
seq distance
453
chain
D
Disordered
begin
516
end
538
score
100.0
distance
21.777836
seq distance
453
chain
D
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
521
score
100.0
distance
25.36659
seq distance
458
chain
D
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
521
score
100.0
distance
25.36659
seq distance
458
chain
D
Disordered
begin
108
end
143
score
100.0
distance
27.50232
seq distance
45
chain
D
Disordered
begin
108
end
143
score
100.0
distance
27.50232
seq distance
45
chain
D
EGF-like
begin
451
end
455
score
54.090909090909086
distance
27.871424
seq distance
False
chain
C
EGF-like
begin
451
end
455
score
54.090909090909086
distance
27.871424
seq distance
False
chain
C
CCP 1
begin
545
end
615
score
83.48271446862996
distance
32.503468
seq distance
482
chain
D
CCP 1
begin
545
end
615
score
83.48271446862996
distance
32.503468
seq distance
482
chain
D
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
420
score
100.0
distance
33.429016
seq distance
357
chain
D
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
420
score
100.0
distance
33.429016
seq distance
357
chain
D
Confirmed at protein level; dbSNP:rs1063499.
original residue
S
variation residue
T
position
389
score
100.0
distance
37.608746
seq distance
326
chain
D
Confirmed at protein level; dbSNP:rs1063499.
original residue
S
variation residue
T
position
389
score
100.0
distance
37.608746
seq distance
326
chain
D
LDL-receptor class A
begin
83
end
121
score
100.0
distance
37.897686
seq distance
20
chain
D
LDL-receptor class A
begin
83
end
121
score
100.0
distance
37.897686
seq distance
20
chain
D
Disordered
begin
41
end
41
score
70.45454545454545
distance
42.799393
seq distance
False
chain
B
Disordered
begin
41
end
41
score
70.45454545454545
distance
42.799393
seq distance
False
chain
B
Disordered
begin
91
end
92
score
68.18181818181817
distance
44.86323
seq distance
False
chain
C
Disordered
begin
91
end
92
score
68.18181818181817
distance
44.86323
seq distance
False
chain
C
LDL-receptor class A
begin
84
end
92
score
56.56565656565656
distance
44.86323
seq distance
False
chain
C
LDL-receptor class A
begin
84
end
92
score
56.56565656565656
distance
44.86323
seq distance
False
chain
C
In dbSNP:rs75345202.
original residue
R
variation residue
H
position
414
score
54.54545454545454
distance
50.992493
seq distance
False
chain
F
In dbSNP:rs75345202.
original residue
R
variation residue
H
position
414
score
54.54545454545454
distance
50.992493
seq distance
False
chain
F
Sushi 1
begin
572
end
628
score
99.04306220095694
distance
54.535686
seq distance
509
chain
D
Sushi 1
begin
572
end
628
score
99.04306220095694
distance
54.535686
seq distance
509
chain
D
TSP type-1 2
begin
512
end
517
score
80.30303030303031
distance
54.63308
seq distance
False
chain
F
TSP type-1 2
begin
512
end
517
score
80.30303030303031
distance
54.63308
seq distance
False
chain
F
LDL-receptor class A
begin
83
end
98
score
52.69886363636363
distance
54.74373
seq distance
False
chain
F
LDL-receptor class A
begin
83
end
98
score
52.69886363636363
distance
54.74373
seq distance
False
chain
F
In dbSNP:rs2271708.
original residue
C
variation residue
R
position
128
score
100.0
distance
57.267902
seq distance
65
chain
D
In dbSNP:rs2271708.
original residue
C
variation residue
R
position
128
score
100.0
distance
57.267902
seq distance
65
chain
D
CCP 2
begin
616
end
691
score
99.2822966507177
distance
57.721092
seq distance
553
chain
D
CCP 2
begin
616
end
691
score
99.2822966507177
distance
57.721092
seq distance
553
chain
D
Disordered
begin
585
end
589
score
50.90909090909091
distance
59.1338
seq distance
False
chain
B
Disordered
begin
585
end
589
score
50.90909090909091
distance
59.1338
seq distance
False
chain
B
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
587
score
68.18181818181817
distance
59.229168
seq distance
False
chain
B
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
587
score
68.18181818181817
distance
59.229168
seq distance
False
chain
B
Disordered
begin
219
end
240
score
100.0
distance
59.830704
seq distance
156
chain
D
Disordered
begin
219
end
240
score
100.0
distance
59.830704
seq distance
156
chain
D
Confirmed at protein level; dbSNP:rs13157656.
original residue
T
variation residue
P
position
587
score
100.0
distance
59.87878
seq distance
524
chain
D
Confirmed at protein level; dbSNP:rs13157656.
original residue
T
variation residue
P
position
587
score
100.0
distance
59.87878
seq distance
524
chain
D
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
61.3376
seq distance
False
chain
X
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
61.3376
seq distance
False
chain
X
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
63.317852
seq distance
False
chain
G
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
63.317852
seq distance
False
chain
G
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
31
score
50.0
distance
68.34122
seq distance
False
chain
F
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
31
score
50.0
distance
68.34122
seq distance
False
chain
F
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
68.42226
seq distance
False
chain
X
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
68.42226
seq distance
False
chain
X
Disordered
begin
138
end
138
score
50.0
distance
78.42548
seq distance
False
chain
E
Disordered
begin
138
end
138
score
50.0
distance
78.42548
seq distance
False
chain
E
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
82.80049
seq distance
False
chain
X
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
82.80049
seq distance
False
chain
X
Sushi 2
begin
629
end
690
score
99.56011730205279
distance
86.98782
seq distance
566
chain
D
Sushi 2
begin
629
end
690
score
99.56011730205279
distance
86.98782
seq distance
566
chain
D
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
87.0006
seq distance
False
chain
P
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
87.0006
seq distance
False
chain
P
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
88.55301
seq distance
False
chain
G
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
88.55301
seq distance
False
chain
G
Confirmed at protein level; dbSNP:rs1063499.
original residue
S
variation residue
T
position
1058
score
54.54545454545454
distance
88.86468
seq distance
False
chain
A
Confirmed at protein level; dbSNP:rs1063499.
original residue
S
variation residue
T
position
1058
score
54.54545454545454
distance
88.86468
seq distance
False
chain
A
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
92.63183
seq distance
False
chain
W
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
92.63183
seq distance
False
chain
W
In C7D; dbSNP:rs369349760.
original residue
R
variation residue
Q
position
220
score
100.0
distance
95.17619
seq distance
157
chain
D
In C7D; dbSNP:rs369349760.
original residue
R
variation residue
Q
position
220
score
100.0
distance
95.17619
seq distance
157
chain
D
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
97.3453
seq distance
False
chain
G
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
97.3453
seq distance
False
chain
G
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
97.38652
seq distance
False
chain
W
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
97.38652
seq distance
False
chain
W
In dbSNP:rs75345202.
original residue
R
variation residue
H
position
222
score
100.0
distance
101.175125
seq distance
159
chain
D
In dbSNP:rs75345202.
original residue
R
variation residue
H
position
222
score
100.0
distance
101.175125
seq distance
159
chain
D
In C7D; dbSNP:rs541873000.
original residue
E
variation residue
Q
position
682
score
100.0
distance
102.08545
seq distance
619
chain
D
In C7D; dbSNP:rs541873000.
original residue
E
variation residue
Q
position
682
score
100.0
distance
102.08545
seq distance
619
chain
D
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
104.58938
seq distance
False
chain
X
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
104.58938
seq distance
False
chain
X
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
106.687256
seq distance
False
chain
W
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
106.687256
seq distance
False
chain
W
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
109.609665
seq distance
False
chain
H
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
109.609665
seq distance
False
chain
H
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
110.32938
seq distance
False
chain
G
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
110.32938
seq distance
False
chain
G
In C7D; dbSNP:rs113187203.
original residue
R
variation residue
H
position
687
score
100.0
distance
111.90678
seq distance
624
chain
D
In C7D; dbSNP:rs113187203.
original residue
R
variation residue
H
position
687
score
100.0
distance
111.90678
seq distance
624
chain
D
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
113.33857
seq distance
False
chain
P
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
113.33857
seq distance
False
chain
P
Confirmed at protein level; dbSNP:rs13157656.
original residue
T
variation residue
P
position
714
score
50.0
distance
114.08078
seq distance
False
chain
B
Confirmed at protein level; dbSNP:rs13157656.
original residue
T
variation residue
P
position
714
score
50.0
distance
114.08078
seq distance
False
chain
B
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
116.586464
seq distance
False
chain
W
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
116.586464
seq distance
False
chain
W
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
121.17015
seq distance
False
chain
V
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
121.17015
seq distance
False
chain
V
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
122.83261
seq distance
False
chain
P
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
122.83261
seq distance
False
chain
P
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
124.02459
seq distance
False
chain
V
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
124.02459
seq distance
False
chain
V
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
125.88258
seq distance
False
chain
P
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
125.88258
seq distance
False
chain
P
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
128.63222
seq distance
False
chain
V
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
128.63222
seq distance
False
chain
V
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
130.2893
seq distance
False
chain
I
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
130.2893
seq distance
False
chain
I
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
130.83853
seq distance
False
chain
V
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
130.83853
seq distance
False
chain
V
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
136.61089
seq distance
False
chain
H
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
136.61089
seq distance
False
chain
H
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
141.67392
seq distance
False
chain
H
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
141.67392
seq distance
False
chain
H
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
145.77441
seq distance
False
chain
U
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
145.77441
seq distance
False
chain
U
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
146.64407
seq distance
False
chain
H
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
146.64407
seq distance
False
chain
H
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
146.8301
seq distance
False
chain
U
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
146.8301
seq distance
False
chain
U
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
147.86964
seq distance
False
chain
U
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
147.86964
seq distance
False
chain
U
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
148.14447
seq distance
False
chain
U
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
148.14447
seq distance
False
chain
U
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
148.70766
seq distance
False
chain
J
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
148.70766
seq distance
False
chain
J
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
156.18039
seq distance
False
chain
I
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
156.18039
seq distance
False
chain
I
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
157.58907
seq distance
False
chain
I
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
157.58907
seq distance
False
chain
I
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
159.80615
seq distance
False
chain
T
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
159.80615
seq distance
False
chain
T
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
164.46844
seq distance
False
chain
K
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
164.46844
seq distance
False
chain
K
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
164.65562
seq distance
False
chain
T
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
164.65562
seq distance
False
chain
T
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
167.9113
seq distance
False
chain
I
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
167.9113
seq distance
False
chain
I
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
168.60219
seq distance
False
chain
J
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
168.60219
seq distance
False
chain
J
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
168.76427
seq distance
False
chain
T
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
168.76427
seq distance
False
chain
T
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
169.63754
seq distance
False
chain
T
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
169.63754
seq distance
False
chain
T
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
171.95328
seq distance
False
chain
S
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
171.95328
seq distance
False
chain
S
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
175.8556
seq distance
False
chain
J
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
175.8556
seq distance
False
chain
J
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
177.2309
seq distance
False
chain
L
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
177.2309
seq distance
False
chain
L
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
177.71199
seq distance
False
chain
S
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
177.71199
seq distance
False
chain
S
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
178.96846
seq distance
False
chain
K
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
178.96846
seq distance
False
chain
K
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
181.79298
seq distance
False
chain
R
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
181.79298
seq distance
False
chain
R
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
185.9938
seq distance
False
chain
S
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
185.9938
seq distance
False
chain
S
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
186.28857
seq distance
False
chain
J
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
186.28857
seq distance
False
chain
J
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
186.65862
seq distance
False
chain
M
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
186.65862
seq distance
False
chain
M
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
186.72963
seq distance
False
chain
L
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
186.72963
seq distance
False
chain
L
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
187.14423
seq distance
False
chain
R
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
187.14423
seq distance
False
chain
R
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
188.72491
seq distance
False
chain
S
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
188.72491
seq distance
False
chain
S
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
189.02518
seq distance
False
chain
Q
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
189.02518
seq distance
False
chain
Q
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
190.97754
seq distance
False
chain
K
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
190.97754
seq distance
False
chain
K
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
191.67212
seq distance
False
chain
M
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
191.67212
seq distance
False
chain
M
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
192.51268
seq distance
False
chain
N
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
192.51268
seq distance
False
chain
N
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
192.74509
seq distance
False
chain
O
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
192.74509
seq distance
False
chain
O
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
192.84335
seq distance
False
chain
Q
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
192.84335
seq distance
False
chain
Q
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
194.07178
seq distance
False
chain
N
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
194.07178
seq distance
False
chain
N
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
194.63718
seq distance
False
chain
O
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
194.63718
seq distance
False
chain
O
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
199.32782
seq distance
False
chain
R
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
199.32782
seq distance
False
chain
R
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
201.32274
seq distance
False
chain
K
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
201.32274
seq distance
False
chain
K
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
202.5997
seq distance
False
chain
L
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
202.5997
seq distance
False
chain
L
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
203.7933
seq distance
False
chain
R
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
203.7933
seq distance
False
chain
R
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
208.53004
seq distance
False
chain
Q
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
208.53004
seq distance
False
chain
Q
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
210.32785
seq distance
False
chain
M
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
210.32785
seq distance
False
chain
M
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
212.64264
seq distance
False
chain
L
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
212.64264
seq distance
False
chain
L
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
213.45415
seq distance
False
chain
O
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
213.45415
seq distance
False
chain
O
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
213.98018
seq distance
False
chain
N
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
213.98018
seq distance
False
chain
N
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
214.6514
seq distance
False
chain
Q
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
214.6514
seq distance
False
chain
Q
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
219.90518
seq distance
False
chain
M
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
219.90518
seq distance
False
chain
M
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
221.07013
seq distance
False
chain
O
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
221.07013
seq distance
False
chain
O
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
222.88724
seq distance
False
chain
N
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
222.88724
seq distance
False
chain
N

Details

Redox score
77.01
PDB code
6h04
Structure name
closed conformation of the membrane attack complex
Structure deposition date
2018-07-06
Thiol separation (Å)
2.03
Half-sphere exposure sum
60
Minimum pKa
nan
% buried
nan
Peptide accession
P10643
Residue number A
28
Residue number B
63
Peptide name
Complement component C7
A redox-regulated disulphide may form within Complement component C7 at these cysteines.

Relevent regions

Factor I module (FIM) 1
begin
695
end
770
score
99.46172248803828
distance
2.789243
seq distance
0
chain
A
Factor I module (FIM) 1
begin
695
end
770
score
99.46172248803828
distance
2.789243
seq distance
0
chain
A
Factor I module (FIM) 2
begin
771
end
843
score
100.0
distance
8.107202
seq distance
28
chain
A
Factor I module (FIM) 2
begin
771
end
843
score
100.0
distance
8.107202
seq distance
28
chain
A
In C7D; dbSNP:rs113187203.
original residue
R
variation residue
H
position
712
score
50.0
distance
17.56117
seq distance
9
chain
A
In C7D; dbSNP:rs113187203.
original residue
R
variation residue
H
position
712
score
50.0
distance
17.56117
seq distance
9
chain
A
LDL-receptor class A
begin
795
end
795
score
70.45454545454545
distance
21.0101
seq distance
52
chain
A
LDL-receptor class A
begin
795
end
795
score
70.45454545454545
distance
21.0101
seq distance
52
chain
A

Details

Redox score
76.92
PDB code
2wcy
Structure name
nmr solution structure of factor i-like modules of complement c7.
Structure deposition date
2009-03-17
Thiol separation (Å)
2.03
Half-sphere exposure sum
64
Minimum pKa
nan
% buried
nan
Peptide accession
P10643
Residue number A
721
Residue number B
743
Peptide name
Complement component C7
A redox-regulated disulphide may form within Complement component C7 at these cysteines.

Relevent regions

CCP 2
begin
594
end
671
score
100.0
distance
2.8213007
seq distance
0
chain
C
CCP 2
begin
594
end
671
score
100.0
distance
2.8213007
seq distance
0
chain
C
Sushi 2
begin
607
end
668
score
100.0
distance
2.8213007
seq distance
0
chain
C
Sushi 2
begin
607
end
668
score
100.0
distance
2.8213007
seq distance
0
chain
C
In C7D; dbSNP:rs113187203.
original residue
R
variation residue
H
position
665
score
100.0
distance
6.34132
seq distance
1
chain
C
In C7D; dbSNP:rs113187203.
original residue
R
variation residue
H
position
665
score
100.0
distance
6.34132
seq distance
1
chain
C
In C7D; dbSNP:rs541873000.
original residue
E
variation residue
Q
position
660
score
100.0
distance
16.144056
seq distance
6
chain
C
In C7D; dbSNP:rs541873000.
original residue
E
variation residue
Q
position
660
score
100.0
distance
16.144056
seq distance
6
chain
C
Factor I module (FIM) 1
begin
673
end
748
score
100.0
distance
22.615614
seq distance
7
chain
C
Factor I module (FIM) 1
begin
673
end
748
score
100.0
distance
22.615614
seq distance
7
chain
C
Sushi 1
begin
547
end
606
score
100.0
distance
29.655682
seq distance
31
chain
C
Sushi 1
begin
547
end
606
score
100.0
distance
29.655682
seq distance
31
chain
C
CCP 1
begin
523
end
593
score
100.0
distance
32.881084
seq distance
44
chain
C
CCP 1
begin
523
end
593
score
100.0
distance
32.881084
seq distance
44
chain
C
Factor I module (FIM) 2
begin
749
end
821
score
100.0
distance
45.813137
seq distance
83
chain
C
Factor I module (FIM) 2
begin
749
end
821
score
100.0
distance
45.813137
seq distance
83
chain
C
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
1560
score
50.0
distance
53.141594
seq distance
False
chain
A
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
1560
score
50.0
distance
53.141594
seq distance
False
chain
A
Confirmed at protein level; dbSNP:rs13157656.
original residue
T
variation residue
P
position
565
score
100.0
distance
58.964268
seq distance
72
chain
C
Confirmed at protein level; dbSNP:rs13157656.
original residue
T
variation residue
P
position
565
score
100.0
distance
58.964268
seq distance
72
chain
C
LDL-receptor class A
begin
61
end
99
score
100.0
distance
78.311424
seq distance
538
chain
C
LDL-receptor class A
begin
61
end
99
score
100.0
distance
78.311424
seq distance
538
chain
C
TSP type-1 2
begin
478
end
527
score
100.0
distance
79.5248
seq distance
110
chain
C
TSP type-1 2
begin
478
end
527
score
100.0
distance
79.5248
seq distance
110
chain
C
TSP type-1 1
begin
5
end
58
score
99.83164983164983
distance
80.5043
seq distance
579
chain
C
TSP type-1 1
begin
5
end
58
score
99.83164983164983
distance
80.5043
seq distance
579
chain
C
Confirmed at protein level; dbSNP:rs1063499.
original residue
S
variation residue
T
position
1040
score
54.54545454545454
distance
81.489365
seq distance
False
chain
A
Confirmed at protein level; dbSNP:rs1063499.
original residue
S
variation residue
T
position
1040
score
54.54545454545454
distance
81.489365
seq distance
False
chain
A
MACPF
begin
102
end
434
score
94.85394485394487
distance
81.76623
seq distance
203
chain
C
MACPF
begin
102
end
434
score
94.85394485394487
distance
81.76623
seq distance
203
chain
C
Confirmed at protein level; dbSNP:rs13157656.
original residue
T
variation residue
P
position
693
score
50.0
distance
83.63925
seq distance
False
chain
B
Confirmed at protein level; dbSNP:rs13157656.
original residue
T
variation residue
P
position
693
score
50.0
distance
83.63925
seq distance
False
chain
B
Disordered
begin
494
end
516
score
100.0
distance
87.875916
seq distance
121
chain
C
Disordered
begin
494
end
516
score
100.0
distance
87.875916
seq distance
121
chain
C
Disordered
begin
86
end
121
score
100.0
distance
92.7477
seq distance
516
chain
C
Disordered
begin
86
end
121
score
100.0
distance
92.7477
seq distance
516
chain
C
Disordered
begin
564
end
573
score
62.272727272727266
distance
95.12959
seq distance
False
chain
B
Disordered
begin
564
end
573
score
62.272727272727266
distance
95.12959
seq distance
False
chain
B
LDL-receptor class A
begin
84
end
92
score
56.56565656565656
distance
99.28726
seq distance
False
chain
D
LDL-receptor class A
begin
84
end
92
score
56.56565656565656
distance
99.28726
seq distance
False
chain
D
In dbSNP:rs2271708.
original residue
C
variation residue
R
position
106
score
100.0
distance
101.52004
seq distance
531
chain
C
In dbSNP:rs2271708.
original residue
C
variation residue
R
position
106
score
100.0
distance
101.52004
seq distance
531
chain
C
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
566
score
86.36363636363636
distance
101.7924
seq distance
False
chain
B
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
566
score
86.36363636363636
distance
101.7924
seq distance
False
chain
B
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
398
score
100.0
distance
102.99239
seq distance
239
chain
C
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
398
score
100.0
distance
102.99239
seq distance
239
chain
C
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
499
score
100.0
distance
105.036804
seq distance
138
chain
C
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
499
score
100.0
distance
105.036804
seq distance
138
chain
C
Disordered
begin
91
end
92
score
68.18181818181817
distance
105.367195
seq distance
False
chain
D
Disordered
begin
91
end
92
score
68.18181818181817
distance
105.367195
seq distance
False
chain
D
EGF-like
begin
435
end
465
score
100.0
distance
109.2882
seq distance
172
chain
C
EGF-like
begin
435
end
465
score
100.0
distance
109.2882
seq distance
172
chain
C
Disordered
begin
504
end
504
score
68.18181818181817
distance
109.92725
seq distance
False
chain
D
Disordered
begin
504
end
504
score
68.18181818181817
distance
109.92725
seq distance
False
chain
D
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
412
score
63.63636363636363
distance
111.88921
seq distance
False
chain
D
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
412
score
63.63636363636363
distance
111.88921
seq distance
False
chain
D
LDL-receptor class A
begin
83
end
95
score
50.87412587412587
distance
116.20761
seq distance
False
chain
E
LDL-receptor class A
begin
83
end
95
score
50.87412587412587
distance
116.20761
seq distance
False
chain
E
In C7D; dbSNP:rs121964921.
original residue
G
variation residue
R
position
357
score
100.0
distance
117.59646
seq distance
280
chain
C
In C7D; dbSNP:rs121964921.
original residue
G
variation residue
R
position
357
score
100.0
distance
117.59646
seq distance
280
chain
C
Disordered
begin
510
end
522
score
53.67132867132868
distance
126.435684
seq distance
False
chain
D
Disordered
begin
510
end
522
score
53.67132867132868
distance
126.435684
seq distance
False
chain
D
Confirmed at protein level; dbSNP:rs1063499.
original residue
S
variation residue
T
position
367
score
100.0
distance
128.99849
seq distance
270
chain
C
Confirmed at protein level; dbSNP:rs1063499.
original residue
S
variation residue
T
position
367
score
100.0
distance
128.99849
seq distance
270
chain
C
EGF-like
begin
451
end
455
score
54.090909090909086
distance
132.89229
seq distance
False
chain
D
EGF-like
begin
451
end
455
score
54.090909090909086
distance
132.89229
seq distance
False
chain
D
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
512
score
81.81818181818183
distance
132.93402
seq distance
False
chain
D
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
512
score
81.81818181818183
distance
132.93402
seq distance
False
chain
D
In C7D; dbSNP:rs369349760.
original residue
R
variation residue
Q
position
25
score
54.54545454545454
distance
137.2563
seq distance
False
chain
B
In C7D; dbSNP:rs369349760.
original residue
R
variation residue
Q
position
25
score
54.54545454545454
distance
137.2563
seq distance
False
chain
B
In dbSNP:rs75345202.
original residue
R
variation residue
H
position
414
score
54.54545454545454
distance
140.1185
seq distance
False
chain
E
In dbSNP:rs75345202.
original residue
R
variation residue
H
position
414
score
54.54545454545454
distance
140.1185
seq distance
False
chain
E
Disordered
begin
138
end
138
score
50.0
distance
140.17328
seq distance
False
chain
F
Disordered
begin
138
end
138
score
50.0
distance
140.17328
seq distance
False
chain
F
MACPF
begin
324
end
332
score
83.08080808080808
distance
148.04
seq distance
False
chain
G
MACPF
begin
324
end
332
score
83.08080808080808
distance
148.04
seq distance
False
chain
G
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
152.07835
seq distance
False
chain
G
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
152.07835
seq distance
False
chain
G
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
530
score
54.54545454545454
distance
153.193
seq distance
False
chain
E
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
530
score
54.54545454545454
distance
153.193
seq distance
False
chain
E
In dbSNP:rs2271708.
original residue
C
variation residue
R
position
532
score
54.54545454545454
distance
155.42867
seq distance
False
chain
E
In dbSNP:rs2271708.
original residue
C
variation residue
R
position
532
score
54.54545454545454
distance
155.42867
seq distance
False
chain
E
Disordered
begin
197
end
218
score
76.85950413223141
distance
163.5858
seq distance
419
chain
C
Disordered
begin
197
end
218
score
76.85950413223141
distance
163.5858
seq distance
419
chain
C
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
165.54338
seq distance
False
chain
G
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
165.54338
seq distance
False
chain
G
MACPF
begin
324
end
332
score
83.08080808080808
distance
167.94456
seq distance
False
chain
H
MACPF
begin
324
end
332
score
83.08080808080808
distance
167.94456
seq distance
False
chain
H
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
172.95946
seq distance
False
chain
H
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
172.95946
seq distance
False
chain
H
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
175.0319
seq distance
False
chain
G
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
175.0319
seq distance
False
chain
G
MACPF
begin
324
end
333
score
84.54545454545456
distance
184.6293
seq distance
False
chain
I
MACPF
begin
324
end
333
score
84.54545454545456
distance
184.6293
seq distance
False
chain
I
Disordered
begin
327
end
328
score
61.36363636363637
distance
188.3288
seq distance
False
chain
I
Disordered
begin
327
end
328
score
61.36363636363637
distance
188.3288
seq distance
False
chain
I
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
189.9938
seq distance
False
chain
H
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
189.9938
seq distance
False
chain
H
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
192.82631
seq distance
False
chain
I
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
192.82631
seq distance
False
chain
I
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
199.79935
seq distance
False
chain
H
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
199.79935
seq distance
False
chain
H
In C7D; dbSNP:rs369349760.
original residue
R
variation residue
Q
position
198
score
72.72727272727273
distance
203.22292
seq distance
439
chain
C
In C7D; dbSNP:rs369349760.
original residue
R
variation residue
Q
position
198
score
72.72727272727273
distance
203.22292
seq distance
439
chain
C
In dbSNP:rs75345202.
original residue
R
variation residue
H
position
200
score
72.72727272727273
distance
209.50304
seq distance
437
chain
C
In dbSNP:rs75345202.
original residue
R
variation residue
H
position
200
score
72.72727272727273
distance
209.50304
seq distance
437
chain
C
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
210.47562
seq distance
False
chain
I
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
210.47562
seq distance
False
chain
I

Details

Redox score
76.75
PDB code
7nyc
Structure name
cryoem structure of 3c9-smac
Structure deposition date
2021-03-22
Thiol separation (Å)
2.01
Half-sphere exposure sum
51
Minimum pKa
nan
% buried
nan
Peptide accession
P10643
Residue number A
659 (Residue 637 in this structure)
Residue number B
688 (Residue 666 in this structure)
Peptide name
Complement component C7
A redox-regulated disulphide may form within Complement component C7 at these cysteines.

Relevent regions

Factor I module (FIM) 2
begin
771
end
843
score
100.0
distance
2.8466582
seq distance
0
chain
A
Factor I module (FIM) 2
begin
771
end
843
score
100.0
distance
2.8466582
seq distance
0
chain
A
Factor I module (FIM) 1
begin
695
end
770
score
99.46172248803828
distance
8.648576
seq distance
3
chain
A
Factor I module (FIM) 1
begin
695
end
770
score
99.46172248803828
distance
8.648576
seq distance
3
chain
A
LDL-receptor class A
begin
795
end
795
score
70.45454545454545
distance
17.044876
seq distance
19
chain
A
LDL-receptor class A
begin
795
end
795
score
70.45454545454545
distance
17.044876
seq distance
19
chain
A
In C7D; dbSNP:rs113187203.
original residue
R
variation residue
H
position
712
score
50.0
distance
36.41227
seq distance
61
chain
A
In C7D; dbSNP:rs113187203.
original residue
R
variation residue
H
position
712
score
50.0
distance
36.41227
seq distance
61
chain
A

Details

Redox score
76.73
PDB code
2wcy
Structure name
nmr solution structure of factor i-like modules of complement c7.
Structure deposition date
2009-03-17
Thiol separation (Å)
5.88
Half-sphere exposure sum
47
Minimum pKa
nan
% buried
1.5
Peptide accession
P10643
Residue number A
773
Residue number B
776
Peptide name
Complement component C7
A redox-regulated disulphide may form within Complement component C7 at these cysteines.

Relevent regions

EGF-like
begin
435
end
465
score
100.0
distance
2.7865968
seq distance
0
chain
C
EGF-like
begin
435
end
465
score
100.0
distance
2.7865968
seq distance
0
chain
C
TSP type-1 1
begin
5
end
58
score
99.83164983164983
distance
7.3639283
seq distance
380
chain
C
TSP type-1 1
begin
5
end
58
score
99.83164983164983
distance
7.3639283
seq distance
380
chain
C
MACPF
begin
102
end
434
score
94.85394485394487
distance
8.560025
seq distance
4
chain
C
MACPF
begin
102
end
434
score
94.85394485394487
distance
8.560025
seq distance
4
chain
C
TSP type-1 2
begin
478
end
527
score
100.0
distance
10.994443
seq distance
25
chain
C
TSP type-1 2
begin
478
end
527
score
100.0
distance
10.994443
seq distance
25
chain
C
Disordered
begin
494
end
516
score
100.0
distance
12.512271
seq distance
41
chain
C
Disordered
begin
494
end
516
score
100.0
distance
12.512271
seq distance
41
chain
C
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
499
score
100.0
distance
18.895031
seq distance
46
chain
C
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
499
score
100.0
distance
18.895031
seq distance
46
chain
C
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
412
score
63.63636363636363
distance
22.987291
seq distance
False
chain
D
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
412
score
63.63636363636363
distance
22.987291
seq distance
False
chain
D
Disordered
begin
86
end
121
score
100.0
distance
24.973307
seq distance
317
chain
C
Disordered
begin
86
end
121
score
100.0
distance
24.973307
seq distance
317
chain
C
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
398
score
100.0
distance
25.221754
seq distance
40
chain
C
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
398
score
100.0
distance
25.221754
seq distance
40
chain
C
Disordered
begin
510
end
522
score
53.67132867132868
distance
25.59978
seq distance
False
chain
D
Disordered
begin
510
end
522
score
53.67132867132868
distance
25.59978
seq distance
False
chain
D
Confirmed at protein level; dbSNP:rs1063499.
original residue
S
variation residue
T
position
367
score
100.0
distance
27.711212
seq distance
71
chain
C
Confirmed at protein level; dbSNP:rs1063499.
original residue
S
variation residue
T
position
367
score
100.0
distance
27.711212
seq distance
71
chain
C
In C7D; dbSNP:rs121964921.
original residue
G
variation residue
R
position
357
score
100.0
distance
28.197184
seq distance
81
chain
C
In C7D; dbSNP:rs121964921.
original residue
G
variation residue
R
position
357
score
100.0
distance
28.197184
seq distance
81
chain
C
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
512
score
81.81818181818183
distance
28.200748
seq distance
False
chain
D
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
512
score
81.81818181818183
distance
28.200748
seq distance
False
chain
D
In C7D; dbSNP:rs369349760.
original residue
R
variation residue
Q
position
25
score
54.54545454545454
distance
28.586592
seq distance
False
chain
B
In C7D; dbSNP:rs369349760.
original residue
R
variation residue
Q
position
25
score
54.54545454545454
distance
28.586592
seq distance
False
chain
B
EGF-like
begin
451
end
455
score
54.090909090909086
distance
33.267887
seq distance
False
chain
D
EGF-like
begin
451
end
455
score
54.090909090909086
distance
33.267887
seq distance
False
chain
D
CCP 1
begin
523
end
593
score
100.0
distance
33.611668
seq distance
70
chain
C
CCP 1
begin
523
end
593
score
100.0
distance
33.611668
seq distance
70
chain
C
Disordered
begin
504
end
504
score
68.18181818181817
distance
35.292625
seq distance
False
chain
D
Disordered
begin
504
end
504
score
68.18181818181817
distance
35.292625
seq distance
False
chain
D
Disordered
begin
564
end
573
score
62.272727272727266
distance
37.465393
seq distance
False
chain
B
Disordered
begin
564
end
573
score
62.272727272727266
distance
37.465393
seq distance
False
chain
B
LDL-receptor class A
begin
61
end
99
score
100.0
distance
41.13251
seq distance
339
chain
C
LDL-receptor class A
begin
61
end
99
score
100.0
distance
41.13251
seq distance
339
chain
C
In dbSNP:rs75345202.
original residue
R
variation residue
H
position
414
score
54.54545454545454
distance
44.19972
seq distance
False
chain
E
In dbSNP:rs75345202.
original residue
R
variation residue
H
position
414
score
54.54545454545454
distance
44.19972
seq distance
False
chain
E
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
566
score
86.36363636363636
distance
45.70498
seq distance
False
chain
B
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
566
score
86.36363636363636
distance
45.70498
seq distance
False
chain
B
Disordered
begin
197
end
218
score
76.85950413223141
distance
46.498783
seq distance
220
chain
C
Disordered
begin
197
end
218
score
76.85950413223141
distance
46.498783
seq distance
220
chain
C
Disordered
begin
91
end
92
score
68.18181818181817
distance
50.314472
seq distance
False
chain
D
Disordered
begin
91
end
92
score
68.18181818181817
distance
50.314472
seq distance
False
chain
D
LDL-receptor class A
begin
84
end
92
score
56.56565656565656
distance
50.314472
seq distance
False
chain
D
LDL-receptor class A
begin
84
end
92
score
56.56565656565656
distance
50.314472
seq distance
False
chain
D
In dbSNP:rs2271708.
original residue
C
variation residue
R
position
106
score
100.0
distance
51.656612
seq distance
332
chain
C
In dbSNP:rs2271708.
original residue
C
variation residue
R
position
106
score
100.0
distance
51.656612
seq distance
332
chain
C
In dbSNP:rs2271708.
original residue
C
variation residue
R
position
532
score
54.54545454545454
distance
56.235794
seq distance
False
chain
E
In dbSNP:rs2271708.
original residue
C
variation residue
R
position
532
score
54.54545454545454
distance
56.235794
seq distance
False
chain
E
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
530
score
54.54545454545454
distance
58.717113
seq distance
False
chain
E
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
530
score
54.54545454545454
distance
58.717113
seq distance
False
chain
E
Sushi 1
begin
547
end
606
score
100.0
distance
58.905155
seq distance
94
chain
C
Sushi 1
begin
547
end
606
score
100.0
distance
58.905155
seq distance
94
chain
C
MACPF
begin
324
end
332
score
83.08080808080808
distance
61.845478
seq distance
False
chain
G
MACPF
begin
324
end
332
score
83.08080808080808
distance
61.845478
seq distance
False
chain
G
LDL-receptor class A
begin
83
end
95
score
50.87412587412587
distance
63.253056
seq distance
False
chain
E
LDL-receptor class A
begin
83
end
95
score
50.87412587412587
distance
63.253056
seq distance
False
chain
E
CCP 2
begin
594
end
671
score
100.0
distance
63.6405
seq distance
141
chain
C
CCP 2
begin
594
end
671
score
100.0
distance
63.6405
seq distance
141
chain
C
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
66.73213
seq distance
False
chain
G
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
66.73213
seq distance
False
chain
G
Disordered
begin
138
end
138
score
50.0
distance
68.77994
seq distance
False
chain
F
Disordered
begin
138
end
138
score
50.0
distance
68.77994
seq distance
False
chain
F
Confirmed at protein level; dbSNP:rs13157656.
original residue
T
variation residue
P
position
565
score
100.0
distance
68.907555
seq distance
112
chain
C
Confirmed at protein level; dbSNP:rs13157656.
original residue
T
variation residue
P
position
565
score
100.0
distance
68.907555
seq distance
112
chain
C
Confirmed at protein level; dbSNP:rs1063499.
original residue
S
variation residue
T
position
1040
score
54.54545454545454
distance
79.03622
seq distance
False
chain
A
Confirmed at protein level; dbSNP:rs1063499.
original residue
S
variation residue
T
position
1040
score
54.54545454545454
distance
79.03622
seq distance
False
chain
A
MACPF
begin
324
end
332
score
83.08080808080808
distance
80.95107
seq distance
False
chain
H
MACPF
begin
324
end
332
score
83.08080808080808
distance
80.95107
seq distance
False
chain
H
In C7D; dbSNP:rs369349760.
original residue
R
variation residue
Q
position
198
score
72.72727272727273
distance
86.384026
seq distance
240
chain
C
In C7D; dbSNP:rs369349760.
original residue
R
variation residue
Q
position
198
score
72.72727272727273
distance
86.384026
seq distance
240
chain
C
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
87.9256
seq distance
False
chain
H
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
87.9256
seq distance
False
chain
H
In dbSNP:rs75345202.
original residue
R
variation residue
H
position
200
score
72.72727272727273
distance
92.76738
seq distance
238
chain
C
In dbSNP:rs75345202.
original residue
R
variation residue
H
position
200
score
72.72727272727273
distance
92.76738
seq distance
238
chain
C
Sushi 2
begin
607
end
668
score
100.0
distance
93.87035
seq distance
154
chain
C
Sushi 2
begin
607
end
668
score
100.0
distance
93.87035
seq distance
154
chain
C
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
94.67331
seq distance
False
chain
G
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
94.67331
seq distance
False
chain
G
MACPF
begin
324
end
333
score
84.54545454545456
distance
98.779335
seq distance
False
chain
I
MACPF
begin
324
end
333
score
84.54545454545456
distance
98.779335
seq distance
False
chain
I
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
102.68166
seq distance
False
chain
G
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
102.68166
seq distance
False
chain
G
Disordered
begin
327
end
328
score
61.36363636363637
distance
105.52416
seq distance
False
chain
I
Disordered
begin
327
end
328
score
61.36363636363637
distance
105.52416
seq distance
False
chain
I
In C7D; dbSNP:rs541873000.
original residue
E
variation residue
Q
position
660
score
100.0
distance
105.6437
seq distance
207
chain
C
In C7D; dbSNP:rs541873000.
original residue
E
variation residue
Q
position
660
score
100.0
distance
105.6437
seq distance
207
chain
C
Confirmed at protein level; dbSNP:rs13157656.
original residue
T
variation residue
P
position
693
score
50.0
distance
107.244446
seq distance
False
chain
B
Confirmed at protein level; dbSNP:rs13157656.
original residue
T
variation residue
P
position
693
score
50.0
distance
107.244446
seq distance
False
chain
B
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
107.663895
seq distance
False
chain
I
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
107.663895
seq distance
False
chain
I
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
116.07677
seq distance
False
chain
H
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
116.07677
seq distance
False
chain
H
In C7D; dbSNP:rs113187203.
original residue
R
variation residue
H
position
665
score
100.0
distance
117.33873
seq distance
212
chain
C
In C7D; dbSNP:rs113187203.
original residue
R
variation residue
H
position
665
score
100.0
distance
117.33873
seq distance
212
chain
C
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
124.80659
seq distance
False
chain
H
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
124.80659
seq distance
False
chain
H
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
135.69887
seq distance
False
chain
I
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
135.69887
seq distance
False
chain
I
Factor I module (FIM) 1
begin
673
end
748
score
100.0
distance
138.9169
seq distance
220
chain
C
Factor I module (FIM) 1
begin
673
end
748
score
100.0
distance
138.9169
seq distance
220
chain
C
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
1560
score
50.0
distance
150.4625
seq distance
False
chain
A
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
1560
score
50.0
distance
150.4625
seq distance
False
chain
A
Factor I module (FIM) 2
begin
749
end
821
score
100.0
distance
164.5149
seq distance
296
chain
C
Factor I module (FIM) 2
begin
749
end
821
score
100.0
distance
164.5149
seq distance
296
chain
C

Details

Redox score
76.72
PDB code
7nyc
Structure name
cryoem structure of 3c9-smac
Structure deposition date
2021-03-22
Thiol separation (Å)
2.03
Half-sphere exposure sum
68
Minimum pKa
nan
% buried
nan
Peptide accession
P10643
Residue number A
460 (Residue 438 in this structure)
Residue number B
475 (Residue 453 in this structure)
Peptide name
Complement component C7
A redox-regulated disulphide may form within Complement component C7 at these cysteines.

Relevent regions

CCP 1
begin
545
end
615
score
83.48271446862996
distance
2.8146024
seq distance
0
chain
D
CCP 1
begin
545
end
615
score
83.48271446862996
distance
2.8146024
seq distance
0
chain
D
Sushi 1
begin
572
end
628
score
99.04306220095694
distance
2.8181598
seq distance
0
chain
D
Sushi 1
begin
572
end
628
score
99.04306220095694
distance
2.8181598
seq distance
0
chain
D
CCP 2
begin
616
end
691
score
99.2822966507177
distance
3.8909845
seq distance
3
chain
D
CCP 2
begin
616
end
691
score
99.2822966507177
distance
3.8909845
seq distance
3
chain
D
Confirmed at protein level; dbSNP:rs13157656.
original residue
T
variation residue
P
position
587
score
100.0
distance
10.947288
seq distance
16
chain
D
Confirmed at protein level; dbSNP:rs13157656.
original residue
T
variation residue
P
position
587
score
100.0
distance
10.947288
seq distance
16
chain
D
TSP type-1 1
begin
27
end
80
score
99.83164983164983
distance
27.36524
seq distance
491
chain
D
TSP type-1 1
begin
27
end
80
score
99.83164983164983
distance
27.36524
seq distance
491
chain
D
TSP type-1 2
begin
500
end
549
score
100.0
distance
29.062557
seq distance
22
chain
D
TSP type-1 2
begin
500
end
549
score
100.0
distance
29.062557
seq distance
22
chain
D
Sushi 2
begin
629
end
690
score
99.56011730205279
distance
30.290915
seq distance
16
chain
D
Sushi 2
begin
629
end
690
score
99.56011730205279
distance
30.290915
seq distance
16
chain
D
MACPF
begin
124
end
456
score
98.9079989079989
distance
31.178986
seq distance
115
chain
D
MACPF
begin
124
end
456
score
98.9079989079989
distance
31.178986
seq distance
115
chain
D
LDL-receptor class A
begin
83
end
121
score
100.0
distance
33.747597
seq distance
450
chain
D
LDL-receptor class A
begin
83
end
121
score
100.0
distance
33.747597
seq distance
450
chain
D
Disordered
begin
516
end
538
score
100.0
distance
39.87089
seq distance
33
chain
D
Disordered
begin
516
end
538
score
100.0
distance
39.87089
seq distance
33
chain
D
In C7D; dbSNP:rs541873000.
original residue
E
variation residue
Q
position
682
score
100.0
distance
44.3472
seq distance
69
chain
D
In C7D; dbSNP:rs541873000.
original residue
E
variation residue
Q
position
682
score
100.0
distance
44.3472
seq distance
69
chain
D
Disordered
begin
108
end
143
score
100.0
distance
50.554058
seq distance
428
chain
D
Disordered
begin
108
end
143
score
100.0
distance
50.554058
seq distance
428
chain
D
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
521
score
100.0
distance
53.044178
seq distance
50
chain
D
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
521
score
100.0
distance
53.044178
seq distance
50
chain
D
In C7D; dbSNP:rs113187203.
original residue
R
variation residue
H
position
687
score
100.0
distance
53.993233
seq distance
74
chain
D
In C7D; dbSNP:rs113187203.
original residue
R
variation residue
H
position
687
score
100.0
distance
53.993233
seq distance
74
chain
D
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
420
score
100.0
distance
56.356342
seq distance
151
chain
D
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
420
score
100.0
distance
56.356342
seq distance
151
chain
D
EGF-like
begin
457
end
487
score
100.0
distance
57.14339
seq distance
84
chain
D
EGF-like
begin
457
end
487
score
100.0
distance
57.14339
seq distance
84
chain
D
LDL-receptor class A
begin
84
end
92
score
56.56565656565656
distance
57.15276
seq distance
False
chain
C
LDL-receptor class A
begin
84
end
92
score
56.56565656565656
distance
57.15276
seq distance
False
chain
C
Disordered
begin
585
end
589
score
50.90909090909091
distance
58.070534
seq distance
False
chain
B
Disordered
begin
585
end
589
score
50.90909090909091
distance
58.070534
seq distance
False
chain
B
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
412
score
63.63636363636363
distance
60.960052
seq distance
False
chain
C
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
412
score
63.63636363636363
distance
60.960052
seq distance
False
chain
C
Disordered
begin
504
end
504
score
68.18181818181817
distance
61.774338
seq distance
False
chain
C
Disordered
begin
504
end
504
score
68.18181818181817
distance
61.774338
seq distance
False
chain
C
Disordered
begin
91
end
92
score
68.18181818181817
distance
61.972263
seq distance
False
chain
C
Disordered
begin
91
end
92
score
68.18181818181817
distance
61.972263
seq distance
False
chain
C
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
587
score
68.18181818181817
distance
62.316986
seq distance
False
chain
B
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
587
score
68.18181818181817
distance
62.316986
seq distance
False
chain
B
Confirmed at protein level; dbSNP:rs1063499.
original residue
S
variation residue
T
position
1058
score
54.54545454545454
distance
64.65802
seq distance
False
chain
A
Confirmed at protein level; dbSNP:rs1063499.
original residue
S
variation residue
T
position
1058
score
54.54545454545454
distance
64.65802
seq distance
False
chain
A
In dbSNP:rs2271708.
original residue
C
variation residue
R
position
128
score
100.0
distance
64.9154
seq distance
443
chain
D
In dbSNP:rs2271708.
original residue
C
variation residue
R
position
128
score
100.0
distance
64.9154
seq distance
443
chain
D
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
65.518394
seq distance
False
chain
X
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
65.518394
seq distance
False
chain
X
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
68.48004
seq distance
False
chain
X
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
68.48004
seq distance
False
chain
X
Disordered
begin
41
end
41
score
70.45454545454545
distance
74.28975
seq distance
False
chain
B
Disordered
begin
41
end
41
score
70.45454545454545
distance
74.28975
seq distance
False
chain
B
LDL-receptor class A
begin
83
end
98
score
52.69886363636363
distance
75.2935
seq distance
False
chain
F
LDL-receptor class A
begin
83
end
98
score
52.69886363636363
distance
75.2935
seq distance
False
chain
F
EGF-like
begin
451
end
455
score
54.090909090909086
distance
80.961876
seq distance
False
chain
C
EGF-like
begin
451
end
455
score
54.090909090909086
distance
80.961876
seq distance
False
chain
C
Confirmed at protein level; dbSNP:rs1063499.
original residue
S
variation residue
T
position
389
score
100.0
distance
81.305
seq distance
182
chain
D
Confirmed at protein level; dbSNP:rs1063499.
original residue
S
variation residue
T
position
389
score
100.0
distance
81.305
seq distance
182
chain
D
Confirmed at protein level; dbSNP:rs13157656.
original residue
T
variation residue
P
position
714
score
50.0
distance
82.6871
seq distance
False
chain
B
Confirmed at protein level; dbSNP:rs13157656.
original residue
T
variation residue
P
position
714
score
50.0
distance
82.6871
seq distance
False
chain
B
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
89.9222
seq distance
False
chain
W
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
89.9222
seq distance
False
chain
W
In dbSNP:rs75345202.
original residue
R
variation residue
H
position
414
score
54.54545454545454
distance
93.1381
seq distance
False
chain
F
In dbSNP:rs75345202.
original residue
R
variation residue
H
position
414
score
54.54545454545454
distance
93.1381
seq distance
False
chain
F
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
93.53744
seq distance
False
chain
W
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
93.53744
seq distance
False
chain
W
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
94.21669
seq distance
False
chain
X
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
94.21669
seq distance
False
chain
X
Disordered
begin
138
end
138
score
50.0
distance
101.11576
seq distance
False
chain
E
Disordered
begin
138
end
138
score
50.0
distance
101.11576
seq distance
False
chain
E
TSP type-1 2
begin
512
end
517
score
80.30303030303031
distance
104.35133
seq distance
False
chain
F
TSP type-1 2
begin
512
end
517
score
80.30303030303031
distance
104.35133
seq distance
False
chain
F
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
106.15677
seq distance
False
chain
G
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
106.15677
seq distance
False
chain
G
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
31
score
50.0
distance
109.63368
seq distance
False
chain
F
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
31
score
50.0
distance
109.63368
seq distance
False
chain
F
Disordered
begin
219
end
240
score
100.0
distance
113.207245
seq distance
331
chain
D
Disordered
begin
219
end
240
score
100.0
distance
113.207245
seq distance
331
chain
D
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
114.402336
seq distance
False
chain
W
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
114.402336
seq distance
False
chain
W
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
117.532875
seq distance
False
chain
V
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
117.532875
seq distance
False
chain
V
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
120.39827
seq distance
False
chain
V
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
120.39827
seq distance
False
chain
V
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
124.581024
seq distance
False
chain
G
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
124.581024
seq distance
False
chain
G
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
129.19098
seq distance
False
chain
P
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
129.19098
seq distance
False
chain
P
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
135.37383
seq distance
False
chain
G
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
135.37383
seq distance
False
chain
G
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
135.83139
seq distance
False
chain
V
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
135.83139
seq distance
False
chain
V
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
144.87625
seq distance
False
chain
U
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
144.87625
seq distance
False
chain
U
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
146.44016
seq distance
False
chain
U
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
146.44016
seq distance
False
chain
U
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
149.68336
seq distance
False
chain
X
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
149.68336
seq distance
False
chain
X
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
150.50182
seq distance
False
chain
P
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
150.50182
seq distance
False
chain
P
In C7D; dbSNP:rs369349760.
original residue
R
variation residue
Q
position
220
score
100.0
distance
150.65807
seq distance
351
chain
D
In C7D; dbSNP:rs369349760.
original residue
R
variation residue
Q
position
220
score
100.0
distance
150.65807
seq distance
351
chain
D
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
151.03694
seq distance
False
chain
H
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
151.03694
seq distance
False
chain
H
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
155.66023
seq distance
False
chain
W
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
155.66023
seq distance
False
chain
W
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
156.65796
seq distance
False
chain
U
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
156.65796
seq distance
False
chain
U
In dbSNP:rs75345202.
original residue
R
variation residue
H
position
222
score
100.0
distance
156.86021
seq distance
349
chain
D
In dbSNP:rs75345202.
original residue
R
variation residue
H
position
222
score
100.0
distance
156.86021
seq distance
349
chain
D
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
161.77344
seq distance
False
chain
P
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
161.77344
seq distance
False
chain
P
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
165.39717
seq distance
False
chain
V
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
165.39717
seq distance
False
chain
V
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
167.97382
seq distance
False
chain
G
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
167.97382
seq distance
False
chain
G
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
170.59268
seq distance
False
chain
I
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
170.59268
seq distance
False
chain
I
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
170.67857
seq distance
False
chain
T
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
170.67857
seq distance
False
chain
T
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
170.81021
seq distance
False
chain
T
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
170.81021
seq distance
False
chain
T
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
173.96577
seq distance
False
chain
H
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
173.96577
seq distance
False
chain
H
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
175.61945
seq distance
False
chain
T
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
175.61945
seq distance
False
chain
T
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
177.59035
seq distance
False
chain
U
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
177.59035
seq distance
False
chain
U
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
181.95534
seq distance
False
chain
P
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
181.95534
seq distance
False
chain
P
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
185.56503
seq distance
False
chain
H
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
185.56503
seq distance
False
chain
H
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
187.46506
seq distance
False
chain
J
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
187.46506
seq distance
False
chain
J
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
190.31346
seq distance
False
chain
T
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
190.31346
seq distance
False
chain
T
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
191.79164
seq distance
False
chain
S
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
191.79164
seq distance
False
chain
S
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
191.85667
seq distance
False
chain
S
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
191.85667
seq distance
False
chain
S
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
193.80629
seq distance
False
chain
S
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
193.80629
seq distance
False
chain
S
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
194.23267
seq distance
False
chain
I
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
194.23267
seq distance
False
chain
I
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
195.72798
seq distance
False
chain
H
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
195.72798
seq distance
False
chain
H
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
201.22862
seq distance
False
chain
K
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
201.22862
seq distance
False
chain
K
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
202.49248
seq distance
False
chain
S
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
202.49248
seq distance
False
chain
S
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
204.70604
seq distance
False
chain
R
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
204.70604
seq distance
False
chain
R
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
205.90344
seq distance
False
chain
I
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
205.90344
seq distance
False
chain
I
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
207.91617
seq distance
False
chain
I
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
207.91617
seq distance
False
chain
I
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
209.49017
seq distance
False
chain
R
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
209.49017
seq distance
False
chain
R
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
211.02371
seq distance
False
chain
J
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
211.02371
seq distance
False
chain
J
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
211.53699
seq distance
False
chain
L
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
211.53699
seq distance
False
chain
L
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
213.2604
seq distance
False
chain
R
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
213.2604
seq distance
False
chain
R
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
213.40884
seq distance
False
chain
R
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
213.40884
seq distance
False
chain
R
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
214.02887
seq distance
False
chain
Q
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
214.02887
seq distance
False
chain
Q
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
217.92531
seq distance
False
chain
J
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
217.92531
seq distance
False
chain
J
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
218.10808
seq distance
False
chain
M
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
218.10808
seq distance
False
chain
M
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
219.43054
seq distance
False
chain
O
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
219.43054
seq distance
False
chain
O
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
220.77147
seq distance
False
chain
N
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
220.77147
seq distance
False
chain
N
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
222.44034
seq distance
False
chain
Q
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
222.44034
seq distance
False
chain
Q
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
222.56517
seq distance
False
chain
J
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
222.56517
seq distance
False
chain
J
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
223.08612
seq distance
False
chain
Q
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
223.08612
seq distance
False
chain
Q
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
223.94775
seq distance
False
chain
K
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
223.94775
seq distance
False
chain
K
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
225.8095
seq distance
False
chain
K
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
225.8095
seq distance
False
chain
K
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
228.6653
seq distance
False
chain
Q
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
228.6653
seq distance
False
chain
Q
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
228.97621
seq distance
False
chain
O
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
228.97621
seq distance
False
chain
O
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
230.97563
seq distance
False
chain
L
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
230.97563
seq distance
False
chain
L
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
232.33458
seq distance
False
chain
O
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
232.33458
seq distance
False
chain
O
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
232.43684
seq distance
False
chain
N
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
232.43684
seq distance
False
chain
N
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
232.76292
seq distance
False
chain
L
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
232.76292
seq distance
False
chain
L
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
233.20114
seq distance
False
chain
M
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
233.20114
seq distance
False
chain
M
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
235.14096
seq distance
False
chain
K
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
235.14096
seq distance
False
chain
K
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
237.0026
seq distance
False
chain
N
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
237.0026
seq distance
False
chain
N
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
237.1341
seq distance
False
chain
M
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
237.1341
seq distance
False
chain
M
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
239.62589
seq distance
False
chain
O
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
239.62589
seq distance
False
chain
O
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
243.39232
seq distance
False
chain
L
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
243.39232
seq distance
False
chain
L
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
245.84625
seq distance
False
chain
N
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
245.84625
seq distance
False
chain
N
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
247.0624
seq distance
False
chain
M
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
247.0624
seq distance
False
chain
M

Details

Redox score
76.72
PDB code
6h04
Structure name
closed conformation of the membrane attack complex
Structure deposition date
2018-07-06
Thiol separation (Å)
2.03
Half-sphere exposure sum
54
Minimum pKa
nan
% buried
nan
Peptide accession
P10643
Residue number A
571
Residue number B
613
Peptide name
Complement component C7
A redox-regulated disulphide may form within Complement component C7 at these cysteines.

Relevent regions

EGF-like
begin
435
end
465
score
100.0
distance
2.8385603
seq distance
0
chain
C
EGF-like
begin
435
end
465
score
100.0
distance
2.8385603
seq distance
0
chain
C
TSP type-1 1
begin
5
end
58
score
99.83164983164983
distance
9.763513
seq distance
397
chain
C
TSP type-1 1
begin
5
end
58
score
99.83164983164983
distance
9.763513
seq distance
397
chain
C
MACPF
begin
102
end
434
score
94.85394485394487
distance
12.944417
seq distance
21
chain
C
MACPF
begin
102
end
434
score
94.85394485394487
distance
12.944417
seq distance
21
chain
C
TSP type-1 2
begin
478
end
527
score
100.0
distance
14.191348
seq distance
14
chain
C
TSP type-1 2
begin
478
end
527
score
100.0
distance
14.191348
seq distance
14
chain
C
Disordered
begin
494
end
516
score
100.0
distance
15.538734
seq distance
30
chain
C
Disordered
begin
494
end
516
score
100.0
distance
15.538734
seq distance
30
chain
C
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
499
score
100.0
distance
23.07404
seq distance
35
chain
C
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
499
score
100.0
distance
23.07404
seq distance
35
chain
C
Disordered
begin
510
end
522
score
53.67132867132868
distance
23.55115
seq distance
False
chain
D
Disordered
begin
510
end
522
score
53.67132867132868
distance
23.55115
seq distance
False
chain
D
Confirmed at protein level; dbSNP:rs1063499.
original residue
S
variation residue
T
position
367
score
100.0
distance
23.56202
seq distance
88
chain
C
Confirmed at protein level; dbSNP:rs1063499.
original residue
S
variation residue
T
position
367
score
100.0
distance
23.56202
seq distance
88
chain
C
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
412
score
63.63636363636363
distance
23.870605
seq distance
False
chain
D
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
412
score
63.63636363636363
distance
23.870605
seq distance
False
chain
D
In C7D; dbSNP:rs121964921.
original residue
G
variation residue
R
position
357
score
100.0
distance
26.064802
seq distance
98
chain
C
In C7D; dbSNP:rs121964921.
original residue
G
variation residue
R
position
357
score
100.0
distance
26.064802
seq distance
98
chain
C
In C7D; dbSNP:rs369349760.
original residue
R
variation residue
Q
position
25
score
54.54545454545454
distance
26.516417
seq distance
False
chain
B
In C7D; dbSNP:rs369349760.
original residue
R
variation residue
Q
position
25
score
54.54545454545454
distance
26.516417
seq distance
False
chain
B
Disordered
begin
86
end
121
score
100.0
distance
26.599152
seq distance
334
chain
C
Disordered
begin
86
end
121
score
100.0
distance
26.599152
seq distance
334
chain
C
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
398
score
100.0
distance
27.14673
seq distance
57
chain
C
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
398
score
100.0
distance
27.14673
seq distance
57
chain
C
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
512
score
81.81818181818183
distance
28.514221
seq distance
False
chain
D
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
512
score
81.81818181818183
distance
28.514221
seq distance
False
chain
D
EGF-like
begin
451
end
455
score
54.090909090909086
distance
32.284504
seq distance
False
chain
D
EGF-like
begin
451
end
455
score
54.090909090909086
distance
32.284504
seq distance
False
chain
D
CCP 1
begin
523
end
593
score
100.0
distance
38.00805
seq distance
59
chain
C
CCP 1
begin
523
end
593
score
100.0
distance
38.00805
seq distance
59
chain
C
Disordered
begin
564
end
573
score
62.272727272727266
distance
38.554276
seq distance
False
chain
B
Disordered
begin
564
end
573
score
62.272727272727266
distance
38.554276
seq distance
False
chain
B
Disordered
begin
504
end
504
score
68.18181818181817
distance
39.105885
seq distance
False
chain
D
Disordered
begin
504
end
504
score
68.18181818181817
distance
39.105885
seq distance
False
chain
D
In dbSNP:rs75345202.
original residue
R
variation residue
H
position
414
score
54.54545454545454
distance
40.31713
seq distance
False
chain
E
In dbSNP:rs75345202.
original residue
R
variation residue
H
position
414
score
54.54545454545454
distance
40.31713
seq distance
False
chain
E
LDL-receptor class A
begin
61
end
99
score
100.0
distance
42.06069
seq distance
356
chain
C
LDL-receptor class A
begin
61
end
99
score
100.0
distance
42.06069
seq distance
356
chain
C
Disordered
begin
197
end
218
score
76.85950413223141
distance
42.209843
seq distance
237
chain
C
Disordered
begin
197
end
218
score
76.85950413223141
distance
42.209843
seq distance
237
chain
C
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
566
score
86.36363636363636
distance
47.717556
seq distance
False
chain
B
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
566
score
86.36363636363636
distance
47.717556
seq distance
False
chain
B
Disordered
begin
91
end
92
score
68.18181818181817
distance
50.74333
seq distance
False
chain
D
Disordered
begin
91
end
92
score
68.18181818181817
distance
50.74333
seq distance
False
chain
D
LDL-receptor class A
begin
84
end
92
score
56.56565656565656
distance
50.74333
seq distance
False
chain
D
LDL-receptor class A
begin
84
end
92
score
56.56565656565656
distance
50.74333
seq distance
False
chain
D
In dbSNP:rs2271708.
original residue
C
variation residue
R
position
106
score
100.0
distance
51.509483
seq distance
349
chain
C
In dbSNP:rs2271708.
original residue
C
variation residue
R
position
106
score
100.0
distance
51.509483
seq distance
349
chain
C
In dbSNP:rs2271708.
original residue
C
variation residue
R
position
532
score
54.54545454545454
distance
54.34755
seq distance
False
chain
E
In dbSNP:rs2271708.
original residue
C
variation residue
R
position
532
score
54.54545454545454
distance
54.34755
seq distance
False
chain
E
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
530
score
54.54545454545454
distance
57.327408
seq distance
False
chain
E
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
530
score
54.54545454545454
distance
57.327408
seq distance
False
chain
E
MACPF
begin
324
end
332
score
83.08080808080808
distance
58.654095
seq distance
False
chain
G
MACPF
begin
324
end
332
score
83.08080808080808
distance
58.654095
seq distance
False
chain
G
LDL-receptor class A
begin
83
end
95
score
50.87412587412587
distance
62.59034
seq distance
False
chain
E
LDL-receptor class A
begin
83
end
95
score
50.87412587412587
distance
62.59034
seq distance
False
chain
E
Sushi 1
begin
547
end
606
score
100.0
distance
63.250404
seq distance
83
chain
C
Sushi 1
begin
547
end
606
score
100.0
distance
63.250404
seq distance
83
chain
C
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
64.367676
seq distance
False
chain
G
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
64.367676
seq distance
False
chain
G
Disordered
begin
138
end
138
score
50.0
distance
65.51665
seq distance
False
chain
F
Disordered
begin
138
end
138
score
50.0
distance
65.51665
seq distance
False
chain
F
CCP 2
begin
594
end
671
score
100.0
distance
68.066124
seq distance
130
chain
C
CCP 2
begin
594
end
671
score
100.0
distance
68.066124
seq distance
130
chain
C
Confirmed at protein level; dbSNP:rs13157656.
original residue
T
variation residue
P
position
565
score
100.0
distance
73.08217
seq distance
101
chain
C
Confirmed at protein level; dbSNP:rs13157656.
original residue
T
variation residue
P
position
565
score
100.0
distance
73.08217
seq distance
101
chain
C
MACPF
begin
324
end
332
score
83.08080808080808
distance
77.202324
seq distance
False
chain
H
MACPF
begin
324
end
332
score
83.08080808080808
distance
77.202324
seq distance
False
chain
H
Confirmed at protein level; dbSNP:rs1063499.
original residue
S
variation residue
T
position
1040
score
54.54545454545454
distance
82.093735
seq distance
False
chain
A
Confirmed at protein level; dbSNP:rs1063499.
original residue
S
variation residue
T
position
1040
score
54.54545454545454
distance
82.093735
seq distance
False
chain
A
In C7D; dbSNP:rs369349760.
original residue
R
variation residue
Q
position
198
score
72.72727272727273
distance
82.922615
seq distance
257
chain
C
In C7D; dbSNP:rs369349760.
original residue
R
variation residue
Q
position
198
score
72.72727272727273
distance
82.922615
seq distance
257
chain
C
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
84.686005
seq distance
False
chain
H
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
84.686005
seq distance
False
chain
H
In dbSNP:rs75345202.
original residue
R
variation residue
H
position
200
score
72.72727272727273
distance
89.42008
seq distance
255
chain
C
In dbSNP:rs75345202.
original residue
R
variation residue
H
position
200
score
72.72727272727273
distance
89.42008
seq distance
255
chain
C
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
92.6928
seq distance
False
chain
G
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
92.6928
seq distance
False
chain
G
MACPF
begin
324
end
333
score
84.54545454545456
distance
94.624756
seq distance
False
chain
I
MACPF
begin
324
end
333
score
84.54545454545456
distance
94.624756
seq distance
False
chain
I
Sushi 2
begin
607
end
668
score
100.0
distance
97.961205
seq distance
143
chain
C
Sushi 2
begin
607
end
668
score
100.0
distance
97.961205
seq distance
143
chain
C
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
100.58966
seq distance
False
chain
G
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
100.58966
seq distance
False
chain
G
Disordered
begin
327
end
328
score
61.36363636363637
distance
101.72301
seq distance
False
chain
I
Disordered
begin
327
end
328
score
61.36363636363637
distance
101.72301
seq distance
False
chain
I
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
103.76574
seq distance
False
chain
I
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
103.76574
seq distance
False
chain
I
In C7D; dbSNP:rs541873000.
original residue
E
variation residue
Q
position
660
score
100.0
distance
109.634056
seq distance
196
chain
C
In C7D; dbSNP:rs541873000.
original residue
E
variation residue
Q
position
660
score
100.0
distance
109.634056
seq distance
196
chain
C
Confirmed at protein level; dbSNP:rs13157656.
original residue
T
variation residue
P
position
693
score
50.0
distance
109.64696
seq distance
False
chain
B
Confirmed at protein level; dbSNP:rs13157656.
original residue
T
variation residue
P
position
693
score
50.0
distance
109.64696
seq distance
False
chain
B
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
113.07258
seq distance
False
chain
H
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
113.07258
seq distance
False
chain
H
In C7D; dbSNP:rs113187203.
original residue
R
variation residue
H
position
665
score
100.0
distance
121.41442
seq distance
201
chain
C
In C7D; dbSNP:rs113187203.
original residue
R
variation residue
H
position
665
score
100.0
distance
121.41442
seq distance
201
chain
C
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
121.701706
seq distance
False
chain
H
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
121.701706
seq distance
False
chain
H
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
132.0021
seq distance
False
chain
I
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
132.0021
seq distance
False
chain
I
Factor I module (FIM) 1
begin
673
end
748
score
100.0
distance
142.94228
seq distance
209
chain
C
Factor I module (FIM) 1
begin
673
end
748
score
100.0
distance
142.94228
seq distance
209
chain
C
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
1560
score
50.0
distance
153.87614
seq distance
False
chain
A
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
1560
score
50.0
distance
153.87614
seq distance
False
chain
A
Factor I module (FIM) 2
begin
749
end
821
score
100.0
distance
168.50378
seq distance
285
chain
C
Factor I module (FIM) 2
begin
749
end
821
score
100.0
distance
168.50378
seq distance
285
chain
C

Details

Redox score
76.68
PDB code
7nyc
Structure name
cryoem structure of 3c9-smac
Structure deposition date
2021-03-22
Thiol separation (Å)
2.06
Half-sphere exposure sum
57
Minimum pKa
nan
% buried
nan
Peptide accession
P10643
Residue number A
477 (Residue 455 in this structure)
Residue number B
486 (Residue 464 in this structure)
Peptide name
Complement component C7
A redox-regulated disulphide may form within Complement component C7 at these cysteines.

Relevent regions

Factor I module (FIM) 2
begin
771
end
843
score
100.0
distance
2.8466582
seq distance
0
chain
A
Factor I module (FIM) 2
begin
771
end
843
score
100.0
distance
2.8466582
seq distance
0
chain
A
Factor I module (FIM) 1
begin
695
end
770
score
99.46172248803828
distance
8.648576
seq distance
6
chain
A
Factor I module (FIM) 1
begin
695
end
770
score
99.46172248803828
distance
8.648576
seq distance
6
chain
A
LDL-receptor class A
begin
795
end
795
score
70.45454545454545
distance
17.044876
seq distance
13
chain
A
LDL-receptor class A
begin
795
end
795
score
70.45454545454545
distance
17.044876
seq distance
13
chain
A
In C7D; dbSNP:rs113187203.
original residue
R
variation residue
H
position
712
score
50.0
distance
36.41227
seq distance
64
chain
A
In C7D; dbSNP:rs113187203.
original residue
R
variation residue
H
position
712
score
50.0
distance
36.41227
seq distance
64
chain
A

Details

Redox score
76.38
PDB code
2wcy
Structure name
nmr solution structure of factor i-like modules of complement c7.
Structure deposition date
2009-03-17
Thiol separation (Å)
5.91
Half-sphere exposure sum
50
Minimum pKa
nan
% buried
1.5
Peptide accession
P10643
Residue number A
776
Residue number B
782
Peptide name
Complement component C7
A redox-regulated disulphide may form within Complement component C7 at these cysteines.

Relevent regions

TSP type-1 1
begin
5
end
58
score
99.83164983164983
distance
2.817033
seq distance
0
chain
C
TSP type-1 1
begin
5
end
58
score
99.83164983164983
distance
2.817033
seq distance
0
chain
C
MACPF
begin
102
end
434
score
94.85394485394487
distance
10.269443
seq distance
51
chain
C
MACPF
begin
102
end
434
score
94.85394485394487
distance
10.269443
seq distance
51
chain
C
CCP 1
begin
523
end
593
score
100.0
distance
10.50434
seq distance
472
chain
C
CCP 1
begin
523
end
593
score
100.0
distance
10.50434
seq distance
472
chain
C
TSP type-1 2
begin
478
end
527
score
100.0
distance
21.41526
seq distance
427
chain
C
TSP type-1 2
begin
478
end
527
score
100.0
distance
21.41526
seq distance
427
chain
C
LDL-receptor class A
begin
61
end
99
score
100.0
distance
23.019737
seq distance
10
chain
C
LDL-receptor class A
begin
61
end
99
score
100.0
distance
23.019737
seq distance
10
chain
C
Disordered
begin
504
end
504
score
68.18181818181817
distance
23.475254
seq distance
False
chain
D
Disordered
begin
504
end
504
score
68.18181818181817
distance
23.475254
seq distance
False
chain
D
Sushi 1
begin
547
end
606
score
100.0
distance
26.182554
seq distance
496
chain
C
Sushi 1
begin
547
end
606
score
100.0
distance
26.182554
seq distance
496
chain
C
EGF-like
begin
435
end
465
score
100.0
distance
27.01808
seq distance
384
chain
C
EGF-like
begin
435
end
465
score
100.0
distance
27.01808
seq distance
384
chain
C
Disordered
begin
494
end
516
score
100.0
distance
29.98692
seq distance
443
chain
C
Disordered
begin
494
end
516
score
100.0
distance
29.98692
seq distance
443
chain
C
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
412
score
63.63636363636363
distance
30.912384
seq distance
False
chain
D
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
412
score
63.63636363636363
distance
30.912384
seq distance
False
chain
D
Confirmed at protein level; dbSNP:rs13157656.
original residue
T
variation residue
P
position
565
score
100.0
distance
31.080103
seq distance
514
chain
C
Confirmed at protein level; dbSNP:rs13157656.
original residue
T
variation residue
P
position
565
score
100.0
distance
31.080103
seq distance
514
chain
C
Disordered
begin
86
end
121
score
100.0
distance
31.87107
seq distance
35
chain
C
Disordered
begin
86
end
121
score
100.0
distance
31.87107
seq distance
35
chain
C
CCP 2
begin
594
end
671
score
100.0
distance
34.34578
seq distance
543
chain
C
CCP 2
begin
594
end
671
score
100.0
distance
34.34578
seq distance
543
chain
C
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
499
score
100.0
distance
36.45533
seq distance
448
chain
C
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
499
score
100.0
distance
36.45533
seq distance
448
chain
C
Disordered
begin
510
end
522
score
53.67132867132868
distance
38.489174
seq distance
False
chain
D
Disordered
begin
510
end
522
score
53.67132867132868
distance
38.489174
seq distance
False
chain
D
LDL-receptor class A
begin
84
end
92
score
56.56565656565656
distance
38.861008
seq distance
False
chain
D
LDL-receptor class A
begin
84
end
92
score
56.56565656565656
distance
38.861008
seq distance
False
chain
D
Disordered
begin
91
end
92
score
68.18181818181817
distance
39.581543
seq distance
False
chain
D
Disordered
begin
91
end
92
score
68.18181818181817
distance
39.581543
seq distance
False
chain
D
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
398
score
100.0
distance
40.17391
seq distance
347
chain
C
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
398
score
100.0
distance
40.17391
seq distance
347
chain
C
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
512
score
81.81818181818183
distance
45.234497
seq distance
False
chain
D
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
512
score
81.81818181818183
distance
45.234497
seq distance
False
chain
D
EGF-like
begin
451
end
455
score
54.090909090909086
distance
45.898006
seq distance
False
chain
D
EGF-like
begin
451
end
455
score
54.090909090909086
distance
45.898006
seq distance
False
chain
D
In C7D; dbSNP:rs121964921.
original residue
G
variation residue
R
position
357
score
100.0
distance
48.91195
seq distance
306
chain
C
In C7D; dbSNP:rs121964921.
original residue
G
variation residue
R
position
357
score
100.0
distance
48.91195
seq distance
306
chain
C
In dbSNP:rs2271708.
original residue
C
variation residue
R
position
106
score
100.0
distance
51.793354
seq distance
55
chain
C
In dbSNP:rs2271708.
original residue
C
variation residue
R
position
106
score
100.0
distance
51.793354
seq distance
55
chain
C
LDL-receptor class A
begin
83
end
95
score
50.87412587412587
distance
52.121925
seq distance
False
chain
E
LDL-receptor class A
begin
83
end
95
score
50.87412587412587
distance
52.121925
seq distance
False
chain
E
Confirmed at protein level; dbSNP:rs1063499.
original residue
S
variation residue
T
position
367
score
100.0
distance
56.18613
seq distance
316
chain
C
Confirmed at protein level; dbSNP:rs1063499.
original residue
S
variation residue
T
position
367
score
100.0
distance
56.18613
seq distance
316
chain
C
Sushi 2
begin
607
end
668
score
100.0
distance
59.863186
seq distance
556
chain
C
Sushi 2
begin
607
end
668
score
100.0
distance
59.863186
seq distance
556
chain
C
Disordered
begin
564
end
573
score
62.272727272727266
distance
60.87853
seq distance
False
chain
B
Disordered
begin
564
end
573
score
62.272727272727266
distance
60.87853
seq distance
False
chain
B
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
566
score
86.36363636363636
distance
62.184883
seq distance
False
chain
B
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
566
score
86.36363636363636
distance
62.184883
seq distance
False
chain
B
In dbSNP:rs75345202.
original residue
R
variation residue
H
position
414
score
54.54545454545454
distance
65.25632
seq distance
False
chain
E
In dbSNP:rs75345202.
original residue
R
variation residue
H
position
414
score
54.54545454545454
distance
65.25632
seq distance
False
chain
E
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
530
score
54.54545454545454
distance
67.897255
seq distance
False
chain
E
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
530
score
54.54545454545454
distance
67.897255
seq distance
False
chain
E
In C7D; dbSNP:rs369349760.
original residue
R
variation residue
Q
position
25
score
54.54545454545454
distance
68.4529
seq distance
False
chain
B
In C7D; dbSNP:rs369349760.
original residue
R
variation residue
Q
position
25
score
54.54545454545454
distance
68.4529
seq distance
False
chain
B
In dbSNP:rs2271708.
original residue
C
variation residue
R
position
532
score
54.54545454545454
distance
69.58438
seq distance
False
chain
E
In dbSNP:rs2271708.
original residue
C
variation residue
R
position
532
score
54.54545454545454
distance
69.58438
seq distance
False
chain
E
MACPF
begin
324
end
332
score
83.08080808080808
distance
72.184685
seq distance
False
chain
G
MACPF
begin
324
end
332
score
83.08080808080808
distance
72.184685
seq distance
False
chain
G
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
74.75325
seq distance
False
chain
G
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
74.75325
seq distance
False
chain
G
In C7D; dbSNP:rs541873000.
original residue
E
variation residue
Q
position
660
score
100.0
distance
74.86197
seq distance
609
chain
C
In C7D; dbSNP:rs541873000.
original residue
E
variation residue
Q
position
660
score
100.0
distance
74.86197
seq distance
609
chain
C
Confirmed at protein level; dbSNP:rs1063499.
original residue
S
variation residue
T
position
1040
score
54.54545454545454
distance
80.220406
seq distance
False
chain
A
Confirmed at protein level; dbSNP:rs1063499.
original residue
S
variation residue
T
position
1040
score
54.54545454545454
distance
80.220406
seq distance
False
chain
A
Disordered
begin
197
end
218
score
76.85950413223141
distance
86.76656
seq distance
146
chain
C
Disordered
begin
197
end
218
score
76.85950413223141
distance
86.76656
seq distance
146
chain
C
In C7D; dbSNP:rs113187203.
original residue
R
variation residue
H
position
665
score
100.0
distance
87.479805
seq distance
614
chain
C
In C7D; dbSNP:rs113187203.
original residue
R
variation residue
H
position
665
score
100.0
distance
87.479805
seq distance
614
chain
C
Disordered
begin
138
end
138
score
50.0
distance
87.92157
seq distance
False
chain
F
Disordered
begin
138
end
138
score
50.0
distance
87.92157
seq distance
False
chain
F
MACPF
begin
324
end
332
score
83.08080808080808
distance
94.85232
seq distance
False
chain
H
MACPF
begin
324
end
332
score
83.08080808080808
distance
94.85232
seq distance
False
chain
H
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
95.57293
seq distance
False
chain
G
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
95.57293
seq distance
False
chain
G
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
99.17188
seq distance
False
chain
H
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
99.17188
seq distance
False
chain
H
Confirmed at protein level; dbSNP:rs13157656.
original residue
T
variation residue
P
position
693
score
50.0
distance
104.36113
seq distance
False
chain
B
Confirmed at protein level; dbSNP:rs13157656.
original residue
T
variation residue
P
position
693
score
50.0
distance
104.36113
seq distance
False
chain
B
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
104.410545
seq distance
False
chain
G
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
104.410545
seq distance
False
chain
G
Factor I module (FIM) 1
begin
673
end
748
score
100.0
distance
109.66082
seq distance
622
chain
C
Factor I module (FIM) 1
begin
673
end
748
score
100.0
distance
109.66082
seq distance
622
chain
C
MACPF
begin
324
end
333
score
84.54545454545456
distance
115.58308
seq distance
False
chain
I
MACPF
begin
324
end
333
score
84.54545454545456
distance
115.58308
seq distance
False
chain
I
Disordered
begin
327
end
328
score
61.36363636363637
distance
119.06538
seq distance
False
chain
I
Disordered
begin
327
end
328
score
61.36363636363637
distance
119.06538
seq distance
False
chain
I
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
122.28134
seq distance
False
chain
I
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
122.28134
seq distance
False
chain
I
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
122.62525
seq distance
False
chain
H
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
122.62525
seq distance
False
chain
H
In C7D; dbSNP:rs369349760.
original residue
R
variation residue
Q
position
198
score
72.72727272727273
distance
124.75462
seq distance
147
chain
C
In C7D; dbSNP:rs369349760.
original residue
R
variation residue
Q
position
198
score
72.72727272727273
distance
124.75462
seq distance
147
chain
C
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
1560
score
50.0
distance
125.68586
seq distance
False
chain
A
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
1560
score
50.0
distance
125.68586
seq distance
False
chain
A
In dbSNP:rs75345202.
original residue
R
variation residue
H
position
200
score
72.72727272727273
distance
130.66273
seq distance
149
chain
C
In dbSNP:rs75345202.
original residue
R
variation residue
H
position
200
score
72.72727272727273
distance
130.66273
seq distance
149
chain
C
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
132.04015
seq distance
False
chain
H
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
132.04015
seq distance
False
chain
H
Factor I module (FIM) 2
begin
749
end
821
score
100.0
distance
133.02072
seq distance
698
chain
C
Factor I module (FIM) 2
begin
749
end
821
score
100.0
distance
133.02072
seq distance
698
chain
C
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
146.44548
seq distance
False
chain
I
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
146.44548
seq distance
False
chain
I

Details

Redox score
76.31
PDB code
7nyc
Structure name
cryoem structure of 3c9-smac
Structure deposition date
2021-03-22
Thiol separation (Å)
2.04
Half-sphere exposure sum
50
Minimum pKa
nan
% buried
nan
Peptide accession
P10643
Residue number A
39 (Residue 17 in this structure)
Residue number B
73 (Residue 51 in this structure)
Peptide name
Complement component C7
A redox-regulated disulphide may form within Complement component C7 at these cysteines.

Relevent regions

Factor I module (FIM) 2
begin
771
end
843
score
100.0
distance
2.807806
seq distance
0
chain
A
Factor I module (FIM) 2
begin
771
end
843
score
100.0
distance
2.807806
seq distance
0
chain
A
Factor I module (FIM) 1
begin
695
end
770
score
99.46172248803828
distance
13.290964
seq distance
35
chain
A
Factor I module (FIM) 1
begin
695
end
770
score
99.46172248803828
distance
13.290964
seq distance
35
chain
A
LDL-receptor class A
begin
795
end
795
score
70.45454545454545
distance
19.374163
seq distance
10
chain
A
LDL-receptor class A
begin
795
end
795
score
70.45454545454545
distance
19.374163
seq distance
10
chain
A
In C7D; dbSNP:rs113187203.
original residue
R
variation residue
H
position
712
score
50.0
distance
27.033096
seq distance
93
chain
A
In C7D; dbSNP:rs113187203.
original residue
R
variation residue
H
position
712
score
50.0
distance
27.033096
seq distance
93
chain
A

Details

Redox score
76.23
PDB code
2wcy
Structure name
nmr solution structure of factor i-like modules of complement c7.
Structure deposition date
2009-03-17
Thiol separation (Å)
2.03
Half-sphere exposure sum
52
Minimum pKa
nan
% buried
nan
Peptide accession
P10643
Residue number A
805
Residue number B
838
Peptide name
Complement component C7
A redox-regulated disulphide may form within Complement component C7 at these cysteines.

Relevent regions

Factor I module (FIM) 1
begin
695
end
770
score
99.46172248803828
distance
2.790966
seq distance
0
chain
A
Factor I module (FIM) 1
begin
695
end
770
score
99.46172248803828
distance
2.790966
seq distance
0
chain
A
In C7D; dbSNP:rs113187203.
original residue
R
variation residue
H
position
712
score
50.0
distance
10.76358
seq distance
3
chain
A
In C7D; dbSNP:rs113187203.
original residue
R
variation residue
H
position
712
score
50.0
distance
10.76358
seq distance
3
chain
A
Factor I module (FIM) 2
begin
771
end
843
score
100.0
distance
12.729168
seq distance
21
chain
A
Factor I module (FIM) 2
begin
771
end
843
score
100.0
distance
12.729168
seq distance
21
chain
A
LDL-receptor class A
begin
795
end
795
score
70.45454545454545
distance
27.740646
seq distance
45
chain
A
LDL-receptor class A
begin
795
end
795
score
70.45454545454545
distance
27.740646
seq distance
45
chain
A

Details

Redox score
76.23
PDB code
2wcy
Structure name
nmr solution structure of factor i-like modules of complement c7.
Structure deposition date
2009-03-17
Thiol separation (Å)
2.03
Half-sphere exposure sum
49
Minimum pKa
nan
% buried
nan
Peptide accession
P10643
Residue number A
715
Residue number B
750
Peptide name
Complement component C7
A redox-regulated disulphide may form within Complement component C7 at these cysteines.

Relevent regions

Factor I module (FIM) 2
begin
771
end
843
score
100.0
distance
2.78732
seq distance
0
chain
A
Factor I module (FIM) 2
begin
771
end
843
score
100.0
distance
2.78732
seq distance
0
chain
A
LDL-receptor class A
begin
795
end
795
score
70.45454545454545
distance
7.4242826
seq distance
2
chain
A
LDL-receptor class A
begin
795
end
795
score
70.45454545454545
distance
7.4242826
seq distance
2
chain
A
Factor I module (FIM) 1
begin
695
end
770
score
99.46172248803828
distance
9.441742
seq distance
27
chain
A
Factor I module (FIM) 1
begin
695
end
770
score
99.46172248803828
distance
9.441742
seq distance
27
chain
A
In C7D; dbSNP:rs113187203.
original residue
R
variation residue
H
position
712
score
50.0
distance
24.678598
seq distance
85
chain
A
In C7D; dbSNP:rs113187203.
original residue
R
variation residue
H
position
712
score
50.0
distance
24.678598
seq distance
85
chain
A

Details

Redox score
76.13
PDB code
2wcy
Structure name
nmr solution structure of factor i-like modules of complement c7.
Structure deposition date
2009-03-17
Thiol separation (Å)
2.03
Half-sphere exposure sum
62
Minimum pKa
nan
% buried
nan
Peptide accession
P10643
Residue number A
797
Residue number B
818
Peptide name
Complement component C7
A redox-regulated disulphide may form within Complement component C7 at these cysteines.

Relevent regions

Factor I module (FIM) 2
begin
771
end
843
score
100.0
distance
2.7983186
seq distance
0
chain
A
Factor I module (FIM) 2
begin
771
end
843
score
100.0
distance
2.7983186
seq distance
0
chain
A
Factor I module (FIM) 1
begin
695
end
770
score
99.46172248803828
distance
4.2923
seq distance
21
chain
A
Factor I module (FIM) 1
begin
695
end
770
score
99.46172248803828
distance
4.2923
seq distance
21
chain
A
LDL-receptor class A
begin
795
end
795
score
70.45454545454545
distance
13.731085
seq distance
4
chain
A
LDL-receptor class A
begin
795
end
795
score
70.45454545454545
distance
13.731085
seq distance
4
chain
A
In C7D; dbSNP:rs113187203.
original residue
R
variation residue
H
position
712
score
50.0
distance
35.82945
seq distance
79
chain
A
In C7D; dbSNP:rs113187203.
original residue
R
variation residue
H
position
712
score
50.0
distance
35.82945
seq distance
79
chain
A

Details

Redox score
76.13
PDB code
2wcy
Structure name
nmr solution structure of factor i-like modules of complement c7.
Structure deposition date
2009-03-17
Thiol separation (Å)
2.03
Half-sphere exposure sum
66
Minimum pKa
nan
% buried
nan
Peptide accession
P10643
Residue number A
791
Residue number B
825
Peptide name
Complement component C7
A redox-regulated disulphide may form within Complement component C7 at these cysteines.

Relevent regions

Factor I module (FIM) 1
begin
695
end
770
score
99.46172248803828
distance
2.8058136
seq distance
0
chain
A
Factor I module (FIM) 1
begin
695
end
770
score
99.46172248803828
distance
2.8058136
seq distance
0
chain
A
Factor I module (FIM) 2
begin
771
end
843
score
100.0
distance
11.229217
seq distance
8
chain
A
Factor I module (FIM) 2
begin
771
end
843
score
100.0
distance
11.229217
seq distance
8
chain
A
LDL-receptor class A
begin
795
end
795
score
70.45454545454545
distance
27.07384
seq distance
32
chain
A
LDL-receptor class A
begin
795
end
795
score
70.45454545454545
distance
27.07384
seq distance
32
chain
A
In C7D; dbSNP:rs113187203.
original residue
R
variation residue
H
position
712
score
50.0
distance
32.90835
seq distance
16
chain
A
In C7D; dbSNP:rs113187203.
original residue
R
variation residue
H
position
712
score
50.0
distance
32.90835
seq distance
16
chain
A

Details

Redox score
76.13
PDB code
2wcy
Structure name
nmr solution structure of factor i-like modules of complement c7.
Structure deposition date
2009-03-17
Thiol separation (Å)
2.03
Half-sphere exposure sum
56
Minimum pKa
nan
% buried
nan
Peptide accession
P10643
Residue number A
728
Residue number B
763
Peptide name
Complement component C7
A redox-regulated disulphide may form within Complement component C7 at these cysteines.

Relevent regions

MACPF
begin
102
end
434
score
94.85394485394487
distance
2.854038
seq distance
0
chain
C
MACPF
begin
102
end
434
score
94.85394485394487
distance
2.854038
seq distance
0
chain
C
Disordered
begin
197
end
218
score
76.85950413223141
distance
5.9805665
seq distance
97
chain
C
Disordered
begin
197
end
218
score
76.85950413223141
distance
5.9805665
seq distance
97
chain
C
In C7D; dbSNP:rs369349760.
original residue
R
variation residue
Q
position
198
score
72.72727272727273
distance
13.293757
seq distance
117
chain
C
In C7D; dbSNP:rs369349760.
original residue
R
variation residue
Q
position
198
score
72.72727272727273
distance
13.293757
seq distance
117
chain
C
In dbSNP:rs75345202.
original residue
R
variation residue
H
position
200
score
72.72727272727273
distance
18.891226
seq distance
115
chain
C
In dbSNP:rs75345202.
original residue
R
variation residue
H
position
200
score
72.72727272727273
distance
18.891226
seq distance
115
chain
C
In C7D; dbSNP:rs369349760.
original residue
R
variation residue
Q
position
25
score
54.54545454545454
distance
61.620193
seq distance
False
chain
B
In C7D; dbSNP:rs369349760.
original residue
R
variation residue
Q
position
25
score
54.54545454545454
distance
61.620193
seq distance
False
chain
B
Disordered
begin
510
end
522
score
53.67132867132868
distance
61.644688
seq distance
False
chain
D
Disordered
begin
510
end
522
score
53.67132867132868
distance
61.644688
seq distance
False
chain
D
EGF-like
begin
435
end
465
score
100.0
distance
67.64763
seq distance
104
chain
C
EGF-like
begin
435
end
465
score
100.0
distance
67.64763
seq distance
104
chain
C
EGF-like
begin
451
end
455
score
54.090909090909086
distance
70.55413
seq distance
False
chain
D
EGF-like
begin
451
end
455
score
54.090909090909086
distance
70.55413
seq distance
False
chain
D
Disordered
begin
494
end
516
score
100.0
distance
71.461586
seq distance
163
chain
C
Disordered
begin
494
end
516
score
100.0
distance
71.461586
seq distance
163
chain
C
TSP type-1 2
begin
478
end
527
score
100.0
distance
71.461586
seq distance
147
chain
C
TSP type-1 2
begin
478
end
527
score
100.0
distance
71.461586
seq distance
147
chain
C
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
512
score
81.81818181818183
distance
75.69647
seq distance
False
chain
D
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
512
score
81.81818181818183
distance
75.69647
seq distance
False
chain
D
TSP type-1 1
begin
5
end
58
score
99.83164983164983
distance
76.13286
seq distance
257
chain
C
TSP type-1 1
begin
5
end
58
score
99.83164983164983
distance
76.13286
seq distance
257
chain
C
Confirmed at protein level; dbSNP:rs1063499.
original residue
S
variation residue
T
position
367
score
100.0
distance
77.46965
seq distance
36
chain
C
Confirmed at protein level; dbSNP:rs1063499.
original residue
S
variation residue
T
position
367
score
100.0
distance
77.46965
seq distance
36
chain
C
In dbSNP:rs2271708.
original residue
C
variation residue
R
position
532
score
54.54545454545454
distance
78.66938
seq distance
False
chain
E
In dbSNP:rs2271708.
original residue
C
variation residue
R
position
532
score
54.54545454545454
distance
78.66938
seq distance
False
chain
E
In dbSNP:rs75345202.
original residue
R
variation residue
H
position
414
score
54.54545454545454
distance
81.4519
seq distance
False
chain
E
In dbSNP:rs75345202.
original residue
R
variation residue
H
position
414
score
54.54545454545454
distance
81.4519
seq distance
False
chain
E
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
530
score
54.54545454545454
distance
84.99834
seq distance
False
chain
E
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
530
score
54.54545454545454
distance
84.99834
seq distance
False
chain
E
In C7D; dbSNP:rs121964921.
original residue
G
variation residue
R
position
357
score
100.0
distance
88.60153
seq distance
26
chain
C
In C7D; dbSNP:rs121964921.
original residue
G
variation residue
R
position
357
score
100.0
distance
88.60153
seq distance
26
chain
C
MACPF
begin
324
end
332
score
83.08080808080808
distance
91.218636
seq distance
False
chain
G
MACPF
begin
324
end
332
score
83.08080808080808
distance
91.218636
seq distance
False
chain
G
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
499
score
100.0
distance
91.261955
seq distance
168
chain
C
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
499
score
100.0
distance
91.261955
seq distance
168
chain
C
Disordered
begin
564
end
573
score
62.272727272727266
distance
92.151436
seq distance
False
chain
B
Disordered
begin
564
end
573
score
62.272727272727266
distance
92.151436
seq distance
False
chain
B
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
412
score
63.63636363636363
distance
92.458206
seq distance
False
chain
D
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
412
score
63.63636363636363
distance
92.458206
seq distance
False
chain
D
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
96.72554
seq distance
False
chain
G
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
96.72554
seq distance
False
chain
G
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
398
score
100.0
distance
96.86398
seq distance
67
chain
C
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
398
score
100.0
distance
96.86398
seq distance
67
chain
C
MACPF
begin
324
end
332
score
83.08080808080808
distance
97.37138
seq distance
False
chain
H
MACPF
begin
324
end
332
score
83.08080808080808
distance
97.37138
seq distance
False
chain
H
Disordered
begin
86
end
121
score
100.0
distance
97.40357
seq distance
194
chain
C
Disordered
begin
86
end
121
score
100.0
distance
97.40357
seq distance
194
chain
C
Disordered
begin
504
end
504
score
68.18181818181817
distance
99.738655
seq distance
False
chain
D
Disordered
begin
504
end
504
score
68.18181818181817
distance
99.738655
seq distance
False
chain
D
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
103.42285
seq distance
False
chain
H
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
103.42285
seq distance
False
chain
H
MACPF
begin
324
end
333
score
84.54545454545456
distance
103.671265
seq distance
False
chain
I
MACPF
begin
324
end
333
score
84.54545454545456
distance
103.671265
seq distance
False
chain
I
Disordered
begin
138
end
138
score
50.0
distance
103.80279
seq distance
False
chain
F
Disordered
begin
138
end
138
score
50.0
distance
103.80279
seq distance
False
chain
F
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
566
score
86.36363636363636
distance
105.899475
seq distance
False
chain
B
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
566
score
86.36363636363636
distance
105.899475
seq distance
False
chain
B
CCP 1
begin
523
end
593
score
100.0
distance
109.91742
seq distance
192
chain
C
CCP 1
begin
523
end
593
score
100.0
distance
109.91742
seq distance
192
chain
C
LDL-receptor class A
begin
61
end
99
score
100.0
distance
111.26951
seq distance
216
chain
C
LDL-receptor class A
begin
61
end
99
score
100.0
distance
111.26951
seq distance
216
chain
C
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
111.88423
seq distance
False
chain
I
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
111.88423
seq distance
False
chain
I
Disordered
begin
327
end
328
score
61.36363636363637
distance
113.406075
seq distance
False
chain
I
Disordered
begin
327
end
328
score
61.36363636363637
distance
113.406075
seq distance
False
chain
I
Disordered
begin
91
end
92
score
68.18181818181817
distance
115.45143
seq distance
False
chain
D
Disordered
begin
91
end
92
score
68.18181818181817
distance
115.45143
seq distance
False
chain
D
LDL-receptor class A
begin
84
end
92
score
56.56565656565656
distance
115.45143
seq distance
False
chain
D
LDL-receptor class A
begin
84
end
92
score
56.56565656565656
distance
115.45143
seq distance
False
chain
D
In dbSNP:rs2271708.
original residue
C
variation residue
R
position
106
score
100.0
distance
116.12095
seq distance
209
chain
C
In dbSNP:rs2271708.
original residue
C
variation residue
R
position
106
score
100.0
distance
116.12095
seq distance
209
chain
C
LDL-receptor class A
begin
83
end
95
score
50.87412587412587
distance
116.83117
seq distance
False
chain
E
LDL-receptor class A
begin
83
end
95
score
50.87412587412587
distance
116.83117
seq distance
False
chain
E
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
121.56389
seq distance
False
chain
G
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
121.56389
seq distance
False
chain
G
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
124.00205
seq distance
False
chain
G
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
124.00205
seq distance
False
chain
G
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
129.8779
seq distance
False
chain
H
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
129.8779
seq distance
False
chain
H
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
133.47134
seq distance
False
chain
H
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
133.47134
seq distance
False
chain
H
Sushi 1
begin
547
end
606
score
100.0
distance
135.52538
seq distance
216
chain
C
Sushi 1
begin
547
end
606
score
100.0
distance
135.52538
seq distance
216
chain
C
CCP 2
begin
594
end
671
score
100.0
distance
139.98512
seq distance
263
chain
C
CCP 2
begin
594
end
671
score
100.0
distance
139.98512
seq distance
263
chain
C
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
140.67226
seq distance
False
chain
I
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
140.67226
seq distance
False
chain
I
Confirmed at protein level; dbSNP:rs1063499.
original residue
S
variation residue
T
position
1040
score
54.54545454545454
distance
141.55771
seq distance
False
chain
A
Confirmed at protein level; dbSNP:rs1063499.
original residue
S
variation residue
T
position
1040
score
54.54545454545454
distance
141.55771
seq distance
False
chain
A
Confirmed at protein level; dbSNP:rs13157656.
original residue
T
variation residue
P
position
565
score
100.0
distance
145.19772
seq distance
234
chain
C
Confirmed at protein level; dbSNP:rs13157656.
original residue
T
variation residue
P
position
565
score
100.0
distance
145.19772
seq distance
234
chain
C
Confirmed at protein level; dbSNP:rs13157656.
original residue
T
variation residue
P
position
693
score
50.0
distance
169.65027
seq distance
False
chain
B
Confirmed at protein level; dbSNP:rs13157656.
original residue
T
variation residue
P
position
693
score
50.0
distance
169.65027
seq distance
False
chain
B
Sushi 2
begin
607
end
668
score
100.0
distance
171.63713
seq distance
276
chain
C
Sushi 2
begin
607
end
668
score
100.0
distance
171.63713
seq distance
276
chain
C
In C7D; dbSNP:rs541873000.
original residue
E
variation residue
Q
position
660
score
100.0
distance
183.2007
seq distance
329
chain
C
In C7D; dbSNP:rs541873000.
original residue
E
variation residue
Q
position
660
score
100.0
distance
183.2007
seq distance
329
chain
C
In C7D; dbSNP:rs113187203.
original residue
R
variation residue
H
position
665
score
100.0
distance
194.47438
seq distance
334
chain
C
In C7D; dbSNP:rs113187203.
original residue
R
variation residue
H
position
665
score
100.0
distance
194.47438
seq distance
334
chain
C
Factor I module (FIM) 1
begin
673
end
748
score
100.0
distance
215.68698
seq distance
342
chain
C
Factor I module (FIM) 1
begin
673
end
748
score
100.0
distance
215.68698
seq distance
342
chain
C
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
1560
score
50.0
distance
225.21739
seq distance
False
chain
A
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
1560
score
50.0
distance
225.21739
seq distance
False
chain
A
Factor I module (FIM) 2
begin
749
end
821
score
100.0
distance
241.7393
seq distance
418
chain
C
Factor I module (FIM) 2
begin
749
end
821
score
100.0
distance
241.7393
seq distance
418
chain
C

Details

Redox score
76.12
PDB code
7nyc
Structure name
cryoem structure of 3c9-smac
Structure deposition date
2021-03-22
Thiol separation (Å)
2.04
Half-sphere exposure sum
53
Minimum pKa
nan
% buried
nan
Peptide accession
P10643
Residue number A
337 (Residue 315 in this structure)
Residue number B
353 (Residue 331 in this structure)
Peptide name
Complement component C7
A redox-regulated disulphide may form within Complement component C7 at these cysteines.

Relevent regions

EGF-like
begin
435
end
465
score
100.0
distance
2.7987742
seq distance
0
chain
C
EGF-like
begin
435
end
465
score
100.0
distance
2.7987742
seq distance
0
chain
C
MACPF
begin
102
end
434
score
94.85394485394487
distance
4.419828
seq distance
1
chain
C
MACPF
begin
102
end
434
score
94.85394485394487
distance
4.419828
seq distance
1
chain
C
TSP type-1 1
begin
5
end
58
score
99.83164983164983
distance
5.273106
seq distance
377
chain
C
TSP type-1 1
begin
5
end
58
score
99.83164983164983
distance
5.273106
seq distance
377
chain
C
TSP type-1 2
begin
478
end
527
score
100.0
distance
9.81254
seq distance
27
chain
C
TSP type-1 2
begin
478
end
527
score
100.0
distance
9.81254
seq distance
27
chain
C
Disordered
begin
494
end
516
score
100.0
distance
11.901647
seq distance
43
chain
C
Disordered
begin
494
end
516
score
100.0
distance
11.901647
seq distance
43
chain
C
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
499
score
100.0
distance
15.656078
seq distance
48
chain
C
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
499
score
100.0
distance
15.656078
seq distance
48
chain
C
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
412
score
63.63636363636363
distance
21.166243
seq distance
False
chain
D
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
412
score
63.63636363636363
distance
21.166243
seq distance
False
chain
D
Disordered
begin
86
end
121
score
100.0
distance
22.719585
seq distance
314
chain
C
Disordered
begin
86
end
121
score
100.0
distance
22.719585
seq distance
314
chain
C
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
398
score
100.0
distance
24.870333
seq distance
37
chain
C
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
398
score
100.0
distance
24.870333
seq distance
37
chain
C
Disordered
begin
510
end
522
score
53.67132867132868
distance
25.176613
seq distance
False
chain
D
Disordered
begin
510
end
522
score
53.67132867132868
distance
25.176613
seq distance
False
chain
D
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
512
score
81.81818181818183
distance
27.923115
seq distance
False
chain
D
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
512
score
81.81818181818183
distance
27.923115
seq distance
False
chain
D
CCP 1
begin
523
end
593
score
100.0
distance
28.226913
seq distance
72
chain
C
CCP 1
begin
523
end
593
score
100.0
distance
28.226913
seq distance
72
chain
C
Disordered
begin
504
end
504
score
68.18181818181817
distance
28.967176
seq distance
False
chain
D
Disordered
begin
504
end
504
score
68.18181818181817
distance
28.967176
seq distance
False
chain
D
In C7D; dbSNP:rs121964921.
original residue
G
variation residue
R
position
357
score
100.0
distance
30.453465
seq distance
78
chain
C
In C7D; dbSNP:rs121964921.
original residue
G
variation residue
R
position
357
score
100.0
distance
30.453465
seq distance
78
chain
C
Confirmed at protein level; dbSNP:rs1063499.
original residue
S
variation residue
T
position
367
score
100.0
distance
32.266907
seq distance
68
chain
C
Confirmed at protein level; dbSNP:rs1063499.
original residue
S
variation residue
T
position
367
score
100.0
distance
32.266907
seq distance
68
chain
C
EGF-like
begin
451
end
455
score
54.090909090909086
distance
34.070145
seq distance
False
chain
D
EGF-like
begin
451
end
455
score
54.090909090909086
distance
34.070145
seq distance
False
chain
D
In C7D; dbSNP:rs369349760.
original residue
R
variation residue
Q
position
25
score
54.54545454545454
distance
34.855526
seq distance
False
chain
B
In C7D; dbSNP:rs369349760.
original residue
R
variation residue
Q
position
25
score
54.54545454545454
distance
34.855526
seq distance
False
chain
B
LDL-receptor class A
begin
61
end
99
score
100.0
distance
38.549587
seq distance
336
chain
C
LDL-receptor class A
begin
61
end
99
score
100.0
distance
38.549587
seq distance
336
chain
C
Disordered
begin
564
end
573
score
62.272727272727266
distance
39.740067
seq distance
False
chain
B
Disordered
begin
564
end
573
score
62.272727272727266
distance
39.740067
seq distance
False
chain
B
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
566
score
86.36363636363636
distance
46.435677
seq distance
False
chain
B
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
566
score
86.36363636363636
distance
46.435677
seq distance
False
chain
B
Disordered
begin
91
end
92
score
68.18181818181817
distance
48.13991
seq distance
False
chain
D
Disordered
begin
91
end
92
score
68.18181818181817
distance
48.13991
seq distance
False
chain
D
LDL-receptor class A
begin
84
end
92
score
56.56565656565656
distance
48.13991
seq distance
False
chain
D
LDL-receptor class A
begin
84
end
92
score
56.56565656565656
distance
48.13991
seq distance
False
chain
D
In dbSNP:rs75345202.
original residue
R
variation residue
H
position
414
score
54.54545454545454
distance
48.215897
seq distance
False
chain
E
In dbSNP:rs75345202.
original residue
R
variation residue
H
position
414
score
54.54545454545454
distance
48.215897
seq distance
False
chain
E
In dbSNP:rs2271708.
original residue
C
variation residue
R
position
106
score
100.0
distance
50.89676
seq distance
329
chain
C
In dbSNP:rs2271708.
original residue
C
variation residue
R
position
106
score
100.0
distance
50.89676
seq distance
329
chain
C
Sushi 1
begin
547
end
606
score
100.0
distance
52.27577
seq distance
96
chain
C
Sushi 1
begin
547
end
606
score
100.0
distance
52.27577
seq distance
96
chain
C
Disordered
begin
197
end
218
score
76.85950413223141
distance
53.373314
seq distance
217
chain
C
Disordered
begin
197
end
218
score
76.85950413223141
distance
53.373314
seq distance
217
chain
C
CCP 2
begin
594
end
671
score
100.0
distance
57.477924
seq distance
143
chain
C
CCP 2
begin
594
end
671
score
100.0
distance
57.477924
seq distance
143
chain
C
In dbSNP:rs2271708.
original residue
C
variation residue
R
position
532
score
54.54545454545454
distance
57.625233
seq distance
False
chain
E
In dbSNP:rs2271708.
original residue
C
variation residue
R
position
532
score
54.54545454545454
distance
57.625233
seq distance
False
chain
E
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
530
score
54.54545454545454
distance
59.298843
seq distance
False
chain
E
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
530
score
54.54545454545454
distance
59.298843
seq distance
False
chain
E
LDL-receptor class A
begin
83
end
95
score
50.87412587412587
distance
61.408623
seq distance
False
chain
E
LDL-receptor class A
begin
83
end
95
score
50.87412587412587
distance
61.408623
seq distance
False
chain
E
Confirmed at protein level; dbSNP:rs13157656.
original residue
T
variation residue
P
position
565
score
100.0
distance
61.94432
seq distance
114
chain
C
Confirmed at protein level; dbSNP:rs13157656.
original residue
T
variation residue
P
position
565
score
100.0
distance
61.94432
seq distance
114
chain
C
MACPF
begin
324
end
332
score
83.08080808080808
distance
64.12117
seq distance
False
chain
G
MACPF
begin
324
end
332
score
83.08080808080808
distance
64.12117
seq distance
False
chain
G
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
68.15015
seq distance
False
chain
G
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
68.15015
seq distance
False
chain
G
Disordered
begin
138
end
138
score
50.0
distance
72.30994
seq distance
False
chain
F
Disordered
begin
138
end
138
score
50.0
distance
72.30994
seq distance
False
chain
F
Confirmed at protein level; dbSNP:rs1063499.
original residue
S
variation residue
T
position
1040
score
54.54545454545454
distance
77.478745
seq distance
False
chain
A
Confirmed at protein level; dbSNP:rs1063499.
original residue
S
variation residue
T
position
1040
score
54.54545454545454
distance
77.478745
seq distance
False
chain
A
MACPF
begin
324
end
332
score
83.08080808080808
distance
84.372505
seq distance
False
chain
H
MACPF
begin
324
end
332
score
83.08080808080808
distance
84.372505
seq distance
False
chain
H
Sushi 2
begin
607
end
668
score
100.0
distance
87.77458
seq distance
156
chain
C
Sushi 2
begin
607
end
668
score
100.0
distance
87.77458
seq distance
156
chain
C
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
90.51423
seq distance
False
chain
H
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
90.51423
seq distance
False
chain
H
In C7D; dbSNP:rs369349760.
original residue
R
variation residue
Q
position
198
score
72.72727272727273
distance
92.581856
seq distance
237
chain
C
In C7D; dbSNP:rs369349760.
original residue
R
variation residue
Q
position
198
score
72.72727272727273
distance
92.581856
seq distance
237
chain
C
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
95.290886
seq distance
False
chain
G
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
95.290886
seq distance
False
chain
G
In dbSNP:rs75345202.
original residue
R
variation residue
H
position
200
score
72.72727272727273
distance
98.80885
seq distance
235
chain
C
In dbSNP:rs75345202.
original residue
R
variation residue
H
position
200
score
72.72727272727273
distance
98.80885
seq distance
235
chain
C
In C7D; dbSNP:rs541873000.
original residue
E
variation residue
Q
position
660
score
100.0
distance
100.07353
seq distance
209
chain
C
In C7D; dbSNP:rs541873000.
original residue
E
variation residue
Q
position
660
score
100.0
distance
100.07353
seq distance
209
chain
C
MACPF
begin
324
end
333
score
84.54545454545456
distance
102.829384
seq distance
False
chain
I
MACPF
begin
324
end
333
score
84.54545454545456
distance
102.829384
seq distance
False
chain
I
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
103.460335
seq distance
False
chain
G
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
103.460335
seq distance
False
chain
G
Confirmed at protein level; dbSNP:rs13157656.
original residue
T
variation residue
P
position
693
score
50.0
distance
106.06868
seq distance
False
chain
B
Confirmed at protein level; dbSNP:rs13157656.
original residue
T
variation residue
P
position
693
score
50.0
distance
106.06868
seq distance
False
chain
B
Disordered
begin
327
end
328
score
61.36363636363637
distance
108.935104
seq distance
False
chain
I
Disordered
begin
327
end
328
score
61.36363636363637
distance
108.935104
seq distance
False
chain
I
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
111.243706
seq distance
False
chain
I
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
111.243706
seq distance
False
chain
I
In C7D; dbSNP:rs113187203.
original residue
R
variation residue
H
position
665
score
100.0
distance
111.8388
seq distance
214
chain
C
In C7D; dbSNP:rs113187203.
original residue
R
variation residue
H
position
665
score
100.0
distance
111.8388
seq distance
214
chain
C
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
118.15354
seq distance
False
chain
H
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
118.15354
seq distance
False
chain
H
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
127.0321
seq distance
False
chain
H
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
127.0321
seq distance
False
chain
H
Factor I module (FIM) 1
begin
673
end
748
score
100.0
distance
133.60039
seq distance
222
chain
C
Factor I module (FIM) 1
begin
673
end
748
score
100.0
distance
133.60039
seq distance
222
chain
C
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
138.85297
seq distance
False
chain
I
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
138.85297
seq distance
False
chain
I
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
1560
score
50.0
distance
146.21225
seq distance
False
chain
A
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
1560
score
50.0
distance
146.21225
seq distance
False
chain
A
Factor I module (FIM) 2
begin
749
end
821
score
100.0
distance
159.04236
seq distance
298
chain
C
Factor I module (FIM) 2
begin
749
end
821
score
100.0
distance
159.04236
seq distance
298
chain
C

Details

Redox score
76.03
PDB code
7nyc
Structure name
cryoem structure of 3c9-smac
Structure deposition date
2021-03-22
Thiol separation (Å)
2.03
Half-sphere exposure sum
79
Minimum pKa
nan
% buried
nan
Peptide accession
P10643
Residue number A
457 (Residue 435 in this structure)
Residue number B
473 (Residue 451 in this structure)
Peptide name
Complement component C7
A redox-regulated disulphide may form within Complement component C7 at these cysteines.

Relevent regions

Disordered
begin
86
end
121
score
100.0
distance
2.7897003
seq distance
0
chain
C
Disordered
begin
86
end
121
score
100.0
distance
2.7897003
seq distance
0
chain
C
LDL-receptor class A
begin
61
end
99
score
100.0
distance
2.7897003
seq distance
0
chain
C
LDL-receptor class A
begin
61
end
99
score
100.0
distance
2.7897003
seq distance
0
chain
C
MACPF
begin
102
end
434
score
94.85394485394487
distance
4.0554366
seq distance
5
chain
C
MACPF
begin
102
end
434
score
94.85394485394487
distance
4.0554366
seq distance
5
chain
C
LDL-receptor class A
begin
84
end
92
score
56.56565656565656
distance
13.171203
seq distance
False
chain
D
LDL-receptor class A
begin
84
end
92
score
56.56565656565656
distance
13.171203
seq distance
False
chain
D
In dbSNP:rs2271708.
original residue
C
variation residue
R
position
106
score
100.0
distance
14.042864
seq distance
9
chain
C
In dbSNP:rs2271708.
original residue
C
variation residue
R
position
106
score
100.0
distance
14.042864
seq distance
9
chain
C
Disordered
begin
91
end
92
score
68.18181818181817
distance
21.3894
seq distance
False
chain
D
Disordered
begin
91
end
92
score
68.18181818181817
distance
21.3894
seq distance
False
chain
D
LDL-receptor class A
begin
83
end
95
score
50.87412587412587
distance
32.368557
seq distance
False
chain
E
LDL-receptor class A
begin
83
end
95
score
50.87412587412587
distance
32.368557
seq distance
False
chain
E
TSP type-1 1
begin
5
end
58
score
99.83164983164983
distance
34.631916
seq distance
23
chain
C
TSP type-1 1
begin
5
end
58
score
99.83164983164983
distance
34.631916
seq distance
23
chain
C
In C7D; dbSNP:rs121964921.
original residue
G
variation residue
R
position
357
score
100.0
distance
37.218433
seq distance
260
chain
C
In C7D; dbSNP:rs121964921.
original residue
G
variation residue
R
position
357
score
100.0
distance
37.218433
seq distance
260
chain
C
CCP 1
begin
523
end
593
score
100.0
distance
37.84759
seq distance
426
chain
C
CCP 1
begin
523
end
593
score
100.0
distance
37.84759
seq distance
426
chain
C
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
398
score
100.0
distance
38.403194
seq distance
301
chain
C
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
398
score
100.0
distance
38.403194
seq distance
301
chain
C
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
412
score
63.63636363636363
distance
39.3896
seq distance
False
chain
D
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
412
score
63.63636363636363
distance
39.3896
seq distance
False
chain
D
TSP type-1 2
begin
478
end
527
score
100.0
distance
44.886562
seq distance
381
chain
C
TSP type-1 2
begin
478
end
527
score
100.0
distance
44.886562
seq distance
381
chain
C
Confirmed at protein level; dbSNP:rs1063499.
original residue
S
variation residue
T
position
367
score
100.0
distance
47.767235
seq distance
270
chain
C
Confirmed at protein level; dbSNP:rs1063499.
original residue
S
variation residue
T
position
367
score
100.0
distance
47.767235
seq distance
270
chain
C
EGF-like
begin
435
end
465
score
100.0
distance
48.111076
seq distance
338
chain
C
EGF-like
begin
435
end
465
score
100.0
distance
48.111076
seq distance
338
chain
C
In dbSNP:rs75345202.
original residue
R
variation residue
H
position
414
score
54.54545454545454
distance
50.510685
seq distance
False
chain
E
In dbSNP:rs75345202.
original residue
R
variation residue
H
position
414
score
54.54545454545454
distance
50.510685
seq distance
False
chain
E
Sushi 1
begin
547
end
606
score
100.0
distance
53.08477
seq distance
450
chain
C
Sushi 1
begin
547
end
606
score
100.0
distance
53.08477
seq distance
450
chain
C
Disordered
begin
138
end
138
score
50.0
distance
53.6832
seq distance
False
chain
F
Disordered
begin
138
end
138
score
50.0
distance
53.6832
seq distance
False
chain
F
Disordered
begin
494
end
516
score
100.0
distance
56.247425
seq distance
397
chain
C
Disordered
begin
494
end
516
score
100.0
distance
56.247425
seq distance
397
chain
C
MACPF
begin
324
end
332
score
83.08080808080808
distance
59.36211
seq distance
False
chain
G
MACPF
begin
324
end
332
score
83.08080808080808
distance
59.36211
seq distance
False
chain
G
Confirmed at protein level; dbSNP:rs13157656.
original residue
T
variation residue
P
position
565
score
100.0
distance
60.43114
seq distance
468
chain
C
Confirmed at protein level; dbSNP:rs13157656.
original residue
T
variation residue
P
position
565
score
100.0
distance
60.43114
seq distance
468
chain
C
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
499
score
100.0
distance
60.647797
seq distance
402
chain
C
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
499
score
100.0
distance
60.647797
seq distance
402
chain
C
CCP 2
begin
594
end
671
score
100.0
distance
61.567806
seq distance
497
chain
C
CCP 2
begin
594
end
671
score
100.0
distance
61.567806
seq distance
497
chain
C
EGF-like
begin
451
end
455
score
54.090909090909086
distance
62.06087
seq distance
False
chain
D
EGF-like
begin
451
end
455
score
54.090909090909086
distance
62.06087
seq distance
False
chain
D
Disordered
begin
564
end
573
score
62.272727272727266
distance
62.06858
seq distance
False
chain
B
Disordered
begin
564
end
573
score
62.272727272727266
distance
62.06858
seq distance
False
chain
B
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
566
score
86.36363636363636
distance
62.698982
seq distance
False
chain
B
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
566
score
86.36363636363636
distance
62.698982
seq distance
False
chain
B
Disordered
begin
504
end
504
score
68.18181818181817
distance
64.61838
seq distance
False
chain
D
Disordered
begin
504
end
504
score
68.18181818181817
distance
64.61838
seq distance
False
chain
D
Disordered
begin
510
end
522
score
53.67132867132868
distance
65.108376
seq distance
False
chain
D
Disordered
begin
510
end
522
score
53.67132867132868
distance
65.108376
seq distance
False
chain
D
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
65.53429
seq distance
False
chain
G
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
65.53429
seq distance
False
chain
G
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
512
score
81.81818181818183
distance
67.961754
seq distance
False
chain
D
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
512
score
81.81818181818183
distance
67.961754
seq distance
False
chain
D
Sushi 2
begin
607
end
668
score
100.0
distance
69.142075
seq distance
510
chain
C
Sushi 2
begin
607
end
668
score
100.0
distance
69.142075
seq distance
510
chain
C
MACPF
begin
324
end
332
score
83.08080808080808
distance
75.094986
seq distance
False
chain
H
MACPF
begin
324
end
332
score
83.08080808080808
distance
75.094986
seq distance
False
chain
H
In C7D; dbSNP:rs369349760.
original residue
R
variation residue
Q
position
25
score
54.54545454545454
distance
77.65904
seq distance
False
chain
B
In C7D; dbSNP:rs369349760.
original residue
R
variation residue
Q
position
25
score
54.54545454545454
distance
77.65904
seq distance
False
chain
B
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
530
score
54.54545454545454
distance
77.72158
seq distance
False
chain
E
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
530
score
54.54545454545454
distance
77.72158
seq distance
False
chain
E
In C7D; dbSNP:rs541873000.
original residue
E
variation residue
Q
position
660
score
100.0
distance
78.26197
seq distance
563
chain
C
In C7D; dbSNP:rs541873000.
original residue
E
variation residue
Q
position
660
score
100.0
distance
78.26197
seq distance
563
chain
C
In dbSNP:rs2271708.
original residue
C
variation residue
R
position
532
score
54.54545454545454
distance
78.29248
seq distance
False
chain
E
In dbSNP:rs2271708.
original residue
C
variation residue
R
position
532
score
54.54545454545454
distance
78.29248
seq distance
False
chain
E
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
81.36762
seq distance
False
chain
G
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
81.36762
seq distance
False
chain
G
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
82.345184
seq distance
False
chain
H
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
82.345184
seq distance
False
chain
H
Confirmed at protein level; dbSNP:rs1063499.
original residue
S
variation residue
T
position
1040
score
54.54545454545454
distance
83.050446
seq distance
False
chain
A
Confirmed at protein level; dbSNP:rs1063499.
original residue
S
variation residue
T
position
1040
score
54.54545454545454
distance
83.050446
seq distance
False
chain
A
Confirmed at protein level; dbSNP:rs13157656.
original residue
T
variation residue
P
position
693
score
50.0
distance
87.32172
seq distance
False
chain
B
Confirmed at protein level; dbSNP:rs13157656.
original residue
T
variation residue
P
position
693
score
50.0
distance
87.32172
seq distance
False
chain
B
MACPF
begin
324
end
333
score
84.54545454545456
distance
90.544174
seq distance
False
chain
I
MACPF
begin
324
end
333
score
84.54545454545456
distance
90.544174
seq distance
False
chain
I
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
91.45348
seq distance
False
chain
G
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
91.45348
seq distance
False
chain
G
In C7D; dbSNP:rs113187203.
original residue
R
variation residue
H
position
665
score
100.0
distance
91.83286
seq distance
568
chain
C
In C7D; dbSNP:rs113187203.
original residue
R
variation residue
H
position
665
score
100.0
distance
91.83286
seq distance
568
chain
C
Disordered
begin
197
end
218
score
76.85950413223141
distance
92.791534
seq distance
100
chain
C
Disordered
begin
197
end
218
score
76.85950413223141
distance
92.791534
seq distance
100
chain
C
Disordered
begin
327
end
328
score
61.36363636363637
distance
95.291214
seq distance
False
chain
I
Disordered
begin
327
end
328
score
61.36363636363637
distance
95.291214
seq distance
False
chain
I
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
99.77986
seq distance
False
chain
I
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
99.77986
seq distance
False
chain
I
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
101.03405
seq distance
False
chain
H
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
101.03405
seq distance
False
chain
H
Factor I module (FIM) 1
begin
673
end
748
score
100.0
distance
110.9516
seq distance
576
chain
C
Factor I module (FIM) 1
begin
673
end
748
score
100.0
distance
110.9516
seq distance
576
chain
C
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
111.00217
seq distance
False
chain
H
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
111.00217
seq distance
False
chain
H
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
1560
score
50.0
distance
112.41388
seq distance
False
chain
A
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
1560
score
50.0
distance
112.41388
seq distance
False
chain
A
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
119.037346
seq distance
False
chain
I
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
119.037346
seq distance
False
chain
I
Factor I module (FIM) 2
begin
749
end
821
score
100.0
distance
132.53754
seq distance
652
chain
C
Factor I module (FIM) 2
begin
749
end
821
score
100.0
distance
132.53754
seq distance
652
chain
C
In C7D; dbSNP:rs369349760.
original residue
R
variation residue
Q
position
198
score
72.72727272727273
distance
135.53203
seq distance
101
chain
C
In C7D; dbSNP:rs369349760.
original residue
R
variation residue
Q
position
198
score
72.72727272727273
distance
135.53203
seq distance
101
chain
C
In dbSNP:rs75345202.
original residue
R
variation residue
H
position
200
score
72.72727272727273
distance
142.33076
seq distance
103
chain
C
In dbSNP:rs75345202.
original residue
R
variation residue
H
position
200
score
72.72727272727273
distance
142.33076
seq distance
103
chain
C

Details

Redox score
75.94
PDB code
7nyc
Structure name
cryoem structure of 3c9-smac
Structure deposition date
2021-03-22
Thiol separation (Å)
2.03
Half-sphere exposure sum
53
Minimum pKa
nan
% buried
nan
Peptide accession
P10643
Residue number A
103 (Residue 81 in this structure)
Residue number B
119 (Residue 97 in this structure)
Peptide name
Complement component C7
A redox-regulated disulphide may form within Complement component C7 at these cysteines.

Relevent regions

CCP 2
begin
594
end
671
score
100.0
distance
2.7905076
seq distance
0
chain
C
CCP 2
begin
594
end
671
score
100.0
distance
2.7905076
seq distance
0
chain
C
Sushi 2
begin
607
end
668
score
100.0
distance
2.7905076
seq distance
0
chain
C
Sushi 2
begin
607
end
668
score
100.0
distance
2.7905076
seq distance
0
chain
C
In C7D; dbSNP:rs541873000.
original residue
E
variation residue
Q
position
660
score
100.0
distance
10.274954
seq distance
9
chain
C
In C7D; dbSNP:rs541873000.
original residue
E
variation residue
Q
position
660
score
100.0
distance
10.274954
seq distance
9
chain
C
Sushi 1
begin
547
end
606
score
100.0
distance
10.418671
seq distance
3
chain
C
Sushi 1
begin
547
end
606
score
100.0
distance
10.418671
seq distance
3
chain
C
CCP 1
begin
523
end
593
score
100.0
distance
11.400582
seq distance
16
chain
C
CCP 1
begin
523
end
593
score
100.0
distance
11.400582
seq distance
16
chain
C
In C7D; dbSNP:rs113187203.
original residue
R
variation residue
H
position
665
score
100.0
distance
22.646282
seq distance
14
chain
C
In C7D; dbSNP:rs113187203.
original residue
R
variation residue
H
position
665
score
100.0
distance
22.646282
seq distance
14
chain
C
Confirmed at protein level; dbSNP:rs13157656.
original residue
T
variation residue
P
position
565
score
100.0
distance
39.2037
seq distance
44
chain
C
Confirmed at protein level; dbSNP:rs13157656.
original residue
T
variation residue
P
position
565
score
100.0
distance
39.2037
seq distance
44
chain
C
Factor I module (FIM) 1
begin
673
end
748
score
100.0
distance
43.931835
seq distance
22
chain
C
Factor I module (FIM) 1
begin
673
end
748
score
100.0
distance
43.931835
seq distance
22
chain
C
LDL-receptor class A
begin
61
end
99
score
100.0
distance
57.329586
seq distance
510
chain
C
LDL-receptor class A
begin
61
end
99
score
100.0
distance
57.329586
seq distance
510
chain
C
TSP type-1 1
begin
5
end
58
score
99.83164983164983
distance
59.46395
seq distance
551
chain
C
TSP type-1 1
begin
5
end
58
score
99.83164983164983
distance
59.46395
seq distance
551
chain
C
MACPF
begin
102
end
434
score
94.85394485394487
distance
61.325397
seq distance
175
chain
C
MACPF
begin
102
end
434
score
94.85394485394487
distance
61.325397
seq distance
175
chain
C
TSP type-1 2
begin
478
end
527
score
100.0
distance
61.505764
seq distance
82
chain
C
TSP type-1 2
begin
478
end
527
score
100.0
distance
61.505764
seq distance
82
chain
C
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
1560
score
50.0
distance
65.42318
seq distance
False
chain
A
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
1560
score
50.0
distance
65.42318
seq distance
False
chain
A
Factor I module (FIM) 2
begin
749
end
821
score
100.0
distance
66.43845
seq distance
98
chain
C
Factor I module (FIM) 2
begin
749
end
821
score
100.0
distance
66.43845
seq distance
98
chain
C
Disordered
begin
494
end
516
score
100.0
distance
71.27769
seq distance
93
chain
C
Disordered
begin
494
end
516
score
100.0
distance
71.27769
seq distance
93
chain
C
Disordered
begin
86
end
121
score
100.0
distance
71.90984
seq distance
488
chain
C
Disordered
begin
86
end
121
score
100.0
distance
71.90984
seq distance
488
chain
C
Confirmed at protein level; dbSNP:rs1063499.
original residue
S
variation residue
T
position
1040
score
54.54545454545454
distance
76.12977
seq distance
False
chain
A
Confirmed at protein level; dbSNP:rs1063499.
original residue
S
variation residue
T
position
1040
score
54.54545454545454
distance
76.12977
seq distance
False
chain
A
LDL-receptor class A
begin
84
end
92
score
56.56565656565656
distance
77.42046
seq distance
False
chain
D
LDL-receptor class A
begin
84
end
92
score
56.56565656565656
distance
77.42046
seq distance
False
chain
D
Confirmed at protein level; dbSNP:rs13157656.
original residue
T
variation residue
P
position
693
score
50.0
distance
81.945114
seq distance
False
chain
B
Confirmed at protein level; dbSNP:rs13157656.
original residue
T
variation residue
P
position
693
score
50.0
distance
81.945114
seq distance
False
chain
B
In dbSNP:rs2271708.
original residue
C
variation residue
R
position
106
score
100.0
distance
82.15294
seq distance
503
chain
C
In dbSNP:rs2271708.
original residue
C
variation residue
R
position
106
score
100.0
distance
82.15294
seq distance
503
chain
C
Disordered
begin
564
end
573
score
62.272727272727266
distance
82.46952
seq distance
False
chain
B
Disordered
begin
564
end
573
score
62.272727272727266
distance
82.46952
seq distance
False
chain
B
Disordered
begin
91
end
92
score
68.18181818181817
distance
83.3186
seq distance
False
chain
D
Disordered
begin
91
end
92
score
68.18181818181817
distance
83.3186
seq distance
False
chain
D
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
398
score
100.0
distance
84.52267
seq distance
211
chain
C
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
398
score
100.0
distance
84.52267
seq distance
211
chain
C
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
499
score
100.0
distance
87.82845
seq distance
110
chain
C
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
499
score
100.0
distance
87.82845
seq distance
110
chain
C
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
566
score
86.36363636363636
distance
88.47402
seq distance
False
chain
B
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
566
score
86.36363636363636
distance
88.47402
seq distance
False
chain
B
EGF-like
begin
435
end
465
score
100.0
distance
89.30307
seq distance
144
chain
C
EGF-like
begin
435
end
465
score
100.0
distance
89.30307
seq distance
144
chain
C
Disordered
begin
504
end
504
score
68.18181818181817
distance
89.950554
seq distance
False
chain
D
Disordered
begin
504
end
504
score
68.18181818181817
distance
89.950554
seq distance
False
chain
D
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
412
score
63.63636363636363
distance
90.9712
seq distance
False
chain
D
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
412
score
63.63636363636363
distance
90.9712
seq distance
False
chain
D
LDL-receptor class A
begin
83
end
95
score
50.87412587412587
distance
93.81483
seq distance
False
chain
E
LDL-receptor class A
begin
83
end
95
score
50.87412587412587
distance
93.81483
seq distance
False
chain
E
In C7D; dbSNP:rs121964921.
original residue
G
variation residue
R
position
357
score
100.0
distance
98.01118
seq distance
252
chain
C
In C7D; dbSNP:rs121964921.
original residue
G
variation residue
R
position
357
score
100.0
distance
98.01118
seq distance
252
chain
C
Disordered
begin
510
end
522
score
53.67132867132868
distance
105.93532
seq distance
False
chain
D
Disordered
begin
510
end
522
score
53.67132867132868
distance
105.93532
seq distance
False
chain
D
Confirmed at protein level; dbSNP:rs1063499.
original residue
S
variation residue
T
position
367
score
100.0
distance
109.326
seq distance
242
chain
C
Confirmed at protein level; dbSNP:rs1063499.
original residue
S
variation residue
T
position
367
score
100.0
distance
109.326
seq distance
242
chain
C
EGF-like
begin
451
end
455
score
54.090909090909086
distance
111.44958
seq distance
False
chain
D
EGF-like
begin
451
end
455
score
54.090909090909086
distance
111.44958
seq distance
False
chain
D
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
512
score
81.81818181818183
distance
112.41165
seq distance
False
chain
D
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
512
score
81.81818181818183
distance
112.41165
seq distance
False
chain
D
In dbSNP:rs75345202.
original residue
R
variation residue
H
position
414
score
54.54545454545454
distance
119.25402
seq distance
False
chain
E
In dbSNP:rs75345202.
original residue
R
variation residue
H
position
414
score
54.54545454545454
distance
119.25402
seq distance
False
chain
E
In C7D; dbSNP:rs369349760.
original residue
R
variation residue
Q
position
25
score
54.54545454545454
distance
120.54797
seq distance
False
chain
B
In C7D; dbSNP:rs369349760.
original residue
R
variation residue
Q
position
25
score
54.54545454545454
distance
120.54797
seq distance
False
chain
B
Disordered
begin
138
end
138
score
50.0
distance
122.34456
seq distance
False
chain
F
Disordered
begin
138
end
138
score
50.0
distance
122.34456
seq distance
False
chain
F
MACPF
begin
324
end
332
score
83.08080808080808
distance
125.60055
seq distance
False
chain
G
MACPF
begin
324
end
332
score
83.08080808080808
distance
125.60055
seq distance
False
chain
G
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
129.58505
seq distance
False
chain
G
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
129.58505
seq distance
False
chain
G
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
530
score
54.54545454545454
distance
130.9455
seq distance
False
chain
E
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
530
score
54.54545454545454
distance
130.9455
seq distance
False
chain
E
In dbSNP:rs2271708.
original residue
C
variation residue
R
position
532
score
54.54545454545454
distance
133.3806
seq distance
False
chain
E
In dbSNP:rs2271708.
original residue
C
variation residue
R
position
532
score
54.54545454545454
distance
133.3806
seq distance
False
chain
E
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
142.82748
seq distance
False
chain
G
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
142.82748
seq distance
False
chain
G
Disordered
begin
197
end
218
score
76.85950413223141
distance
145.37782
seq distance
391
chain
C
Disordered
begin
197
end
218
score
76.85950413223141
distance
145.37782
seq distance
391
chain
C
MACPF
begin
324
end
332
score
83.08080808080808
distance
145.88582
seq distance
False
chain
H
MACPF
begin
324
end
332
score
83.08080808080808
distance
145.88582
seq distance
False
chain
H
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
150.67651
seq distance
False
chain
H
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
150.67651
seq distance
False
chain
H
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
152.26906
seq distance
False
chain
G
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
152.26906
seq distance
False
chain
G
MACPF
begin
324
end
333
score
84.54545454545456
distance
163.43004
seq distance
False
chain
I
MACPF
begin
324
end
333
score
84.54545454545456
distance
163.43004
seq distance
False
chain
I
Disordered
begin
327
end
328
score
61.36363636363637
distance
166.64944
seq distance
False
chain
I
Disordered
begin
327
end
328
score
61.36363636363637
distance
166.64944
seq distance
False
chain
I
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
167.78912
seq distance
False
chain
H
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
167.78912
seq distance
False
chain
H
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
171.07954
seq distance
False
chain
I
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
171.07954
seq distance
False
chain
I
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
177.56728
seq distance
False
chain
H
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
177.56728
seq distance
False
chain
H
In C7D; dbSNP:rs369349760.
original residue
R
variation residue
Q
position
198
score
72.72727272727273
distance
185.62485
seq distance
411
chain
C
In C7D; dbSNP:rs369349760.
original residue
R
variation residue
Q
position
198
score
72.72727272727273
distance
185.62485
seq distance
411
chain
C
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
189.06949
seq distance
False
chain
I
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
189.06949
seq distance
False
chain
I
In dbSNP:rs75345202.
original residue
R
variation residue
H
position
200
score
72.72727272727273
distance
191.94861
seq distance
409
chain
C
In dbSNP:rs75345202.
original residue
R
variation residue
H
position
200
score
72.72727272727273
distance
191.94861
seq distance
409
chain
C

Details

Redox score
75.81
PDB code
7nyc
Structure name
cryoem structure of 3c9-smac
Structure deposition date
2021-03-22
Thiol separation (Å)
2.04
Half-sphere exposure sum
63
Minimum pKa
nan
% buried
nan
Peptide accession
P10643
Residue number A
631 (Residue 609 in this structure)
Residue number B
673 (Residue 651 in this structure)
Peptide name
Complement component C7
A redox-regulated disulphide may form within Complement component C7 at these cysteines.

Relevent regions

LDL-receptor class A
begin
61
end
99
score
100.0
distance
2.757768
seq distance
0
chain
C
LDL-receptor class A
begin
61
end
99
score
100.0
distance
2.757768
seq distance
0
chain
C
Disordered
begin
86
end
121
score
100.0
distance
2.7696192
seq distance
0
chain
C
Disordered
begin
86
end
121
score
100.0
distance
2.7696192
seq distance
0
chain
C
MACPF
begin
102
end
434
score
94.85394485394487
distance
7.5852995
seq distance
15
chain
C
MACPF
begin
102
end
434
score
94.85394485394487
distance
7.5852995
seq distance
15
chain
C
LDL-receptor class A
begin
84
end
92
score
56.56565656565656
distance
12.3690605
seq distance
False
chain
D
LDL-receptor class A
begin
84
end
92
score
56.56565656565656
distance
12.3690605
seq distance
False
chain
D
Disordered
begin
91
end
92
score
68.18181818181817
distance
16.726353
seq distance
False
chain
D
Disordered
begin
91
end
92
score
68.18181818181817
distance
16.726353
seq distance
False
chain
D
In dbSNP:rs2271708.
original residue
C
variation residue
R
position
106
score
100.0
distance
19.601404
seq distance
19
chain
C
In dbSNP:rs2271708.
original residue
C
variation residue
R
position
106
score
100.0
distance
19.601404
seq distance
19
chain
C
TSP type-1 1
begin
5
end
58
score
99.83164983164983
distance
21.985123
seq distance
11
chain
C
TSP type-1 1
begin
5
end
58
score
99.83164983164983
distance
21.985123
seq distance
11
chain
C
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
412
score
63.63636363636363
distance
26.575136
seq distance
False
chain
D
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
412
score
63.63636363636363
distance
26.575136
seq distance
False
chain
D
CCP 1
begin
523
end
593
score
100.0
distance
26.599909
seq distance
436
chain
C
CCP 1
begin
523
end
593
score
100.0
distance
26.599909
seq distance
436
chain
C
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
398
score
100.0
distance
29.219593
seq distance
311
chain
C
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
398
score
100.0
distance
29.219593
seq distance
311
chain
C
In C7D; dbSNP:rs121964921.
original residue
G
variation residue
R
position
357
score
100.0
distance
30.311775
seq distance
270
chain
C
In C7D; dbSNP:rs121964921.
original residue
G
variation residue
R
position
357
score
100.0
distance
30.311775
seq distance
270
chain
C
LDL-receptor class A
begin
83
end
95
score
50.87412587412587
distance
32.97331
seq distance
False
chain
E
LDL-receptor class A
begin
83
end
95
score
50.87412587412587
distance
32.97331
seq distance
False
chain
E
TSP type-1 2
begin
478
end
527
score
100.0
distance
33.362442
seq distance
391
chain
C
TSP type-1 2
begin
478
end
527
score
100.0
distance
33.362442
seq distance
391
chain
C
EGF-like
begin
435
end
465
score
100.0
distance
34.27908
seq distance
348
chain
C
EGF-like
begin
435
end
465
score
100.0
distance
34.27908
seq distance
348
chain
C
Confirmed at protein level; dbSNP:rs1063499.
original residue
S
variation residue
T
position
367
score
100.0
distance
40.83274
seq distance
280
chain
C
Confirmed at protein level; dbSNP:rs1063499.
original residue
S
variation residue
T
position
367
score
100.0
distance
40.83274
seq distance
280
chain
C
Disordered
begin
494
end
516
score
100.0
distance
44.56726
seq distance
407
chain
C
Disordered
begin
494
end
516
score
100.0
distance
44.56726
seq distance
407
chain
C
Sushi 1
begin
547
end
606
score
100.0
distance
44.889854
seq distance
460
chain
C
Sushi 1
begin
547
end
606
score
100.0
distance
44.889854
seq distance
460
chain
C
In dbSNP:rs75345202.
original residue
R
variation residue
H
position
414
score
54.54545454545454
distance
46.445045
seq distance
False
chain
E
In dbSNP:rs75345202.
original residue
R
variation residue
H
position
414
score
54.54545454545454
distance
46.445045
seq distance
False
chain
E
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
499
score
100.0
distance
47.97177
seq distance
412
chain
C
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
499
score
100.0
distance
47.97177
seq distance
412
chain
C
Disordered
begin
504
end
504
score
68.18181818181817
distance
50.430286
seq distance
False
chain
D
Disordered
begin
504
end
504
score
68.18181818181817
distance
50.430286
seq distance
False
chain
D
EGF-like
begin
451
end
455
score
54.090909090909086
distance
50.55626
seq distance
False
chain
D
EGF-like
begin
451
end
455
score
54.090909090909086
distance
50.55626
seq distance
False
chain
D
Confirmed at protein level; dbSNP:rs13157656.
original residue
T
variation residue
P
position
565
score
100.0
distance
51.17184
seq distance
478
chain
C
Confirmed at protein level; dbSNP:rs13157656.
original residue
T
variation residue
P
position
565
score
100.0
distance
51.17184
seq distance
478
chain
C
Disordered
begin
510
end
522
score
53.67132867132868
distance
51.78504
seq distance
False
chain
D
Disordered
begin
510
end
522
score
53.67132867132868
distance
51.78504
seq distance
False
chain
D
CCP 2
begin
594
end
671
score
100.0
distance
52.539528
seq distance
507
chain
C
CCP 2
begin
594
end
671
score
100.0
distance
52.539528
seq distance
507
chain
C
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
512
score
81.81818181818183
distance
55.22815
seq distance
False
chain
D
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
512
score
81.81818181818183
distance
55.22815
seq distance
False
chain
D
Disordered
begin
564
end
573
score
62.272727272727266
distance
55.94605
seq distance
False
chain
B
Disordered
begin
564
end
573
score
62.272727272727266
distance
55.94605
seq distance
False
chain
B
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
566
score
86.36363636363636
distance
56.89526
seq distance
False
chain
B
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
566
score
86.36363636363636
distance
56.89526
seq distance
False
chain
B
MACPF
begin
324
end
332
score
83.08080808080808
distance
57.138897
seq distance
False
chain
G
MACPF
begin
324
end
332
score
83.08080808080808
distance
57.138897
seq distance
False
chain
G
Disordered
begin
138
end
138
score
50.0
distance
58.59081
seq distance
False
chain
F
Disordered
begin
138
end
138
score
50.0
distance
58.59081
seq distance
False
chain
F
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
62.170357
seq distance
False
chain
G
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
62.170357
seq distance
False
chain
G
Sushi 2
begin
607
end
668
score
100.0
distance
67.18717
seq distance
520
chain
C
Sushi 2
begin
607
end
668
score
100.0
distance
67.18717
seq distance
520
chain
C
In C7D; dbSNP:rs369349760.
original residue
R
variation residue
Q
position
25
score
54.54545454545454
distance
67.95112
seq distance
False
chain
B
In C7D; dbSNP:rs369349760.
original residue
R
variation residue
Q
position
25
score
54.54545454545454
distance
67.95112
seq distance
False
chain
B
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
530
score
54.54545454545454
distance
69.03013
seq distance
False
chain
E
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
530
score
54.54545454545454
distance
69.03013
seq distance
False
chain
E
In dbSNP:rs2271708.
original residue
C
variation residue
R
position
532
score
54.54545454545454
distance
69.54721
seq distance
False
chain
E
In dbSNP:rs2271708.
original residue
C
variation residue
R
position
532
score
54.54545454545454
distance
69.54721
seq distance
False
chain
E
MACPF
begin
324
end
332
score
83.08080808080808
distance
75.50647
seq distance
False
chain
H
MACPF
begin
324
end
332
score
83.08080808080808
distance
75.50647
seq distance
False
chain
H
In C7D; dbSNP:rs541873000.
original residue
E
variation residue
Q
position
660
score
100.0
distance
77.5083
seq distance
573
chain
C
In C7D; dbSNP:rs541873000.
original residue
E
variation residue
Q
position
660
score
100.0
distance
77.5083
seq distance
573
chain
C
Confirmed at protein level; dbSNP:rs1063499.
original residue
S
variation residue
T
position
1040
score
54.54545454545454
distance
79.69831
seq distance
False
chain
A
Confirmed at protein level; dbSNP:rs1063499.
original residue
S
variation residue
T
position
1040
score
54.54545454545454
distance
79.69831
seq distance
False
chain
A
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
81.67362
seq distance
False
chain
G
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
81.67362
seq distance
False
chain
G
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
82.181526
seq distance
False
chain
H
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
82.181526
seq distance
False
chain
H
Disordered
begin
197
end
218
score
76.85950413223141
distance
83.9254
seq distance
110
chain
C
Disordered
begin
197
end
218
score
76.85950413223141
distance
83.9254
seq distance
110
chain
C
In C7D; dbSNP:rs113187203.
original residue
R
variation residue
H
position
665
score
100.0
distance
91.17194
seq distance
578
chain
C
In C7D; dbSNP:rs113187203.
original residue
R
variation residue
H
position
665
score
100.0
distance
91.17194
seq distance
578
chain
C
Confirmed at protein level; dbSNP:rs13157656.
original residue
T
variation residue
P
position
693
score
50.0
distance
91.346886
seq distance
False
chain
B
Confirmed at protein level; dbSNP:rs13157656.
original residue
T
variation residue
P
position
693
score
50.0
distance
91.346886
seq distance
False
chain
B
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
91.581696
seq distance
False
chain
G
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
91.581696
seq distance
False
chain
G
MACPF
begin
324
end
333
score
84.54545454545456
distance
92.84802
seq distance
False
chain
I
MACPF
begin
324
end
333
score
84.54545454545456
distance
92.84802
seq distance
False
chain
I
Disordered
begin
327
end
328
score
61.36363636363637
distance
97.747665
seq distance
False
chain
I
Disordered
begin
327
end
328
score
61.36363636363637
distance
97.747665
seq distance
False
chain
I
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
101.7385
seq distance
False
chain
I
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
101.7385
seq distance
False
chain
I
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
103.935646
seq distance
False
chain
H
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
103.935646
seq distance
False
chain
H
Factor I module (FIM) 1
begin
673
end
748
score
100.0
distance
111.73903
seq distance
586
chain
C
Factor I module (FIM) 1
begin
673
end
748
score
100.0
distance
111.73903
seq distance
586
chain
C
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
113.829384
seq distance
False
chain
H
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
113.829384
seq distance
False
chain
H
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
1560
score
50.0
distance
117.72947
seq distance
False
chain
A
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
1560
score
50.0
distance
117.72947
seq distance
False
chain
A
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
123.758545
seq distance
False
chain
I
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
123.758545
seq distance
False
chain
I
In C7D; dbSNP:rs369349760.
original residue
R
variation residue
Q
position
198
score
72.72727272727273
distance
126.286705
seq distance
111
chain
C
In C7D; dbSNP:rs369349760.
original residue
R
variation residue
Q
position
198
score
72.72727272727273
distance
126.286705
seq distance
111
chain
C
In dbSNP:rs75345202.
original residue
R
variation residue
H
position
200
score
72.72727272727273
distance
132.95255
seq distance
113
chain
C
In dbSNP:rs75345202.
original residue
R
variation residue
H
position
200
score
72.72727272727273
distance
132.95255
seq distance
113
chain
C
Factor I module (FIM) 2
begin
749
end
821
score
100.0
distance
134.53154
seq distance
662
chain
C
Factor I module (FIM) 2
begin
749
end
821
score
100.0
distance
134.53154
seq distance
662
chain
C

Details

Redox score
75.58
PDB code
7nyc
Structure name
cryoem structure of 3c9-smac
Structure deposition date
2021-03-22
Thiol separation (Å)
2
Half-sphere exposure sum
77
Minimum pKa
nan
% buried
nan
Peptide accession
P10643
Residue number A
91 (Residue 69 in this structure)
Residue number B
109 (Residue 87 in this structure)
Peptide name
Complement component C7
A redox-regulated disulphide may form within Complement component C7 at these cysteines.

Relevent regions

TSP type-1 2
begin
478
end
527
score
100.0
distance
2.8009105
seq distance
0
chain
C
TSP type-1 2
begin
478
end
527
score
100.0
distance
2.8009105
seq distance
0
chain
C
MACPF
begin
102
end
434
score
94.85394485394487
distance
2.8263528
seq distance
0
chain
C
MACPF
begin
102
end
434
score
94.85394485394487
distance
2.8263528
seq distance
0
chain
C
EGF-like
begin
435
end
465
score
100.0
distance
7.06739
seq distance
2
chain
C
EGF-like
begin
435
end
465
score
100.0
distance
7.06739
seq distance
2
chain
C
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
499
score
100.0
distance
8.934289
seq distance
16
chain
C
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
499
score
100.0
distance
8.934289
seq distance
16
chain
C
Disordered
begin
494
end
516
score
100.0
distance
8.934289
seq distance
11
chain
C
Disordered
begin
494
end
516
score
100.0
distance
8.934289
seq distance
11
chain
C
TSP type-1 1
begin
5
end
58
score
99.83164983164983
distance
9.613247
seq distance
375
chain
C
TSP type-1 1
begin
5
end
58
score
99.83164983164983
distance
9.613247
seq distance
375
chain
C
CCP 1
begin
523
end
593
score
100.0
distance
21.036222
seq distance
40
chain
C
CCP 1
begin
523
end
593
score
100.0
distance
21.036222
seq distance
40
chain
C
Disordered
begin
86
end
121
score
100.0
distance
22.645227
seq distance
312
chain
C
Disordered
begin
86
end
121
score
100.0
distance
22.645227
seq distance
312
chain
C
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
398
score
100.0
distance
23.110939
seq distance
35
chain
C
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
398
score
100.0
distance
23.110939
seq distance
35
chain
C
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
412
score
63.63636363636363
distance
25.965015
seq distance
False
chain
D
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
412
score
63.63636363636363
distance
25.965015
seq distance
False
chain
D
Disordered
begin
504
end
504
score
68.18181818181817
distance
30.704733
seq distance
False
chain
D
Disordered
begin
504
end
504
score
68.18181818181817
distance
30.704733
seq distance
False
chain
D
Disordered
begin
510
end
522
score
53.67132867132868
distance
32.108353
seq distance
False
chain
D
Disordered
begin
510
end
522
score
53.67132867132868
distance
32.108353
seq distance
False
chain
D
In C7D; dbSNP:rs121964921.
original residue
G
variation residue
R
position
357
score
100.0
distance
33.392414
seq distance
76
chain
C
In C7D; dbSNP:rs121964921.
original residue
G
variation residue
R
position
357
score
100.0
distance
33.392414
seq distance
76
chain
C
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
512
score
81.81818181818183
distance
35.72263
seq distance
False
chain
D
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
512
score
81.81818181818183
distance
35.72263
seq distance
False
chain
D
Disordered
begin
564
end
573
score
62.272727272727266
distance
35.831608
seq distance
False
chain
B
Disordered
begin
564
end
573
score
62.272727272727266
distance
35.831608
seq distance
False
chain
B
In C7D; dbSNP:rs369349760.
original residue
R
variation residue
Q
position
25
score
54.54545454545454
distance
36.854313
seq distance
False
chain
B
In C7D; dbSNP:rs369349760.
original residue
R
variation residue
Q
position
25
score
54.54545454545454
distance
36.854313
seq distance
False
chain
B
Confirmed at protein level; dbSNP:rs1063499.
original residue
S
variation residue
T
position
367
score
100.0
distance
37.14384
seq distance
66
chain
C
Confirmed at protein level; dbSNP:rs1063499.
original residue
S
variation residue
T
position
367
score
100.0
distance
37.14384
seq distance
66
chain
C
LDL-receptor class A
begin
61
end
99
score
100.0
distance
38.07873
seq distance
334
chain
C
LDL-receptor class A
begin
61
end
99
score
100.0
distance
38.07873
seq distance
334
chain
C
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
566
score
86.36363636363636
distance
41.40624
seq distance
False
chain
B
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
566
score
86.36363636363636
distance
41.40624
seq distance
False
chain
B
EGF-like
begin
451
end
455
score
54.090909090909086
distance
42.209694
seq distance
False
chain
D
EGF-like
begin
451
end
455
score
54.090909090909086
distance
42.209694
seq distance
False
chain
D
Sushi 1
begin
547
end
606
score
100.0
distance
46.35771
seq distance
64
chain
C
Sushi 1
begin
547
end
606
score
100.0
distance
46.35771
seq distance
64
chain
C
Disordered
begin
91
end
92
score
68.18181818181817
distance
50.50279
seq distance
False
chain
D
Disordered
begin
91
end
92
score
68.18181818181817
distance
50.50279
seq distance
False
chain
D
LDL-receptor class A
begin
84
end
92
score
56.56565656565656
distance
50.50279
seq distance
False
chain
D
LDL-receptor class A
begin
84
end
92
score
56.56565656565656
distance
50.50279
seq distance
False
chain
D
CCP 2
begin
594
end
671
score
100.0
distance
50.842247
seq distance
111
chain
C
CCP 2
begin
594
end
671
score
100.0
distance
50.842247
seq distance
111
chain
C
In dbSNP:rs2271708.
original residue
C
variation residue
R
position
106
score
100.0
distance
50.86071
seq distance
327
chain
C
In dbSNP:rs2271708.
original residue
C
variation residue
R
position
106
score
100.0
distance
50.86071
seq distance
327
chain
C
In dbSNP:rs75345202.
original residue
R
variation residue
H
position
414
score
54.54545454545454
distance
54.260513
seq distance
False
chain
E
In dbSNP:rs75345202.
original residue
R
variation residue
H
position
414
score
54.54545454545454
distance
54.260513
seq distance
False
chain
E
Confirmed at protein level; dbSNP:rs13157656.
original residue
T
variation residue
P
position
565
score
100.0
distance
56.92781
seq distance
82
chain
C
Confirmed at protein level; dbSNP:rs13157656.
original residue
T
variation residue
P
position
565
score
100.0
distance
56.92781
seq distance
82
chain
C
Disordered
begin
197
end
218
score
76.85950413223141
distance
58.665443
seq distance
215
chain
C
Disordered
begin
197
end
218
score
76.85950413223141
distance
58.665443
seq distance
215
chain
C
LDL-receptor class A
begin
83
end
95
score
50.87412587412587
distance
65.413536
seq distance
False
chain
E
LDL-receptor class A
begin
83
end
95
score
50.87412587412587
distance
65.413536
seq distance
False
chain
E
In dbSNP:rs2271708.
original residue
C
variation residue
R
position
532
score
54.54545454545454
distance
66.06104
seq distance
False
chain
E
In dbSNP:rs2271708.
original residue
C
variation residue
R
position
532
score
54.54545454545454
distance
66.06104
seq distance
False
chain
E
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
530
score
54.54545454545454
distance
67.44598
seq distance
False
chain
E
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
530
score
54.54545454545454
distance
67.44598
seq distance
False
chain
E
Confirmed at protein level; dbSNP:rs1063499.
original residue
S
variation residue
T
position
1040
score
54.54545454545454
distance
70.55032
seq distance
False
chain
A
Confirmed at protein level; dbSNP:rs1063499.
original residue
S
variation residue
T
position
1040
score
54.54545454545454
distance
70.55032
seq distance
False
chain
A
MACPF
begin
324
end
332
score
83.08080808080808
distance
71.24586
seq distance
False
chain
G
MACPF
begin
324
end
332
score
83.08080808080808
distance
71.24586
seq distance
False
chain
G
Disordered
begin
138
end
138
score
50.0
distance
74.795135
seq distance
False
chain
F
Disordered
begin
138
end
138
score
50.0
distance
74.795135
seq distance
False
chain
F
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
75.595406
seq distance
False
chain
G
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
75.595406
seq distance
False
chain
G
Sushi 2
begin
607
end
668
score
100.0
distance
82.17437
seq distance
124
chain
C
Sushi 2
begin
607
end
668
score
100.0
distance
82.17437
seq distance
124
chain
C
MACPF
begin
324
end
332
score
83.08080808080808
distance
91.16613
seq distance
False
chain
H
MACPF
begin
324
end
332
score
83.08080808080808
distance
91.16613
seq distance
False
chain
H
In C7D; dbSNP:rs541873000.
original residue
E
variation residue
Q
position
660
score
100.0
distance
94.13918
seq distance
177
chain
C
In C7D; dbSNP:rs541873000.
original residue
E
variation residue
Q
position
660
score
100.0
distance
94.13918
seq distance
177
chain
C
In C7D; dbSNP:rs369349760.
original residue
R
variation residue
Q
position
198
score
72.72727272727273
distance
97.559166
seq distance
235
chain
C
In C7D; dbSNP:rs369349760.
original residue
R
variation residue
Q
position
198
score
72.72727272727273
distance
97.559166
seq distance
235
chain
C
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
97.865364
seq distance
False
chain
H
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
97.865364
seq distance
False
chain
H
Confirmed at protein level; dbSNP:rs13157656.
original residue
T
variation residue
P
position
693
score
50.0
distance
100.38957
seq distance
False
chain
B
Confirmed at protein level; dbSNP:rs13157656.
original residue
T
variation residue
P
position
693
score
50.0
distance
100.38957
seq distance
False
chain
B
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
102.247635
seq distance
False
chain
G
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
102.247635
seq distance
False
chain
G
In dbSNP:rs75345202.
original residue
R
variation residue
H
position
200
score
72.72727272727273
distance
103.76941
seq distance
233
chain
C
In dbSNP:rs75345202.
original residue
R
variation residue
H
position
200
score
72.72727272727273
distance
103.76941
seq distance
233
chain
C
In C7D; dbSNP:rs113187203.
original residue
R
variation residue
H
position
665
score
100.0
distance
105.53023
seq distance
182
chain
C
In C7D; dbSNP:rs113187203.
original residue
R
variation residue
H
position
665
score
100.0
distance
105.53023
seq distance
182
chain
C
MACPF
begin
324
end
333
score
84.54545454545456
distance
109.32423
seq distance
False
chain
I
MACPF
begin
324
end
333
score
84.54545454545456
distance
109.32423
seq distance
False
chain
I
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
110.71896
seq distance
False
chain
G
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
110.71896
seq distance
False
chain
G
Disordered
begin
327
end
328
score
61.36363636363637
distance
115.755875
seq distance
False
chain
I
Disordered
begin
327
end
328
score
61.36363636363637
distance
115.755875
seq distance
False
chain
I
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
118.274734
seq distance
False
chain
I
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
118.274734
seq distance
False
chain
I
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
125.11765
seq distance
False
chain
H
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
125.11765
seq distance
False
chain
H
Factor I module (FIM) 1
begin
673
end
748
score
100.0
distance
127.20719
seq distance
190
chain
C
Factor I module (FIM) 1
begin
673
end
748
score
100.0
distance
127.20719
seq distance
190
chain
C
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
134.18251
seq distance
False
chain
H
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
134.18251
seq distance
False
chain
H
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
1560
score
50.0
distance
140.47978
seq distance
False
chain
A
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
1560
score
50.0
distance
140.47978
seq distance
False
chain
A
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
145.43233
seq distance
False
chain
I
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
145.43233
seq distance
False
chain
I
Factor I module (FIM) 2
begin
749
end
821
score
100.0
distance
152.90663
seq distance
266
chain
C
Factor I module (FIM) 2
begin
749
end
821
score
100.0
distance
152.90663
seq distance
266
chain
C

Details

Redox score
75.51
PDB code
7nyc
Structure name
cryoem structure of 3c9-smac
Structure deposition date
2021-03-22
Thiol separation (Å)
2.04
Half-sphere exposure sum
60
Minimum pKa
nan
% buried
nan
Peptide accession
P10643
Residue number A
455 (Residue 433 in this structure)
Residue number B
505 (Residue 483 in this structure)
Peptide name
Complement component C7
A redox-regulated disulphide may form within Complement component C7 at these cysteines.

Relevent regions

Factor I module (FIM) 2
begin
771
end
843
score
100.0
distance
2.840693
seq distance
0
chain
A
Factor I module (FIM) 2
begin
771
end
843
score
100.0
distance
2.840693
seq distance
0
chain
A
Factor I module (FIM) 1
begin
695
end
770
score
99.46172248803828
distance
4.2923
seq distance
19
chain
A
Factor I module (FIM) 1
begin
695
end
770
score
99.46172248803828
distance
4.2923
seq distance
19
chain
A
LDL-receptor class A
begin
795
end
795
score
70.45454545454545
distance
14.100631
seq distance
6
chain
A
LDL-receptor class A
begin
795
end
795
score
70.45454545454545
distance
14.100631
seq distance
6
chain
A
In C7D; dbSNP:rs113187203.
original residue
R
variation residue
H
position
712
score
50.0
distance
35.82945
seq distance
77
chain
A
In C7D; dbSNP:rs113187203.
original residue
R
variation residue
H
position
712
score
50.0
distance
35.82945
seq distance
77
chain
A

Details

Redox score
75.45
PDB code
2wcy
Structure name
nmr solution structure of factor i-like modules of complement c7.
Structure deposition date
2009-03-17
Thiol separation (Å)
5.7
Half-sphere exposure sum
59
Minimum pKa
nan
% buried
11
Peptide accession
P10643
Residue number A
789
Residue number B
825
Peptide name
Complement component C7
A redox-regulated disulphide may form within Complement component C7 at these cysteines.

Relevent regions

Factor I module (FIM) 2
begin
771
end
843
score
100.0
distance
2.7983186
seq distance
0
chain
A
Factor I module (FIM) 2
begin
771
end
843
score
100.0
distance
2.7983186
seq distance
0
chain
A
Factor I module (FIM) 1
begin
695
end
770
score
99.46172248803828
distance
5.129116
seq distance
19
chain
A
Factor I module (FIM) 1
begin
695
end
770
score
99.46172248803828
distance
5.129116
seq distance
19
chain
A
LDL-receptor class A
begin
795
end
795
score
70.45454545454545
distance
13.731085
seq distance
4
chain
A
LDL-receptor class A
begin
795
end
795
score
70.45454545454545
distance
13.731085
seq distance
4
chain
A
In C7D; dbSNP:rs113187203.
original residue
R
variation residue
H
position
712
score
50.0
distance
36.730682
seq distance
77
chain
A
In C7D; dbSNP:rs113187203.
original residue
R
variation residue
H
position
712
score
50.0
distance
36.730682
seq distance
77
chain
A

Details

Redox score
75.41
PDB code
2wcy
Structure name
nmr solution structure of factor i-like modules of complement c7.
Structure deposition date
2009-03-17
Thiol separation (Å)
6.05
Half-sphere exposure sum
59
Minimum pKa
nan
% buried
4.5
Peptide accession
P10643
Residue number A
789
Residue number B
791
Peptide name
Complement component C7
A redox-regulated disulphide may form within Complement component C7 at these cysteines.

Relevent regions

LDL-receptor class A
begin
61
end
99
score
100.0
distance
2.7957861
seq distance
0
chain
C
LDL-receptor class A
begin
61
end
99
score
100.0
distance
2.7957861
seq distance
0
chain
C
MACPF
begin
102
end
434
score
94.85394485394487
distance
7.3749647
seq distance
28
chain
C
MACPF
begin
102
end
434
score
94.85394485394487
distance
7.3749647
seq distance
28
chain
C
Disordered
begin
86
end
121
score
100.0
distance
10.578465
seq distance
12
chain
C
Disordered
begin
86
end
121
score
100.0
distance
10.578465
seq distance
12
chain
C
TSP type-1 1
begin
5
end
58
score
99.83164983164983
distance
16.078758
seq distance
5
chain
C
TSP type-1 1
begin
5
end
58
score
99.83164983164983
distance
16.078758
seq distance
5
chain
C
CCP 1
begin
523
end
593
score
100.0
distance
18.425951
seq distance
449
chain
C
CCP 1
begin
523
end
593
score
100.0
distance
18.425951
seq distance
449
chain
C
LDL-receptor class A
begin
84
end
92
score
56.56565656565656
distance
19.614918
seq distance
False
chain
D
LDL-receptor class A
begin
84
end
92
score
56.56565656565656
distance
19.614918
seq distance
False
chain
D
Disordered
begin
91
end
92
score
68.18181818181817
distance
24.70278
seq distance
False
chain
D
Disordered
begin
91
end
92
score
68.18181818181817
distance
24.70278
seq distance
False
chain
D
In dbSNP:rs2271708.
original residue
C
variation residue
R
position
106
score
100.0
distance
25.211727
seq distance
32
chain
C
In dbSNP:rs2271708.
original residue
C
variation residue
R
position
106
score
100.0
distance
25.211727
seq distance
32
chain
C
TSP type-1 2
begin
478
end
527
score
100.0
distance
26.017117
seq distance
404
chain
C
TSP type-1 2
begin
478
end
527
score
100.0
distance
26.017117
seq distance
404
chain
C
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
398
score
100.0
distance
29.757437
seq distance
324
chain
C
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
398
score
100.0
distance
29.757437
seq distance
324
chain
C
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
412
score
63.63636363636363
distance
31.64694
seq distance
False
chain
D
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
412
score
63.63636363636363
distance
31.64694
seq distance
False
chain
D
EGF-like
begin
435
end
465
score
100.0
distance
35.781326
seq distance
361
chain
C
EGF-like
begin
435
end
465
score
100.0
distance
35.781326
seq distance
361
chain
C
Sushi 1
begin
547
end
606
score
100.0
distance
35.87312
seq distance
473
chain
C
Sushi 1
begin
547
end
606
score
100.0
distance
35.87312
seq distance
473
chain
C
In C7D; dbSNP:rs121964921.
original residue
G
variation residue
R
position
357
score
100.0
distance
36.542946
seq distance
283
chain
C
In C7D; dbSNP:rs121964921.
original residue
G
variation residue
R
position
357
score
100.0
distance
36.542946
seq distance
283
chain
C
Disordered
begin
494
end
516
score
100.0
distance
38.71365
seq distance
420
chain
C
Disordered
begin
494
end
516
score
100.0
distance
38.71365
seq distance
420
chain
C
LDL-receptor class A
begin
83
end
95
score
50.87412587412587
distance
40.454666
seq distance
False
chain
E
LDL-receptor class A
begin
83
end
95
score
50.87412587412587
distance
40.454666
seq distance
False
chain
E
CCP 2
begin
594
end
671
score
100.0
distance
43.36116
seq distance
520
chain
C
CCP 2
begin
594
end
671
score
100.0
distance
43.36116
seq distance
520
chain
C
Confirmed at protein level; dbSNP:rs13157656.
original residue
T
variation residue
P
position
565
score
100.0
distance
43.439095
seq distance
491
chain
C
Confirmed at protein level; dbSNP:rs13157656.
original residue
T
variation residue
P
position
565
score
100.0
distance
43.439095
seq distance
491
chain
C
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
499
score
100.0
distance
45.584404
seq distance
425
chain
C
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
499
score
100.0
distance
45.584404
seq distance
425
chain
C
Confirmed at protein level; dbSNP:rs1063499.
original residue
S
variation residue
T
position
367
score
100.0
distance
47.635616
seq distance
293
chain
C
Confirmed at protein level; dbSNP:rs1063499.
original residue
S
variation residue
T
position
367
score
100.0
distance
47.635616
seq distance
293
chain
C
Disordered
begin
504
end
504
score
68.18181818181817
distance
49.90706
seq distance
False
chain
D
Disordered
begin
504
end
504
score
68.18181818181817
distance
49.90706
seq distance
False
chain
D
Disordered
begin
564
end
573
score
62.272727272727266
distance
52.288506
seq distance
False
chain
B
Disordered
begin
564
end
573
score
62.272727272727266
distance
52.288506
seq distance
False
chain
B
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
566
score
86.36363636363636
distance
53.5764
seq distance
False
chain
B
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
566
score
86.36363636363636
distance
53.5764
seq distance
False
chain
B
Disordered
begin
510
end
522
score
53.67132867132868
distance
55.014465
seq distance
False
chain
D
Disordered
begin
510
end
522
score
53.67132867132868
distance
55.014465
seq distance
False
chain
D
In dbSNP:rs75345202.
original residue
R
variation residue
H
position
414
score
54.54545454545454
distance
55.887466
seq distance
False
chain
E
In dbSNP:rs75345202.
original residue
R
variation residue
H
position
414
score
54.54545454545454
distance
55.887466
seq distance
False
chain
E
EGF-like
begin
451
end
455
score
54.090909090909086
distance
56.25678
seq distance
False
chain
D
EGF-like
begin
451
end
455
score
54.090909090909086
distance
56.25678
seq distance
False
chain
D
Sushi 2
begin
607
end
668
score
100.0
distance
58.577534
seq distance
533
chain
C
Sushi 2
begin
607
end
668
score
100.0
distance
58.577534
seq distance
533
chain
C
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
512
score
81.81818181818183
distance
59.38262
seq distance
False
chain
D
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
512
score
81.81818181818183
distance
59.38262
seq distance
False
chain
D
Disordered
begin
138
end
138
score
50.0
distance
65.91763
seq distance
False
chain
F
Disordered
begin
138
end
138
score
50.0
distance
65.91763
seq distance
False
chain
F
MACPF
begin
324
end
332
score
83.08080808080808
distance
66.55663
seq distance
False
chain
G
MACPF
begin
324
end
332
score
83.08080808080808
distance
66.55663
seq distance
False
chain
G
In C7D; dbSNP:rs541873000.
original residue
E
variation residue
Q
position
660
score
100.0
distance
68.93691
seq distance
586
chain
C
In C7D; dbSNP:rs541873000.
original residue
E
variation residue
Q
position
660
score
100.0
distance
68.93691
seq distance
586
chain
C
In C7D; dbSNP:rs369349760.
original residue
R
variation residue
Q
position
25
score
54.54545454545454
distance
69.944115
seq distance
False
chain
B
In C7D; dbSNP:rs369349760.
original residue
R
variation residue
Q
position
25
score
54.54545454545454
distance
69.944115
seq distance
False
chain
B
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
70.98067
seq distance
False
chain
G
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
70.98067
seq distance
False
chain
G
Confirmed at protein level; dbSNP:rs1063499.
original residue
S
variation residue
T
position
1040
score
54.54545454545454
distance
72.44719
seq distance
False
chain
A
Confirmed at protein level; dbSNP:rs1063499.
original residue
S
variation residue
T
position
1040
score
54.54545454545454
distance
72.44719
seq distance
False
chain
A
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
530
score
54.54545454545454
distance
76.04604
seq distance
False
chain
E
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
530
score
54.54545454545454
distance
76.04604
seq distance
False
chain
E
In dbSNP:rs2271708.
original residue
C
variation residue
R
position
532
score
54.54545454545454
distance
76.92233
seq distance
False
chain
E
In dbSNP:rs2271708.
original residue
C
variation residue
R
position
532
score
54.54545454545454
distance
76.92233
seq distance
False
chain
E
In C7D; dbSNP:rs113187203.
original residue
R
variation residue
H
position
665
score
100.0
distance
82.49403
seq distance
591
chain
C
In C7D; dbSNP:rs113187203.
original residue
R
variation residue
H
position
665
score
100.0
distance
82.49403
seq distance
591
chain
C
MACPF
begin
324
end
332
score
83.08080808080808
distance
85.33116
seq distance
False
chain
H
MACPF
begin
324
end
332
score
83.08080808080808
distance
85.33116
seq distance
False
chain
H
Confirmed at protein level; dbSNP:rs13157656.
original residue
T
variation residue
P
position
693
score
50.0
distance
85.422295
seq distance
False
chain
B
Confirmed at protein level; dbSNP:rs13157656.
original residue
T
variation residue
P
position
693
score
50.0
distance
85.422295
seq distance
False
chain
B
Disordered
begin
197
end
218
score
76.85950413223141
distance
88.82862
seq distance
123
chain
C
Disordered
begin
197
end
218
score
76.85950413223141
distance
88.82862
seq distance
123
chain
C
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
89.87935
seq distance
False
chain
G
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
89.87935
seq distance
False
chain
G
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
91.56579
seq distance
False
chain
H
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
91.56579
seq distance
False
chain
H
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
99.76027
seq distance
False
chain
G
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
99.76027
seq distance
False
chain
G
MACPF
begin
324
end
333
score
84.54545454545456
distance
102.70779
seq distance
False
chain
I
MACPF
begin
324
end
333
score
84.54545454545456
distance
102.70779
seq distance
False
chain
I
Factor I module (FIM) 1
begin
673
end
748
score
100.0
distance
103.30091
seq distance
599
chain
C
Factor I module (FIM) 1
begin
673
end
748
score
100.0
distance
103.30091
seq distance
599
chain
C
Disordered
begin
327
end
328
score
61.36363636363637
distance
107.39517
seq distance
False
chain
I
Disordered
begin
327
end
328
score
61.36363636363637
distance
107.39517
seq distance
False
chain
I
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
1560
score
50.0
distance
110.66222
seq distance
False
chain
A
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
1560
score
50.0
distance
110.66222
seq distance
False
chain
A
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
111.43556
seq distance
False
chain
I
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
111.43556
seq distance
False
chain
I
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
112.8086
seq distance
False
chain
H
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
112.8086
seq distance
False
chain
H
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
122.721085
seq distance
False
chain
H
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
122.721085
seq distance
False
chain
H
Factor I module (FIM) 2
begin
749
end
821
score
100.0
distance
126.49324
seq distance
675
chain
C
Factor I module (FIM) 2
begin
749
end
821
score
100.0
distance
126.49324
seq distance
675
chain
C
In C7D; dbSNP:rs369349760.
original residue
R
variation residue
Q
position
198
score
72.72727272727273
distance
131.07967
seq distance
124
chain
C
In C7D; dbSNP:rs369349760.
original residue
R
variation residue
Q
position
198
score
72.72727272727273
distance
131.07967
seq distance
124
chain
C
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
133.0173
seq distance
False
chain
I
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
133.0173
seq distance
False
chain
I
In dbSNP:rs75345202.
original residue
R
variation residue
H
position
200
score
72.72727272727273
distance
137.72316
seq distance
126
chain
C
In dbSNP:rs75345202.
original residue
R
variation residue
H
position
200
score
72.72727272727273
distance
137.72316
seq distance
126
chain
C

Details

Redox score
75.14
PDB code
7nyc
Structure name
cryoem structure of 3c9-smac
Structure deposition date
2021-03-22
Thiol separation (Å)
2.03
Half-sphere exposure sum
66
Minimum pKa
nan
% buried
nan
Peptide accession
P10643
Residue number A
85 (Residue 63 in this structure)
Residue number B
96 (Residue 74 in this structure)
Peptide name
Complement component C7
A redox-regulated disulphide may form within Complement component C7 at these cysteines.

Relevent regions

TSP type-1 1
begin
5
end
58
score
99.83164983164983
distance
2.7431734
seq distance
0
chain
C
TSP type-1 1
begin
5
end
58
score
99.83164983164983
distance
2.7431734
seq distance
0
chain
C
MACPF
begin
102
end
434
score
94.85394485394487
distance
5.986332
seq distance
45
chain
C
MACPF
begin
102
end
434
score
94.85394485394487
distance
5.986332
seq distance
45
chain
C
CCP 1
begin
523
end
593
score
100.0
distance
10.054392
seq distance
466
chain
C
CCP 1
begin
523
end
593
score
100.0
distance
10.054392
seq distance
466
chain
C
LDL-receptor class A
begin
61
end
99
score
100.0
distance
11.7832365
seq distance
4
chain
C
LDL-receptor class A
begin
61
end
99
score
100.0
distance
11.7832365
seq distance
4
chain
C
TSP type-1 2
begin
478
end
527
score
100.0
distance
20.683119
seq distance
421
chain
C
TSP type-1 2
begin
478
end
527
score
100.0
distance
20.683119
seq distance
421
chain
C
Disordered
begin
86
end
121
score
100.0
distance
24.153767
seq distance
29
chain
C
Disordered
begin
86
end
121
score
100.0
distance
24.153767
seq distance
29
chain
C
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
412
score
63.63636363636363
distance
27.050196
seq distance
False
chain
D
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
412
score
63.63636363636363
distance
27.050196
seq distance
False
chain
D
EGF-like
begin
435
end
465
score
100.0
distance
27.234606
seq distance
378
chain
C
EGF-like
begin
435
end
465
score
100.0
distance
27.234606
seq distance
378
chain
C
LDL-receptor class A
begin
84
end
92
score
56.56565656565656
distance
28.246048
seq distance
False
chain
D
LDL-receptor class A
begin
84
end
92
score
56.56565656565656
distance
28.246048
seq distance
False
chain
D
Sushi 1
begin
547
end
606
score
100.0
distance
29.334354
seq distance
490
chain
C
Sushi 1
begin
547
end
606
score
100.0
distance
29.334354
seq distance
490
chain
C
Disordered
begin
91
end
92
score
68.18181818181817
distance
30.224298
seq distance
False
chain
D
Disordered
begin
91
end
92
score
68.18181818181817
distance
30.224298
seq distance
False
chain
D
Disordered
begin
494
end
516
score
100.0
distance
32.480434
seq distance
437
chain
C
Disordered
begin
494
end
516
score
100.0
distance
32.480434
seq distance
437
chain
C
Disordered
begin
504
end
504
score
68.18181818181817
distance
32.82318
seq distance
False
chain
D
Disordered
begin
504
end
504
score
68.18181818181817
distance
32.82318
seq distance
False
chain
D
Confirmed at protein level; dbSNP:rs13157656.
original residue
T
variation residue
P
position
565
score
100.0
distance
33.324688
seq distance
508
chain
C
Confirmed at protein level; dbSNP:rs13157656.
original residue
T
variation residue
P
position
565
score
100.0
distance
33.324688
seq distance
508
chain
C
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
398
score
100.0
distance
34.866276
seq distance
341
chain
C
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
398
score
100.0
distance
34.866276
seq distance
341
chain
C
CCP 2
begin
594
end
671
score
100.0
distance
36.59041
seq distance
537
chain
C
CCP 2
begin
594
end
671
score
100.0
distance
36.59041
seq distance
537
chain
C
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
499
score
100.0
distance
38.808514
seq distance
442
chain
C
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
499
score
100.0
distance
38.808514
seq distance
442
chain
C
In dbSNP:rs2271708.
original residue
C
variation residue
R
position
106
score
100.0
distance
41.43981
seq distance
49
chain
C
In dbSNP:rs2271708.
original residue
C
variation residue
R
position
106
score
100.0
distance
41.43981
seq distance
49
chain
C
In C7D; dbSNP:rs121964921.
original residue
G
variation residue
R
position
357
score
100.0
distance
42.507023
seq distance
300
chain
C
In C7D; dbSNP:rs121964921.
original residue
G
variation residue
R
position
357
score
100.0
distance
42.507023
seq distance
300
chain
C
Disordered
begin
510
end
522
score
53.67132867132868
distance
42.6399
seq distance
False
chain
D
Disordered
begin
510
end
522
score
53.67132867132868
distance
42.6399
seq distance
False
chain
D
LDL-receptor class A
begin
83
end
95
score
50.87412587412587
distance
44.568832
seq distance
False
chain
E
LDL-receptor class A
begin
83
end
95
score
50.87412587412587
distance
44.568832
seq distance
False
chain
E
EGF-like
begin
451
end
455
score
54.090909090909086
distance
46.868824
seq distance
False
chain
D
EGF-like
begin
451
end
455
score
54.090909090909086
distance
46.868824
seq distance
False
chain
D
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
512
score
81.81818181818183
distance
48.454334
seq distance
False
chain
D
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
512
score
81.81818181818183
distance
48.454334
seq distance
False
chain
D
Confirmed at protein level; dbSNP:rs1063499.
original residue
S
variation residue
T
position
367
score
100.0
distance
51.12728
seq distance
310
chain
C
Confirmed at protein level; dbSNP:rs1063499.
original residue
S
variation residue
T
position
367
score
100.0
distance
51.12728
seq distance
310
chain
C
Sushi 2
begin
607
end
668
score
100.0
distance
57.504616
seq distance
550
chain
C
Sushi 2
begin
607
end
668
score
100.0
distance
57.504616
seq distance
550
chain
C
Disordered
begin
564
end
573
score
62.272727272727266
distance
58.350548
seq distance
False
chain
B
Disordered
begin
564
end
573
score
62.272727272727266
distance
58.350548
seq distance
False
chain
B
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
566
score
86.36363636363636
distance
59.26088
seq distance
False
chain
B
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
566
score
86.36363636363636
distance
59.26088
seq distance
False
chain
B
In dbSNP:rs75345202.
original residue
R
variation residue
H
position
414
score
54.54545454545454
distance
59.410484
seq distance
False
chain
E
In dbSNP:rs75345202.
original residue
R
variation residue
H
position
414
score
54.54545454545454
distance
59.410484
seq distance
False
chain
E
MACPF
begin
324
end
332
score
83.08080808080808
distance
67.281494
seq distance
False
chain
G
MACPF
begin
324
end
332
score
83.08080808080808
distance
67.281494
seq distance
False
chain
G
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
530
score
54.54545454545454
distance
68.28101
seq distance
False
chain
E
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
530
score
54.54545454545454
distance
68.28101
seq distance
False
chain
E
In C7D; dbSNP:rs369349760.
original residue
R
variation residue
Q
position
25
score
54.54545454545454
distance
68.30911
seq distance
False
chain
B
In C7D; dbSNP:rs369349760.
original residue
R
variation residue
Q
position
25
score
54.54545454545454
distance
68.30911
seq distance
False
chain
B
In dbSNP:rs2271708.
original residue
C
variation residue
R
position
532
score
54.54545454545454
distance
69.712814
seq distance
False
chain
E
In dbSNP:rs2271708.
original residue
C
variation residue
R
position
532
score
54.54545454545454
distance
69.712814
seq distance
False
chain
E
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
70.44338
seq distance
False
chain
G
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
70.44338
seq distance
False
chain
G
In C7D; dbSNP:rs541873000.
original residue
E
variation residue
Q
position
660
score
100.0
distance
71.28139
seq distance
603
chain
C
In C7D; dbSNP:rs541873000.
original residue
E
variation residue
Q
position
660
score
100.0
distance
71.28139
seq distance
603
chain
C
Confirmed at protein level; dbSNP:rs1063499.
original residue
S
variation residue
T
position
1040
score
54.54545454545454
distance
78.35411
seq distance
False
chain
A
Confirmed at protein level; dbSNP:rs1063499.
original residue
S
variation residue
T
position
1040
score
54.54545454545454
distance
78.35411
seq distance
False
chain
A
Disordered
begin
138
end
138
score
50.0
distance
79.1897
seq distance
False
chain
F
Disordered
begin
138
end
138
score
50.0
distance
79.1897
seq distance
False
chain
F
In C7D; dbSNP:rs113187203.
original residue
R
variation residue
H
position
665
score
100.0
distance
84.594795
seq distance
608
chain
C
In C7D; dbSNP:rs113187203.
original residue
R
variation residue
H
position
665
score
100.0
distance
84.594795
seq distance
608
chain
C
Disordered
begin
197
end
218
score
76.85950413223141
distance
86.48026
seq distance
140
chain
C
Disordered
begin
197
end
218
score
76.85950413223141
distance
86.48026
seq distance
140
chain
C
MACPF
begin
324
end
332
score
83.08080808080808
distance
89.12244
seq distance
False
chain
H
MACPF
begin
324
end
332
score
83.08080808080808
distance
89.12244
seq distance
False
chain
H
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
90.75278
seq distance
False
chain
G
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
90.75278
seq distance
False
chain
G
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
93.92531
seq distance
False
chain
H
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
93.92531
seq distance
False
chain
H
Confirmed at protein level; dbSNP:rs13157656.
original residue
T
variation residue
P
position
693
score
50.0
distance
98.21653
seq distance
False
chain
B
Confirmed at protein level; dbSNP:rs13157656.
original residue
T
variation residue
P
position
693
score
50.0
distance
98.21653
seq distance
False
chain
B
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
100.075325
seq distance
False
chain
G
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
100.075325
seq distance
False
chain
G
Factor I module (FIM) 1
begin
673
end
748
score
100.0
distance
106.459694
seq distance
616
chain
C
Factor I module (FIM) 1
begin
673
end
748
score
100.0
distance
106.459694
seq distance
616
chain
C
MACPF
begin
324
end
333
score
84.54545454545456
distance
108.911804
seq distance
False
chain
I
MACPF
begin
324
end
333
score
84.54545454545456
distance
108.911804
seq distance
False
chain
I
Disordered
begin
327
end
328
score
61.36363636363637
distance
112.70558
seq distance
False
chain
I
Disordered
begin
327
end
328
score
61.36363636363637
distance
112.70558
seq distance
False
chain
I
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
116.21342
seq distance
False
chain
I
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
116.21342
seq distance
False
chain
I
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
116.74327
seq distance
False
chain
H
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
116.74327
seq distance
False
chain
H
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
1560
score
50.0
distance
119.35502
seq distance
False
chain
A
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
1560
score
50.0
distance
119.35502
seq distance
False
chain
A
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
126.39899
seq distance
False
chain
H
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
126.39899
seq distance
False
chain
H
In C7D; dbSNP:rs369349760.
original residue
R
variation residue
Q
position
198
score
72.72727272727273
distance
126.601295
seq distance
141
chain
C
In C7D; dbSNP:rs369349760.
original residue
R
variation residue
Q
position
198
score
72.72727272727273
distance
126.601295
seq distance
141
chain
C
Factor I module (FIM) 2
begin
749
end
821
score
100.0
distance
129.73242
seq distance
692
chain
C
Factor I module (FIM) 2
begin
749
end
821
score
100.0
distance
129.73242
seq distance
692
chain
C
In dbSNP:rs75345202.
original residue
R
variation residue
H
position
200
score
72.72727272727273
distance
132.8407
seq distance
143
chain
C
In dbSNP:rs75345202.
original residue
R
variation residue
H
position
200
score
72.72727272727273
distance
132.8407
seq distance
143
chain
C
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
139.60835
seq distance
False
chain
I
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
139.60835
seq distance
False
chain
I

Details

Redox score
75.12
PDB code
7nyc
Structure name
cryoem structure of 3c9-smac
Structure deposition date
2021-03-22
Thiol separation (Å)
1.99
Half-sphere exposure sum
70
Minimum pKa
nan
% buried
nan
Peptide accession
P10643
Residue number A
42 (Residue 20 in this structure)
Residue number B
79 (Residue 57 in this structure)
Peptide name
Complement component C7
A redox-regulated disulphide may form within Complement component C7 at these cysteines.

Relevent regions

CCP 1
begin
523
end
593
score
100.0
distance
2.819245
seq distance
0
chain
C
CCP 1
begin
523
end
593
score
100.0
distance
2.819245
seq distance
0
chain
C
MACPF
begin
102
end
434
score
94.85394485394487
distance
2.8307612
seq distance
0
chain
C
MACPF
begin
102
end
434
score
94.85394485394487
distance
2.8307612
seq distance
0
chain
C
TSP type-1 1
begin
5
end
58
score
99.83164983164983
distance
5.713682
seq distance
353
chain
C
TSP type-1 1
begin
5
end
58
score
99.83164983164983
distance
5.713682
seq distance
353
chain
C
LDL-receptor class A
begin
61
end
99
score
100.0
distance
10.901575
seq distance
312
chain
C
LDL-receptor class A
begin
61
end
99
score
100.0
distance
10.901575
seq distance
312
chain
C
TSP type-1 2
begin
478
end
527
score
100.0
distance
11.5927725
seq distance
11
chain
C
TSP type-1 2
begin
478
end
527
score
100.0
distance
11.5927725
seq distance
11
chain
C
Sushi 1
begin
547
end
606
score
100.0
distance
23.984491
seq distance
9
chain
C
Sushi 1
begin
547
end
606
score
100.0
distance
23.984491
seq distance
9
chain
C
Disordered
begin
86
end
121
score
100.0
distance
24.207834
seq distance
290
chain
C
Disordered
begin
86
end
121
score
100.0
distance
24.207834
seq distance
290
chain
C
Disordered
begin
494
end
516
score
100.0
distance
25.734095
seq distance
22
chain
C
Disordered
begin
494
end
516
score
100.0
distance
25.734095
seq distance
22
chain
C
EGF-like
begin
435
end
465
score
100.0
distance
29.568892
seq distance
24
chain
C
EGF-like
begin
435
end
465
score
100.0
distance
29.568892
seq distance
24
chain
C
CCP 2
begin
594
end
671
score
100.0
distance
29.759138
seq distance
56
chain
C
CCP 2
begin
594
end
671
score
100.0
distance
29.759138
seq distance
56
chain
C
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
398
score
100.0
distance
30.764166
seq distance
13
chain
C
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
398
score
100.0
distance
30.764166
seq distance
13
chain
C
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
412
score
63.63636363636363
distance
31.148735
seq distance
False
chain
D
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
412
score
63.63636363636363
distance
31.148735
seq distance
False
chain
D
Confirmed at protein level; dbSNP:rs13157656.
original residue
T
variation residue
P
position
565
score
100.0
distance
31.483936
seq distance
27
chain
C
Confirmed at protein level; dbSNP:rs13157656.
original residue
T
variation residue
P
position
565
score
100.0
distance
31.483936
seq distance
27
chain
C
LDL-receptor class A
begin
84
end
92
score
56.56565656565656
distance
32.678257
seq distance
False
chain
D
LDL-receptor class A
begin
84
end
92
score
56.56565656565656
distance
32.678257
seq distance
False
chain
D
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
499
score
100.0
distance
35.429802
seq distance
39
chain
C
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
499
score
100.0
distance
35.429802
seq distance
39
chain
C
Disordered
begin
91
end
92
score
68.18181818181817
distance
35.593693
seq distance
False
chain
D
Disordered
begin
91
end
92
score
68.18181818181817
distance
35.593693
seq distance
False
chain
D
Disordered
begin
504
end
504
score
68.18181818181817
distance
38.7446
seq distance
False
chain
D
Disordered
begin
504
end
504
score
68.18181818181817
distance
38.7446
seq distance
False
chain
D
In dbSNP:rs2271708.
original residue
C
variation residue
R
position
106
score
100.0
distance
39.38075
seq distance
305
chain
C
In dbSNP:rs2271708.
original residue
C
variation residue
R
position
106
score
100.0
distance
39.38075
seq distance
305
chain
C
In C7D; dbSNP:rs121964921.
original residue
G
variation residue
R
position
357
score
100.0
distance
41.965195
seq distance
54
chain
C
In C7D; dbSNP:rs121964921.
original residue
G
variation residue
R
position
357
score
100.0
distance
41.965195
seq distance
54
chain
C
Disordered
begin
510
end
522
score
53.67132867132868
distance
48.521442
seq distance
False
chain
D
Disordered
begin
510
end
522
score
53.67132867132868
distance
48.521442
seq distance
False
chain
D
Disordered
begin
564
end
573
score
62.272727272727266
distance
49.20853
seq distance
False
chain
B
Disordered
begin
564
end
573
score
62.272727272727266
distance
49.20853
seq distance
False
chain
B
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
566
score
86.36363636363636
distance
50.903946
seq distance
False
chain
B
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
566
score
86.36363636363636
distance
50.903946
seq distance
False
chain
B
LDL-receptor class A
begin
83
end
95
score
50.87412587412587
distance
51.56035
seq distance
False
chain
E
LDL-receptor class A
begin
83
end
95
score
50.87412587412587
distance
51.56035
seq distance
False
chain
E
Confirmed at protein level; dbSNP:rs1063499.
original residue
S
variation residue
T
position
367
score
100.0
distance
51.699936
seq distance
44
chain
C
Confirmed at protein level; dbSNP:rs1063499.
original residue
S
variation residue
T
position
367
score
100.0
distance
51.699936
seq distance
44
chain
C
Sushi 2
begin
607
end
668
score
100.0
distance
53.282734
seq distance
69
chain
C
Sushi 2
begin
607
end
668
score
100.0
distance
53.282734
seq distance
69
chain
C
EGF-like
begin
451
end
455
score
54.090909090909086
distance
53.68366
seq distance
False
chain
D
EGF-like
begin
451
end
455
score
54.090909090909086
distance
53.68366
seq distance
False
chain
D
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
512
score
81.81818181818183
distance
54.09368
seq distance
False
chain
D
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
512
score
81.81818181818183
distance
54.09368
seq distance
False
chain
D
In dbSNP:rs75345202.
original residue
R
variation residue
H
position
414
score
54.54545454545454
distance
62.62345
seq distance
False
chain
E
In dbSNP:rs75345202.
original residue
R
variation residue
H
position
414
score
54.54545454545454
distance
62.62345
seq distance
False
chain
E
In C7D; dbSNP:rs541873000.
original residue
E
variation residue
Q
position
660
score
100.0
distance
65.87486
seq distance
122
chain
C
In C7D; dbSNP:rs541873000.
original residue
E
variation residue
Q
position
660
score
100.0
distance
65.87486
seq distance
122
chain
C
In C7D; dbSNP:rs369349760.
original residue
R
variation residue
Q
position
25
score
54.54545454545454
distance
66.39899
seq distance
False
chain
B
In C7D; dbSNP:rs369349760.
original residue
R
variation residue
Q
position
25
score
54.54545454545454
distance
66.39899
seq distance
False
chain
B
Confirmed at protein level; dbSNP:rs1063499.
original residue
S
variation residue
T
position
1040
score
54.54545454545454
distance
67.447685
seq distance
False
chain
A
Confirmed at protein level; dbSNP:rs1063499.
original residue
S
variation residue
T
position
1040
score
54.54545454545454
distance
67.447685
seq distance
False
chain
A
MACPF
begin
324
end
332
score
83.08080808080808
distance
73.77445
seq distance
False
chain
G
MACPF
begin
324
end
332
score
83.08080808080808
distance
73.77445
seq distance
False
chain
G
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
530
score
54.54545454545454
distance
76.079124
seq distance
False
chain
E
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
530
score
54.54545454545454
distance
76.079124
seq distance
False
chain
E
In dbSNP:rs2271708.
original residue
C
variation residue
R
position
532
score
54.54545454545454
distance
76.99187
seq distance
False
chain
E
In dbSNP:rs2271708.
original residue
C
variation residue
R
position
532
score
54.54545454545454
distance
76.99187
seq distance
False
chain
E
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
77.34416
seq distance
False
chain
G
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
77.34416
seq distance
False
chain
G
Disordered
begin
138
end
138
score
50.0
distance
77.678276
seq distance
False
chain
F
Disordered
begin
138
end
138
score
50.0
distance
77.678276
seq distance
False
chain
F
In C7D; dbSNP:rs113187203.
original residue
R
variation residue
H
position
665
score
100.0
distance
78.63366
seq distance
127
chain
C
In C7D; dbSNP:rs113187203.
original residue
R
variation residue
H
position
665
score
100.0
distance
78.63366
seq distance
127
chain
C
Disordered
begin
197
end
218
score
76.85950413223141
distance
87.189514
seq distance
193
chain
C
Disordered
begin
197
end
218
score
76.85950413223141
distance
87.189514
seq distance
193
chain
C
Confirmed at protein level; dbSNP:rs13157656.
original residue
T
variation residue
P
position
693
score
50.0
distance
88.50542
seq distance
False
chain
B
Confirmed at protein level; dbSNP:rs13157656.
original residue
T
variation residue
P
position
693
score
50.0
distance
88.50542
seq distance
False
chain
B
MACPF
begin
324
end
332
score
83.08080808080808
distance
94.63057
seq distance
False
chain
H
MACPF
begin
324
end
332
score
83.08080808080808
distance
94.63057
seq distance
False
chain
H
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
98.26914
seq distance
False
chain
G
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
98.26914
seq distance
False
chain
G
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
100.112785
seq distance
False
chain
H
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
100.112785
seq distance
False
chain
H
Factor I module (FIM) 1
begin
673
end
748
score
100.0
distance
100.52227
seq distance
135
chain
C
Factor I module (FIM) 1
begin
673
end
748
score
100.0
distance
100.52227
seq distance
135
chain
C
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
107.73045
seq distance
False
chain
G
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
107.73045
seq distance
False
chain
G
MACPF
begin
324
end
333
score
84.54545454545456
distance
113.24078
seq distance
False
chain
I
MACPF
begin
324
end
333
score
84.54545454545456
distance
113.24078
seq distance
False
chain
I
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
1560
score
50.0
distance
113.53706
seq distance
False
chain
A
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
1560
score
50.0
distance
113.53706
seq distance
False
chain
A
Disordered
begin
327
end
328
score
61.36363636363637
distance
117.87434
seq distance
False
chain
I
Disordered
begin
327
end
328
score
61.36363636363637
distance
117.87434
seq distance
False
chain
I
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
121.476776
seq distance
False
chain
I
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
121.476776
seq distance
False
chain
I
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
123.15703
seq distance
False
chain
H
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
123.15703
seq distance
False
chain
H
Factor I module (FIM) 2
begin
749
end
821
score
100.0
distance
124.94001
seq distance
211
chain
C
Factor I module (FIM) 2
begin
749
end
821
score
100.0
distance
124.94001
seq distance
211
chain
C
In C7D; dbSNP:rs369349760.
original residue
R
variation residue
Q
position
198
score
72.72727272727273
distance
127.91915
seq distance
213
chain
C
In C7D; dbSNP:rs369349760.
original residue
R
variation residue
Q
position
198
score
72.72727272727273
distance
127.91915
seq distance
213
chain
C
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
132.88684
seq distance
False
chain
H
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
132.88684
seq distance
False
chain
H
In dbSNP:rs75345202.
original residue
R
variation residue
H
position
200
score
72.72727272727273
distance
134.30167
seq distance
211
chain
C
In dbSNP:rs75345202.
original residue
R
variation residue
H
position
200
score
72.72727272727273
distance
134.30167
seq distance
211
chain
C
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
144.83266
seq distance
False
chain
I
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
144.83266
seq distance
False
chain
I

Details

Redox score
75.02
PDB code
7nyc
Structure name
cryoem structure of 3c9-smac
Structure deposition date
2021-03-22
Thiol separation (Å)
2.04
Half-sphere exposure sum
79
Minimum pKa
nan
% buried
nan
Peptide accession
P10643
Residue number A
433 (Residue 411 in this structure)
Residue number B
560 (Residue 538 in this structure)
Peptide name
Complement component C7
A redox-regulated disulphide may form within Complement component C7 at these cysteines.

Relevent regions

Factor I module (FIM) 2
begin
771
end
843
score
100.0
distance
2.840693
seq distance
0
chain
A
Factor I module (FIM) 2
begin
771
end
843
score
100.0
distance
2.840693
seq distance
0
chain
A
Factor I module (FIM) 1
begin
695
end
770
score
99.46172248803828
distance
7.1713576
seq distance
12
chain
A
Factor I module (FIM) 1
begin
695
end
770
score
99.46172248803828
distance
7.1713576
seq distance
12
chain
A
LDL-receptor class A
begin
795
end
795
score
70.45454545454545
distance
15.969687
seq distance
6
chain
A
LDL-receptor class A
begin
795
end
795
score
70.45454545454545
distance
15.969687
seq distance
6
chain
A
In C7D; dbSNP:rs113187203.
original residue
R
variation residue
H
position
712
score
50.0
distance
36.730682
seq distance
70
chain
A
In C7D; dbSNP:rs113187203.
original residue
R
variation residue
H
position
712
score
50.0
distance
36.730682
seq distance
70
chain
A

Details

Redox score
74.93
PDB code
2wcy
Structure name
nmr solution structure of factor i-like modules of complement c7.
Structure deposition date
2009-03-17
Thiol separation (Å)
6.7
Half-sphere exposure sum
48
Minimum pKa
nan
% buried
1
Peptide accession
P10643
Residue number A
782
Residue number B
789
Peptide name
Complement component C7
A redox-regulated disulphide may form within Complement component C7 at these cysteines.

Relevent regions

Factor I module (FIM) 2
begin
771
end
843
score
100.0
distance
2.840693
seq distance
0
chain
A
Factor I module (FIM) 2
begin
771
end
843
score
100.0
distance
2.840693
seq distance
0
chain
A
Factor I module (FIM) 1
begin
695
end
770
score
99.46172248803828
distance
7.1713576
seq distance
3
chain
A
Factor I module (FIM) 1
begin
695
end
770
score
99.46172248803828
distance
7.1713576
seq distance
3
chain
A
LDL-receptor class A
begin
795
end
795
score
70.45454545454545
distance
15.969687
seq distance
6
chain
A
LDL-receptor class A
begin
795
end
795
score
70.45454545454545
distance
15.969687
seq distance
6
chain
A
In C7D; dbSNP:rs113187203.
original residue
R
variation residue
H
position
712
score
50.0
distance
36.730682
seq distance
61
chain
A
In C7D; dbSNP:rs113187203.
original residue
R
variation residue
H
position
712
score
50.0
distance
36.730682
seq distance
61
chain
A

Details

Redox score
74.73
PDB code
2wcy
Structure name
nmr solution structure of factor i-like modules of complement c7.
Structure deposition date
2009-03-17
Thiol separation (Å)
7
Half-sphere exposure sum
45
Minimum pKa
nan
% buried
1
Peptide accession
P10643
Residue number A
773
Residue number B
789
Peptide name
Complement component C7
A redox-regulated disulphide may form within Complement component C7 at these cysteines.

Relevent regions

EGF-like
begin
435
end
465
score
100.0
distance
2.7865968
seq distance
0
chain
C
EGF-like
begin
435
end
465
score
100.0
distance
2.7865968
seq distance
0
chain
C
TSP type-1 1
begin
5
end
58
score
99.83164983164983
distance
7.3639283
seq distance
395
chain
C
TSP type-1 1
begin
5
end
58
score
99.83164983164983
distance
7.3639283
seq distance
395
chain
C
MACPF
begin
102
end
434
score
94.85394485394487
distance
9.421162
seq distance
19
chain
C
MACPF
begin
102
end
434
score
94.85394485394487
distance
9.421162
seq distance
19
chain
C
TSP type-1 2
begin
478
end
527
score
100.0
distance
12.812489
seq distance
14
chain
C
TSP type-1 2
begin
478
end
527
score
100.0
distance
12.812489
seq distance
14
chain
C
Disordered
begin
494
end
516
score
100.0
distance
13.641172
seq distance
30
chain
C
Disordered
begin
494
end
516
score
100.0
distance
13.641172
seq distance
30
chain
C
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
499
score
100.0
distance
20.252222
seq distance
35
chain
C
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
499
score
100.0
distance
20.252222
seq distance
35
chain
C
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
412
score
63.63636363636363
distance
22.987291
seq distance
False
chain
D
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
412
score
63.63636363636363
distance
22.987291
seq distance
False
chain
D
Disordered
begin
510
end
522
score
53.67132867132868
distance
24.674238
seq distance
False
chain
D
Disordered
begin
510
end
522
score
53.67132867132868
distance
24.674238
seq distance
False
chain
D
Disordered
begin
86
end
121
score
100.0
distance
25.228344
seq distance
332
chain
C
Disordered
begin
86
end
121
score
100.0
distance
25.228344
seq distance
332
chain
C
Confirmed at protein level; dbSNP:rs1063499.
original residue
S
variation residue
T
position
367
score
100.0
distance
25.250935
seq distance
86
chain
C
Confirmed at protein level; dbSNP:rs1063499.
original residue
S
variation residue
T
position
367
score
100.0
distance
25.250935
seq distance
86
chain
C
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
398
score
100.0
distance
26.3162
seq distance
55
chain
C
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
398
score
100.0
distance
26.3162
seq distance
55
chain
C
In C7D; dbSNP:rs369349760.
original residue
R
variation residue
Q
position
25
score
54.54545454545454
distance
26.516417
seq distance
False
chain
B
In C7D; dbSNP:rs369349760.
original residue
R
variation residue
Q
position
25
score
54.54545454545454
distance
26.516417
seq distance
False
chain
B
In C7D; dbSNP:rs121964921.
original residue
G
variation residue
R
position
357
score
100.0
distance
27.351627
seq distance
96
chain
C
In C7D; dbSNP:rs121964921.
original residue
G
variation residue
R
position
357
score
100.0
distance
27.351627
seq distance
96
chain
C
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
512
score
81.81818181818183
distance
28.200748
seq distance
False
chain
D
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
512
score
81.81818181818183
distance
28.200748
seq distance
False
chain
D
EGF-like
begin
451
end
455
score
54.090909090909086
distance
33.267887
seq distance
False
chain
D
EGF-like
begin
451
end
455
score
54.090909090909086
distance
33.267887
seq distance
False
chain
D
CCP 1
begin
523
end
593
score
100.0
distance
34.58265
seq distance
59
chain
C
CCP 1
begin
523
end
593
score
100.0
distance
34.58265
seq distance
59
chain
C
Disordered
begin
504
end
504
score
68.18181818181817
distance
35.292625
seq distance
False
chain
D
Disordered
begin
504
end
504
score
68.18181818181817
distance
35.292625
seq distance
False
chain
D
Disordered
begin
564
end
573
score
62.272727272727266
distance
38.554276
seq distance
False
chain
B
Disordered
begin
564
end
573
score
62.272727272727266
distance
38.554276
seq distance
False
chain
B
LDL-receptor class A
begin
61
end
99
score
100.0
distance
41.13251
seq distance
354
chain
C
LDL-receptor class A
begin
61
end
99
score
100.0
distance
41.13251
seq distance
354
chain
C
In dbSNP:rs75345202.
original residue
R
variation residue
H
position
414
score
54.54545454545454
distance
42.34305
seq distance
False
chain
E
In dbSNP:rs75345202.
original residue
R
variation residue
H
position
414
score
54.54545454545454
distance
42.34305
seq distance
False
chain
E
Disordered
begin
197
end
218
score
76.85950413223141
distance
42.52512
seq distance
235
chain
C
Disordered
begin
197
end
218
score
76.85950413223141
distance
42.52512
seq distance
235
chain
C
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
566
score
86.36363636363636
distance
47.64668
seq distance
False
chain
B
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
566
score
86.36363636363636
distance
47.64668
seq distance
False
chain
B
Disordered
begin
91
end
92
score
68.18181818181817
distance
50.314472
seq distance
False
chain
D
Disordered
begin
91
end
92
score
68.18181818181817
distance
50.314472
seq distance
False
chain
D
LDL-receptor class A
begin
84
end
92
score
56.56565656565656
distance
50.314472
seq distance
False
chain
D
LDL-receptor class A
begin
84
end
92
score
56.56565656565656
distance
50.314472
seq distance
False
chain
D
In dbSNP:rs2271708.
original residue
C
variation residue
R
position
106
score
100.0
distance
51.91789
seq distance
347
chain
C
In dbSNP:rs2271708.
original residue
C
variation residue
R
position
106
score
100.0
distance
51.91789
seq distance
347
chain
C
In dbSNP:rs2271708.
original residue
C
variation residue
R
position
532
score
54.54545454545454
distance
55.901302
seq distance
False
chain
E
In dbSNP:rs2271708.
original residue
C
variation residue
R
position
532
score
54.54545454545454
distance
55.901302
seq distance
False
chain
E
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
530
score
54.54545454545454
distance
58.717113
seq distance
False
chain
E
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
530
score
54.54545454545454
distance
58.717113
seq distance
False
chain
E
Sushi 1
begin
547
end
606
score
100.0
distance
59.2692
seq distance
83
chain
C
Sushi 1
begin
547
end
606
score
100.0
distance
59.2692
seq distance
83
chain
C
MACPF
begin
324
end
332
score
83.08080808080808
distance
60.69447
seq distance
False
chain
G
MACPF
begin
324
end
332
score
83.08080808080808
distance
60.69447
seq distance
False
chain
G
LDL-receptor class A
begin
83
end
95
score
50.87412587412587
distance
63.253056
seq distance
False
chain
E
LDL-receptor class A
begin
83
end
95
score
50.87412587412587
distance
63.253056
seq distance
False
chain
E
CCP 2
begin
594
end
671
score
100.0
distance
64.31587
seq distance
130
chain
C
CCP 2
begin
594
end
671
score
100.0
distance
64.31587
seq distance
130
chain
C
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
66.301315
seq distance
False
chain
G
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
66.301315
seq distance
False
chain
G
Disordered
begin
138
end
138
score
50.0
distance
66.86905
seq distance
False
chain
F
Disordered
begin
138
end
138
score
50.0
distance
66.86905
seq distance
False
chain
F
Confirmed at protein level; dbSNP:rs13157656.
original residue
T
variation residue
P
position
565
score
100.0
distance
69.01386
seq distance
101
chain
C
Confirmed at protein level; dbSNP:rs13157656.
original residue
T
variation residue
P
position
565
score
100.0
distance
69.01386
seq distance
101
chain
C
MACPF
begin
324
end
332
score
83.08080808080808
distance
79.25769
seq distance
False
chain
H
MACPF
begin
324
end
332
score
83.08080808080808
distance
79.25769
seq distance
False
chain
H
Confirmed at protein level; dbSNP:rs1063499.
original residue
S
variation residue
T
position
1040
score
54.54545454545454
distance
80.86495
seq distance
False
chain
A
Confirmed at protein level; dbSNP:rs1063499.
original residue
S
variation residue
T
position
1040
score
54.54545454545454
distance
80.86495
seq distance
False
chain
A
In C7D; dbSNP:rs369349760.
original residue
R
variation residue
Q
position
198
score
72.72727272727273
distance
82.96533
seq distance
255
chain
C
In C7D; dbSNP:rs369349760.
original residue
R
variation residue
Q
position
198
score
72.72727272727273
distance
82.96533
seq distance
255
chain
C
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
86.71347
seq distance
False
chain
H
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
86.71347
seq distance
False
chain
H
In dbSNP:rs75345202.
original residue
R
variation residue
H
position
200
score
72.72727272727273
distance
89.44061
seq distance
253
chain
C
In dbSNP:rs75345202.
original residue
R
variation residue
H
position
200
score
72.72727272727273
distance
89.44061
seq distance
253
chain
C
Sushi 2
begin
607
end
668
score
100.0
distance
94.3448
seq distance
143
chain
C
Sushi 2
begin
607
end
668
score
100.0
distance
94.3448
seq distance
143
chain
C
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
94.59337
seq distance
False
chain
G
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
94.59337
seq distance
False
chain
G
MACPF
begin
324
end
333
score
84.54545454545456
distance
96.6582
seq distance
False
chain
I
MACPF
begin
324
end
333
score
84.54545454545456
distance
96.6582
seq distance
False
chain
I
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
102.48932
seq distance
False
chain
G
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
102.48932
seq distance
False
chain
G
Disordered
begin
327
end
328
score
61.36363636363637
distance
103.776306
seq distance
False
chain
I
Disordered
begin
327
end
328
score
61.36363636363637
distance
103.776306
seq distance
False
chain
I
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
105.81182
seq distance
False
chain
I
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
105.81182
seq distance
False
chain
I
In C7D; dbSNP:rs541873000.
original residue
E
variation residue
Q
position
660
score
100.0
distance
106.32672
seq distance
196
chain
C
In C7D; dbSNP:rs541873000.
original residue
E
variation residue
Q
position
660
score
100.0
distance
106.32672
seq distance
196
chain
C
Confirmed at protein level; dbSNP:rs13157656.
original residue
T
variation residue
P
position
693
score
50.0
distance
108.85139
seq distance
False
chain
B
Confirmed at protein level; dbSNP:rs13157656.
original residue
T
variation residue
P
position
693
score
50.0
distance
108.85139
seq distance
False
chain
B
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
115.09997
seq distance
False
chain
H
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
115.09997
seq distance
False
chain
H
In C7D; dbSNP:rs113187203.
original residue
R
variation residue
H
position
665
score
100.0
distance
118.130806
seq distance
201
chain
C
In C7D; dbSNP:rs113187203.
original residue
R
variation residue
H
position
665
score
100.0
distance
118.130806
seq distance
201
chain
C
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
123.72899
seq distance
False
chain
H
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
123.72899
seq distance
False
chain
H
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
134.05775
seq distance
False
chain
I
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
134.05775
seq distance
False
chain
I
Factor I module (FIM) 1
begin
673
end
748
score
100.0
distance
139.7736
seq distance
209
chain
C
Factor I module (FIM) 1
begin
673
end
748
score
100.0
distance
139.7736
seq distance
209
chain
C
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
1560
score
50.0
distance
151.39392
seq distance
False
chain
A
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
1560
score
50.0
distance
151.39392
seq distance
False
chain
A
Factor I module (FIM) 2
begin
749
end
821
score
100.0
distance
165.26796
seq distance
285
chain
C
Factor I module (FIM) 2
begin
749
end
821
score
100.0
distance
165.26796
seq distance
285
chain
C

Details

Redox score
72.98
PDB code
7nyc
Structure name
cryoem structure of 3c9-smac
Structure deposition date
2021-03-22
Thiol separation (Å)
4.32
Half-sphere exposure sum
62
Minimum pKa
nan
% buried
nan
Peptide accession
P10643
Residue number A
475 (Residue 453 in this structure)
Residue number B
486 (Residue 464 in this structure)
Peptide name
Complement component C7
A redox-regulated disulphide may form within Complement component C7 at these cysteines.

Relevent regions

Factor I module (FIM) 2
begin
771
end
843
score
100.0
distance
2.8466582
seq distance
0
chain
A
Factor I module (FIM) 2
begin
771
end
843
score
100.0
distance
2.8466582
seq distance
0
chain
A
Factor I module (FIM) 1
begin
695
end
770
score
99.46172248803828
distance
4.2923
seq distance
6
chain
A
Factor I module (FIM) 1
begin
695
end
770
score
99.46172248803828
distance
4.2923
seq distance
6
chain
A
LDL-receptor class A
begin
795
end
795
score
70.45454545454545
distance
14.100631
seq distance
19
chain
A
LDL-receptor class A
begin
795
end
795
score
70.45454545454545
distance
14.100631
seq distance
19
chain
A
In C7D; dbSNP:rs113187203.
original residue
R
variation residue
H
position
712
score
50.0
distance
35.82945
seq distance
64
chain
A
In C7D; dbSNP:rs113187203.
original residue
R
variation residue
H
position
712
score
50.0
distance
35.82945
seq distance
64
chain
A

Details

Redox score
72.62
PDB code
2wcy
Structure name
nmr solution structure of factor i-like modules of complement c7.
Structure deposition date
2009-03-17
Thiol separation (Å)
7.52
Half-sphere exposure sum
61
Minimum pKa
nan
% buried
11.5
Peptide accession
P10643
Residue number A
776
Residue number B
825
Peptide name
Complement component C7
A redox-regulated disulphide may form within Complement component C7 at these cysteines.

Relevent regions

Factor I module (FIM) 1
begin
695
end
770
score
99.46172248803828
distance
2.818704
seq distance
0
chain
A
Factor I module (FIM) 1
begin
695
end
770
score
99.46172248803828
distance
2.818704
seq distance
0
chain
A
In C7D; dbSNP:rs113187203.
original residue
R
variation residue
H
position
712
score
50.0
distance
4.9483523
seq distance
1
chain
A
In C7D; dbSNP:rs113187203.
original residue
R
variation residue
H
position
712
score
50.0
distance
4.9483523
seq distance
1
chain
A
Factor I module (FIM) 2
begin
771
end
843
score
100.0
distance
12.729168
seq distance
21
chain
A
Factor I module (FIM) 2
begin
771
end
843
score
100.0
distance
12.729168
seq distance
21
chain
A
LDL-receptor class A
begin
795
end
795
score
70.45454545454545
distance
26.659138
seq distance
45
chain
A
LDL-receptor class A
begin
795
end
795
score
70.45454545454545
distance
26.659138
seq distance
45
chain
A

Details

Redox score
72.47
PDB code
2wcy
Structure name
nmr solution structure of factor i-like modules of complement c7.
Structure deposition date
2009-03-17
Thiol separation (Å)
8.03
Half-sphere exposure sum
40
Minimum pKa
nan
% buried
4.5
Peptide accession
P10643
Residue number A
713
Residue number B
750
Peptide name
Complement component C7
A redox-regulated disulphide may form within Complement component C7 at these cysteines.

Relevent regions

Factor I module (FIM) 2
begin
771
end
843
score
100.0
distance
2.8496232
seq distance
0
chain
A
Factor I module (FIM) 2
begin
771
end
843
score
100.0
distance
2.8496232
seq distance
0
chain
A
Factor I module (FIM) 1
begin
695
end
770
score
99.46172248803828
distance
4.2923
seq distance
12
chain
A
Factor I module (FIM) 1
begin
695
end
770
score
99.46172248803828
distance
4.2923
seq distance
12
chain
A
LDL-receptor class A
begin
795
end
795
score
70.45454545454545
distance
14.100631
seq distance
13
chain
A
LDL-receptor class A
begin
795
end
795
score
70.45454545454545
distance
14.100631
seq distance
13
chain
A
In C7D; dbSNP:rs113187203.
original residue
R
variation residue
H
position
712
score
50.0
distance
35.82945
seq distance
70
chain
A
In C7D; dbSNP:rs113187203.
original residue
R
variation residue
H
position
712
score
50.0
distance
35.82945
seq distance
70
chain
A

Details

Redox score
72.43
PDB code
2wcy
Structure name
nmr solution structure of factor i-like modules of complement c7.
Structure deposition date
2009-03-17
Thiol separation (Å)
7.53
Half-sphere exposure sum
55
Minimum pKa
nan
% buried
10
Peptide accession
P10643
Residue number A
782
Residue number B
825
Peptide name
Complement component C7
A redox-regulated disulphide may form within Complement component C7 at these cysteines.

Relevent regions

Factor I module (FIM) 2
begin
771
end
843
score
100.0
distance
2.7983186
seq distance
0
chain
A
Factor I module (FIM) 2
begin
771
end
843
score
100.0
distance
2.7983186
seq distance
0
chain
A
Factor I module (FIM) 1
begin
695
end
770
score
99.46172248803828
distance
5.129116
seq distance
6
chain
A
Factor I module (FIM) 1
begin
695
end
770
score
99.46172248803828
distance
5.129116
seq distance
6
chain
A
LDL-receptor class A
begin
795
end
795
score
70.45454545454545
distance
13.731085
seq distance
4
chain
A
LDL-receptor class A
begin
795
end
795
score
70.45454545454545
distance
13.731085
seq distance
4
chain
A
In C7D; dbSNP:rs113187203.
original residue
R
variation residue
H
position
712
score
50.0
distance
36.41227
seq distance
64
chain
A
In C7D; dbSNP:rs113187203.
original residue
R
variation residue
H
position
712
score
50.0
distance
36.41227
seq distance
64
chain
A

Details

Redox score
72.29
PDB code
2wcy
Structure name
nmr solution structure of factor i-like modules of complement c7.
Structure deposition date
2009-03-17
Thiol separation (Å)
8.05
Half-sphere exposure sum
61
Minimum pKa
nan
% buried
5
Peptide accession
P10643
Residue number A
776
Residue number B
791
Peptide name
Complement component C7
A redox-regulated disulphide may form within Complement component C7 at these cysteines.

Relevent regions

Factor I module (FIM) 2
begin
771
end
843
score
100.0
distance
2.7983186
seq distance
0
chain
A
Factor I module (FIM) 2
begin
771
end
843
score
100.0
distance
2.7983186
seq distance
0
chain
A
Factor I module (FIM) 1
begin
695
end
770
score
99.46172248803828
distance
5.129116
seq distance
3
chain
A
Factor I module (FIM) 1
begin
695
end
770
score
99.46172248803828
distance
5.129116
seq distance
3
chain
A
LDL-receptor class A
begin
795
end
795
score
70.45454545454545
distance
13.731085
seq distance
4
chain
A
LDL-receptor class A
begin
795
end
795
score
70.45454545454545
distance
13.731085
seq distance
4
chain
A
In C7D; dbSNP:rs113187203.
original residue
R
variation residue
H
position
712
score
50.0
distance
37.294395
seq distance
61
chain
A
In C7D; dbSNP:rs113187203.
original residue
R
variation residue
H
position
712
score
50.0
distance
37.294395
seq distance
61
chain
A

Details

Redox score
71.64
PDB code
2wcy
Structure name
nmr solution structure of factor i-like modules of complement c7.
Structure deposition date
2009-03-17
Thiol separation (Å)
8.53
Half-sphere exposure sum
52
Minimum pKa
nan
% buried
3.5
Peptide accession
P10643
Residue number A
773
Residue number B
791
Peptide name
Complement component C7
A redox-regulated disulphide may form within Complement component C7 at these cysteines.

Relevent regions

Factor I module (FIM) 2
begin
771
end
843
score
100.0
distance
2.8517427
seq distance
0
chain
A
Factor I module (FIM) 2
begin
771
end
843
score
100.0
distance
2.8517427
seq distance
0
chain
A
Factor I module (FIM) 1
begin
695
end
770
score
99.46172248803828
distance
4.2923
seq distance
3
chain
A
Factor I module (FIM) 1
begin
695
end
770
score
99.46172248803828
distance
4.2923
seq distance
3
chain
A
LDL-receptor class A
begin
795
end
795
score
70.45454545454545
distance
14.100631
seq distance
22
chain
A
LDL-receptor class A
begin
795
end
795
score
70.45454545454545
distance
14.100631
seq distance
22
chain
A
In C7D; dbSNP:rs113187203.
original residue
R
variation residue
H
position
712
score
50.0
distance
35.82945
seq distance
61
chain
A
In C7D; dbSNP:rs113187203.
original residue
R
variation residue
H
position
712
score
50.0
distance
35.82945
seq distance
61
chain
A

Details

Redox score
71.03
PDB code
2wcy
Structure name
nmr solution structure of factor i-like modules of complement c7.
Structure deposition date
2009-03-17
Thiol separation (Å)
8.57
Half-sphere exposure sum
52
Minimum pKa
nan
% buried
10
Peptide accession
P10643
Residue number A
773
Residue number B
825
Peptide name
Complement component C7
A redox-regulated disulphide may form within Complement component C7 at these cysteines. However, the redox score of this cysteine pair is lower than any known redox-active disulphide.

Relevent regions

EGF-like
begin
457
end
487
score
100.0
distance
2.8088515
seq distance
0
chain
D
EGF-like
begin
457
end
487
score
100.0
distance
2.8088515
seq distance
0
chain
D
TSP type-1 1
begin
27
end
80
score
99.83164983164983
distance
8.904277
seq distance
380
chain
D
TSP type-1 1
begin
27
end
80
score
99.83164983164983
distance
8.904277
seq distance
380
chain
D
MACPF
begin
124
end
456
score
98.9079989079989
distance
9.220186
seq distance
4
chain
D
MACPF
begin
124
end
456
score
98.9079989079989
distance
9.220186
seq distance
4
chain
D
Disordered
begin
516
end
538
score
100.0
distance
10.9926405
seq distance
30
chain
D
Disordered
begin
516
end
538
score
100.0
distance
10.9926405
seq distance
30
chain
D
TSP type-1 2
begin
500
end
549
score
100.0
distance
10.9926405
seq distance
14
chain
D
TSP type-1 2
begin
500
end
549
score
100.0
distance
10.9926405
seq distance
14
chain
D
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
521
score
100.0
distance
19.722815
seq distance
35
chain
D
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
521
score
100.0
distance
19.722815
seq distance
35
chain
D
Confirmed at protein level; dbSNP:rs1063499.
original residue
S
variation residue
T
position
389
score
100.0
distance
23.49186
seq distance
71
chain
D
Confirmed at protein level; dbSNP:rs1063499.
original residue
S
variation residue
T
position
389
score
100.0
distance
23.49186
seq distance
71
chain
D
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
412
score
63.63636363636363
distance
24.797327
seq distance
False
chain
C
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
412
score
63.63636363636363
distance
24.797327
seq distance
False
chain
C
Disordered
begin
41
end
41
score
70.45454545454545
distance
26.508217
seq distance
False
chain
B
Disordered
begin
41
end
41
score
70.45454545454545
distance
26.508217
seq distance
False
chain
B
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
420
score
100.0
distance
26.759352
seq distance
40
chain
D
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
420
score
100.0
distance
26.759352
seq distance
40
chain
D
Disordered
begin
108
end
143
score
100.0
distance
27.03489
seq distance
317
chain
D
Disordered
begin
108
end
143
score
100.0
distance
27.03489
seq distance
317
chain
D
EGF-like
begin
451
end
455
score
54.090909090909086
distance
32.6049
seq distance
False
chain
C
EGF-like
begin
451
end
455
score
54.090909090909086
distance
32.6049
seq distance
False
chain
C
CCP 1
begin
545
end
615
score
83.48271446862996
distance
34.71138
seq distance
59
chain
D
CCP 1
begin
545
end
615
score
83.48271446862996
distance
34.71138
seq distance
59
chain
D
Disordered
begin
504
end
504
score
68.18181818181817
distance
36.977745
seq distance
False
chain
C
Disordered
begin
504
end
504
score
68.18181818181817
distance
36.977745
seq distance
False
chain
C
Disordered
begin
219
end
240
score
100.0
distance
41.709736
seq distance
220
chain
D
Disordered
begin
219
end
240
score
100.0
distance
41.709736
seq distance
220
chain
D
LDL-receptor class A
begin
83
end
121
score
100.0
distance
43.50405
seq distance
339
chain
D
LDL-receptor class A
begin
83
end
121
score
100.0
distance
43.50405
seq distance
339
chain
D
In dbSNP:rs75345202.
original residue
R
variation residue
H
position
414
score
54.54545454545454
distance
43.660423
seq distance
False
chain
F
In dbSNP:rs75345202.
original residue
R
variation residue
H
position
414
score
54.54545454545454
distance
43.660423
seq distance
False
chain
F
Disordered
begin
585
end
589
score
50.90909090909091
distance
47.20918
seq distance
False
chain
B
Disordered
begin
585
end
589
score
50.90909090909091
distance
47.20918
seq distance
False
chain
B
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
587
score
68.18181818181817
distance
49.099102
seq distance
False
chain
B
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
587
score
68.18181818181817
distance
49.099102
seq distance
False
chain
B
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
51.716393
seq distance
False
chain
X
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
51.716393
seq distance
False
chain
X
Disordered
begin
91
end
92
score
68.18181818181817
distance
52.422165
seq distance
False
chain
C
Disordered
begin
91
end
92
score
68.18181818181817
distance
52.422165
seq distance
False
chain
C
LDL-receptor class A
begin
84
end
92
score
56.56565656565656
distance
52.422165
seq distance
False
chain
C
LDL-receptor class A
begin
84
end
92
score
56.56565656565656
distance
52.422165
seq distance
False
chain
C
In dbSNP:rs2271708.
original residue
C
variation residue
R
position
128
score
100.0
distance
55.70358
seq distance
332
chain
D
In dbSNP:rs2271708.
original residue
C
variation residue
R
position
128
score
100.0
distance
55.70358
seq distance
332
chain
D
TSP type-1 2
begin
512
end
517
score
80.30303030303031
distance
56.98538
seq distance
False
chain
F
TSP type-1 2
begin
512
end
517
score
80.30303030303031
distance
56.98538
seq distance
False
chain
F
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
57.919403
seq distance
False
chain
X
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
57.919403
seq distance
False
chain
X
Sushi 1
begin
572
end
628
score
99.04306220095694
distance
63.50192
seq distance
86
chain
D
Sushi 1
begin
572
end
628
score
99.04306220095694
distance
63.50192
seq distance
86
chain
D
LDL-receptor class A
begin
83
end
98
score
52.69886363636363
distance
64.41563
seq distance
False
chain
F
LDL-receptor class A
begin
83
end
98
score
52.69886363636363
distance
64.41563
seq distance
False
chain
F
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
64.92532
seq distance
False
chain
G
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
64.92532
seq distance
False
chain
G
CCP 2
begin
616
end
691
score
99.2822966507177
distance
65.43076
seq distance
130
chain
D
CCP 2
begin
616
end
691
score
99.2822966507177
distance
65.43076
seq distance
130
chain
D
Disordered
begin
138
end
138
score
50.0
distance
66.64205
seq distance
False
chain
E
Disordered
begin
138
end
138
score
50.0
distance
66.64205
seq distance
False
chain
E
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
67.82075
seq distance
False
chain
X
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
67.82075
seq distance
False
chain
X
Confirmed at protein level; dbSNP:rs13157656.
original residue
T
variation residue
P
position
587
score
100.0
distance
71.31676
seq distance
101
chain
D
Confirmed at protein level; dbSNP:rs13157656.
original residue
T
variation residue
P
position
587
score
100.0
distance
71.31676
seq distance
101
chain
D
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
31
score
50.0
distance
75.186676
seq distance
False
chain
F
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
31
score
50.0
distance
75.186676
seq distance
False
chain
F
In C7D; dbSNP:rs369349760.
original residue
R
variation residue
Q
position
220
score
100.0
distance
80.47969
seq distance
240
chain
D
In C7D; dbSNP:rs369349760.
original residue
R
variation residue
Q
position
220
score
100.0
distance
80.47969
seq distance
240
chain
D
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
80.78582
seq distance
False
chain
W
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
80.78582
seq distance
False
chain
W
Confirmed at protein level; dbSNP:rs1063499.
original residue
S
variation residue
T
position
1058
score
54.54545454545454
distance
83.03419
seq distance
False
chain
A
Confirmed at protein level; dbSNP:rs1063499.
original residue
S
variation residue
T
position
1058
score
54.54545454545454
distance
83.03419
seq distance
False
chain
A
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
85.213684
seq distance
False
chain
W
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
85.213684
seq distance
False
chain
W
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
85.50705
seq distance
False
chain
P
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
85.50705
seq distance
False
chain
P
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
86.38679
seq distance
False
chain
X
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
86.38679
seq distance
False
chain
X
In dbSNP:rs75345202.
original residue
R
variation residue
H
position
222
score
100.0
distance
86.92716
seq distance
238
chain
D
In dbSNP:rs75345202.
original residue
R
variation residue
H
position
222
score
100.0
distance
86.92716
seq distance
238
chain
D
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
91.02185
seq distance
False
chain
W
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
91.02185
seq distance
False
chain
W
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
93.23817
seq distance
False
chain
G
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
93.23817
seq distance
False
chain
G
Sushi 2
begin
629
end
690
score
99.56011730205279
distance
96.03488
seq distance
143
chain
D
Sushi 2
begin
629
end
690
score
99.56011730205279
distance
96.03488
seq distance
143
chain
D
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
97.49248
seq distance
False
chain
W
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
97.49248
seq distance
False
chain
W
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
99.01552
seq distance
False
chain
G
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
99.01552
seq distance
False
chain
G
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
101.76508
seq distance
False
chain
G
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
101.76508
seq distance
False
chain
G
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
105.30265
seq distance
False
chain
H
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
105.30265
seq distance
False
chain
H
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
107.926834
seq distance
False
chain
V
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
107.926834
seq distance
False
chain
V
Confirmed at protein level; dbSNP:rs13157656.
original residue
T
variation residue
P
position
714
score
50.0
distance
109.28099
seq distance
False
chain
B
Confirmed at protein level; dbSNP:rs13157656.
original residue
T
variation residue
P
position
714
score
50.0
distance
109.28099
seq distance
False
chain
B
In C7D; dbSNP:rs541873000.
original residue
E
variation residue
Q
position
682
score
100.0
distance
109.41801
seq distance
196
chain
D
In C7D; dbSNP:rs541873000.
original residue
E
variation residue
Q
position
682
score
100.0
distance
109.41801
seq distance
196
chain
D
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
110.755844
seq distance
False
chain
V
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
110.755844
seq distance
False
chain
V
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
111.029625
seq distance
False
chain
V
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
111.029625
seq distance
False
chain
V
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
112.16155
seq distance
False
chain
V
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
112.16155
seq distance
False
chain
V
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
113.4517
seq distance
False
chain
P
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
113.4517
seq distance
False
chain
P
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
113.95964
seq distance
False
chain
P
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
113.95964
seq distance
False
chain
P
In C7D; dbSNP:rs113187203.
original residue
R
variation residue
H
position
687
score
100.0
distance
118.582405
seq distance
201
chain
D
In C7D; dbSNP:rs113187203.
original residue
R
variation residue
H
position
687
score
100.0
distance
118.582405
seq distance
201
chain
D
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
123.07295
seq distance
False
chain
P
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
123.07295
seq distance
False
chain
P
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
123.432396
seq distance
False
chain
I
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
123.432396
seq distance
False
chain
I
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
125.342964
seq distance
False
chain
U
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
125.342964
seq distance
False
chain
U
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
127.89072
seq distance
False
chain
H
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
127.89072
seq distance
False
chain
H
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
130.9648
seq distance
False
chain
U
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
130.9648
seq distance
False
chain
U
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
132.42653
seq distance
False
chain
U
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
132.42653
seq distance
False
chain
U
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
133.24835
seq distance
False
chain
U
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
133.24835
seq distance
False
chain
U
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
133.7111
seq distance
False
chain
H
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
133.7111
seq distance
False
chain
H
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
138.88968
seq distance
False
chain
T
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
138.88968
seq distance
False
chain
T
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
139.54065
seq distance
False
chain
J
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
139.54065
seq distance
False
chain
J
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
140.9635
seq distance
False
chain
I
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
140.9635
seq distance
False
chain
I
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
143.2638
seq distance
False
chain
H
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
143.2638
seq distance
False
chain
H
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
146.96448
seq distance
False
chain
T
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
146.96448
seq distance
False
chain
T
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
150.702
seq distance
False
chain
S
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
150.702
seq distance
False
chain
S
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
151.6315
seq distance
False
chain
I
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
151.6315
seq distance
False
chain
I
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
152.01833
seq distance
False
chain
J
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
152.01833
seq distance
False
chain
J
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
152.93266
seq distance
False
chain
T
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
152.93266
seq distance
False
chain
T
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
153.21483
seq distance
False
chain
K
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
153.21483
seq distance
False
chain
K
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
153.78725
seq distance
False
chain
T
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
153.78725
seq distance
False
chain
T
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
159.76741
seq distance
False
chain
S
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
159.76741
seq distance
False
chain
S
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
160.37991
seq distance
False
chain
R
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
160.37991
seq distance
False
chain
R
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
160.97946
seq distance
False
chain
K
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
160.97946
seq distance
False
chain
K
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
161.3973
seq distance
False
chain
I
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
161.3973
seq distance
False
chain
I
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
164.14816
seq distance
False
chain
L
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
164.14816
seq distance
False
chain
L
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
167.21608
seq distance
False
chain
J
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
167.21608
seq distance
False
chain
J
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
167.65924
seq distance
False
chain
Q
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
167.65924
seq distance
False
chain
Q
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
167.66588
seq distance
False
chain
L
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
167.66588
seq distance
False
chain
L
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
169.23996
seq distance
False
chain
R
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
169.23996
seq distance
False
chain
R
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
169.37178
seq distance
False
chain
S
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
169.37178
seq distance
False
chain
S
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
171.61467
seq distance
False
chain
O
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
171.61467
seq distance
False
chain
O
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
171.71907
seq distance
False
chain
M
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
171.71907
seq distance
False
chain
M
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
171.8864
seq distance
False
chain
S
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
171.8864
seq distance
False
chain
S
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
172.01843
seq distance
False
chain
M
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
172.01843
seq distance
False
chain
M
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
173.44034
seq distance
False
chain
N
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
173.44034
seq distance
False
chain
N
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
175.29077
seq distance
False
chain
Q
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
175.29077
seq distance
False
chain
Q
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
176.59512
seq distance
False
chain
N
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
176.59512
seq distance
False
chain
N
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
177.04086
seq distance
False
chain
J
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
177.04086
seq distance
False
chain
J
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
177.74564
seq distance
False
chain
O
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
177.74564
seq distance
False
chain
O
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
180.01778
seq distance
False
chain
K
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
180.01778
seq distance
False
chain
K
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
182.31877
seq distance
False
chain
R
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
182.31877
seq distance
False
chain
R
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
186.39362
seq distance
False
chain
R
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
186.39362
seq distance
False
chain
R
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
189.68115
seq distance
False
chain
L
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
189.68115
seq distance
False
chain
L
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
189.7163
seq distance
False
chain
K
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
189.7163
seq distance
False
chain
K
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
191.54909
seq distance
False
chain
Q
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
191.54909
seq distance
False
chain
Q
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
195.81862
seq distance
False
chain
M
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
195.81862
seq distance
False
chain
M
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
196.90211
seq distance
False
chain
O
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
196.90211
seq distance
False
chain
O
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
197.13205
seq distance
False
chain
Q
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
197.13205
seq distance
False
chain
Q
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
198.25119
seq distance
False
chain
N
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
198.25119
seq distance
False
chain
N
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
199.07649
seq distance
False
chain
L
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
199.07649
seq distance
False
chain
L
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
203.8534
seq distance
False
chain
O
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
203.8534
seq distance
False
chain
O
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
204.775
seq distance
False
chain
M
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
204.775
seq distance
False
chain
M
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
206.38806
seq distance
False
chain
N
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
206.38806
seq distance
False
chain
N

Details

Redox score
70.7
PDB code
6h04
Structure name
closed conformation of the membrane attack complex
Structure deposition date
2018-07-06
Thiol separation (Å)
5.83
Half-sphere exposure sum
58
Minimum pKa
nan
% buried
nan
Peptide accession
P10643
Residue number A
460
Residue number B
486
Peptide name
Complement component C7
A redox-regulated disulphide may form within Complement component C7 at these cysteines. However, the redox score of this cysteine pair is lower than any known redox-active disulphide.

Relevent regions

Factor I module (FIM) 1
begin
695
end
770
score
99.46172248803828
distance
2.790966
seq distance
0
chain
A
Factor I module (FIM) 1
begin
695
end
770
score
99.46172248803828
distance
2.790966
seq distance
0
chain
A
In C7D; dbSNP:rs113187203.
original residue
R
variation residue
H
position
712
score
50.0
distance
4.9483523
seq distance
1
chain
A
In C7D; dbSNP:rs113187203.
original residue
R
variation residue
H
position
712
score
50.0
distance
4.9483523
seq distance
1
chain
A
Factor I module (FIM) 2
begin
771
end
843
score
100.0
distance
14.044354
seq distance
56
chain
A
Factor I module (FIM) 2
begin
771
end
843
score
100.0
distance
14.044354
seq distance
56
chain
A
LDL-receptor class A
begin
795
end
795
score
70.45454545454545
distance
26.659138
seq distance
80
chain
A
LDL-receptor class A
begin
795
end
795
score
70.45454545454545
distance
26.659138
seq distance
80
chain
A

Details

Redox score
70.49
PDB code
2wcy
Structure name
nmr solution structure of factor i-like modules of complement c7.
Structure deposition date
2009-03-17
Thiol separation (Å)
9.48
Half-sphere exposure sum
45
Minimum pKa
nan
% buried
1
Peptide accession
P10643
Residue number A
713
Residue number B
715
Peptide name
Complement component C7
A redox-regulated disulphide may form within Complement component C7 at these cysteines. However, the redox score of this cysteine pair is lower than any known redox-active disulphide.

Relevent regions

Factor I module (FIM) 1
begin
695
end
770
score
99.46172248803828
distance
2.790966
seq distance
0
chain
A
Factor I module (FIM) 1
begin
695
end
770
score
99.46172248803828
distance
2.790966
seq distance
0
chain
A
In C7D; dbSNP:rs113187203.
original residue
R
variation residue
H
position
712
score
50.0
distance
5.8846464
seq distance
3
chain
A
In C7D; dbSNP:rs113187203.
original residue
R
variation residue
H
position
712
score
50.0
distance
5.8846464
seq distance
3
chain
A
Factor I module (FIM) 2
begin
771
end
843
score
100.0
distance
14.044354
seq distance
56
chain
A
Factor I module (FIM) 2
begin
771
end
843
score
100.0
distance
14.044354
seq distance
56
chain
A
LDL-receptor class A
begin
795
end
795
score
70.45454545454545
distance
25.312286
seq distance
80
chain
A
LDL-receptor class A
begin
795
end
795
score
70.45454545454545
distance
25.312286
seq distance
80
chain
A

Details

Redox score
70.37
PDB code
2wcy
Structure name
nmr solution structure of factor i-like modules of complement c7.
Structure deposition date
2009-03-17
Thiol separation (Å)
9.73
Half-sphere exposure sum
43
Minimum pKa
nan
% buried
1
Peptide accession
P10643
Residue number A
702
Residue number B
715
Peptide name
Complement component C7
A redox-regulated disulphide may form within Complement component C7 at these cysteines. However, the redox score of this cysteine pair is lower than any known redox-active disulphide.

Relevent regions

Factor I module (FIM) 2
begin
771
end
843
score
100.0
distance
2.7983186
seq distance
0
chain
A
Factor I module (FIM) 2
begin
771
end
843
score
100.0
distance
2.7983186
seq distance
0
chain
A
Factor I module (FIM) 1
begin
695
end
770
score
99.46172248803828
distance
5.129116
seq distance
21
chain
A
Factor I module (FIM) 1
begin
695
end
770
score
99.46172248803828
distance
5.129116
seq distance
21
chain
A
LDL-receptor class A
begin
795
end
795
score
70.45454545454545
distance
7.4242826
seq distance
2
chain
A
LDL-receptor class A
begin
795
end
795
score
70.45454545454545
distance
7.4242826
seq distance
2
chain
A
In C7D; dbSNP:rs113187203.
original residue
R
variation residue
H
position
712
score
50.0
distance
24.678598
seq distance
79
chain
A
In C7D; dbSNP:rs113187203.
original residue
R
variation residue
H
position
712
score
50.0
distance
24.678598
seq distance
79
chain
A

Details

Redox score
70.25
PDB code
2wcy
Structure name
nmr solution structure of factor i-like modules of complement c7.
Structure deposition date
2009-03-17
Thiol separation (Å)
9.06
Half-sphere exposure sum
59
Minimum pKa
nan
% buried
8.5
Peptide accession
P10643
Residue number A
791
Residue number B
797
Peptide name
Complement component C7
A redox-regulated disulphide may form within Complement component C7 at these cysteines. However, the redox score of this cysteine pair is lower than any known redox-active disulphide.

Relevent regions

Factor I module (FIM) 2
begin
771
end
843
score
100.0
distance
2.8335195
seq distance
0
chain
A
Factor I module (FIM) 2
begin
771
end
843
score
100.0
distance
2.8335195
seq distance
0
chain
A
Factor I module (FIM) 1
begin
695
end
770
score
99.46172248803828
distance
7.1713576
seq distance
19
chain
A
Factor I module (FIM) 1
begin
695
end
770
score
99.46172248803828
distance
7.1713576
seq distance
19
chain
A
LDL-receptor class A
begin
795
end
795
score
70.45454545454545
distance
7.4242826
seq distance
2
chain
A
LDL-receptor class A
begin
795
end
795
score
70.45454545454545
distance
7.4242826
seq distance
2
chain
A
In C7D; dbSNP:rs113187203.
original residue
R
variation residue
H
position
712
score
50.0
distance
24.678598
seq distance
77
chain
A
In C7D; dbSNP:rs113187203.
original residue
R
variation residue
H
position
712
score
50.0
distance
24.678598
seq distance
77
chain
A

Details

Redox score
70.25
PDB code
2wcy
Structure name
nmr solution structure of factor i-like modules of complement c7.
Structure deposition date
2009-03-17
Thiol separation (Å)
9.43
Half-sphere exposure sum
52
Minimum pKa
nan
% buried
6
Peptide accession
P10643
Residue number A
789
Residue number B
797
Peptide name
Complement component C7
A redox-regulated disulphide may form within Complement component C7 at these cysteines. However, the redox score of this cysteine pair is lower than any known redox-active disulphide.

Relevent regions

Factor I module (FIM) 1
begin
695
end
770
score
99.46172248803828
distance
2.8040588
seq distance
0
chain
A
Factor I module (FIM) 1
begin
695
end
770
score
99.46172248803828
distance
2.8040588
seq distance
0
chain
A
In C7D; dbSNP:rs113187203.
original residue
R
variation residue
H
position
712
score
50.0
distance
5.8846464
seq distance
10
chain
A
In C7D; dbSNP:rs113187203.
original residue
R
variation residue
H
position
712
score
50.0
distance
5.8846464
seq distance
10
chain
A
Factor I module (FIM) 2
begin
771
end
843
score
100.0
distance
12.729168
seq distance
21
chain
A
Factor I module (FIM) 2
begin
771
end
843
score
100.0
distance
12.729168
seq distance
21
chain
A
LDL-receptor class A
begin
795
end
795
score
70.45454545454545
distance
25.312286
seq distance
45
chain
A
LDL-receptor class A
begin
795
end
795
score
70.45454545454545
distance
25.312286
seq distance
45
chain
A

Details

Redox score
70.25
PDB code
2wcy
Structure name
nmr solution structure of factor i-like modules of complement c7.
Structure deposition date
2009-03-17
Thiol separation (Å)
9.56
Half-sphere exposure sum
38
Minimum pKa
nan
% buried
4.5
Peptide accession
P10643
Residue number A
702
Residue number B
750
Peptide name
Complement component C7
A redox-regulated disulphide may form within Complement component C7 at these cysteines. However, the redox score of this cysteine pair is lower than any known redox-active disulphide.

Relevent regions

EGF-like
begin
435
end
465
score
100.0
distance
2.8385603
seq distance
0
chain
C
EGF-like
begin
435
end
465
score
100.0
distance
2.8385603
seq distance
0
chain
C
MACPF
begin
102
end
434
score
94.85394485394487
distance
8.560025
seq distance
4
chain
C
MACPF
begin
102
end
434
score
94.85394485394487
distance
8.560025
seq distance
4
chain
C
TSP type-1 1
begin
5
end
58
score
99.83164983164983
distance
8.988335
seq distance
380
chain
C
TSP type-1 1
begin
5
end
58
score
99.83164983164983
distance
8.988335
seq distance
380
chain
C
TSP type-1 2
begin
478
end
527
score
100.0
distance
10.994443
seq distance
23
chain
C
TSP type-1 2
begin
478
end
527
score
100.0
distance
10.994443
seq distance
23
chain
C
Disordered
begin
494
end
516
score
100.0
distance
12.512271
seq distance
39
chain
C
Disordered
begin
494
end
516
score
100.0
distance
12.512271
seq distance
39
chain
C
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
499
score
100.0
distance
18.895031
seq distance
44
chain
C
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
499
score
100.0
distance
18.895031
seq distance
44
chain
C
Disordered
begin
510
end
522
score
53.67132867132868
distance
23.55115
seq distance
False
chain
D
Disordered
begin
510
end
522
score
53.67132867132868
distance
23.55115
seq distance
False
chain
D
Confirmed at protein level; dbSNP:rs1063499.
original residue
S
variation residue
T
position
367
score
100.0
distance
23.56202
seq distance
71
chain
C
Confirmed at protein level; dbSNP:rs1063499.
original residue
S
variation residue
T
position
367
score
100.0
distance
23.56202
seq distance
71
chain
C
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
412
score
63.63636363636363
distance
23.870605
seq distance
False
chain
D
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
412
score
63.63636363636363
distance
23.870605
seq distance
False
chain
D
Disordered
begin
86
end
121
score
100.0
distance
24.973307
seq distance
317
chain
C
Disordered
begin
86
end
121
score
100.0
distance
24.973307
seq distance
317
chain
C
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
398
score
100.0
distance
25.221754
seq distance
40
chain
C
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
398
score
100.0
distance
25.221754
seq distance
40
chain
C
In C7D; dbSNP:rs121964921.
original residue
G
variation residue
R
position
357
score
100.0
distance
26.064802
seq distance
81
chain
C
In C7D; dbSNP:rs121964921.
original residue
G
variation residue
R
position
357
score
100.0
distance
26.064802
seq distance
81
chain
C
In C7D; dbSNP:rs369349760.
original residue
R
variation residue
Q
position
25
score
54.54545454545454
distance
27.409761
seq distance
False
chain
B
In C7D; dbSNP:rs369349760.
original residue
R
variation residue
Q
position
25
score
54.54545454545454
distance
27.409761
seq distance
False
chain
B
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
512
score
81.81818181818183
distance
28.514221
seq distance
False
chain
D
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
512
score
81.81818181818183
distance
28.514221
seq distance
False
chain
D
EGF-like
begin
451
end
455
score
54.090909090909086
distance
32.284504
seq distance
False
chain
D
EGF-like
begin
451
end
455
score
54.090909090909086
distance
32.284504
seq distance
False
chain
D
CCP 1
begin
523
end
593
score
100.0
distance
33.611668
seq distance
68
chain
C
CCP 1
begin
523
end
593
score
100.0
distance
33.611668
seq distance
68
chain
C
Disordered
begin
504
end
504
score
68.18181818181817
distance
36.497147
seq distance
False
chain
D
Disordered
begin
504
end
504
score
68.18181818181817
distance
36.497147
seq distance
False
chain
D
Disordered
begin
564
end
573
score
62.272727272727266
distance
37.465393
seq distance
False
chain
B
Disordered
begin
564
end
573
score
62.272727272727266
distance
37.465393
seq distance
False
chain
B
In dbSNP:rs75345202.
original residue
R
variation residue
H
position
414
score
54.54545454545454
distance
40.31713
seq distance
False
chain
E
In dbSNP:rs75345202.
original residue
R
variation residue
H
position
414
score
54.54545454545454
distance
40.31713
seq distance
False
chain
E
LDL-receptor class A
begin
61
end
99
score
100.0
distance
41.211086
seq distance
339
chain
C
LDL-receptor class A
begin
61
end
99
score
100.0
distance
41.211086
seq distance
339
chain
C
Disordered
begin
197
end
218
score
76.85950413223141
distance
42.209843
seq distance
220
chain
C
Disordered
begin
197
end
218
score
76.85950413223141
distance
42.209843
seq distance
220
chain
C
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
566
score
86.36363636363636
distance
45.70498
seq distance
False
chain
B
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
566
score
86.36363636363636
distance
45.70498
seq distance
False
chain
B
Disordered
begin
91
end
92
score
68.18181818181817
distance
50.74333
seq distance
False
chain
D
Disordered
begin
91
end
92
score
68.18181818181817
distance
50.74333
seq distance
False
chain
D
LDL-receptor class A
begin
84
end
92
score
56.56565656565656
distance
50.74333
seq distance
False
chain
D
LDL-receptor class A
begin
84
end
92
score
56.56565656565656
distance
50.74333
seq distance
False
chain
D
In dbSNP:rs2271708.
original residue
C
variation residue
R
position
106
score
100.0
distance
51.509483
seq distance
332
chain
C
In dbSNP:rs2271708.
original residue
C
variation residue
R
position
106
score
100.0
distance
51.509483
seq distance
332
chain
C
In dbSNP:rs2271708.
original residue
C
variation residue
R
position
532
score
54.54545454545454
distance
54.34755
seq distance
False
chain
E
In dbSNP:rs2271708.
original residue
C
variation residue
R
position
532
score
54.54545454545454
distance
54.34755
seq distance
False
chain
E
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
530
score
54.54545454545454
distance
57.327408
seq distance
False
chain
E
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
530
score
54.54545454545454
distance
57.327408
seq distance
False
chain
E
MACPF
begin
324
end
332
score
83.08080808080808
distance
58.654095
seq distance
False
chain
G
MACPF
begin
324
end
332
score
83.08080808080808
distance
58.654095
seq distance
False
chain
G
Sushi 1
begin
547
end
606
score
100.0
distance
58.905155
seq distance
92
chain
C
Sushi 1
begin
547
end
606
score
100.0
distance
58.905155
seq distance
92
chain
C
LDL-receptor class A
begin
83
end
95
score
50.87412587412587
distance
62.59034
seq distance
False
chain
E
LDL-receptor class A
begin
83
end
95
score
50.87412587412587
distance
62.59034
seq distance
False
chain
E
CCP 2
begin
594
end
671
score
100.0
distance
63.6405
seq distance
139
chain
C
CCP 2
begin
594
end
671
score
100.0
distance
63.6405
seq distance
139
chain
C
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
64.367676
seq distance
False
chain
G
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
64.367676
seq distance
False
chain
G
Disordered
begin
138
end
138
score
50.0
distance
65.51665
seq distance
False
chain
F
Disordered
begin
138
end
138
score
50.0
distance
65.51665
seq distance
False
chain
F
Confirmed at protein level; dbSNP:rs13157656.
original residue
T
variation residue
P
position
565
score
100.0
distance
68.907555
seq distance
110
chain
C
Confirmed at protein level; dbSNP:rs13157656.
original residue
T
variation residue
P
position
565
score
100.0
distance
68.907555
seq distance
110
chain
C
MACPF
begin
324
end
332
score
83.08080808080808
distance
77.202324
seq distance
False
chain
H
MACPF
begin
324
end
332
score
83.08080808080808
distance
77.202324
seq distance
False
chain
H
Confirmed at protein level; dbSNP:rs1063499.
original residue
S
variation residue
T
position
1040
score
54.54545454545454
distance
79.03622
seq distance
False
chain
A
Confirmed at protein level; dbSNP:rs1063499.
original residue
S
variation residue
T
position
1040
score
54.54545454545454
distance
79.03622
seq distance
False
chain
A
In C7D; dbSNP:rs369349760.
original residue
R
variation residue
Q
position
198
score
72.72727272727273
distance
82.922615
seq distance
240
chain
C
In C7D; dbSNP:rs369349760.
original residue
R
variation residue
Q
position
198
score
72.72727272727273
distance
82.922615
seq distance
240
chain
C
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
84.686005
seq distance
False
chain
H
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
84.686005
seq distance
False
chain
H
In dbSNP:rs75345202.
original residue
R
variation residue
H
position
200
score
72.72727272727273
distance
89.42008
seq distance
238
chain
C
In dbSNP:rs75345202.
original residue
R
variation residue
H
position
200
score
72.72727272727273
distance
89.42008
seq distance
238
chain
C
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
92.6928
seq distance
False
chain
G
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
92.6928
seq distance
False
chain
G
Sushi 2
begin
607
end
668
score
100.0
distance
93.87035
seq distance
152
chain
C
Sushi 2
begin
607
end
668
score
100.0
distance
93.87035
seq distance
152
chain
C
MACPF
begin
324
end
333
score
84.54545454545456
distance
94.624756
seq distance
False
chain
I
MACPF
begin
324
end
333
score
84.54545454545456
distance
94.624756
seq distance
False
chain
I
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
100.58966
seq distance
False
chain
G
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
100.58966
seq distance
False
chain
G
Disordered
begin
327
end
328
score
61.36363636363637
distance
101.72301
seq distance
False
chain
I
Disordered
begin
327
end
328
score
61.36363636363637
distance
101.72301
seq distance
False
chain
I
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
103.76574
seq distance
False
chain
I
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
103.76574
seq distance
False
chain
I
In C7D; dbSNP:rs541873000.
original residue
E
variation residue
Q
position
660
score
100.0
distance
105.6437
seq distance
205
chain
C
In C7D; dbSNP:rs541873000.
original residue
E
variation residue
Q
position
660
score
100.0
distance
105.6437
seq distance
205
chain
C
Confirmed at protein level; dbSNP:rs13157656.
original residue
T
variation residue
P
position
693
score
50.0
distance
107.244446
seq distance
False
chain
B
Confirmed at protein level; dbSNP:rs13157656.
original residue
T
variation residue
P
position
693
score
50.0
distance
107.244446
seq distance
False
chain
B
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
113.07258
seq distance
False
chain
H
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
113.07258
seq distance
False
chain
H
In C7D; dbSNP:rs113187203.
original residue
R
variation residue
H
position
665
score
100.0
distance
117.33873
seq distance
210
chain
C
In C7D; dbSNP:rs113187203.
original residue
R
variation residue
H
position
665
score
100.0
distance
117.33873
seq distance
210
chain
C
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
121.701706
seq distance
False
chain
H
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
121.701706
seq distance
False
chain
H
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
132.0021
seq distance
False
chain
I
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
132.0021
seq distance
False
chain
I
Factor I module (FIM) 1
begin
673
end
748
score
100.0
distance
138.9169
seq distance
218
chain
C
Factor I module (FIM) 1
begin
673
end
748
score
100.0
distance
138.9169
seq distance
218
chain
C
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
1560
score
50.0
distance
150.4625
seq distance
False
chain
A
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
1560
score
50.0
distance
150.4625
seq distance
False
chain
A
Factor I module (FIM) 2
begin
749
end
821
score
100.0
distance
164.5149
seq distance
294
chain
C
Factor I module (FIM) 2
begin
749
end
821
score
100.0
distance
164.5149
seq distance
294
chain
C

Details

Redox score
70.21
PDB code
7nyc
Structure name
cryoem structure of 3c9-smac
Structure deposition date
2021-03-22
Thiol separation (Å)
6.01
Half-sphere exposure sum
63
Minimum pKa
nan
% buried
nan
Peptide accession
P10643
Residue number A
460 (Residue 438 in this structure)
Residue number B
477 (Residue 455 in this structure)
Peptide name
Complement component C7
A redox-regulated disulphide may form within Complement component C7 at these cysteines. However, the redox score of this cysteine pair is lower than any known redox-active disulphide.

Relevent regions

Factor I module (FIM) 1
begin
695
end
770
score
99.46172248803828
distance
2.789243
seq distance
0
chain
A
Factor I module (FIM) 1
begin
695
end
770
score
99.46172248803828
distance
2.789243
seq distance
0
chain
A
Factor I module (FIM) 2
begin
771
end
843
score
100.0
distance
8.602017
seq distance
21
chain
A
Factor I module (FIM) 2
begin
771
end
843
score
100.0
distance
8.602017
seq distance
21
chain
A
In C7D; dbSNP:rs113187203.
original residue
R
variation residue
H
position
712
score
50.0
distance
12.581762
seq distance
9
chain
A
In C7D; dbSNP:rs113187203.
original residue
R
variation residue
H
position
712
score
50.0
distance
12.581762
seq distance
9
chain
A
LDL-receptor class A
begin
795
end
795
score
70.45454545454545
distance
21.0101
seq distance
45
chain
A
LDL-receptor class A
begin
795
end
795
score
70.45454545454545
distance
21.0101
seq distance
45
chain
A

Details

Redox score
69.94
PDB code
2wcy
Structure name
nmr solution structure of factor i-like modules of complement c7.
Structure deposition date
2009-03-17
Thiol separation (Å)
9.33
Half-sphere exposure sum
50
Minimum pKa
nan
% buried
13
Peptide accession
P10643
Residue number A
721
Residue number B
750
Peptide name
Complement component C7
A redox-regulated disulphide may form within Complement component C7 at these cysteines. However, the redox score of this cysteine pair is lower than any known redox-active disulphide.

Relevent regions

Factor I module (FIM) 2
begin
771
end
843
score
100.0
distance
2.78732
seq distance
0
chain
A
Factor I module (FIM) 2
begin
771
end
843
score
100.0
distance
2.78732
seq distance
0
chain
A
Factor I module (FIM) 1
begin
695
end
770
score
99.46172248803828
distance
5.129116
seq distance
21
chain
A
Factor I module (FIM) 1
begin
695
end
770
score
99.46172248803828
distance
5.129116
seq distance
21
chain
A
LDL-receptor class A
begin
795
end
795
score
70.45454545454545
distance
7.9612045
seq distance
4
chain
A
LDL-receptor class A
begin
795
end
795
score
70.45454545454545
distance
7.9612045
seq distance
4
chain
A
In C7D; dbSNP:rs113187203.
original residue
R
variation residue
H
position
712
score
50.0
distance
25.152733
seq distance
79
chain
A
In C7D; dbSNP:rs113187203.
original residue
R
variation residue
H
position
712
score
50.0
distance
25.152733
seq distance
79
chain
A

Details

Redox score
69.7
PDB code
2wcy
Structure name
nmr solution structure of factor i-like modules of complement c7.
Structure deposition date
2009-03-17
Thiol separation (Å)
8.59
Half-sphere exposure sum
69
Minimum pKa
nan
% buried
12.5
Peptide accession
P10643
Residue number A
791
Residue number B
818
Peptide name
Complement component C7
A redox-regulated disulphide may form within Complement component C7 at these cysteines. However, the redox score of this cysteine pair is lower than any known redox-active disulphide.

Relevent regions

Factor I module (FIM) 1
begin
695
end
770
score
99.46172248803828
distance
2.8101158
seq distance
0
chain
A
Factor I module (FIM) 1
begin
695
end
770
score
99.46172248803828
distance
2.8101158
seq distance
0
chain
A
Factor I module (FIM) 2
begin
771
end
843
score
100.0
distance
8.107202
seq distance
21
chain
A
Factor I module (FIM) 2
begin
771
end
843
score
100.0
distance
8.107202
seq distance
21
chain
A
In C7D; dbSNP:rs113187203.
original residue
R
variation residue
H
position
712
score
50.0
distance
12.581762
seq distance
31
chain
A
In C7D; dbSNP:rs113187203.
original residue
R
variation residue
H
position
712
score
50.0
distance
12.581762
seq distance
31
chain
A
LDL-receptor class A
begin
795
end
795
score
70.45454545454545
distance
21.449831
seq distance
45
chain
A
LDL-receptor class A
begin
795
end
795
score
70.45454545454545
distance
21.449831
seq distance
45
chain
A

Details

Redox score
69.68
PDB code
2wcy
Structure name
nmr solution structure of factor i-like modules of complement c7.
Structure deposition date
2009-03-17
Thiol separation (Å)
8.53
Half-sphere exposure sum
58
Minimum pKa
nan
% buried
17.5
Peptide accession
P10643
Residue number A
743
Residue number B
750
Peptide name
Complement component C7
A redox-regulated disulphide may form within Complement component C7 at these cysteines. However, the redox score of this cysteine pair is lower than any known redox-active disulphide.

Relevent regions

Factor I module (FIM) 2
begin
771
end
843
score
100.0
distance
2.8335195
seq distance
0
chain
A
Factor I module (FIM) 2
begin
771
end
843
score
100.0
distance
2.8335195
seq distance
0
chain
A
LDL-receptor class A
begin
795
end
795
score
70.45454545454545
distance
7.4242826
seq distance
2
chain
A
LDL-receptor class A
begin
795
end
795
score
70.45454545454545
distance
7.4242826
seq distance
2
chain
A
Factor I module (FIM) 1
begin
695
end
770
score
99.46172248803828
distance
8.648576
seq distance
6
chain
A
Factor I module (FIM) 1
begin
695
end
770
score
99.46172248803828
distance
8.648576
seq distance
6
chain
A
In C7D; dbSNP:rs113187203.
original residue
R
variation residue
H
position
712
score
50.0
distance
24.678598
seq distance
64
chain
A
In C7D; dbSNP:rs113187203.
original residue
R
variation residue
H
position
712
score
50.0
distance
24.678598
seq distance
64
chain
A

Details

Redox score
69.68
PDB code
2wcy
Structure name
nmr solution structure of factor i-like modules of complement c7.
Structure deposition date
2009-03-17
Thiol separation (Å)
9.87
Half-sphere exposure sum
54
Minimum pKa
nan
% buried
6.5
Peptide accession
P10643
Residue number A
776
Residue number B
797
Peptide name
Complement component C7
A redox-regulated disulphide may form within Complement component C7 at these cysteines. However, the redox score of this cysteine pair is lower than any known redox-active disulphide.

Relevent regions

Factor I module (FIM) 2
begin
771
end
843
score
100.0
distance
2.7983186
seq distance
0
chain
A
Factor I module (FIM) 2
begin
771
end
843
score
100.0
distance
2.7983186
seq distance
0
chain
A
Factor I module (FIM) 1
begin
695
end
770
score
99.46172248803828
distance
5.129116
seq distance
12
chain
A
Factor I module (FIM) 1
begin
695
end
770
score
99.46172248803828
distance
5.129116
seq distance
12
chain
A
LDL-receptor class A
begin
795
end
795
score
70.45454545454545
distance
13.731085
seq distance
4
chain
A
LDL-receptor class A
begin
795
end
795
score
70.45454545454545
distance
13.731085
seq distance
4
chain
A
In C7D; dbSNP:rs113187203.
original residue
R
variation residue
H
position
712
score
50.0
distance
37.294395
seq distance
70
chain
A
In C7D; dbSNP:rs113187203.
original residue
R
variation residue
H
position
712
score
50.0
distance
37.294395
seq distance
70
chain
A

Details

Redox score
69.63
PDB code
2wcy
Structure name
nmr solution structure of factor i-like modules of complement c7.
Structure deposition date
2009-03-17
Thiol separation (Å)
9.57
Half-sphere exposure sum
55
Minimum pKa
nan
% buried
3.5
Peptide accession
P10643
Residue number A
782
Residue number B
791
Peptide name
Complement component C7
A redox-regulated disulphide may form within Complement component C7 at these cysteines. However, the redox score of this cysteine pair is lower than any known redox-active disulphide.

Relevent regions

Factor I module (FIM) 1
begin
695
end
770
score
99.46172248803828
distance
2.789243
seq distance
0
chain
A
Factor I module (FIM) 1
begin
695
end
770
score
99.46172248803828
distance
2.789243
seq distance
0
chain
A
Factor I module (FIM) 2
begin
771
end
843
score
100.0
distance
8.602017
seq distance
50
chain
A
Factor I module (FIM) 2
begin
771
end
843
score
100.0
distance
8.602017
seq distance
50
chain
A
In C7D; dbSNP:rs113187203.
original residue
R
variation residue
H
position
712
score
50.0
distance
10.76358
seq distance
3
chain
A
In C7D; dbSNP:rs113187203.
original residue
R
variation residue
H
position
712
score
50.0
distance
10.76358
seq distance
3
chain
A
LDL-receptor class A
begin
795
end
795
score
70.45454545454545
distance
21.0101
seq distance
74
chain
A
LDL-receptor class A
begin
795
end
795
score
70.45454545454545
distance
21.0101
seq distance
74
chain
A

Details

Redox score
69.26
PDB code
2wcy
Structure name
nmr solution structure of factor i-like modules of complement c7.
Structure deposition date
2009-03-17
Thiol separation (Å)
9.98
Half-sphere exposure sum
55
Minimum pKa
nan
% buried
9.5
Peptide accession
P10643
Residue number A
715
Residue number B
721
Peptide name
Complement component C7
A redox-regulated disulphide may form within Complement component C7 at these cysteines. However, the redox score of this cysteine pair is lower than any known redox-active disulphide.

Relevent regions

EGF-like
begin
457
end
487
score
100.0
distance
2.8052964
seq distance
0
chain
D
EGF-like
begin
457
end
487
score
100.0
distance
2.8052964
seq distance
0
chain
D
TSP type-1 1
begin
27
end
80
score
99.83164983164983
distance
7.4997187
seq distance
395
chain
D
TSP type-1 1
begin
27
end
80
score
99.83164983164983
distance
7.4997187
seq distance
395
chain
D
MACPF
begin
124
end
456
score
98.9079989079989
distance
10.343865
seq distance
19
chain
D
MACPF
begin
124
end
456
score
98.9079989079989
distance
10.343865
seq distance
19
chain
D
Disordered
begin
516
end
538
score
100.0
distance
12.500476
seq distance
39
chain
D
Disordered
begin
516
end
538
score
100.0
distance
12.500476
seq distance
39
chain
D
TSP type-1 2
begin
500
end
549
score
100.0
distance
12.500476
seq distance
23
chain
D
TSP type-1 2
begin
500
end
549
score
100.0
distance
12.500476
seq distance
23
chain
D
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
521
score
100.0
distance
21.375362
seq distance
44
chain
D
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
521
score
100.0
distance
21.375362
seq distance
44
chain
D
Confirmed at protein level; dbSNP:rs1063499.
original residue
S
variation residue
T
position
389
score
100.0
distance
21.948374
seq distance
86
chain
D
Confirmed at protein level; dbSNP:rs1063499.
original residue
S
variation residue
T
position
389
score
100.0
distance
21.948374
seq distance
86
chain
D
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
412
score
63.63636363636363
distance
23.95964
seq distance
False
chain
C
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
412
score
63.63636363636363
distance
23.95964
seq distance
False
chain
C
Disordered
begin
108
end
143
score
100.0
distance
27.53081
seq distance
332
chain
D
Disordered
begin
108
end
143
score
100.0
distance
27.53081
seq distance
332
chain
D
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
420
score
100.0
distance
27.953527
seq distance
55
chain
D
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
420
score
100.0
distance
27.953527
seq distance
55
chain
D
Disordered
begin
41
end
41
score
70.45454545454545
distance
28.24333
seq distance
False
chain
B
Disordered
begin
41
end
41
score
70.45454545454545
distance
28.24333
seq distance
False
chain
B
EGF-like
begin
451
end
455
score
54.090909090909086
distance
31.146608
seq distance
False
chain
C
EGF-like
begin
451
end
455
score
54.090909090909086
distance
31.146608
seq distance
False
chain
C
Disordered
begin
504
end
504
score
68.18181818181817
distance
35.82827
seq distance
False
chain
C
Disordered
begin
504
end
504
score
68.18181818181817
distance
35.82827
seq distance
False
chain
C
CCP 1
begin
545
end
615
score
83.48271446862996
distance
35.996113
seq distance
68
chain
D
CCP 1
begin
545
end
615
score
83.48271446862996
distance
35.996113
seq distance
68
chain
D
Disordered
begin
219
end
240
score
100.0
distance
40.770786
seq distance
235
chain
D
Disordered
begin
219
end
240
score
100.0
distance
40.770786
seq distance
235
chain
D
In dbSNP:rs75345202.
original residue
R
variation residue
H
position
414
score
54.54545454545454
distance
41.8351
seq distance
False
chain
F
In dbSNP:rs75345202.
original residue
R
variation residue
H
position
414
score
54.54545454545454
distance
41.8351
seq distance
False
chain
F
LDL-receptor class A
begin
83
end
121
score
100.0
distance
43.61735
seq distance
354
chain
D
LDL-receptor class A
begin
83
end
121
score
100.0
distance
43.61735
seq distance
354
chain
D
Disordered
begin
585
end
589
score
50.90909090909091
distance
49.152287
seq distance
False
chain
B
Disordered
begin
585
end
589
score
50.90909090909091
distance
49.152287
seq distance
False
chain
B
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
587
score
68.18181818181817
distance
51.042152
seq distance
False
chain
B
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
587
score
68.18181818181817
distance
51.042152
seq distance
False
chain
B
Disordered
begin
91
end
92
score
68.18181818181817
distance
51.865253
seq distance
False
chain
C
Disordered
begin
91
end
92
score
68.18181818181817
distance
51.865253
seq distance
False
chain
C
LDL-receptor class A
begin
84
end
92
score
56.56565656565656
distance
51.865253
seq distance
False
chain
C
LDL-receptor class A
begin
84
end
92
score
56.56565656565656
distance
51.865253
seq distance
False
chain
C
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
53.69706
seq distance
False
chain
X
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
53.69706
seq distance
False
chain
X
In dbSNP:rs2271708.
original residue
C
variation residue
R
position
128
score
100.0
distance
55.3486
seq distance
347
chain
D
In dbSNP:rs2271708.
original residue
C
variation residue
R
position
128
score
100.0
distance
55.3486
seq distance
347
chain
D
TSP type-1 2
begin
512
end
517
score
80.30303030303031
distance
55.371494
seq distance
False
chain
F
TSP type-1 2
begin
512
end
517
score
80.30303030303031
distance
55.371494
seq distance
False
chain
F
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
59.948494
seq distance
False
chain
X
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
59.948494
seq distance
False
chain
X
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
63.160133
seq distance
False
chain
G
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
63.160133
seq distance
False
chain
G
LDL-receptor class A
begin
83
end
98
score
52.69886363636363
distance
63.28307
seq distance
False
chain
F
LDL-receptor class A
begin
83
end
98
score
52.69886363636363
distance
63.28307
seq distance
False
chain
F
Sushi 1
begin
572
end
628
score
99.04306220095694
distance
64.44021
seq distance
95
chain
D
Sushi 1
begin
572
end
628
score
99.04306220095694
distance
64.44021
seq distance
95
chain
D
Disordered
begin
138
end
138
score
50.0
distance
65.61279
seq distance
False
chain
E
Disordered
begin
138
end
138
score
50.0
distance
65.61279
seq distance
False
chain
E
CCP 2
begin
616
end
691
score
99.2822966507177
distance
66.38348
seq distance
139
chain
D
CCP 2
begin
616
end
691
score
99.2822966507177
distance
66.38348
seq distance
139
chain
D
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
68.75401
seq distance
False
chain
X
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
68.75401
seq distance
False
chain
X
Confirmed at protein level; dbSNP:rs13157656.
original residue
T
variation residue
P
position
587
score
100.0
distance
71.84133
seq distance
110
chain
D
Confirmed at protein level; dbSNP:rs13157656.
original residue
T
variation residue
P
position
587
score
100.0
distance
71.84133
seq distance
110
chain
D
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
31
score
50.0
distance
73.68488
seq distance
False
chain
F
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
31
score
50.0
distance
73.68488
seq distance
False
chain
F
In C7D; dbSNP:rs369349760.
original residue
R
variation residue
Q
position
220
score
100.0
distance
79.783936
seq distance
255
chain
D
In C7D; dbSNP:rs369349760.
original residue
R
variation residue
Q
position
220
score
100.0
distance
79.783936
seq distance
255
chain
D
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
82.80142
seq distance
False
chain
W
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
82.80142
seq distance
False
chain
W
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
83.58747
seq distance
False
chain
P
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
83.58747
seq distance
False
chain
P
Confirmed at protein level; dbSNP:rs1063499.
original residue
S
variation residue
T
position
1058
score
54.54545454545454
distance
84.958115
seq distance
False
chain
A
Confirmed at protein level; dbSNP:rs1063499.
original residue
S
variation residue
T
position
1058
score
54.54545454545454
distance
84.958115
seq distance
False
chain
A
In dbSNP:rs75345202.
original residue
R
variation residue
H
position
222
score
100.0
distance
86.24367
seq distance
253
chain
D
In dbSNP:rs75345202.
original residue
R
variation residue
H
position
222
score
100.0
distance
86.24367
seq distance
253
chain
D
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
86.35721
seq distance
False
chain
X
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
86.35721
seq distance
False
chain
X
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
87.20008
seq distance
False
chain
W
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
87.20008
seq distance
False
chain
W
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
91.569824
seq distance
False
chain
G
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
91.569824
seq distance
False
chain
G
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
91.72352
seq distance
False
chain
W
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
91.72352
seq distance
False
chain
W
Sushi 2
begin
629
end
690
score
99.56011730205279
distance
96.823654
seq distance
152
chain
D
Sushi 2
begin
629
end
690
score
99.56011730205279
distance
96.823654
seq distance
152
chain
D
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
97.35039
seq distance
False
chain
G
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
97.35039
seq distance
False
chain
G
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
97.64695
seq distance
False
chain
W
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
97.64695
seq distance
False
chain
W
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
100.063194
seq distance
False
chain
G
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
100.063194
seq distance
False
chain
G
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
103.31336
seq distance
False
chain
H
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
103.31336
seq distance
False
chain
H
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
109.78786
seq distance
False
chain
V
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
109.78786
seq distance
False
chain
V
In C7D; dbSNP:rs541873000.
original residue
E
variation residue
Q
position
682
score
100.0
distance
110.416534
seq distance
205
chain
D
In C7D; dbSNP:rs541873000.
original residue
E
variation residue
Q
position
682
score
100.0
distance
110.416534
seq distance
205
chain
D
Confirmed at protein level; dbSNP:rs13157656.
original residue
T
variation residue
P
position
714
score
50.0
distance
111.02775
seq distance
False
chain
B
Confirmed at protein level; dbSNP:rs13157656.
original residue
T
variation residue
P
position
714
score
50.0
distance
111.02775
seq distance
False
chain
B
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
111.20231
seq distance
False
chain
V
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
111.20231
seq distance
False
chain
V
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
111.70723
seq distance
False
chain
P
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
111.70723
seq distance
False
chain
P
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
111.923
seq distance
False
chain
V
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
111.923
seq distance
False
chain
V
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
112.09296
seq distance
False
chain
P
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
112.09296
seq distance
False
chain
P
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
112.60417
seq distance
False
chain
V
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
112.60417
seq distance
False
chain
V
In C7D; dbSNP:rs113187203.
original residue
R
variation residue
H
position
687
score
100.0
distance
119.66516
seq distance
210
chain
D
In C7D; dbSNP:rs113187203.
original residue
R
variation residue
H
position
687
score
100.0
distance
119.66516
seq distance
210
chain
D
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
121.176605
seq distance
False
chain
P
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
121.176605
seq distance
False
chain
P
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
121.43378
seq distance
False
chain
I
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
121.43378
seq distance
False
chain
I
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
125.42426
seq distance
False
chain
U
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
125.42426
seq distance
False
chain
U
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
126.12049
seq distance
False
chain
H
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
126.12049
seq distance
False
chain
H
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
131.13248
seq distance
False
chain
U
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
131.13248
seq distance
False
chain
U
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
131.7514
seq distance
False
chain
H
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
131.7514
seq distance
False
chain
H
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
133.18715
seq distance
False
chain
U
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
133.18715
seq distance
False
chain
U
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
133.82254
seq distance
False
chain
U
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
133.82254
seq distance
False
chain
U
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
137.58165
seq distance
False
chain
J
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
137.58165
seq distance
False
chain
J
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
138.82419
seq distance
False
chain
T
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
138.82419
seq distance
False
chain
T
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
139.2198
seq distance
False
chain
I
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
139.2198
seq distance
False
chain
I
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
141.27895
seq distance
False
chain
H
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
141.27895
seq distance
False
chain
H
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
146.84807
seq distance
False
chain
T
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
146.84807
seq distance
False
chain
T
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
149.6571
seq distance
False
chain
I
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
149.6571
seq distance
False
chain
I
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
150.34532
seq distance
False
chain
J
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
150.34532
seq distance
False
chain
J
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
150.45384
seq distance
False
chain
S
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
150.45384
seq distance
False
chain
S
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
151.33919
seq distance
False
chain
K
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
151.33919
seq distance
False
chain
K
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
153.17403
seq distance
False
chain
T
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
153.17403
seq distance
False
chain
T
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
154.19537
seq distance
False
chain
T
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
154.19537
seq distance
False
chain
T
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
159.36841
seq distance
False
chain
S
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
159.36841
seq distance
False
chain
S
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
159.40439
seq distance
False
chain
I
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
159.40439
seq distance
False
chain
I
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
159.43373
seq distance
False
chain
K
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
159.43373
seq distance
False
chain
K
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
159.92537
seq distance
False
chain
R
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
159.92537
seq distance
False
chain
R
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
162.39558
seq distance
False
chain
L
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
162.39558
seq distance
False
chain
L
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
165.28935
seq distance
False
chain
J
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
165.28935
seq distance
False
chain
J
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
166.25464
seq distance
False
chain
L
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
166.25464
seq distance
False
chain
L
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
166.98953
seq distance
False
chain
Q
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
166.98953
seq distance
False
chain
Q
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
168.5648
seq distance
False
chain
R
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
168.5648
seq distance
False
chain
R
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
169.28444
seq distance
False
chain
S
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
169.28444
seq distance
False
chain
S
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
170.42484
seq distance
False
chain
M
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
170.42484
seq distance
False
chain
M
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
170.46696
seq distance
False
chain
M
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
170.46696
seq distance
False
chain
M
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
170.74219
seq distance
False
chain
O
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
170.74219
seq distance
False
chain
O
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
171.94655
seq distance
False
chain
S
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
171.94655
seq distance
False
chain
S
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
172.36806
seq distance
False
chain
N
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
172.36806
seq distance
False
chain
N
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
174.35258
seq distance
False
chain
Q
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
174.35258
seq distance
False
chain
Q
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
175.10475
seq distance
False
chain
J
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
175.10475
seq distance
False
chain
J
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
175.19305
seq distance
False
chain
N
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
175.19305
seq distance
False
chain
N
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
176.56384
seq distance
False
chain
O
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
176.56384
seq distance
False
chain
O
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
178.19275
seq distance
False
chain
K
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
178.19275
seq distance
False
chain
K
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
181.91072
seq distance
False
chain
R
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
181.91072
seq distance
False
chain
R
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
186.11409
seq distance
False
chain
R
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
186.11409
seq distance
False
chain
R
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
187.8937
seq distance
False
chain
K
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
187.8937
seq distance
False
chain
K
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
188.00471
seq distance
False
chain
L
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
188.00471
seq distance
False
chain
L
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
190.83475
seq distance
False
chain
Q
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
190.83475
seq distance
False
chain
Q
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
194.33286
seq distance
False
chain
M
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
194.33286
seq distance
False
chain
M
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
195.90302
seq distance
False
chain
O
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
195.90302
seq distance
False
chain
O
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
196.52698
seq distance
False
chain
Q
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
196.52698
seq distance
False
chain
Q
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
196.9929
seq distance
False
chain
N
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
196.9929
seq distance
False
chain
N
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
197.4156
seq distance
False
chain
L
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
197.4156
seq distance
False
chain
L
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
202.94403
seq distance
False
chain
O
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
202.94403
seq distance
False
chain
O
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
203.31796
seq distance
False
chain
M
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
203.31796
seq distance
False
chain
M
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
205.20012
seq distance
False
chain
N
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
205.20012
seq distance
False
chain
N

Details

Redox score
68.83
PDB code
6h04
Structure name
closed conformation of the membrane attack complex
Structure deposition date
2018-07-06
Thiol separation (Å)
6.92
Half-sphere exposure sum
56
Minimum pKa
nan
% buried
nan
Peptide accession
P10643
Residue number A
475
Residue number B
477
Peptide name
Complement component C7
A redox-regulated disulphide may form within Complement component C7 at these cysteines. However, the redox score of this cysteine pair is lower than any known redox-active disulphide.

Relevent regions

Factor I module (FIM) 2
begin
771
end
843
score
100.0
distance
2.8335195
seq distance
0
chain
A
Factor I module (FIM) 2
begin
771
end
843
score
100.0
distance
2.8335195
seq distance
0
chain
A
Factor I module (FIM) 1
begin
695
end
770
score
99.46172248803828
distance
4.2923
seq distance
27
chain
A
Factor I module (FIM) 1
begin
695
end
770
score
99.46172248803828
distance
4.2923
seq distance
27
chain
A
LDL-receptor class A
begin
795
end
795
score
70.45454545454545
distance
7.4242826
seq distance
2
chain
A
LDL-receptor class A
begin
795
end
795
score
70.45454545454545
distance
7.4242826
seq distance
2
chain
A
In C7D; dbSNP:rs113187203.
original residue
R
variation residue
H
position
712
score
50.0
distance
24.678598
seq distance
85
chain
A
In C7D; dbSNP:rs113187203.
original residue
R
variation residue
H
position
712
score
50.0
distance
24.678598
seq distance
85
chain
A

Details

Redox score
68.75
PDB code
2wcy
Structure name
nmr solution structure of factor i-like modules of complement c7.
Structure deposition date
2009-03-17
Thiol separation (Å)
9.65
Half-sphere exposure sum
59
Minimum pKa
nan
% buried
15
Peptide accession
P10643
Residue number A
797
Residue number B
825
Peptide name
Complement component C7
A redox-regulated disulphide may form within Complement component C7 at these cysteines. However, the redox score of this cysteine pair is lower than any known redox-active disulphide.

Relevent regions

Factor I module (FIM) 1
begin
695
end
770
score
99.46172248803828
distance
2.790966
seq distance
0
chain
A
Factor I module (FIM) 1
begin
695
end
770
score
99.46172248803828
distance
2.790966
seq distance
0
chain
A
Factor I module (FIM) 2
begin
771
end
843
score
100.0
distance
8.107202
seq distance
28
chain
A
Factor I module (FIM) 2
begin
771
end
843
score
100.0
distance
8.107202
seq distance
28
chain
A
In C7D; dbSNP:rs113187203.
original residue
R
variation residue
H
position
712
score
50.0
distance
10.76358
seq distance
3
chain
A
In C7D; dbSNP:rs113187203.
original residue
R
variation residue
H
position
712
score
50.0
distance
10.76358
seq distance
3
chain
A
LDL-receptor class A
begin
795
end
795
score
70.45454545454545
distance
21.449831
seq distance
52
chain
A
LDL-receptor class A
begin
795
end
795
score
70.45454545454545
distance
21.449831
seq distance
52
chain
A

Details

Redox score
68.34
PDB code
2wcy
Structure name
nmr solution structure of factor i-like modules of complement c7.
Structure deposition date
2009-03-17
Thiol separation (Å)
9.59
Half-sphere exposure sum
63
Minimum pKa
nan
% buried
14
Peptide accession
P10643
Residue number A
715
Residue number B
743
Peptide name
Complement component C7
A redox-regulated disulphide may form within Complement component C7 at these cysteines. However, the redox score of this cysteine pair is lower than any known redox-active disulphide.

Relevent regions

EGF-like
begin
435
end
465
score
100.0
distance
2.7865968
seq distance
0
chain
C
EGF-like
begin
435
end
465
score
100.0
distance
2.7865968
seq distance
0
chain
C
MACPF
begin
102
end
434
score
94.85394485394487
distance
4.419828
seq distance
1
chain
C
MACPF
begin
102
end
434
score
94.85394485394487
distance
4.419828
seq distance
1
chain
C
TSP type-1 1
begin
5
end
58
score
99.83164983164983
distance
6.9549074
seq distance
377
chain
C
TSP type-1 1
begin
5
end
58
score
99.83164983164983
distance
6.9549074
seq distance
377
chain
C
TSP type-1 2
begin
478
end
527
score
100.0
distance
9.81254
seq distance
25
chain
C
TSP type-1 2
begin
478
end
527
score
100.0
distance
9.81254
seq distance
25
chain
C
Disordered
begin
494
end
516
score
100.0
distance
11.901647
seq distance
41
chain
C
Disordered
begin
494
end
516
score
100.0
distance
11.901647
seq distance
41
chain
C
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
499
score
100.0
distance
15.656078
seq distance
46
chain
C
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
499
score
100.0
distance
15.656078
seq distance
46
chain
C
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
412
score
63.63636363636363
distance
21.68009
seq distance
False
chain
D
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
412
score
63.63636363636363
distance
21.68009
seq distance
False
chain
D
Disordered
begin
86
end
121
score
100.0
distance
22.719585
seq distance
314
chain
C
Disordered
begin
86
end
121
score
100.0
distance
22.719585
seq distance
314
chain
C
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
398
score
100.0
distance
24.870333
seq distance
37
chain
C
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
398
score
100.0
distance
24.870333
seq distance
37
chain
C
Disordered
begin
510
end
522
score
53.67132867132868
distance
25.59978
seq distance
False
chain
D
Disordered
begin
510
end
522
score
53.67132867132868
distance
25.59978
seq distance
False
chain
D
Confirmed at protein level; dbSNP:rs1063499.
original residue
S
variation residue
T
position
367
score
100.0
distance
27.711212
seq distance
68
chain
C
Confirmed at protein level; dbSNP:rs1063499.
original residue
S
variation residue
T
position
367
score
100.0
distance
27.711212
seq distance
68
chain
C
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
512
score
81.81818181818183
distance
28.200748
seq distance
False
chain
D
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
512
score
81.81818181818183
distance
28.200748
seq distance
False
chain
D
CCP 1
begin
523
end
593
score
100.0
distance
28.226913
seq distance
70
chain
C
CCP 1
begin
523
end
593
score
100.0
distance
28.226913
seq distance
70
chain
C
In C7D; dbSNP:rs121964921.
original residue
G
variation residue
R
position
357
score
100.0
distance
28.33525
seq distance
78
chain
C
In C7D; dbSNP:rs121964921.
original residue
G
variation residue
R
position
357
score
100.0
distance
28.33525
seq distance
78
chain
C
In C7D; dbSNP:rs369349760.
original residue
R
variation residue
Q
position
25
score
54.54545454545454
distance
29.757685
seq distance
False
chain
B
In C7D; dbSNP:rs369349760.
original residue
R
variation residue
Q
position
25
score
54.54545454545454
distance
29.757685
seq distance
False
chain
B
Disordered
begin
504
end
504
score
68.18181818181817
distance
30.706549
seq distance
False
chain
D
Disordered
begin
504
end
504
score
68.18181818181817
distance
30.706549
seq distance
False
chain
D
EGF-like
begin
451
end
455
score
54.090909090909086
distance
33.267887
seq distance
False
chain
D
EGF-like
begin
451
end
455
score
54.090909090909086
distance
33.267887
seq distance
False
chain
D
LDL-receptor class A
begin
61
end
99
score
100.0
distance
38.549587
seq distance
336
chain
C
LDL-receptor class A
begin
61
end
99
score
100.0
distance
38.549587
seq distance
336
chain
C
Disordered
begin
564
end
573
score
62.272727272727266
distance
39.449135
seq distance
False
chain
B
Disordered
begin
564
end
573
score
62.272727272727266
distance
39.449135
seq distance
False
chain
B
In dbSNP:rs75345202.
original residue
R
variation residue
H
position
414
score
54.54545454545454
distance
44.19972
seq distance
False
chain
E
In dbSNP:rs75345202.
original residue
R
variation residue
H
position
414
score
54.54545454545454
distance
44.19972
seq distance
False
chain
E
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
566
score
86.36363636363636
distance
46.435677
seq distance
False
chain
B
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
566
score
86.36363636363636
distance
46.435677
seq distance
False
chain
B
Disordered
begin
197
end
218
score
76.85950413223141
distance
46.498783
seq distance
217
chain
C
Disordered
begin
197
end
218
score
76.85950413223141
distance
46.498783
seq distance
217
chain
C
Disordered
begin
91
end
92
score
68.18181818181817
distance
48.389465
seq distance
False
chain
D
Disordered
begin
91
end
92
score
68.18181818181817
distance
48.389465
seq distance
False
chain
D
LDL-receptor class A
begin
84
end
92
score
56.56565656565656
distance
48.389465
seq distance
False
chain
D
LDL-receptor class A
begin
84
end
92
score
56.56565656565656
distance
48.389465
seq distance
False
chain
D
In dbSNP:rs2271708.
original residue
C
variation residue
R
position
106
score
100.0
distance
50.89676
seq distance
329
chain
C
In dbSNP:rs2271708.
original residue
C
variation residue
R
position
106
score
100.0
distance
50.89676
seq distance
329
chain
C
Sushi 1
begin
547
end
606
score
100.0
distance
52.27577
seq distance
94
chain
C
Sushi 1
begin
547
end
606
score
100.0
distance
52.27577
seq distance
94
chain
C
In dbSNP:rs2271708.
original residue
C
variation residue
R
position
532
score
54.54545454545454
distance
56.235794
seq distance
False
chain
E
In dbSNP:rs2271708.
original residue
C
variation residue
R
position
532
score
54.54545454545454
distance
56.235794
seq distance
False
chain
E
CCP 2
begin
594
end
671
score
100.0
distance
57.477924
seq distance
141
chain
C
CCP 2
begin
594
end
671
score
100.0
distance
57.477924
seq distance
141
chain
C
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
530
score
54.54545454545454
distance
58.717113
seq distance
False
chain
E
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
530
score
54.54545454545454
distance
58.717113
seq distance
False
chain
E
MACPF
begin
324
end
332
score
83.08080808080808
distance
61.845478
seq distance
False
chain
G
MACPF
begin
324
end
332
score
83.08080808080808
distance
61.845478
seq distance
False
chain
G
LDL-receptor class A
begin
83
end
95
score
50.87412587412587
distance
62.0706
seq distance
False
chain
E
LDL-receptor class A
begin
83
end
95
score
50.87412587412587
distance
62.0706
seq distance
False
chain
E
Confirmed at protein level; dbSNP:rs13157656.
original residue
T
variation residue
P
position
565
score
100.0
distance
62.07445
seq distance
112
chain
C
Confirmed at protein level; dbSNP:rs13157656.
original residue
T
variation residue
P
position
565
score
100.0
distance
62.07445
seq distance
112
chain
C
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
66.73213
seq distance
False
chain
G
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
66.73213
seq distance
False
chain
G
Disordered
begin
138
end
138
score
50.0
distance
69.081314
seq distance
False
chain
F
Disordered
begin
138
end
138
score
50.0
distance
69.081314
seq distance
False
chain
F
Confirmed at protein level; dbSNP:rs1063499.
original residue
S
variation residue
T
position
1040
score
54.54545454545454
distance
77.478745
seq distance
False
chain
A
Confirmed at protein level; dbSNP:rs1063499.
original residue
S
variation residue
T
position
1040
score
54.54545454545454
distance
77.478745
seq distance
False
chain
A
MACPF
begin
324
end
332
score
83.08080808080808
distance
80.95107
seq distance
False
chain
H
MACPF
begin
324
end
332
score
83.08080808080808
distance
80.95107
seq distance
False
chain
H
In C7D; dbSNP:rs369349760.
original residue
R
variation residue
Q
position
198
score
72.72727272727273
distance
86.384026
seq distance
237
chain
C
In C7D; dbSNP:rs369349760.
original residue
R
variation residue
Q
position
198
score
72.72727272727273
distance
86.384026
seq distance
237
chain
C
Sushi 2
begin
607
end
668
score
100.0
distance
87.77458
seq distance
154
chain
C
Sushi 2
begin
607
end
668
score
100.0
distance
87.77458
seq distance
154
chain
C
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
87.9256
seq distance
False
chain
H
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
87.9256
seq distance
False
chain
H
In dbSNP:rs75345202.
original residue
R
variation residue
H
position
200
score
72.72727272727273
distance
92.76738
seq distance
235
chain
C
In dbSNP:rs75345202.
original residue
R
variation residue
H
position
200
score
72.72727272727273
distance
92.76738
seq distance
235
chain
C
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
94.67331
seq distance
False
chain
G
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
94.67331
seq distance
False
chain
G
MACPF
begin
324
end
333
score
84.54545454545456
distance
98.779335
seq distance
False
chain
I
MACPF
begin
324
end
333
score
84.54545454545456
distance
98.779335
seq distance
False
chain
I
In C7D; dbSNP:rs541873000.
original residue
E
variation residue
Q
position
660
score
100.0
distance
100.07353
seq distance
207
chain
C
In C7D; dbSNP:rs541873000.
original residue
E
variation residue
Q
position
660
score
100.0
distance
100.07353
seq distance
207
chain
C
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
102.68166
seq distance
False
chain
G
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
102.68166
seq distance
False
chain
G
Disordered
begin
327
end
328
score
61.36363636363637
distance
105.52416
seq distance
False
chain
I
Disordered
begin
327
end
328
score
61.36363636363637
distance
105.52416
seq distance
False
chain
I
Confirmed at protein level; dbSNP:rs13157656.
original residue
T
variation residue
P
position
693
score
50.0
distance
106.06868
seq distance
False
chain
B
Confirmed at protein level; dbSNP:rs13157656.
original residue
T
variation residue
P
position
693
score
50.0
distance
106.06868
seq distance
False
chain
B
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
107.663895
seq distance
False
chain
I
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
107.663895
seq distance
False
chain
I
In C7D; dbSNP:rs113187203.
original residue
R
variation residue
H
position
665
score
100.0
distance
111.8388
seq distance
212
chain
C
In C7D; dbSNP:rs113187203.
original residue
R
variation residue
H
position
665
score
100.0
distance
111.8388
seq distance
212
chain
C
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
116.07677
seq distance
False
chain
H
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
116.07677
seq distance
False
chain
H
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
124.80659
seq distance
False
chain
H
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
124.80659
seq distance
False
chain
H
Factor I module (FIM) 1
begin
673
end
748
score
100.0
distance
133.60039
seq distance
220
chain
C
Factor I module (FIM) 1
begin
673
end
748
score
100.0
distance
133.60039
seq distance
220
chain
C
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
135.69887
seq distance
False
chain
I
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
135.69887
seq distance
False
chain
I
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
1560
score
50.0
distance
146.21225
seq distance
False
chain
A
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
1560
score
50.0
distance
146.21225
seq distance
False
chain
A
Factor I module (FIM) 2
begin
749
end
821
score
100.0
distance
159.04236
seq distance
296
chain
C
Factor I module (FIM) 2
begin
749
end
821
score
100.0
distance
159.04236
seq distance
296
chain
C

Details

Redox score
68.32
PDB code
7nyc
Structure name
cryoem structure of 3c9-smac
Structure deposition date
2021-03-22
Thiol separation (Å)
7.11
Half-sphere exposure sum
71
Minimum pKa
nan
% buried
nan
Peptide accession
P10643
Residue number A
457 (Residue 435 in this structure)
Residue number B
475 (Residue 453 in this structure)
Peptide name
Complement component C7
A redox-regulated disulphide may form within Complement component C7 at these cysteines. However, the redox score of this cysteine pair is lower than any known redox-active disulphide.

Relevent regions

EGF-like
begin
435
end
465
score
100.0
distance
2.8475137
seq distance
0
chain
C
EGF-like
begin
435
end
465
score
100.0
distance
2.8475137
seq distance
0
chain
C
MACPF
begin
102
end
434
score
94.85394485394487
distance
4.419828
seq distance
1
chain
C
MACPF
begin
102
end
434
score
94.85394485394487
distance
4.419828
seq distance
1
chain
C
TSP type-1 1
begin
5
end
58
score
99.83164983164983
distance
6.9549074
seq distance
377
chain
C
TSP type-1 1
begin
5
end
58
score
99.83164983164983
distance
6.9549074
seq distance
377
chain
C
TSP type-1 2
begin
478
end
527
score
100.0
distance
9.81254
seq distance
40
chain
C
TSP type-1 2
begin
478
end
527
score
100.0
distance
9.81254
seq distance
40
chain
C
Disordered
begin
494
end
516
score
100.0
distance
11.901647
seq distance
56
chain
C
Disordered
begin
494
end
516
score
100.0
distance
11.901647
seq distance
56
chain
C
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
499
score
100.0
distance
15.656078
seq distance
61
chain
C
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
499
score
100.0
distance
15.656078
seq distance
61
chain
C
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
412
score
63.63636363636363
distance
21.68009
seq distance
False
chain
D
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
412
score
63.63636363636363
distance
21.68009
seq distance
False
chain
D
Disordered
begin
86
end
121
score
100.0
distance
22.719585
seq distance
314
chain
C
Disordered
begin
86
end
121
score
100.0
distance
22.719585
seq distance
314
chain
C
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
398
score
100.0
distance
24.870333
seq distance
37
chain
C
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
398
score
100.0
distance
24.870333
seq distance
37
chain
C
Disordered
begin
510
end
522
score
53.67132867132868
distance
27.145147
seq distance
False
chain
D
Disordered
begin
510
end
522
score
53.67132867132868
distance
27.145147
seq distance
False
chain
D
Confirmed at protein level; dbSNP:rs1063499.
original residue
S
variation residue
T
position
367
score
100.0
distance
27.91972
seq distance
68
chain
C
Confirmed at protein level; dbSNP:rs1063499.
original residue
S
variation residue
T
position
367
score
100.0
distance
27.91972
seq distance
68
chain
C
In C7D; dbSNP:rs121964921.
original residue
G
variation residue
R
position
357
score
100.0
distance
28.197184
seq distance
78
chain
C
In C7D; dbSNP:rs121964921.
original residue
G
variation residue
R
position
357
score
100.0
distance
28.197184
seq distance
78
chain
C
CCP 1
begin
523
end
593
score
100.0
distance
28.226913
seq distance
85
chain
C
CCP 1
begin
523
end
593
score
100.0
distance
28.226913
seq distance
85
chain
C
In C7D; dbSNP:rs369349760.
original residue
R
variation residue
Q
position
25
score
54.54545454545454
distance
28.586592
seq distance
False
chain
B
In C7D; dbSNP:rs369349760.
original residue
R
variation residue
Q
position
25
score
54.54545454545454
distance
28.586592
seq distance
False
chain
B
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
512
score
81.81818181818183
distance
29.738043
seq distance
False
chain
D
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
512
score
81.81818181818183
distance
29.738043
seq distance
False
chain
D
Disordered
begin
504
end
504
score
68.18181818181817
distance
30.706549
seq distance
False
chain
D
Disordered
begin
504
end
504
score
68.18181818181817
distance
30.706549
seq distance
False
chain
D
EGF-like
begin
451
end
455
score
54.090909090909086
distance
35.28667
seq distance
False
chain
D
EGF-like
begin
451
end
455
score
54.090909090909086
distance
35.28667
seq distance
False
chain
D
Disordered
begin
564
end
573
score
62.272727272727266
distance
37.465393
seq distance
False
chain
B
Disordered
begin
564
end
573
score
62.272727272727266
distance
37.465393
seq distance
False
chain
B
LDL-receptor class A
begin
61
end
99
score
100.0
distance
38.549587
seq distance
336
chain
C
LDL-receptor class A
begin
61
end
99
score
100.0
distance
38.549587
seq distance
336
chain
C
In dbSNP:rs75345202.
original residue
R
variation residue
H
position
414
score
54.54545454545454
distance
45.165287
seq distance
False
chain
E
In dbSNP:rs75345202.
original residue
R
variation residue
H
position
414
score
54.54545454545454
distance
45.165287
seq distance
False
chain
E
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
566
score
86.36363636363636
distance
45.70498
seq distance
False
chain
B
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
566
score
86.36363636363636
distance
45.70498
seq distance
False
chain
B
Disordered
begin
197
end
218
score
76.85950413223141
distance
46.596878
seq distance
217
chain
C
Disordered
begin
197
end
218
score
76.85950413223141
distance
46.596878
seq distance
217
chain
C
Disordered
begin
91
end
92
score
68.18181818181817
distance
48.389465
seq distance
False
chain
D
Disordered
begin
91
end
92
score
68.18181818181817
distance
48.389465
seq distance
False
chain
D
LDL-receptor class A
begin
84
end
92
score
56.56565656565656
distance
48.389465
seq distance
False
chain
D
LDL-receptor class A
begin
84
end
92
score
56.56565656565656
distance
48.389465
seq distance
False
chain
D
In dbSNP:rs2271708.
original residue
C
variation residue
R
position
106
score
100.0
distance
50.89676
seq distance
329
chain
C
In dbSNP:rs2271708.
original residue
C
variation residue
R
position
106
score
100.0
distance
50.89676
seq distance
329
chain
C
Sushi 1
begin
547
end
606
score
100.0
distance
52.27577
seq distance
109
chain
C
Sushi 1
begin
547
end
606
score
100.0
distance
52.27577
seq distance
109
chain
C
CCP 2
begin
594
end
671
score
100.0
distance
57.477924
seq distance
156
chain
C
CCP 2
begin
594
end
671
score
100.0
distance
57.477924
seq distance
156
chain
C
In dbSNP:rs2271708.
original residue
C
variation residue
R
position
532
score
54.54545454545454
distance
58.197758
seq distance
False
chain
E
In dbSNP:rs2271708.
original residue
C
variation residue
R
position
532
score
54.54545454545454
distance
58.197758
seq distance
False
chain
E
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
530
score
54.54545454545454
distance
60.71216
seq distance
False
chain
E
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
530
score
54.54545454545454
distance
60.71216
seq distance
False
chain
E
LDL-receptor class A
begin
83
end
95
score
50.87412587412587
distance
62.0706
seq distance
False
chain
E
LDL-receptor class A
begin
83
end
95
score
50.87412587412587
distance
62.0706
seq distance
False
chain
E
Confirmed at protein level; dbSNP:rs13157656.
original residue
T
variation residue
P
position
565
score
100.0
distance
62.07445
seq distance
127
chain
C
Confirmed at protein level; dbSNP:rs13157656.
original residue
T
variation residue
P
position
565
score
100.0
distance
62.07445
seq distance
127
chain
C
MACPF
begin
324
end
332
score
83.08080808080808
distance
63.22599
seq distance
False
chain
G
MACPF
begin
324
end
332
score
83.08080808080808
distance
63.22599
seq distance
False
chain
G
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
68.39042
seq distance
False
chain
G
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
68.39042
seq distance
False
chain
G
Disordered
begin
138
end
138
score
50.0
distance
68.77994
seq distance
False
chain
F
Disordered
begin
138
end
138
score
50.0
distance
68.77994
seq distance
False
chain
F
Confirmed at protein level; dbSNP:rs1063499.
original residue
S
variation residue
T
position
1040
score
54.54545454545454
distance
77.478745
seq distance
False
chain
A
Confirmed at protein level; dbSNP:rs1063499.
original residue
S
variation residue
T
position
1040
score
54.54545454545454
distance
77.478745
seq distance
False
chain
A
MACPF
begin
324
end
332
score
83.08080808080808
distance
82.19877
seq distance
False
chain
H
MACPF
begin
324
end
332
score
83.08080808080808
distance
82.19877
seq distance
False
chain
H
In C7D; dbSNP:rs369349760.
original residue
R
variation residue
Q
position
198
score
72.72727272727273
distance
86.61567
seq distance
237
chain
C
In C7D; dbSNP:rs369349760.
original residue
R
variation residue
Q
position
198
score
72.72727272727273
distance
86.61567
seq distance
237
chain
C
Sushi 2
begin
607
end
668
score
100.0
distance
87.77458
seq distance
169
chain
C
Sushi 2
begin
607
end
668
score
100.0
distance
87.77458
seq distance
169
chain
C
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
89.42111
seq distance
False
chain
H
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
89.42111
seq distance
False
chain
H
In dbSNP:rs75345202.
original residue
R
variation residue
H
position
200
score
72.72727272727273
distance
93.033485
seq distance
235
chain
C
In dbSNP:rs75345202.
original residue
R
variation residue
H
position
200
score
72.72727272727273
distance
93.033485
seq distance
235
chain
C
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
96.3136
seq distance
False
chain
G
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
96.3136
seq distance
False
chain
G
MACPF
begin
324
end
333
score
84.54545454545456
distance
99.864075
seq distance
False
chain
I
MACPF
begin
324
end
333
score
84.54545454545456
distance
99.864075
seq distance
False
chain
I
In C7D; dbSNP:rs541873000.
original residue
E
variation residue
Q
position
660
score
100.0
distance
100.07353
seq distance
222
chain
C
In C7D; dbSNP:rs541873000.
original residue
E
variation residue
Q
position
660
score
100.0
distance
100.07353
seq distance
222
chain
C
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
104.383736
seq distance
False
chain
G
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
104.383736
seq distance
False
chain
G
Confirmed at protein level; dbSNP:rs13157656.
original residue
T
variation residue
P
position
693
score
50.0
distance
106.06868
seq distance
False
chain
B
Confirmed at protein level; dbSNP:rs13157656.
original residue
T
variation residue
P
position
693
score
50.0
distance
106.06868
seq distance
False
chain
B
Disordered
begin
327
end
328
score
61.36363636363637
distance
106.77992
seq distance
False
chain
I
Disordered
begin
327
end
328
score
61.36363636363637
distance
106.77992
seq distance
False
chain
I
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
108.9472
seq distance
False
chain
I
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
108.9472
seq distance
False
chain
I
In C7D; dbSNP:rs113187203.
original residue
R
variation residue
H
position
665
score
100.0
distance
111.8388
seq distance
227
chain
C
In C7D; dbSNP:rs113187203.
original residue
R
variation residue
H
position
665
score
100.0
distance
111.8388
seq distance
227
chain
C
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
117.54856
seq distance
False
chain
H
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
117.54856
seq distance
False
chain
H
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
126.3035
seq distance
False
chain
H
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
126.3035
seq distance
False
chain
H
Factor I module (FIM) 1
begin
673
end
748
score
100.0
distance
133.60039
seq distance
235
chain
C
Factor I module (FIM) 1
begin
673
end
748
score
100.0
distance
133.60039
seq distance
235
chain
C
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
136.93285
seq distance
False
chain
I
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
136.93285
seq distance
False
chain
I
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
1560
score
50.0
distance
146.21225
seq distance
False
chain
A
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
1560
score
50.0
distance
146.21225
seq distance
False
chain
A
Factor I module (FIM) 2
begin
749
end
821
score
100.0
distance
159.04236
seq distance
311
chain
C
Factor I module (FIM) 2
begin
749
end
821
score
100.0
distance
159.04236
seq distance
311
chain
C

Details

Redox score
67.88
PDB code
7nyc
Structure name
cryoem structure of 3c9-smac
Structure deposition date
2021-03-22
Thiol separation (Å)
7.13
Half-sphere exposure sum
75
Minimum pKa
nan
% buried
nan
Peptide accession
P10643
Residue number A
457 (Residue 435 in this structure)
Residue number B
460 (Residue 438 in this structure)
Peptide name
Complement component C7
A redox-regulated disulphide may form within Complement component C7 at these cysteines. However, the redox score of this cysteine pair is lower than any known redox-active disulphide.

Relevent regions

EGF-like
begin
457
end
487
score
100.0
distance
2.8101344
seq distance
0
chain
D
EGF-like
begin
457
end
487
score
100.0
distance
2.8101344
seq distance
0
chain
D
TSP type-1 1
begin
27
end
80
score
99.83164983164983
distance
4.9242854
seq distance
393
chain
D
TSP type-1 1
begin
27
end
80
score
99.83164983164983
distance
4.9242854
seq distance
393
chain
D
MACPF
begin
124
end
456
score
98.9079989079989
distance
6.283733
seq distance
17
chain
D
MACPF
begin
124
end
456
score
98.9079989079989
distance
6.283733
seq distance
17
chain
D
Disordered
begin
516
end
538
score
100.0
distance
12.500476
seq distance
41
chain
D
Disordered
begin
516
end
538
score
100.0
distance
12.500476
seq distance
41
chain
D
TSP type-1 2
begin
500
end
549
score
100.0
distance
12.500476
seq distance
25
chain
D
TSP type-1 2
begin
500
end
549
score
100.0
distance
12.500476
seq distance
25
chain
D
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
521
score
100.0
distance
18.81662
seq distance
46
chain
D
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
521
score
100.0
distance
18.81662
seq distance
46
chain
D
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
412
score
63.63636363636363
distance
21.075468
seq distance
False
chain
C
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
412
score
63.63636363636363
distance
21.075468
seq distance
False
chain
C
Disordered
begin
108
end
143
score
100.0
distance
25.213755
seq distance
330
chain
D
Disordered
begin
108
end
143
score
100.0
distance
25.213755
seq distance
330
chain
D
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
420
score
100.0
distance
27.594952
seq distance
53
chain
D
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
420
score
100.0
distance
27.594952
seq distance
53
chain
D
Confirmed at protein level; dbSNP:rs1063499.
original residue
S
variation residue
T
position
389
score
100.0
distance
27.68171
seq distance
84
chain
D
Confirmed at protein level; dbSNP:rs1063499.
original residue
S
variation residue
T
position
389
score
100.0
distance
27.68171
seq distance
84
chain
D
Disordered
begin
41
end
41
score
70.45454545454545
distance
28.316162
seq distance
False
chain
B
Disordered
begin
41
end
41
score
70.45454545454545
distance
28.316162
seq distance
False
chain
B
Disordered
begin
504
end
504
score
68.18181818181817
distance
30.151415
seq distance
False
chain
C
Disordered
begin
504
end
504
score
68.18181818181817
distance
30.151415
seq distance
False
chain
C
CCP 1
begin
545
end
615
score
83.48271446862996
distance
31.036415
seq distance
70
chain
D
CCP 1
begin
545
end
615
score
83.48271446862996
distance
31.036415
seq distance
70
chain
D
EGF-like
begin
451
end
455
score
54.090909090909086
distance
32.852055
seq distance
False
chain
C
EGF-like
begin
451
end
455
score
54.090909090909086
distance
32.852055
seq distance
False
chain
C
LDL-receptor class A
begin
83
end
121
score
100.0
distance
40.49788
seq distance
352
chain
D
LDL-receptor class A
begin
83
end
121
score
100.0
distance
40.49788
seq distance
352
chain
D
Disordered
begin
219
end
240
score
100.0
distance
46.091713
seq distance
233
chain
D
Disordered
begin
219
end
240
score
100.0
distance
46.091713
seq distance
233
chain
D
In dbSNP:rs75345202.
original residue
R
variation residue
H
position
414
score
54.54545454545454
distance
46.90885
seq distance
False
chain
F
In dbSNP:rs75345202.
original residue
R
variation residue
H
position
414
score
54.54545454545454
distance
46.90885
seq distance
False
chain
F
Disordered
begin
91
end
92
score
68.18181818181817
distance
48.76474
seq distance
False
chain
C
Disordered
begin
91
end
92
score
68.18181818181817
distance
48.76474
seq distance
False
chain
C
LDL-receptor class A
begin
84
end
92
score
56.56565656565656
distance
48.76474
seq distance
False
chain
C
LDL-receptor class A
begin
84
end
92
score
56.56565656565656
distance
48.76474
seq distance
False
chain
C
Disordered
begin
585
end
589
score
50.90909090909091
distance
49.152287
seq distance
False
chain
B
Disordered
begin
585
end
589
score
50.90909090909091
distance
49.152287
seq distance
False
chain
B
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
587
score
68.18181818181817
distance
51.042152
seq distance
False
chain
B
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
587
score
68.18181818181817
distance
51.042152
seq distance
False
chain
B
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
53.69706
seq distance
False
chain
X
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
53.69706
seq distance
False
chain
X
In dbSNP:rs2271708.
original residue
C
variation residue
R
position
128
score
100.0
distance
55.598724
seq distance
345
chain
D
In dbSNP:rs2271708.
original residue
C
variation residue
R
position
128
score
100.0
distance
55.598724
seq distance
345
chain
D
TSP type-1 2
begin
512
end
517
score
80.30303030303031
distance
57.900505
seq distance
False
chain
F
TSP type-1 2
begin
512
end
517
score
80.30303030303031
distance
57.900505
seq distance
False
chain
F
Sushi 1
begin
572
end
628
score
99.04306220095694
distance
58.216953
seq distance
97
chain
D
Sushi 1
begin
572
end
628
score
99.04306220095694
distance
58.216953
seq distance
97
chain
D
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
59.948494
seq distance
False
chain
X
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
59.948494
seq distance
False
chain
X
CCP 2
begin
616
end
691
score
99.2822966507177
distance
60.219807
seq distance
141
chain
D
CCP 2
begin
616
end
691
score
99.2822966507177
distance
60.219807
seq distance
141
chain
D
LDL-receptor class A
begin
83
end
98
score
52.69886363636363
distance
60.72509
seq distance
False
chain
F
LDL-receptor class A
begin
83
end
98
score
52.69886363636363
distance
60.72509
seq distance
False
chain
F
Confirmed at protein level; dbSNP:rs13157656.
original residue
T
variation residue
P
position
587
score
100.0
distance
64.963295
seq distance
112
chain
D
Confirmed at protein level; dbSNP:rs13157656.
original residue
T
variation residue
P
position
587
score
100.0
distance
64.963295
seq distance
112
chain
D
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
66.396835
seq distance
False
chain
G
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
66.396835
seq distance
False
chain
G
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
69.70275
seq distance
False
chain
X
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
69.70275
seq distance
False
chain
X
Disordered
begin
138
end
138
score
50.0
distance
70.35145
seq distance
False
chain
E
Disordered
begin
138
end
138
score
50.0
distance
70.35145
seq distance
False
chain
E
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
31
score
50.0
distance
74.43596
seq distance
False
chain
F
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
31
score
50.0
distance
74.43596
seq distance
False
chain
F
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
82.80142
seq distance
False
chain
W
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
82.80142
seq distance
False
chain
W
Confirmed at protein level; dbSNP:rs1063499.
original residue
S
variation residue
T
position
1058
score
54.54545454545454
distance
83.524956
seq distance
False
chain
A
Confirmed at protein level; dbSNP:rs1063499.
original residue
S
variation residue
T
position
1058
score
54.54545454545454
distance
83.524956
seq distance
False
chain
A
In C7D; dbSNP:rs369349760.
original residue
R
variation residue
Q
position
220
score
100.0
distance
83.83289
seq distance
253
chain
D
In C7D; dbSNP:rs369349760.
original residue
R
variation residue
Q
position
220
score
100.0
distance
83.83289
seq distance
253
chain
D
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
87.20008
seq distance
False
chain
W
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
87.20008
seq distance
False
chain
W
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
87.85294
seq distance
False
chain
P
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
87.85294
seq distance
False
chain
P
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
89.81318
seq distance
False
chain
X
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
89.81318
seq distance
False
chain
X
In dbSNP:rs75345202.
original residue
R
variation residue
H
position
222
score
100.0
distance
90.17525
seq distance
251
chain
D
In dbSNP:rs75345202.
original residue
R
variation residue
H
position
222
score
100.0
distance
90.17525
seq distance
251
chain
D
Sushi 2
begin
629
end
690
score
99.56011730205279
distance
90.64483
seq distance
154
chain
D
Sushi 2
begin
629
end
690
score
99.56011730205279
distance
90.64483
seq distance
154
chain
D
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
93.39317
seq distance
False
chain
W
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
93.39317
seq distance
False
chain
W
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
93.713486
seq distance
False
chain
G
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
93.713486
seq distance
False
chain
G
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
100.94385
seq distance
False
chain
W
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
100.94385
seq distance
False
chain
W
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
102.5465
seq distance
False
chain
G
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
102.5465
seq distance
False
chain
G
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
102.86066
seq distance
False
chain
G
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
102.86066
seq distance
False
chain
G
In C7D; dbSNP:rs541873000.
original residue
E
variation residue
Q
position
682
score
100.0
distance
104.655426
seq distance
207
chain
D
In C7D; dbSNP:rs541873000.
original residue
E
variation residue
Q
position
682
score
100.0
distance
104.655426
seq distance
207
chain
D
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
108.36057
seq distance
False
chain
H
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
108.36057
seq distance
False
chain
H
Confirmed at protein level; dbSNP:rs13157656.
original residue
T
variation residue
P
position
714
score
50.0
distance
109.589966
seq distance
False
chain
B
Confirmed at protein level; dbSNP:rs13157656.
original residue
T
variation residue
P
position
714
score
50.0
distance
109.589966
seq distance
False
chain
B
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
109.87459
seq distance
False
chain
V
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
109.87459
seq distance
False
chain
V
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
112.63923
seq distance
False
chain
V
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
112.63923
seq distance
False
chain
V
In C7D; dbSNP:rs113187203.
original residue
R
variation residue
H
position
687
score
100.0
distance
114.069374
seq distance
212
chain
D
In C7D; dbSNP:rs113187203.
original residue
R
variation residue
H
position
687
score
100.0
distance
114.069374
seq distance
212
chain
D
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
114.65107
seq distance
False
chain
V
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
114.65107
seq distance
False
chain
V
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
115.055046
seq distance
False
chain
V
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
115.055046
seq distance
False
chain
V
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
115.95706
seq distance
False
chain
P
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
115.95706
seq distance
False
chain
P
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
117.676605
seq distance
False
chain
P
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
117.676605
seq distance
False
chain
P
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
125.15567
seq distance
False
chain
P
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
125.15567
seq distance
False
chain
P
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
127.07321
seq distance
False
chain
I
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
127.07321
seq distance
False
chain
I
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
129.23286
seq distance
False
chain
U
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
129.23286
seq distance
False
chain
U
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
132.47375
seq distance
False
chain
H
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
132.47375
seq distance
False
chain
H
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
134.36237
seq distance
False
chain
U
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
134.36237
seq distance
False
chain
U
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
134.50937
seq distance
False
chain
U
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
134.50937
seq distance
False
chain
U
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
135.64735
seq distance
False
chain
U
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
135.64735
seq distance
False
chain
U
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
136.55661
seq distance
False
chain
H
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
136.55661
seq distance
False
chain
H
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
143.07529
seq distance
False
chain
T
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
143.07529
seq distance
False
chain
T
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
143.6534
seq distance
False
chain
J
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
143.6534
seq distance
False
chain
J
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
145.8514
seq distance
False
chain
I
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
145.8514
seq distance
False
chain
I
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
146.21605
seq distance
False
chain
H
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
146.21605
seq distance
False
chain
H
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
150.82317
seq distance
False
chain
T
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
150.82317
seq distance
False
chain
T
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
155.14987
seq distance
False
chain
I
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
155.14987
seq distance
False
chain
I
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
155.18616
seq distance
False
chain
S
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
155.18616
seq distance
False
chain
S
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
156.00981
seq distance
False
chain
T
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
156.00981
seq distance
False
chain
T
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
156.6341
seq distance
False
chain
T
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
156.6341
seq distance
False
chain
T
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
157.1368
seq distance
False
chain
J
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
157.1368
seq distance
False
chain
J
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
157.69809
seq distance
False
chain
K
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
157.69809
seq distance
False
chain
K
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
164.0213
seq distance
False
chain
S
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
164.0213
seq distance
False
chain
S
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
165.03442
seq distance
False
chain
I
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
165.03442
seq distance
False
chain
I
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
165.14809
seq distance
False
chain
R
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
165.14809
seq distance
False
chain
R
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
166.26163
seq distance
False
chain
K
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
166.26163
seq distance
False
chain
K
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
168.89836
seq distance
False
chain
L
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
168.89836
seq distance
False
chain
L
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
171.26076
seq distance
False
chain
J
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
171.26076
seq distance
False
chain
J
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
172.6729
seq distance
False
chain
Q
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
172.6729
seq distance
False
chain
Q
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
173.02002
seq distance
False
chain
S
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
173.02002
seq distance
False
chain
S
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
173.03278
seq distance
False
chain
L
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
173.03278
seq distance
False
chain
L
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
173.81189
seq distance
False
chain
R
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
173.81189
seq distance
False
chain
R
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
175.37715
seq distance
False
chain
S
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
175.37715
seq distance
False
chain
S
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
176.81026
seq distance
False
chain
O
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
176.81026
seq distance
False
chain
O
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
176.93295
seq distance
False
chain
M
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
176.93295
seq distance
False
chain
M
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
177.09857
seq distance
False
chain
M
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
177.09857
seq distance
False
chain
M
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
178.76256
seq distance
False
chain
N
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
178.76256
seq distance
False
chain
N
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
180.09323
seq distance
False
chain
Q
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
180.09323
seq distance
False
chain
Q
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
181.20735
seq distance
False
chain
J
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
181.20735
seq distance
False
chain
J
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
181.57281
seq distance
False
chain
N
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
181.57281
seq distance
False
chain
N
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
182.68483
seq distance
False
chain
O
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
182.68483
seq distance
False
chain
O
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
184.4517
seq distance
False
chain
K
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
184.4517
seq distance
False
chain
K
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
186.43333
seq distance
False
chain
R
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
186.43333
seq distance
False
chain
R
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
190.41527
seq distance
False
chain
R
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
190.41527
seq distance
False
chain
R
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
194.26834
seq distance
False
chain
K
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
194.26834
seq distance
False
chain
K
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
194.37296
seq distance
False
chain
L
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
194.37296
seq distance
False
chain
L
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
196.01787
seq distance
False
chain
Q
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
196.01787
seq distance
False
chain
Q
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
200.6399
seq distance
False
chain
M
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
200.6399
seq distance
False
chain
M
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
201.56561
seq distance
False
chain
Q
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
201.56561
seq distance
False
chain
Q
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
201.60886
seq distance
False
chain
O
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
201.60886
seq distance
False
chain
O
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
203.07744
seq distance
False
chain
N
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
203.07744
seq distance
False
chain
N
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
203.87259
seq distance
False
chain
L
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
203.87259
seq distance
False
chain
L
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
208.57692
seq distance
False
chain
O
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
208.57692
seq distance
False
chain
O
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
209.67998
seq distance
False
chain
M
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
209.67998
seq distance
False
chain
M
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
211.27742
seq distance
False
chain
N
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
211.27742
seq distance
False
chain
N

Details

Redox score
67.48
PDB code
6h04
Structure name
closed conformation of the membrane attack complex
Structure deposition date
2018-07-06
Thiol separation (Å)
7.38
Half-sphere exposure sum
68
Minimum pKa
nan
% buried
nan
Peptide accession
P10643
Residue number A
473
Residue number B
475
Peptide name
Complement component C7
A redox-regulated disulphide may form within Complement component C7 at these cysteines. However, the redox score of this cysteine pair is lower than any known redox-active disulphide.

Relevent regions

Factor I module (FIM) 2
begin
771
end
843
score
100.0
distance
2.78732
seq distance
0
chain
A
Factor I module (FIM) 2
begin
771
end
843
score
100.0
distance
2.78732
seq distance
0
chain
A
Factor I module (FIM) 1
begin
695
end
770
score
99.46172248803828
distance
4.2923
seq distance
48
chain
A
Factor I module (FIM) 1
begin
695
end
770
score
99.46172248803828
distance
4.2923
seq distance
48
chain
A
LDL-receptor class A
begin
795
end
795
score
70.45454545454545
distance
7.9612045
seq distance
23
chain
A
LDL-receptor class A
begin
795
end
795
score
70.45454545454545
distance
7.9612045
seq distance
23
chain
A
In C7D; dbSNP:rs113187203.
original residue
R
variation residue
H
position
712
score
50.0
distance
25.152733
seq distance
106
chain
A
In C7D; dbSNP:rs113187203.
original residue
R
variation residue
H
position
712
score
50.0
distance
25.152733
seq distance
106
chain
A

Details

Redox score
67.15
PDB code
2wcy
Structure name
nmr solution structure of factor i-like modules of complement c7.
Structure deposition date
2009-03-17
Thiol separation (Å)
9.83
Half-sphere exposure sum
69
Minimum pKa
nan
% buried
19
Peptide accession
P10643
Residue number A
818
Residue number B
825
Peptide name
Complement component C7
A redox-regulated disulphide may form within Complement component C7 at these cysteines. However, the redox score of this cysteine pair is lower than any known redox-active disulphide.

Relevent regions

EGF-like
begin
435
end
465
score
100.0
distance
2.7987742
seq distance
0
chain
C
EGF-like
begin
435
end
465
score
100.0
distance
2.7987742
seq distance
0
chain
C
TSP type-1 1
begin
5
end
58
score
99.83164983164983
distance
5.273106
seq distance
380
chain
C
TSP type-1 1
begin
5
end
58
score
99.83164983164983
distance
5.273106
seq distance
380
chain
C
MACPF
begin
102
end
434
score
94.85394485394487
distance
5.3191686
seq distance
4
chain
C
MACPF
begin
102
end
434
score
94.85394485394487
distance
5.3191686
seq distance
4
chain
C
TSP type-1 2
begin
478
end
527
score
100.0
distance
10.938999
seq distance
27
chain
C
TSP type-1 2
begin
478
end
527
score
100.0
distance
10.938999
seq distance
27
chain
C
Disordered
begin
494
end
516
score
100.0
distance
12.512271
seq distance
43
chain
C
Disordered
begin
494
end
516
score
100.0
distance
12.512271
seq distance
43
chain
C
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
499
score
100.0
distance
16.885994
seq distance
48
chain
C
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
499
score
100.0
distance
16.885994
seq distance
48
chain
C
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
412
score
63.63636363636363
distance
21.166243
seq distance
False
chain
D
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
412
score
63.63636363636363
distance
21.166243
seq distance
False
chain
D
Disordered
begin
86
end
121
score
100.0
distance
23.625822
seq distance
317
chain
C
Disordered
begin
86
end
121
score
100.0
distance
23.625822
seq distance
317
chain
C
Disordered
begin
510
end
522
score
53.67132867132868
distance
25.176613
seq distance
False
chain
D
Disordered
begin
510
end
522
score
53.67132867132868
distance
25.176613
seq distance
False
chain
D
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
398
score
100.0
distance
25.221754
seq distance
40
chain
C
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
398
score
100.0
distance
25.221754
seq distance
40
chain
C
Confirmed at protein level; dbSNP:rs1063499.
original residue
S
variation residue
T
position
367
score
100.0
distance
27.91972
seq distance
71
chain
C
Confirmed at protein level; dbSNP:rs1063499.
original residue
S
variation residue
T
position
367
score
100.0
distance
27.91972
seq distance
71
chain
C
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
512
score
81.81818181818183
distance
27.923115
seq distance
False
chain
D
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
512
score
81.81818181818183
distance
27.923115
seq distance
False
chain
D
In C7D; dbSNP:rs121964921.
original residue
G
variation residue
R
position
357
score
100.0
distance
28.197184
seq distance
81
chain
C
In C7D; dbSNP:rs121964921.
original residue
G
variation residue
R
position
357
score
100.0
distance
28.197184
seq distance
81
chain
C
In C7D; dbSNP:rs369349760.
original residue
R
variation residue
Q
position
25
score
54.54545454545454
distance
28.586592
seq distance
False
chain
B
In C7D; dbSNP:rs369349760.
original residue
R
variation residue
Q
position
25
score
54.54545454545454
distance
28.586592
seq distance
False
chain
B
Disordered
begin
504
end
504
score
68.18181818181817
distance
28.967176
seq distance
False
chain
D
Disordered
begin
504
end
504
score
68.18181818181817
distance
28.967176
seq distance
False
chain
D
CCP 1
begin
523
end
593
score
100.0
distance
29.125893
seq distance
72
chain
C
CCP 1
begin
523
end
593
score
100.0
distance
29.125893
seq distance
72
chain
C
EGF-like
begin
451
end
455
score
54.090909090909086
distance
34.070145
seq distance
False
chain
D
EGF-like
begin
451
end
455
score
54.090909090909086
distance
34.070145
seq distance
False
chain
D
Disordered
begin
564
end
573
score
62.272727272727266
distance
37.465393
seq distance
False
chain
B
Disordered
begin
564
end
573
score
62.272727272727266
distance
37.465393
seq distance
False
chain
B
LDL-receptor class A
begin
61
end
99
score
100.0
distance
39.046356
seq distance
339
chain
C
LDL-receptor class A
begin
61
end
99
score
100.0
distance
39.046356
seq distance
339
chain
C
In dbSNP:rs75345202.
original residue
R
variation residue
H
position
414
score
54.54545454545454
distance
45.165287
seq distance
False
chain
E
In dbSNP:rs75345202.
original residue
R
variation residue
H
position
414
score
54.54545454545454
distance
45.165287
seq distance
False
chain
E
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
566
score
86.36363636363636
distance
45.70498
seq distance
False
chain
B
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
566
score
86.36363636363636
distance
45.70498
seq distance
False
chain
B
Disordered
begin
197
end
218
score
76.85950413223141
distance
46.596878
seq distance
220
chain
C
Disordered
begin
197
end
218
score
76.85950413223141
distance
46.596878
seq distance
220
chain
C
Disordered
begin
91
end
92
score
68.18181818181817
distance
48.13991
seq distance
False
chain
D
Disordered
begin
91
end
92
score
68.18181818181817
distance
48.13991
seq distance
False
chain
D
LDL-receptor class A
begin
84
end
92
score
56.56565656565656
distance
48.13991
seq distance
False
chain
D
LDL-receptor class A
begin
84
end
92
score
56.56565656565656
distance
48.13991
seq distance
False
chain
D
In dbSNP:rs2271708.
original residue
C
variation residue
R
position
106
score
100.0
distance
51.656612
seq distance
332
chain
C
In dbSNP:rs2271708.
original residue
C
variation residue
R
position
106
score
100.0
distance
51.656612
seq distance
332
chain
C
Sushi 1
begin
547
end
606
score
100.0
distance
52.397068
seq distance
96
chain
C
Sushi 1
begin
547
end
606
score
100.0
distance
52.397068
seq distance
96
chain
C
In dbSNP:rs2271708.
original residue
C
variation residue
R
position
532
score
54.54545454545454
distance
57.625233
seq distance
False
chain
E
In dbSNP:rs2271708.
original residue
C
variation residue
R
position
532
score
54.54545454545454
distance
57.625233
seq distance
False
chain
E
CCP 2
begin
594
end
671
score
100.0
distance
57.9083
seq distance
143
chain
C
CCP 2
begin
594
end
671
score
100.0
distance
57.9083
seq distance
143
chain
C
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
530
score
54.54545454545454
distance
59.298843
seq distance
False
chain
E
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
530
score
54.54545454545454
distance
59.298843
seq distance
False
chain
E
LDL-receptor class A
begin
83
end
95
score
50.87412587412587
distance
61.408623
seq distance
False
chain
E
LDL-receptor class A
begin
83
end
95
score
50.87412587412587
distance
61.408623
seq distance
False
chain
E
Confirmed at protein level; dbSNP:rs13157656.
original residue
T
variation residue
P
position
565
score
100.0
distance
61.94432
seq distance
114
chain
C
Confirmed at protein level; dbSNP:rs13157656.
original residue
T
variation residue
P
position
565
score
100.0
distance
61.94432
seq distance
114
chain
C
MACPF
begin
324
end
332
score
83.08080808080808
distance
63.22599
seq distance
False
chain
G
MACPF
begin
324
end
332
score
83.08080808080808
distance
63.22599
seq distance
False
chain
G
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
68.15015
seq distance
False
chain
G
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
68.15015
seq distance
False
chain
G
Disordered
begin
138
end
138
score
50.0
distance
68.77994
seq distance
False
chain
F
Disordered
begin
138
end
138
score
50.0
distance
68.77994
seq distance
False
chain
F
Confirmed at protein level; dbSNP:rs1063499.
original residue
S
variation residue
T
position
1040
score
54.54545454545454
distance
79.03622
seq distance
False
chain
A
Confirmed at protein level; dbSNP:rs1063499.
original residue
S
variation residue
T
position
1040
score
54.54545454545454
distance
79.03622
seq distance
False
chain
A
MACPF
begin
324
end
332
score
83.08080808080808
distance
82.19877
seq distance
False
chain
H
MACPF
begin
324
end
332
score
83.08080808080808
distance
82.19877
seq distance
False
chain
H
In C7D; dbSNP:rs369349760.
original residue
R
variation residue
Q
position
198
score
72.72727272727273
distance
86.61567
seq distance
240
chain
C
In C7D; dbSNP:rs369349760.
original residue
R
variation residue
Q
position
198
score
72.72727272727273
distance
86.61567
seq distance
240
chain
C
Sushi 2
begin
607
end
668
score
100.0
distance
88.13071
seq distance
156
chain
C
Sushi 2
begin
607
end
668
score
100.0
distance
88.13071
seq distance
156
chain
C
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
89.42111
seq distance
False
chain
H
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
89.42111
seq distance
False
chain
H
In dbSNP:rs75345202.
original residue
R
variation residue
H
position
200
score
72.72727272727273
distance
93.033485
seq distance
238
chain
C
In dbSNP:rs75345202.
original residue
R
variation residue
H
position
200
score
72.72727272727273
distance
93.033485
seq distance
238
chain
C
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
95.290886
seq distance
False
chain
G
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
95.290886
seq distance
False
chain
G
MACPF
begin
324
end
333
score
84.54545454545456
distance
99.864075
seq distance
False
chain
I
MACPF
begin
324
end
333
score
84.54545454545456
distance
99.864075
seq distance
False
chain
I
In C7D; dbSNP:rs541873000.
original residue
E
variation residue
Q
position
660
score
100.0
distance
100.6835
seq distance
209
chain
C
In C7D; dbSNP:rs541873000.
original residue
E
variation residue
Q
position
660
score
100.0
distance
100.6835
seq distance
209
chain
C
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
103.460335
seq distance
False
chain
G
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
103.460335
seq distance
False
chain
G
Disordered
begin
327
end
328
score
61.36363636363637
distance
106.77992
seq distance
False
chain
I
Disordered
begin
327
end
328
score
61.36363636363637
distance
106.77992
seq distance
False
chain
I
Confirmed at protein level; dbSNP:rs13157656.
original residue
T
variation residue
P
position
693
score
50.0
distance
107.244446
seq distance
False
chain
B
Confirmed at protein level; dbSNP:rs13157656.
original residue
T
variation residue
P
position
693
score
50.0
distance
107.244446
seq distance
False
chain
B
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
108.9472
seq distance
False
chain
I
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
108.9472
seq distance
False
chain
I
In C7D; dbSNP:rs113187203.
original residue
R
variation residue
H
position
665
score
100.0
distance
112.51329
seq distance
214
chain
C
In C7D; dbSNP:rs113187203.
original residue
R
variation residue
H
position
665
score
100.0
distance
112.51329
seq distance
214
chain
C
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
117.54856
seq distance
False
chain
H
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
117.54856
seq distance
False
chain
H
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
126.3035
seq distance
False
chain
H
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
126.3035
seq distance
False
chain
H
Factor I module (FIM) 1
begin
673
end
748
score
100.0
distance
134.3428
seq distance
222
chain
C
Factor I module (FIM) 1
begin
673
end
748
score
100.0
distance
134.3428
seq distance
222
chain
C
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
136.93285
seq distance
False
chain
I
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
136.93285
seq distance
False
chain
I
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
1560
score
50.0
distance
147.21188
seq distance
False
chain
A
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
1560
score
50.0
distance
147.21188
seq distance
False
chain
A
Factor I module (FIM) 2
begin
749
end
821
score
100.0
distance
159.68898
seq distance
298
chain
C
Factor I module (FIM) 2
begin
749
end
821
score
100.0
distance
159.68898
seq distance
298
chain
C

Details

Redox score
66.24
PDB code
7nyc
Structure name
cryoem structure of 3c9-smac
Structure deposition date
2021-03-22
Thiol separation (Å)
8.08
Half-sphere exposure sum
76
Minimum pKa
nan
% buried
nan
Peptide accession
P10643
Residue number A
460 (Residue 438 in this structure)
Residue number B
473 (Residue 451 in this structure)
Peptide name
Complement component C7
A redox-regulated disulphide may form within Complement component C7 at these cysteines. However, the redox score of this cysteine pair is lower than any known redox-active disulphide.

Relevent regions

MACPF
begin
124
end
456
score
98.9079989079989
distance
2.8091636
seq distance
0
chain
D
MACPF
begin
124
end
456
score
98.9079989079989
distance
2.8091636
seq distance
0
chain
D
EGF-like
begin
457
end
487
score
100.0
distance
2.8127024
seq distance
0
chain
D
EGF-like
begin
457
end
487
score
100.0
distance
2.8127024
seq distance
0
chain
D
TSP type-1 2
begin
500
end
549
score
100.0
distance
3.1448064
seq distance
43
chain
D
TSP type-1 2
begin
500
end
549
score
100.0
distance
3.1448064
seq distance
43
chain
D
TSP type-1 1
begin
27
end
80
score
99.83164983164983
distance
6.2438025
seq distance
375
chain
D
TSP type-1 1
begin
27
end
80
score
99.83164983164983
distance
6.2438025
seq distance
375
chain
D
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
521
score
100.0
distance
9.381221
seq distance
64
chain
D
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
521
score
100.0
distance
9.381221
seq distance
64
chain
D
Disordered
begin
516
end
538
score
100.0
distance
9.381221
seq distance
59
chain
D
Disordered
begin
516
end
538
score
100.0
distance
9.381221
seq distance
59
chain
D
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
412
score
63.63636363636363
distance
21.29998
seq distance
False
chain
C
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
412
score
63.63636363636363
distance
21.29998
seq distance
False
chain
C
CCP 1
begin
545
end
615
score
83.48271446862996
distance
22.010685
seq distance
88
chain
D
CCP 1
begin
545
end
615
score
83.48271446862996
distance
22.010685
seq distance
88
chain
D
Disordered
begin
108
end
143
score
100.0
distance
23.977854
seq distance
312
chain
D
Disordered
begin
108
end
143
score
100.0
distance
23.977854
seq distance
312
chain
D
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
420
score
100.0
distance
24.206007
seq distance
35
chain
D
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
420
score
100.0
distance
24.206007
seq distance
35
chain
D
Disordered
begin
41
end
41
score
70.45454545454545
distance
28.814257
seq distance
False
chain
B
Disordered
begin
41
end
41
score
70.45454545454545
distance
28.814257
seq distance
False
chain
B
Confirmed at protein level; dbSNP:rs1063499.
original residue
S
variation residue
T
position
389
score
100.0
distance
31.611002
seq distance
66
chain
D
Confirmed at protein level; dbSNP:rs1063499.
original residue
S
variation residue
T
position
389
score
100.0
distance
31.611002
seq distance
66
chain
D
Disordered
begin
504
end
504
score
68.18181818181817
distance
31.688251
seq distance
False
chain
C
Disordered
begin
504
end
504
score
68.18181818181817
distance
31.688251
seq distance
False
chain
C
EGF-like
begin
451
end
455
score
54.090909090909086
distance
34.66142
seq distance
False
chain
C
EGF-like
begin
451
end
455
score
54.090909090909086
distance
34.66142
seq distance
False
chain
C
LDL-receptor class A
begin
83
end
121
score
100.0
distance
39.11544
seq distance
334
chain
D
LDL-receptor class A
begin
83
end
121
score
100.0
distance
39.11544
seq distance
334
chain
D
Disordered
begin
585
end
589
score
50.90909090909091
distance
43.671814
seq distance
False
chain
B
Disordered
begin
585
end
589
score
50.90909090909091
distance
43.671814
seq distance
False
chain
B
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
587
score
68.18181818181817
distance
43.83087
seq distance
False
chain
B
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
587
score
68.18181818181817
distance
43.83087
seq distance
False
chain
B
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
45.132664
seq distance
False
chain
X
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
45.132664
seq distance
False
chain
X
Disordered
begin
91
end
92
score
68.18181818181817
distance
48.615536
seq distance
False
chain
C
Disordered
begin
91
end
92
score
68.18181818181817
distance
48.615536
seq distance
False
chain
C
LDL-receptor class A
begin
84
end
92
score
56.56565656565656
distance
48.615536
seq distance
False
chain
C
LDL-receptor class A
begin
84
end
92
score
56.56565656565656
distance
48.615536
seq distance
False
chain
C
In dbSNP:rs75345202.
original residue
R
variation residue
H
position
414
score
54.54545454545454
distance
49.727745
seq distance
False
chain
F
In dbSNP:rs75345202.
original residue
R
variation residue
H
position
414
score
54.54545454545454
distance
49.727745
seq distance
False
chain
F
Sushi 1
begin
572
end
628
score
99.04306220095694
distance
50.78856
seq distance
115
chain
D
Sushi 1
begin
572
end
628
score
99.04306220095694
distance
50.78856
seq distance
115
chain
D
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
52.097977
seq distance
False
chain
X
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
52.097977
seq distance
False
chain
X
CCP 2
begin
616
end
691
score
99.2822966507177
distance
52.54426
seq distance
159
chain
D
CCP 2
begin
616
end
691
score
99.2822966507177
distance
52.54426
seq distance
159
chain
D
Disordered
begin
219
end
240
score
100.0
distance
53.602844
seq distance
215
chain
D
Disordered
begin
219
end
240
score
100.0
distance
53.602844
seq distance
215
chain
D
In dbSNP:rs2271708.
original residue
C
variation residue
R
position
128
score
100.0
distance
54.424034
seq distance
327
chain
D
In dbSNP:rs2271708.
original residue
C
variation residue
R
position
128
score
100.0
distance
54.424034
seq distance
327
chain
D
Confirmed at protein level; dbSNP:rs13157656.
original residue
T
variation residue
P
position
587
score
100.0
distance
59.230427
seq distance
130
chain
D
Confirmed at protein level; dbSNP:rs13157656.
original residue
T
variation residue
P
position
587
score
100.0
distance
59.230427
seq distance
130
chain
D
TSP type-1 2
begin
512
end
517
score
80.30303030303031
distance
60.431168
seq distance
False
chain
F
TSP type-1 2
begin
512
end
517
score
80.30303030303031
distance
60.431168
seq distance
False
chain
F
LDL-receptor class A
begin
83
end
98
score
52.69886363636363
distance
61.152653
seq distance
False
chain
F
LDL-receptor class A
begin
83
end
98
score
52.69886363636363
distance
61.152653
seq distance
False
chain
F
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
67.47657
seq distance
False
chain
X
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
67.47657
seq distance
False
chain
X
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
67.9398
seq distance
False
chain
G
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
67.9398
seq distance
False
chain
G
Disordered
begin
138
end
138
score
50.0
distance
72.38043
seq distance
False
chain
E
Disordered
begin
138
end
138
score
50.0
distance
72.38043
seq distance
False
chain
E
Confirmed at protein level; dbSNP:rs1063499.
original residue
S
variation residue
T
position
1058
score
54.54545454545454
distance
74.125046
seq distance
False
chain
A
Confirmed at protein level; dbSNP:rs1063499.
original residue
S
variation residue
T
position
1058
score
54.54545454545454
distance
74.125046
seq distance
False
chain
A
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
31
score
50.0
distance
75.87101
seq distance
False
chain
F
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
31
score
50.0
distance
75.87101
seq distance
False
chain
F
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
76.20298
seq distance
False
chain
W
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
76.20298
seq distance
False
chain
W
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
81.28161
seq distance
False
chain
W
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
81.28161
seq distance
False
chain
W
Sushi 2
begin
629
end
690
score
99.56011730205279
distance
84.05372
seq distance
172
chain
D
Sushi 2
begin
629
end
690
score
99.56011730205279
distance
84.05372
seq distance
172
chain
D
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
90.32017
seq distance
False
chain
P
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
90.32017
seq distance
False
chain
P
In C7D; dbSNP:rs369349760.
original residue
R
variation residue
Q
position
220
score
100.0
distance
91.0171
seq distance
235
chain
D
In C7D; dbSNP:rs369349760.
original residue
R
variation residue
Q
position
220
score
100.0
distance
91.0171
seq distance
235
chain
D
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
91.77431
seq distance
False
chain
W
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
91.77431
seq distance
False
chain
W
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
94.83532
seq distance
False
chain
G
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
94.83532
seq distance
False
chain
G
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
96.45212
seq distance
False
chain
X
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
96.45212
seq distance
False
chain
X
In C7D; dbSNP:rs541873000.
original residue
E
variation residue
Q
position
682
score
100.0
distance
97.2397
seq distance
225
chain
D
In C7D; dbSNP:rs541873000.
original residue
E
variation residue
Q
position
682
score
100.0
distance
97.2397
seq distance
225
chain
D
In dbSNP:rs75345202.
original residue
R
variation residue
H
position
222
score
100.0
distance
97.30049
seq distance
233
chain
D
In dbSNP:rs75345202.
original residue
R
variation residue
H
position
222
score
100.0
distance
97.30049
seq distance
233
chain
D
Confirmed at protein level; dbSNP:rs13157656.
original residue
T
variation residue
P
position
714
score
50.0
distance
101.2665
seq distance
False
chain
B
Confirmed at protein level; dbSNP:rs13157656.
original residue
T
variation residue
P
position
714
score
50.0
distance
101.2665
seq distance
False
chain
B
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
103.79817
seq distance
False
chain
G
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
103.79817
seq distance
False
chain
G
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
105.08612
seq distance
False
chain
V
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
105.08612
seq distance
False
chain
V
In C7D; dbSNP:rs113187203.
original residue
R
variation residue
H
position
687
score
100.0
distance
106.321686
seq distance
230
chain
D
In C7D; dbSNP:rs113187203.
original residue
R
variation residue
H
position
687
score
100.0
distance
106.321686
seq distance
230
chain
D
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
107.07703
seq distance
False
chain
W
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
107.07703
seq distance
False
chain
W
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
108.49451
seq distance
False
chain
V
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
108.49451
seq distance
False
chain
V
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
109.465675
seq distance
False
chain
G
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
109.465675
seq distance
False
chain
G
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
111.5141
seq distance
False
chain
H
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
111.5141
seq distance
False
chain
H
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
114.47538
seq distance
False
chain
V
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
114.47538
seq distance
False
chain
V
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
117.761375
seq distance
False
chain
P
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
117.761375
seq distance
False
chain
P
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
120.45769
seq distance
False
chain
V
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
120.45769
seq distance
False
chain
V
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
124.31569
seq distance
False
chain
P
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
124.31569
seq distance
False
chain
P
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
127.294395
seq distance
False
chain
P
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
127.294395
seq distance
False
chain
P
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
130.73914
seq distance
False
chain
I
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
130.73914
seq distance
False
chain
I
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
131.5142
seq distance
False
chain
U
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
131.5142
seq distance
False
chain
U
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
133.25174
seq distance
False
chain
U
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
133.25174
seq distance
False
chain
U
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
134.90569
seq distance
False
chain
U
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
134.90569
seq distance
False
chain
U
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
135.02954
seq distance
False
chain
U
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
135.02954
seq distance
False
chain
U
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
139.1529
seq distance
False
chain
H
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
139.1529
seq distance
False
chain
H
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
139.2069
seq distance
False
chain
H
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
139.2069
seq distance
False
chain
H
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
147.69763
seq distance
False
chain
J
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
147.69763
seq distance
False
chain
J
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
148.73639
seq distance
False
chain
T
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
148.73639
seq distance
False
chain
T
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
149.17294
seq distance
False
chain
H
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
149.17294
seq distance
False
chain
H
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
152.56256
seq distance
False
chain
I
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
152.56256
seq distance
False
chain
I
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
152.84857
seq distance
False
chain
T
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
152.84857
seq distance
False
chain
T
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
155.3754
seq distance
False
chain
T
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
155.3754
seq distance
False
chain
T
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
155.46083
seq distance
False
chain
T
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
155.46083
seq distance
False
chain
T
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
158.41217
seq distance
False
chain
I
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
158.41217
seq distance
False
chain
I
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
160.93526
seq distance
False
chain
S
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
160.93526
seq distance
False
chain
S
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
162.0067
seq distance
False
chain
K
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
162.0067
seq distance
False
chain
K
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
163.86465
seq distance
False
chain
J
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
163.86465
seq distance
False
chain
J
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
167.43416
seq distance
False
chain
S
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
167.43416
seq distance
False
chain
S
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
168.58054
seq distance
False
chain
I
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
168.58054
seq distance
False
chain
I
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
171.04742
seq distance
False
chain
R
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
171.04742
seq distance
False
chain
R
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
173.029
seq distance
False
chain
K
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
173.029
seq distance
False
chain
K
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
173.36115
seq distance
False
chain
L
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
173.36115
seq distance
False
chain
L
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
174.11276
seq distance
False
chain
S
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
174.11276
seq distance
False
chain
S
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
174.95746
seq distance
False
chain
J
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
174.95746
seq distance
False
chain
J
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
176.00465
seq distance
False
chain
S
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
176.00465
seq distance
False
chain
S
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
177.65042
seq distance
False
chain
R
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
177.65042
seq distance
False
chain
R
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
178.74672
seq distance
False
chain
Q
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
178.74672
seq distance
False
chain
Q
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
179.73654
seq distance
False
chain
L
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
179.73654
seq distance
False
chain
L
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
181.44815
seq distance
False
chain
M
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
181.44815
seq distance
False
chain
M
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
183.12909
seq distance
False
chain
O
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
183.12909
seq distance
False
chain
O
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
183.70546
seq distance
False
chain
M
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
183.70546
seq distance
False
chain
M
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
184.21909
seq distance
False
chain
Q
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
184.21909
seq distance
False
chain
Q
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
185.16441
seq distance
False
chain
J
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
185.16441
seq distance
False
chain
J
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
185.22327
seq distance
False
chain
N
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
185.22327
seq distance
False
chain
N
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
186.04669
seq distance
False
chain
N
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
186.04669
seq distance
False
chain
N
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
187.02576
seq distance
False
chain
O
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
187.02576
seq distance
False
chain
O
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
188.42569
seq distance
False
chain
K
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
188.42569
seq distance
False
chain
K
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
189.20448
seq distance
False
chain
R
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
189.20448
seq distance
False
chain
R
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
192.80765
seq distance
False
chain
R
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
192.80765
seq distance
False
chain
R
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
198.4786
seq distance
False
chain
K
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
198.4786
seq distance
False
chain
K
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
198.48592
seq distance
False
chain
L
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
198.48592
seq distance
False
chain
L
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
199.48701
seq distance
False
chain
Q
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
199.48701
seq distance
False
chain
Q
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
204.76187
seq distance
False
chain
M
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
204.76187
seq distance
False
chain
M
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
205.11208
seq distance
False
chain
Q
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
205.11208
seq distance
False
chain
Q
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
205.40063
seq distance
False
chain
O
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
205.40063
seq distance
False
chain
O
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
207.09174
seq distance
False
chain
N
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
207.09174
seq distance
False
chain
N
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
208.19318
seq distance
False
chain
L
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
208.19318
seq distance
False
chain
L
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
212.49088
seq distance
False
chain
O
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
212.49088
seq distance
False
chain
O
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
213.98016
seq distance
False
chain
M
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
213.98016
seq distance
False
chain
M
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
215.45923
seq distance
False
chain
N
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
215.45923
seq distance
False
chain
N

Details

Redox score
65.32
PDB code
6h04
Structure name
closed conformation of the membrane attack complex
Structure deposition date
2018-07-06
Thiol separation (Å)
8.4
Half-sphere exposure sum
70
Minimum pKa
nan
% buried
nan
Peptide accession
P10643
Residue number A
455
Residue number B
457
Peptide name
Complement component C7
A redox-regulated disulphide may form within Complement component C7 at these cysteines. However, the redox score of this cysteine pair is lower than any known redox-active disulphide.

Relevent regions

TSP type-1 2
begin
500
end
549
score
100.0
distance
2.7957351
seq distance
0
chain
D
TSP type-1 2
begin
500
end
549
score
100.0
distance
2.7957351
seq distance
0
chain
D
EGF-like
begin
457
end
487
score
100.0
distance
2.8127024
seq distance
0
chain
D
EGF-like
begin
457
end
487
score
100.0
distance
2.8127024
seq distance
0
chain
D
MACPF
begin
124
end
456
score
98.9079989079989
distance
3.7485821
seq distance
1
chain
D
MACPF
begin
124
end
456
score
98.9079989079989
distance
3.7485821
seq distance
1
chain
D
TSP type-1 1
begin
27
end
80
score
99.83164983164983
distance
6.2438025
seq distance
377
chain
D
TSP type-1 1
begin
27
end
80
score
99.83164983164983
distance
6.2438025
seq distance
377
chain
D
Disordered
begin
516
end
538
score
100.0
distance
9.583976
seq distance
11
chain
D
Disordered
begin
516
end
538
score
100.0
distance
9.583976
seq distance
11
chain
D
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
521
score
100.0
distance
9.633959
seq distance
16
chain
D
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
521
score
100.0
distance
9.633959
seq distance
16
chain
D
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
412
score
63.63636363636363
distance
21.29998
seq distance
False
chain
C
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
412
score
63.63636363636363
distance
21.29998
seq distance
False
chain
C
CCP 1
begin
545
end
615
score
83.48271446862996
distance
22.404346
seq distance
40
chain
D
CCP 1
begin
545
end
615
score
83.48271446862996
distance
22.404346
seq distance
40
chain
D
Disordered
begin
108
end
143
score
100.0
distance
23.977854
seq distance
314
chain
D
Disordered
begin
108
end
143
score
100.0
distance
23.977854
seq distance
314
chain
D
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
420
score
100.0
distance
25.832808
seq distance
37
chain
D
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
420
score
100.0
distance
25.832808
seq distance
37
chain
D
Disordered
begin
41
end
41
score
70.45454545454545
distance
29.831944
seq distance
False
chain
B
Disordered
begin
41
end
41
score
70.45454545454545
distance
29.831944
seq distance
False
chain
B
Confirmed at protein level; dbSNP:rs1063499.
original residue
S
variation residue
T
position
389
score
100.0
distance
31.611002
seq distance
68
chain
D
Confirmed at protein level; dbSNP:rs1063499.
original residue
S
variation residue
T
position
389
score
100.0
distance
31.611002
seq distance
68
chain
D
Disordered
begin
504
end
504
score
68.18181818181817
distance
31.688251
seq distance
False
chain
C
Disordered
begin
504
end
504
score
68.18181818181817
distance
31.688251
seq distance
False
chain
C
EGF-like
begin
451
end
455
score
54.090909090909086
distance
34.66142
seq distance
False
chain
C
EGF-like
begin
451
end
455
score
54.090909090909086
distance
34.66142
seq distance
False
chain
C
LDL-receptor class A
begin
83
end
121
score
100.0
distance
39.68376
seq distance
336
chain
D
LDL-receptor class A
begin
83
end
121
score
100.0
distance
39.68376
seq distance
336
chain
D
Disordered
begin
585
end
589
score
50.90909090909091
distance
45.068157
seq distance
False
chain
B
Disordered
begin
585
end
589
score
50.90909090909091
distance
45.068157
seq distance
False
chain
B
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
587
score
68.18181818181817
distance
45.245262
seq distance
False
chain
B
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
587
score
68.18181818181817
distance
45.245262
seq distance
False
chain
B
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
45.55111
seq distance
False
chain
X
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
45.55111
seq distance
False
chain
X
Disordered
begin
91
end
92
score
68.18181818181817
distance
48.615536
seq distance
False
chain
C
Disordered
begin
91
end
92
score
68.18181818181817
distance
48.615536
seq distance
False
chain
C
LDL-receptor class A
begin
84
end
92
score
56.56565656565656
distance
48.615536
seq distance
False
chain
C
LDL-receptor class A
begin
84
end
92
score
56.56565656565656
distance
48.615536
seq distance
False
chain
C
In dbSNP:rs75345202.
original residue
R
variation residue
H
position
414
score
54.54545454545454
distance
49.727745
seq distance
False
chain
F
In dbSNP:rs75345202.
original residue
R
variation residue
H
position
414
score
54.54545454545454
distance
49.727745
seq distance
False
chain
F
Sushi 1
begin
572
end
628
score
99.04306220095694
distance
50.857265
seq distance
67
chain
D
Sushi 1
begin
572
end
628
score
99.04306220095694
distance
50.857265
seq distance
67
chain
D
CCP 2
begin
616
end
691
score
99.2822966507177
distance
52.4999
seq distance
111
chain
D
CCP 2
begin
616
end
691
score
99.2822966507177
distance
52.4999
seq distance
111
chain
D
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
53.03058
seq distance
False
chain
X
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
53.03058
seq distance
False
chain
X
Disordered
begin
219
end
240
score
100.0
distance
53.602844
seq distance
217
chain
D
Disordered
begin
219
end
240
score
100.0
distance
53.602844
seq distance
217
chain
D
In dbSNP:rs2271708.
original residue
C
variation residue
R
position
128
score
100.0
distance
54.424034
seq distance
329
chain
D
In dbSNP:rs2271708.
original residue
C
variation residue
R
position
128
score
100.0
distance
54.424034
seq distance
329
chain
D
Confirmed at protein level; dbSNP:rs13157656.
original residue
T
variation residue
P
position
587
score
100.0
distance
59.036705
seq distance
82
chain
D
Confirmed at protein level; dbSNP:rs13157656.
original residue
T
variation residue
P
position
587
score
100.0
distance
59.036705
seq distance
82
chain
D
TSP type-1 2
begin
512
end
517
score
80.30303030303031
distance
60.431168
seq distance
False
chain
F
TSP type-1 2
begin
512
end
517
score
80.30303030303031
distance
60.431168
seq distance
False
chain
F
LDL-receptor class A
begin
83
end
98
score
52.69886363636363
distance
61.152653
seq distance
False
chain
F
LDL-receptor class A
begin
83
end
98
score
52.69886363636363
distance
61.152653
seq distance
False
chain
F
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
67.9398
seq distance
False
chain
G
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
67.9398
seq distance
False
chain
G
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
68.7685
seq distance
False
chain
X
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
68.7685
seq distance
False
chain
X
Disordered
begin
138
end
138
score
50.0
distance
72.38043
seq distance
False
chain
E
Disordered
begin
138
end
138
score
50.0
distance
72.38043
seq distance
False
chain
E
Confirmed at protein level; dbSNP:rs1063499.
original residue
S
variation residue
T
position
1058
score
54.54545454545454
distance
75.036575
seq distance
False
chain
A
Confirmed at protein level; dbSNP:rs1063499.
original residue
S
variation residue
T
position
1058
score
54.54545454545454
distance
75.036575
seq distance
False
chain
A
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
31
score
50.0
distance
75.87101
seq distance
False
chain
F
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
31
score
50.0
distance
75.87101
seq distance
False
chain
F
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
77.039696
seq distance
False
chain
W
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
77.039696
seq distance
False
chain
W
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
82.43329
seq distance
False
chain
W
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
82.43329
seq distance
False
chain
W
Sushi 2
begin
629
end
690
score
99.56011730205279
distance
84.32133
seq distance
124
chain
D
Sushi 2
begin
629
end
690
score
99.56011730205279
distance
84.32133
seq distance
124
chain
D
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
90.32017
seq distance
False
chain
P
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
90.32017
seq distance
False
chain
P
In C7D; dbSNP:rs369349760.
original residue
R
variation residue
Q
position
220
score
100.0
distance
91.0171
seq distance
237
chain
D
In C7D; dbSNP:rs369349760.
original residue
R
variation residue
Q
position
220
score
100.0
distance
91.0171
seq distance
237
chain
D
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
93.184616
seq distance
False
chain
W
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
93.184616
seq distance
False
chain
W
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
94.83532
seq distance
False
chain
G
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
94.83532
seq distance
False
chain
G
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
96.45212
seq distance
False
chain
X
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
96.45212
seq distance
False
chain
X
In dbSNP:rs75345202.
original residue
R
variation residue
H
position
222
score
100.0
distance
97.30049
seq distance
235
chain
D
In dbSNP:rs75345202.
original residue
R
variation residue
H
position
222
score
100.0
distance
97.30049
seq distance
235
chain
D
In C7D; dbSNP:rs541873000.
original residue
E
variation residue
Q
position
682
score
100.0
distance
97.601494
seq distance
177
chain
D
In C7D; dbSNP:rs541873000.
original residue
E
variation residue
Q
position
682
score
100.0
distance
97.601494
seq distance
177
chain
D
Confirmed at protein level; dbSNP:rs13157656.
original residue
T
variation residue
P
position
714
score
50.0
distance
102.585846
seq distance
False
chain
B
Confirmed at protein level; dbSNP:rs13157656.
original residue
T
variation residue
P
position
714
score
50.0
distance
102.585846
seq distance
False
chain
B
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
103.79817
seq distance
False
chain
G
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
103.79817
seq distance
False
chain
G
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
106.228424
seq distance
False
chain
V
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
106.228424
seq distance
False
chain
V
In C7D; dbSNP:rs113187203.
original residue
R
variation residue
H
position
687
score
100.0
distance
106.69588
seq distance
182
chain
D
In C7D; dbSNP:rs113187203.
original residue
R
variation residue
H
position
687
score
100.0
distance
106.69588
seq distance
182
chain
D
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
107.07703
seq distance
False
chain
W
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
107.07703
seq distance
False
chain
W
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
109.465675
seq distance
False
chain
G
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
109.465675
seq distance
False
chain
G
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
109.85549
seq distance
False
chain
V
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
109.85549
seq distance
False
chain
V
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
111.5141
seq distance
False
chain
H
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
111.5141
seq distance
False
chain
H
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
116.013374
seq distance
False
chain
V
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
116.013374
seq distance
False
chain
V
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
117.761375
seq distance
False
chain
P
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
117.761375
seq distance
False
chain
P
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
120.45769
seq distance
False
chain
V
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
120.45769
seq distance
False
chain
V
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
124.31569
seq distance
False
chain
P
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
124.31569
seq distance
False
chain
P
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
127.294395
seq distance
False
chain
P
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
127.294395
seq distance
False
chain
P
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
130.73914
seq distance
False
chain
I
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
130.73914
seq distance
False
chain
I
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
132.89888
seq distance
False
chain
U
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
132.89888
seq distance
False
chain
U
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
134.79509
seq distance
False
chain
U
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
134.79509
seq distance
False
chain
U
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
134.90569
seq distance
False
chain
U
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
134.90569
seq distance
False
chain
U
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
136.68352
seq distance
False
chain
U
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
136.68352
seq distance
False
chain
U
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
139.1529
seq distance
False
chain
H
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
139.1529
seq distance
False
chain
H
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
139.2069
seq distance
False
chain
H
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
139.2069
seq distance
False
chain
H
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
147.69763
seq distance
False
chain
J
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
147.69763
seq distance
False
chain
J
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
148.73639
seq distance
False
chain
T
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
148.73639
seq distance
False
chain
T
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
149.17294
seq distance
False
chain
H
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
149.17294
seq distance
False
chain
H
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
152.56256
seq distance
False
chain
I
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
152.56256
seq distance
False
chain
I
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
153.91403
seq distance
False
chain
T
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
153.91403
seq distance
False
chain
T
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
157.0376
seq distance
False
chain
T
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
157.0376
seq distance
False
chain
T
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
157.06711
seq distance
False
chain
T
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
157.06711
seq distance
False
chain
T
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
158.41217
seq distance
False
chain
I
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
158.41217
seq distance
False
chain
I
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
160.93526
seq distance
False
chain
S
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
160.93526
seq distance
False
chain
S
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
162.0067
seq distance
False
chain
K
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
162.0067
seq distance
False
chain
K
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
163.86465
seq distance
False
chain
J
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
163.86465
seq distance
False
chain
J
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
167.50975
seq distance
False
chain
S
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
167.50975
seq distance
False
chain
S
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
168.58054
seq distance
False
chain
I
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
168.58054
seq distance
False
chain
I
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
171.04742
seq distance
False
chain
R
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
171.04742
seq distance
False
chain
R
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
173.029
seq distance
False
chain
K
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
173.029
seq distance
False
chain
K
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
173.36115
seq distance
False
chain
L
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
173.36115
seq distance
False
chain
L
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
174.95746
seq distance
False
chain
J
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
174.95746
seq distance
False
chain
J
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
175.56685
seq distance
False
chain
S
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
175.56685
seq distance
False
chain
S
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
177.65042
seq distance
False
chain
R
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
177.65042
seq distance
False
chain
R
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
177.72557
seq distance
False
chain
S
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
177.72557
seq distance
False
chain
S
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
178.74672
seq distance
False
chain
Q
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
178.74672
seq distance
False
chain
Q
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
179.73654
seq distance
False
chain
L
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
179.73654
seq distance
False
chain
L
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
181.44815
seq distance
False
chain
M
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
181.44815
seq distance
False
chain
M
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
183.12909
seq distance
False
chain
O
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
183.12909
seq distance
False
chain
O
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
183.70546
seq distance
False
chain
M
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
183.70546
seq distance
False
chain
M
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
184.21909
seq distance
False
chain
Q
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
184.21909
seq distance
False
chain
Q
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
185.16441
seq distance
False
chain
J
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
185.16441
seq distance
False
chain
J
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
185.22327
seq distance
False
chain
N
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
185.22327
seq distance
False
chain
N
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
186.04669
seq distance
False
chain
N
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
186.04669
seq distance
False
chain
N
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
187.02576
seq distance
False
chain
O
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
187.02576
seq distance
False
chain
O
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
188.42569
seq distance
False
chain
K
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
188.42569
seq distance
False
chain
K
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
189.48557
seq distance
False
chain
R
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
189.48557
seq distance
False
chain
R
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
193.5015
seq distance
False
chain
R
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
193.5015
seq distance
False
chain
R
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
198.4786
seq distance
False
chain
K
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
198.4786
seq distance
False
chain
K
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
198.48592
seq distance
False
chain
L
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
198.48592
seq distance
False
chain
L
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
199.48701
seq distance
False
chain
Q
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
199.48701
seq distance
False
chain
Q
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
204.76187
seq distance
False
chain
M
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
204.76187
seq distance
False
chain
M
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
205.11208
seq distance
False
chain
Q
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
205.11208
seq distance
False
chain
Q
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
205.40063
seq distance
False
chain
O
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
205.40063
seq distance
False
chain
O
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
207.09174
seq distance
False
chain
N
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
207.09174
seq distance
False
chain
N
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
208.19318
seq distance
False
chain
L
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
208.19318
seq distance
False
chain
L
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
212.49088
seq distance
False
chain
O
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
212.49088
seq distance
False
chain
O
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
213.98016
seq distance
False
chain
M
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
213.98016
seq distance
False
chain
M
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
215.45923
seq distance
False
chain
N
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
215.45923
seq distance
False
chain
N

Details

Redox score
65.2
PDB code
6h04
Structure name
closed conformation of the membrane attack complex
Structure deposition date
2018-07-06
Thiol separation (Å)
8.71
Half-sphere exposure sum
64
Minimum pKa
nan
% buried
nan
Peptide accession
P10643
Residue number A
457
Residue number B
505
Peptide name
Complement component C7
A redox-regulated disulphide may form within Complement component C7 at these cysteines. However, the redox score of this cysteine pair is lower than any known redox-active disulphide.

Relevent regions

EGF-like
begin
435
end
465
score
100.0
distance
2.7987742
seq distance
0
chain
C
EGF-like
begin
435
end
465
score
100.0
distance
2.7987742
seq distance
0
chain
C
TSP type-1 1
begin
5
end
58
score
99.83164983164983
distance
2.8384473
seq distance
0
chain
C
TSP type-1 1
begin
5
end
58
score
99.83164983164983
distance
2.8384473
seq distance
0
chain
C
MACPF
begin
102
end
434
score
94.85394485394487
distance
5.3191686
seq distance
17
chain
C
MACPF
begin
102
end
434
score
94.85394485394487
distance
5.3191686
seq distance
17
chain
C
TSP type-1 2
begin
478
end
527
score
100.0
distance
10.938999
seq distance
27
chain
C
TSP type-1 2
begin
478
end
527
score
100.0
distance
10.938999
seq distance
27
chain
C
Disordered
begin
494
end
516
score
100.0
distance
12.722659
seq distance
43
chain
C
Disordered
begin
494
end
516
score
100.0
distance
12.722659
seq distance
43
chain
C
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
499
score
100.0
distance
16.885994
seq distance
48
chain
C
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
499
score
100.0
distance
16.885994
seq distance
48
chain
C
Disordered
begin
510
end
522
score
53.67132867132868
distance
19.483156
seq distance
False
chain
D
Disordered
begin
510
end
522
score
53.67132867132868
distance
19.483156
seq distance
False
chain
D
Disordered
begin
504
end
504
score
68.18181818181817
distance
19.996948
seq distance
False
chain
D
Disordered
begin
504
end
504
score
68.18181818181817
distance
19.996948
seq distance
False
chain
D
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
412
score
63.63636363636363
distance
20.850302
seq distance
False
chain
D
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
412
score
63.63636363636363
distance
20.850302
seq distance
False
chain
D
Disordered
begin
86
end
121
score
100.0
distance
23.625822
seq distance
80
chain
C
Disordered
begin
86
end
121
score
100.0
distance
23.625822
seq distance
80
chain
C
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
512
score
81.81818181818183
distance
24.179226
seq distance
False
chain
D
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
512
score
81.81818181818183
distance
24.179226
seq distance
False
chain
D
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
398
score
100.0
distance
26.507042
seq distance
53
chain
C
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
398
score
100.0
distance
26.507042
seq distance
53
chain
C
CCP 1
begin
523
end
593
score
100.0
distance
29.125893
seq distance
72
chain
C
CCP 1
begin
523
end
593
score
100.0
distance
29.125893
seq distance
72
chain
C
EGF-like
begin
451
end
455
score
54.090909090909086
distance
30.401018
seq distance
False
chain
D
EGF-like
begin
451
end
455
score
54.090909090909086
distance
30.401018
seq distance
False
chain
D
In C7D; dbSNP:rs121964921.
original residue
G
variation residue
R
position
357
score
100.0
distance
31.420965
seq distance
94
chain
C
In C7D; dbSNP:rs121964921.
original residue
G
variation residue
R
position
357
score
100.0
distance
31.420965
seq distance
94
chain
C
Confirmed at protein level; dbSNP:rs1063499.
original residue
S
variation residue
T
position
367
score
100.0
distance
32.94554
seq distance
84
chain
C
Confirmed at protein level; dbSNP:rs1063499.
original residue
S
variation residue
T
position
367
score
100.0
distance
32.94554
seq distance
84
chain
C
In C7D; dbSNP:rs369349760.
original residue
R
variation residue
Q
position
25
score
54.54545454545454
distance
35.99026
seq distance
False
chain
B
In C7D; dbSNP:rs369349760.
original residue
R
variation residue
Q
position
25
score
54.54545454545454
distance
35.99026
seq distance
False
chain
B
LDL-receptor class A
begin
61
end
99
score
100.0
distance
38.59131
seq distance
55
chain
C
LDL-receptor class A
begin
61
end
99
score
100.0
distance
38.59131
seq distance
55
chain
C
Disordered
begin
564
end
573
score
62.272727272727266
distance
41.75662
seq distance
False
chain
B
Disordered
begin
564
end
573
score
62.272727272727266
distance
41.75662
seq distance
False
chain
B
Disordered
begin
91
end
92
score
68.18181818181817
distance
46.674847
seq distance
False
chain
D
Disordered
begin
91
end
92
score
68.18181818181817
distance
46.674847
seq distance
False
chain
D
LDL-receptor class A
begin
84
end
92
score
56.56565656565656
distance
46.674847
seq distance
False
chain
D
LDL-receptor class A
begin
84
end
92
score
56.56565656565656
distance
46.674847
seq distance
False
chain
D
In dbSNP:rs75345202.
original residue
R
variation residue
H
position
414
score
54.54545454545454
distance
48.215897
seq distance
False
chain
E
In dbSNP:rs75345202.
original residue
R
variation residue
H
position
414
score
54.54545454545454
distance
48.215897
seq distance
False
chain
E
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
566
score
86.36363636363636
distance
48.42753
seq distance
False
chain
B
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
566
score
86.36363636363636
distance
48.42753
seq distance
False
chain
B
Sushi 1
begin
547
end
606
score
100.0
distance
49.095844
seq distance
96
chain
C
Sushi 1
begin
547
end
606
score
100.0
distance
49.095844
seq distance
96
chain
C
In dbSNP:rs2271708.
original residue
C
variation residue
R
position
106
score
100.0
distance
51.81832
seq distance
100
chain
C
In dbSNP:rs2271708.
original residue
C
variation residue
R
position
106
score
100.0
distance
51.81832
seq distance
100
chain
C
Disordered
begin
197
end
218
score
76.85950413223141
distance
53.608536
seq distance
191
chain
C
Disordered
begin
197
end
218
score
76.85950413223141
distance
53.608536
seq distance
191
chain
C
In dbSNP:rs2271708.
original residue
C
variation residue
R
position
532
score
54.54545454545454
distance
54.835365
seq distance
False
chain
E
In dbSNP:rs2271708.
original residue
C
variation residue
R
position
532
score
54.54545454545454
distance
54.835365
seq distance
False
chain
E
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
530
score
54.54545454545454
distance
55.629402
seq distance
False
chain
E
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
530
score
54.54545454545454
distance
55.629402
seq distance
False
chain
E
CCP 2
begin
594
end
671
score
100.0
distance
55.88239
seq distance
143
chain
C
CCP 2
begin
594
end
671
score
100.0
distance
55.88239
seq distance
143
chain
C
Confirmed at protein level; dbSNP:rs13157656.
original residue
T
variation residue
P
position
565
score
100.0
distance
57.49708
seq distance
114
chain
C
Confirmed at protein level; dbSNP:rs13157656.
original residue
T
variation residue
P
position
565
score
100.0
distance
57.49708
seq distance
114
chain
C
LDL-receptor class A
begin
83
end
95
score
50.87412587412587
distance
58.60731
seq distance
False
chain
E
LDL-receptor class A
begin
83
end
95
score
50.87412587412587
distance
58.60731
seq distance
False
chain
E
MACPF
begin
324
end
332
score
83.08080808080808
distance
63.683243
seq distance
False
chain
G
MACPF
begin
324
end
332
score
83.08080808080808
distance
63.683243
seq distance
False
chain
G
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
66.58412
seq distance
False
chain
G
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
66.58412
seq distance
False
chain
G
Disordered
begin
138
end
138
score
50.0
distance
73.38961
seq distance
False
chain
F
Disordered
begin
138
end
138
score
50.0
distance
73.38961
seq distance
False
chain
F
Confirmed at protein level; dbSNP:rs1063499.
original residue
S
variation residue
T
position
1040
score
54.54545454545454
distance
79.20232
seq distance
False
chain
A
Confirmed at protein level; dbSNP:rs1063499.
original residue
S
variation residue
T
position
1040
score
54.54545454545454
distance
79.20232
seq distance
False
chain
A
MACPF
begin
324
end
332
score
83.08080808080808
distance
84.372505
seq distance
False
chain
H
MACPF
begin
324
end
332
score
83.08080808080808
distance
84.372505
seq distance
False
chain
H
Sushi 2
begin
607
end
668
score
100.0
distance
85.55278
seq distance
156
chain
C
Sushi 2
begin
607
end
668
score
100.0
distance
85.55278
seq distance
156
chain
C
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
90.15724
seq distance
False
chain
H
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
90.15724
seq distance
False
chain
H
In C7D; dbSNP:rs369349760.
original residue
R
variation residue
Q
position
198
score
72.72727272727273
distance
92.581856
seq distance
192
chain
C
In C7D; dbSNP:rs369349760.
original residue
R
variation residue
Q
position
198
score
72.72727272727273
distance
92.581856
seq distance
192
chain
C
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
92.772224
seq distance
False
chain
G
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
92.772224
seq distance
False
chain
G
In dbSNP:rs75345202.
original residue
R
variation residue
H
position
200
score
72.72727272727273
distance
98.80885
seq distance
194
chain
C
In dbSNP:rs75345202.
original residue
R
variation residue
H
position
200
score
72.72727272727273
distance
98.80885
seq distance
194
chain
C
In C7D; dbSNP:rs541873000.
original residue
E
variation residue
Q
position
660
score
100.0
distance
99.18899
seq distance
209
chain
C
In C7D; dbSNP:rs541873000.
original residue
E
variation residue
Q
position
660
score
100.0
distance
99.18899
seq distance
209
chain
C
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
100.80971
seq distance
False
chain
G
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
100.80971
seq distance
False
chain
G
MACPF
begin
324
end
333
score
84.54545454545456
distance
102.829384
seq distance
False
chain
I
MACPF
begin
324
end
333
score
84.54545454545456
distance
102.829384
seq distance
False
chain
I
Confirmed at protein level; dbSNP:rs13157656.
original residue
T
variation residue
P
position
693
score
50.0
distance
107.82245
seq distance
False
chain
B
Confirmed at protein level; dbSNP:rs13157656.
original residue
T
variation residue
P
position
693
score
50.0
distance
107.82245
seq distance
False
chain
B
Disordered
begin
327
end
328
score
61.36363636363637
distance
108.935104
seq distance
False
chain
I
Disordered
begin
327
end
328
score
61.36363636363637
distance
108.935104
seq distance
False
chain
I
In C7D; dbSNP:rs113187203.
original residue
R
variation residue
H
position
665
score
100.0
distance
111.21515
seq distance
214
chain
C
In C7D; dbSNP:rs113187203.
original residue
R
variation residue
H
position
665
score
100.0
distance
111.21515
seq distance
214
chain
C
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
111.243706
seq distance
False
chain
I
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
111.243706
seq distance
False
chain
I
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
117.28864
seq distance
False
chain
H
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
117.28864
seq distance
False
chain
H
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
126.14185
seq distance
False
chain
H
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
126.14185
seq distance
False
chain
H
Factor I module (FIM) 1
begin
673
end
748
score
100.0
distance
133.29489
seq distance
222
chain
C
Factor I module (FIM) 1
begin
673
end
748
score
100.0
distance
133.29489
seq distance
222
chain
C
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
138.85297
seq distance
False
chain
I
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
138.85297
seq distance
False
chain
I
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
1560
score
50.0
distance
147.21188
seq distance
False
chain
A
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
1560
score
50.0
distance
147.21188
seq distance
False
chain
A
Factor I module (FIM) 2
begin
749
end
821
score
100.0
distance
158.16487
seq distance
298
chain
C
Factor I module (FIM) 2
begin
749
end
821
score
100.0
distance
158.16487
seq distance
298
chain
C

Details

Redox score
64.93
PDB code
7nyc
Structure name
cryoem structure of 3c9-smac
Structure deposition date
2021-03-22
Thiol separation (Å)
9
Half-sphere exposure sum
71
Minimum pKa
nan
% buried
nan
Peptide accession
P10643
Residue number A
28 (Residue 6 in this structure)
Residue number B
473 (Residue 451 in this structure)
Peptide name
Complement component C7
A redox-regulated disulphide may form within Complement component C7 at these cysteines. However, the redox score of this cysteine pair is lower than any known redox-active disulphide.

Relevent regions

TSP type-1 1
begin
27
end
80
score
99.83164983164983
distance
2.8017223
seq distance
0
chain
D
TSP type-1 1
begin
27
end
80
score
99.83164983164983
distance
2.8017223
seq distance
0
chain
D
MACPF
begin
124
end
456
score
98.9079989079989
distance
7.9496393
seq distance
45
chain
D
MACPF
begin
124
end
456
score
98.9079989079989
distance
7.9496393
seq distance
45
chain
D
CCP 1
begin
545
end
615
score
83.48271446862996
distance
12.9349985
seq distance
466
chain
D
CCP 1
begin
545
end
615
score
83.48271446862996
distance
12.9349985
seq distance
466
chain
D
LDL-receptor class A
begin
83
end
121
score
100.0
distance
14.255013
seq distance
4
chain
D
LDL-receptor class A
begin
83
end
121
score
100.0
distance
14.255013
seq distance
4
chain
D
TSP type-1 2
begin
500
end
549
score
100.0
distance
20.527573
seq distance
421
chain
D
TSP type-1 2
begin
500
end
549
score
100.0
distance
20.527573
seq distance
421
chain
D
Disordered
begin
108
end
143
score
100.0
distance
26.523146
seq distance
29
chain
D
Disordered
begin
108
end
143
score
100.0
distance
26.523146
seq distance
29
chain
D
EGF-like
begin
457
end
487
score
100.0
distance
27.276064
seq distance
378
chain
D
EGF-like
begin
457
end
487
score
100.0
distance
27.276064
seq distance
378
chain
D
Sushi 1
begin
572
end
628
score
99.04306220095694
distance
27.853014
seq distance
493
chain
D
Sushi 1
begin
572
end
628
score
99.04306220095694
distance
27.853014
seq distance
493
chain
D
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
412
score
63.63636363636363
distance
29.937197
seq distance
False
chain
C
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
412
score
63.63636363636363
distance
29.937197
seq distance
False
chain
C
LDL-receptor class A
begin
84
end
92
score
56.56565656565656
distance
30.457493
seq distance
False
chain
C
LDL-receptor class A
begin
84
end
92
score
56.56565656565656
distance
30.457493
seq distance
False
chain
C
Disordered
begin
504
end
504
score
68.18181818181817
distance
30.599499
seq distance
False
chain
C
Disordered
begin
504
end
504
score
68.18181818181817
distance
30.599499
seq distance
False
chain
C
Disordered
begin
516
end
538
score
100.0
distance
31.363056
seq distance
437
chain
D
Disordered
begin
516
end
538
score
100.0
distance
31.363056
seq distance
437
chain
D
Disordered
begin
91
end
92
score
68.18181818181817
distance
32.80958
seq distance
False
chain
C
Disordered
begin
91
end
92
score
68.18181818181817
distance
32.80958
seq distance
False
chain
C
Confirmed at protein level; dbSNP:rs13157656.
original residue
T
variation residue
P
position
587
score
100.0
distance
33.357956
seq distance
508
chain
D
Confirmed at protein level; dbSNP:rs13157656.
original residue
T
variation residue
P
position
587
score
100.0
distance
33.357956
seq distance
508
chain
D
CCP 2
begin
616
end
691
score
99.2822966507177
distance
35.45213
seq distance
537
chain
D
CCP 2
begin
616
end
691
score
99.2822966507177
distance
35.45213
seq distance
537
chain
D
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
521
score
100.0
distance
36.429207
seq distance
442
chain
D
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
521
score
100.0
distance
36.429207
seq distance
442
chain
D
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
420
score
100.0
distance
38.043858
seq distance
341
chain
D
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
420
score
100.0
distance
38.043858
seq distance
341
chain
D
LDL-receptor class A
begin
83
end
98
score
52.69886363636363
distance
45.416668
seq distance
False
chain
F
LDL-receptor class A
begin
83
end
98
score
52.69886363636363
distance
45.416668
seq distance
False
chain
F
EGF-like
begin
451
end
455
score
54.090909090909086
distance
46.32755
seq distance
False
chain
C
EGF-like
begin
451
end
455
score
54.090909090909086
distance
46.32755
seq distance
False
chain
C
In dbSNP:rs2271708.
original residue
C
variation residue
R
position
128
score
100.0
distance
46.44539
seq distance
49
chain
D
In dbSNP:rs2271708.
original residue
C
variation residue
R
position
128
score
100.0
distance
46.44539
seq distance
49
chain
D
Confirmed at protein level; dbSNP:rs1063499.
original residue
S
variation residue
T
position
389
score
100.0
distance
54.83163
seq distance
310
chain
D
Confirmed at protein level; dbSNP:rs1063499.
original residue
S
variation residue
T
position
389
score
100.0
distance
54.83163
seq distance
310
chain
D
Sushi 2
begin
629
end
690
score
99.56011730205279
distance
57.251286
seq distance
550
chain
D
Sushi 2
begin
629
end
690
score
99.56011730205279
distance
57.251286
seq distance
550
chain
D
Disordered
begin
41
end
41
score
70.45454545454545
distance
59.07035
seq distance
False
chain
B
Disordered
begin
41
end
41
score
70.45454545454545
distance
59.07035
seq distance
False
chain
B
Disordered
begin
585
end
589
score
50.90909090909091
distance
59.84596
seq distance
False
chain
B
Disordered
begin
585
end
589
score
50.90909090909091
distance
59.84596
seq distance
False
chain
B
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
587
score
68.18181818181817
distance
60.962616
seq distance
False
chain
B
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
587
score
68.18181818181817
distance
60.962616
seq distance
False
chain
B
In dbSNP:rs75345202.
original residue
R
variation residue
H
position
414
score
54.54545454545454
distance
62.901337
seq distance
False
chain
F
In dbSNP:rs75345202.
original residue
R
variation residue
H
position
414
score
54.54545454545454
distance
62.901337
seq distance
False
chain
F
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
66.47826
seq distance
False
chain
X
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
66.47826
seq distance
False
chain
X
TSP type-1 2
begin
512
end
517
score
80.30303030303031
distance
69.81311
seq distance
False
chain
F
TSP type-1 2
begin
512
end
517
score
80.30303030303031
distance
69.81311
seq distance
False
chain
F
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
71.728546
seq distance
False
chain
X
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
71.728546
seq distance
False
chain
X
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
73.30201
seq distance
False
chain
G
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
73.30201
seq distance
False
chain
G
In C7D; dbSNP:rs541873000.
original residue
E
variation residue
Q
position
682
score
100.0
distance
73.47239
seq distance
603
chain
D
In C7D; dbSNP:rs541873000.
original residue
E
variation residue
Q
position
682
score
100.0
distance
73.47239
seq distance
603
chain
D
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
31
score
50.0
distance
76.78802
seq distance
False
chain
F
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
31
score
50.0
distance
76.78802
seq distance
False
chain
F
Confirmed at protein level; dbSNP:rs1063499.
original residue
S
variation residue
T
position
1058
score
54.54545454545454
distance
80.51579
seq distance
False
chain
A
Confirmed at protein level; dbSNP:rs1063499.
original residue
S
variation residue
T
position
1058
score
54.54545454545454
distance
80.51579
seq distance
False
chain
A
Disordered
begin
138
end
138
score
50.0
distance
80.581314
seq distance
False
chain
E
Disordered
begin
138
end
138
score
50.0
distance
80.581314
seq distance
False
chain
E
In C7D; dbSNP:rs113187203.
original residue
R
variation residue
H
position
687
score
100.0
distance
83.879
seq distance
608
chain
D
In C7D; dbSNP:rs113187203.
original residue
R
variation residue
H
position
687
score
100.0
distance
83.879
seq distance
608
chain
D
Disordered
begin
219
end
240
score
100.0
distance
86.517334
seq distance
140
chain
D
Disordered
begin
219
end
240
score
100.0
distance
86.517334
seq distance
140
chain
D
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
91.44713
seq distance
False
chain
X
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
91.44713
seq distance
False
chain
X
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
92.83138
seq distance
False
chain
G
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
92.83138
seq distance
False
chain
G
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
96.55723
seq distance
False
chain
W
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
96.55723
seq distance
False
chain
W
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
96.67438
seq distance
False
chain
P
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
96.67438
seq distance
False
chain
P
Confirmed at protein level; dbSNP:rs13157656.
original residue
T
variation residue
P
position
714
score
50.0
distance
98.70755
seq distance
False
chain
B
Confirmed at protein level; dbSNP:rs13157656.
original residue
T
variation residue
P
position
714
score
50.0
distance
98.70755
seq distance
False
chain
B
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
99.43291
seq distance
False
chain
W
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
99.43291
seq distance
False
chain
W
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
103.50595
seq distance
False
chain
G
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
103.50595
seq distance
False
chain
G
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
113.19602
seq distance
False
chain
W
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
113.19602
seq distance
False
chain
W
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
118.79022
seq distance
False
chain
P
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
118.79022
seq distance
False
chain
P
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
119.106674
seq distance
False
chain
H
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
119.106674
seq distance
False
chain
H
In C7D; dbSNP:rs369349760.
original residue
R
variation residue
Q
position
220
score
100.0
distance
123.53208
seq distance
141
chain
D
In C7D; dbSNP:rs369349760.
original residue
R
variation residue
Q
position
220
score
100.0
distance
123.53208
seq distance
141
chain
D
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
124.0993
seq distance
False
chain
V
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
124.0993
seq distance
False
chain
V
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
125.42502
seq distance
False
chain
V
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
125.42502
seq distance
False
chain
V
In dbSNP:rs75345202.
original residue
R
variation residue
H
position
222
score
100.0
distance
129.62904
seq distance
143
chain
D
In dbSNP:rs75345202.
original residue
R
variation residue
H
position
222
score
100.0
distance
129.62904
seq distance
143
chain
D
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
129.798
seq distance
False
chain
P
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
129.798
seq distance
False
chain
P
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
130.06062
seq distance
False
chain
X
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
130.06062
seq distance
False
chain
X
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
134.08281
seq distance
False
chain
V
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
134.08281
seq distance
False
chain
V
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
135.47398
seq distance
False
chain
G
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
135.47398
seq distance
False
chain
G
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
139.56845
seq distance
False
chain
I
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
139.56845
seq distance
False
chain
I
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
139.8049
seq distance
False
chain
W
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
139.8049
seq distance
False
chain
W
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
142.72763
seq distance
False
chain
H
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
142.72763
seq distance
False
chain
H
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
149.15054
seq distance
False
chain
U
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
149.15054
seq distance
False
chain
U
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
149.26888
seq distance
False
chain
U
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
149.26888
seq distance
False
chain
U
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
149.97208
seq distance
False
chain
P
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
149.97208
seq distance
False
chain
P
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
152.14948
seq distance
False
chain
V
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
152.14948
seq distance
False
chain
V
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
153.15565
seq distance
False
chain
U
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
153.15565
seq distance
False
chain
U
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
154.03996
seq distance
False
chain
H
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
154.03996
seq distance
False
chain
H
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
157.7038
seq distance
False
chain
J
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
157.7038
seq distance
False
chain
J
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
163.96593
seq distance
False
chain
I
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
163.96593
seq distance
False
chain
I
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
164.77808
seq distance
False
chain
H
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
164.77808
seq distance
False
chain
H
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
165.71075
seq distance
False
chain
U
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
165.71075
seq distance
False
chain
U
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
169.623
seq distance
False
chain
T
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
169.623
seq distance
False
chain
T
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
170.28543
seq distance
False
chain
T
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
170.28543
seq distance
False
chain
T
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
172.08664
seq distance
False
chain
T
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
172.08664
seq distance
False
chain
T
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
173.11081
seq distance
False
chain
K
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
173.11081
seq distance
False
chain
K
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
175.39928
seq distance
False
chain
I
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
175.39928
seq distance
False
chain
I
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
178.42587
seq distance
False
chain
I
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
178.42587
seq distance
False
chain
I
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
178.81737
seq distance
False
chain
T
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
178.81737
seq distance
False
chain
T
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
182.22621
seq distance
False
chain
J
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
182.22621
seq distance
False
chain
J
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
182.90173
seq distance
False
chain
S
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
182.90173
seq distance
False
chain
S
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
185.43373
seq distance
False
chain
L
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
185.43373
seq distance
False
chain
L
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
187.96147
seq distance
False
chain
S
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
187.96147
seq distance
False
chain
S
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
189.97722
seq distance
False
chain
J
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
189.97722
seq distance
False
chain
J
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
190.48793
seq distance
False
chain
S
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
190.48793
seq distance
False
chain
S
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
191.48347
seq distance
False
chain
S
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
191.48347
seq distance
False
chain
S
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
192.71967
seq distance
False
chain
R
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
192.71967
seq distance
False
chain
R
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
193.63216
seq distance
False
chain
J
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
193.63216
seq distance
False
chain
J
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
194.35948
seq distance
False
chain
M
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
194.35948
seq distance
False
chain
M
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
197.11293
seq distance
False
chain
K
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
197.11293
seq distance
False
chain
K
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
198.90236
seq distance
False
chain
Q
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
198.90236
seq distance
False
chain
Q
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
199.4195
seq distance
False
chain
K
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
199.4195
seq distance
False
chain
K
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
199.67833
seq distance
False
chain
N
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
199.67833
seq distance
False
chain
N
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
199.78476
seq distance
False
chain
R
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
199.78476
seq distance
False
chain
R
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
201.24123
seq distance
False
chain
O
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
201.24123
seq distance
False
chain
O
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
201.88948
seq distance
False
chain
R
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
201.88948
seq distance
False
chain
R
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
206.50058
seq distance
False
chain
L
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
206.50058
seq distance
False
chain
L
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
206.75708
seq distance
False
chain
Q
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
206.75708
seq distance
False
chain
Q
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
207.08311
seq distance
False
chain
R
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
207.08311
seq distance
False
chain
R
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
208.31757
seq distance
False
chain
K
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
208.31757
seq distance
False
chain
K
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
208.33838
seq distance
False
chain
L
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
208.33838
seq distance
False
chain
L
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
210.79982
seq distance
False
chain
M
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
210.79982
seq distance
False
chain
M
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
211.04778
seq distance
False
chain
O
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
211.04778
seq distance
False
chain
O
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
211.7481
seq distance
False
chain
Q
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
211.7481
seq distance
False
chain
Q
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
212.20178
seq distance
False
chain
N
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
212.20178
seq distance
False
chain
N
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
215.53268
seq distance
False
chain
M
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
215.53268
seq distance
False
chain
M
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
217.3602
seq distance
False
chain
O
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
217.3602
seq distance
False
chain
O
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
218.57211
seq distance
False
chain
N
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
218.57211
seq distance
False
chain
N
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
218.5723
seq distance
False
chain
Q
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
218.5723
seq distance
False
chain
Q
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
219.14255
seq distance
False
chain
L
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
219.14255
seq distance
False
chain
L
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
225.69357
seq distance
False
chain
O
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
225.69357
seq distance
False
chain
O
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
225.79768
seq distance
False
chain
M
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
225.79768
seq distance
False
chain
M
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
228.10211
seq distance
False
chain
N
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
228.10211
seq distance
False
chain
N

Details

Redox score
64.75
PDB code
6h04
Structure name
closed conformation of the membrane attack complex
Structure deposition date
2018-07-06
Thiol separation (Å)
8.75
Half-sphere exposure sum
61
Minimum pKa
nan
% buried
nan
Peptide accession
P10643
Residue number A
39
Residue number B
79
Peptide name
Complement component C7
A redox-regulated disulphide may form within Complement component C7 at these cysteines. However, the redox score of this cysteine pair is lower than any known redox-active disulphide.

Relevent regions

LDL-receptor class A
begin
61
end
99
score
100.0
distance
2.757768
seq distance
0
chain
C
LDL-receptor class A
begin
61
end
99
score
100.0
distance
2.757768
seq distance
0
chain
C
Disordered
begin
86
end
121
score
100.0
distance
4.3414235
seq distance
17
chain
C
Disordered
begin
86
end
121
score
100.0
distance
4.3414235
seq distance
17
chain
C
MACPF
begin
102
end
434
score
94.85394485394487
distance
8.758229
seq distance
33
chain
C
MACPF
begin
102
end
434
score
94.85394485394487
distance
8.758229
seq distance
33
chain
C
LDL-receptor class A
begin
84
end
92
score
56.56565656565656
distance
12.3690605
seq distance
False
chain
D
LDL-receptor class A
begin
84
end
92
score
56.56565656565656
distance
12.3690605
seq distance
False
chain
D
TSP type-1 1
begin
5
end
58
score
99.83164983164983
distance
16.570862
seq distance
5
chain
C
TSP type-1 1
begin
5
end
58
score
99.83164983164983
distance
16.570862
seq distance
5
chain
C
Disordered
begin
91
end
92
score
68.18181818181817
distance
16.726353
seq distance
False
chain
D
Disordered
begin
91
end
92
score
68.18181818181817
distance
16.726353
seq distance
False
chain
D
CCP 1
begin
523
end
593
score
100.0
distance
19.655361
seq distance
454
chain
C
CCP 1
begin
523
end
593
score
100.0
distance
19.655361
seq distance
454
chain
C
In dbSNP:rs2271708.
original residue
C
variation residue
R
position
106
score
100.0
distance
20.837814
seq distance
37
chain
C
In dbSNP:rs2271708.
original residue
C
variation residue
R
position
106
score
100.0
distance
20.837814
seq distance
37
chain
C
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
412
score
63.63636363636363
distance
27.608892
seq distance
False
chain
D
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
412
score
63.63636363636363
distance
27.608892
seq distance
False
chain
D
TSP type-1 2
begin
478
end
527
score
100.0
distance
27.668177
seq distance
409
chain
C
TSP type-1 2
begin
478
end
527
score
100.0
distance
27.668177
seq distance
409
chain
C
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
398
score
100.0
distance
30.963488
seq distance
329
chain
C
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
398
score
100.0
distance
30.963488
seq distance
329
chain
C
In C7D; dbSNP:rs121964921.
original residue
G
variation residue
R
position
357
score
100.0
distance
32.251713
seq distance
288
chain
C
In C7D; dbSNP:rs121964921.
original residue
G
variation residue
R
position
357
score
100.0
distance
32.251713
seq distance
288
chain
C
LDL-receptor class A
begin
83
end
95
score
50.87412587412587
distance
32.97331
seq distance
False
chain
E
LDL-receptor class A
begin
83
end
95
score
50.87412587412587
distance
32.97331
seq distance
False
chain
E
EGF-like
begin
435
end
465
score
100.0
distance
35.278004
seq distance
366
chain
C
EGF-like
begin
435
end
465
score
100.0
distance
35.278004
seq distance
366
chain
C
Sushi 1
begin
547
end
606
score
100.0
distance
36.303062
seq distance
478
chain
C
Sushi 1
begin
547
end
606
score
100.0
distance
36.303062
seq distance
478
chain
C
Disordered
begin
494
end
516
score
100.0
distance
40.55257
seq distance
425
chain
C
Disordered
begin
494
end
516
score
100.0
distance
40.55257
seq distance
425
chain
C
Confirmed at protein level; dbSNP:rs1063499.
original residue
S
variation residue
T
position
367
score
100.0
distance
42.668194
seq distance
298
chain
C
Confirmed at protein level; dbSNP:rs1063499.
original residue
S
variation residue
T
position
367
score
100.0
distance
42.668194
seq distance
298
chain
C
Confirmed at protein level; dbSNP:rs13157656.
original residue
T
variation residue
P
position
565
score
100.0
distance
43.555374
seq distance
496
chain
C
Confirmed at protein level; dbSNP:rs13157656.
original residue
T
variation residue
P
position
565
score
100.0
distance
43.555374
seq distance
496
chain
C
CCP 2
begin
594
end
671
score
100.0
distance
44.135193
seq distance
525
chain
C
CCP 2
begin
594
end
671
score
100.0
distance
44.135193
seq distance
525
chain
C
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
499
score
100.0
distance
47.36704
seq distance
430
chain
C
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
499
score
100.0
distance
47.36704
seq distance
430
chain
C
In dbSNP:rs75345202.
original residue
R
variation residue
H
position
414
score
54.54545454545454
distance
47.809998
seq distance
False
chain
E
In dbSNP:rs75345202.
original residue
R
variation residue
H
position
414
score
54.54545454545454
distance
47.809998
seq distance
False
chain
E
Disordered
begin
504
end
504
score
68.18181818181817
distance
50.484154
seq distance
False
chain
D
Disordered
begin
504
end
504
score
68.18181818181817
distance
50.484154
seq distance
False
chain
D
EGF-like
begin
451
end
455
score
54.090909090909086
distance
51.135777
seq distance
False
chain
D
EGF-like
begin
451
end
455
score
54.090909090909086
distance
51.135777
seq distance
False
chain
D
Disordered
begin
510
end
522
score
53.67132867132868
distance
52.387966
seq distance
False
chain
D
Disordered
begin
510
end
522
score
53.67132867132868
distance
52.387966
seq distance
False
chain
D
Disordered
begin
564
end
573
score
62.272727272727266
distance
54.220146
seq distance
False
chain
B
Disordered
begin
564
end
573
score
62.272727272727266
distance
54.220146
seq distance
False
chain
B
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
566
score
86.36363636363636
distance
55.533157
seq distance
False
chain
B
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
566
score
86.36363636363636
distance
55.533157
seq distance
False
chain
B
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
512
score
81.81818181818183
distance
55.985012
seq distance
False
chain
D
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
512
score
81.81818181818183
distance
55.985012
seq distance
False
chain
D
MACPF
begin
324
end
332
score
83.08080808080808
distance
57.742043
seq distance
False
chain
G
MACPF
begin
324
end
332
score
83.08080808080808
distance
57.742043
seq distance
False
chain
G
Sushi 2
begin
607
end
668
score
100.0
distance
58.577534
seq distance
538
chain
C
Sushi 2
begin
607
end
668
score
100.0
distance
58.577534
seq distance
538
chain
C
Disordered
begin
138
end
138
score
50.0
distance
60.148308
seq distance
False
chain
F
Disordered
begin
138
end
138
score
50.0
distance
60.148308
seq distance
False
chain
F
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
62.49762
seq distance
False
chain
G
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
62.49762
seq distance
False
chain
G
In C7D; dbSNP:rs541873000.
original residue
E
variation residue
Q
position
660
score
100.0
distance
68.93691
seq distance
591
chain
C
In C7D; dbSNP:rs541873000.
original residue
E
variation residue
Q
position
660
score
100.0
distance
68.93691
seq distance
591
chain
C
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
530
score
54.54545454545454
distance
69.36849
seq distance
False
chain
E
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
530
score
54.54545454545454
distance
69.36849
seq distance
False
chain
E
In C7D; dbSNP:rs369349760.
original residue
R
variation residue
Q
position
25
score
54.54545454545454
distance
69.71424
seq distance
False
chain
B
In C7D; dbSNP:rs369349760.
original residue
R
variation residue
Q
position
25
score
54.54545454545454
distance
69.71424
seq distance
False
chain
B
In dbSNP:rs2271708.
original residue
C
variation residue
R
position
532
score
54.54545454545454
distance
70.07314
seq distance
False
chain
E
In dbSNP:rs2271708.
original residue
C
variation residue
R
position
532
score
54.54545454545454
distance
70.07314
seq distance
False
chain
E
Confirmed at protein level; dbSNP:rs1063499.
original residue
S
variation residue
T
position
1040
score
54.54545454545454
distance
74.11725
seq distance
False
chain
A
Confirmed at protein level; dbSNP:rs1063499.
original residue
S
variation residue
T
position
1040
score
54.54545454545454
distance
74.11725
seq distance
False
chain
A
MACPF
begin
324
end
332
score
83.08080808080808
distance
76.23648
seq distance
False
chain
H
MACPF
begin
324
end
332
score
83.08080808080808
distance
76.23648
seq distance
False
chain
H
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
81.67362
seq distance
False
chain
G
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
81.67362
seq distance
False
chain
G
In C7D; dbSNP:rs113187203.
original residue
R
variation residue
H
position
665
score
100.0
distance
82.50409
seq distance
596
chain
C
In C7D; dbSNP:rs113187203.
original residue
R
variation residue
H
position
665
score
100.0
distance
82.50409
seq distance
596
chain
C
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
82.613235
seq distance
False
chain
H
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
82.613235
seq distance
False
chain
H
Disordered
begin
197
end
218
score
76.85950413223141
distance
85.66048
seq distance
128
chain
C
Disordered
begin
197
end
218
score
76.85950413223141
distance
85.66048
seq distance
128
chain
C
Confirmed at protein level; dbSNP:rs13157656.
original residue
T
variation residue
P
position
693
score
50.0
distance
86.383766
seq distance
False
chain
B
Confirmed at protein level; dbSNP:rs13157656.
original residue
T
variation residue
P
position
693
score
50.0
distance
86.383766
seq distance
False
chain
B
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
91.581696
seq distance
False
chain
G
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
91.581696
seq distance
False
chain
G
MACPF
begin
324
end
333
score
84.54545454545456
distance
93.642136
seq distance
False
chain
I
MACPF
begin
324
end
333
score
84.54545454545456
distance
93.642136
seq distance
False
chain
I
Disordered
begin
327
end
328
score
61.36363636363637
distance
98.3066
seq distance
False
chain
I
Disordered
begin
327
end
328
score
61.36363636363637
distance
98.3066
seq distance
False
chain
I
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
102.33391
seq distance
False
chain
I
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
102.33391
seq distance
False
chain
I
Factor I module (FIM) 1
begin
673
end
748
score
100.0
distance
103.30091
seq distance
604
chain
C
Factor I module (FIM) 1
begin
673
end
748
score
100.0
distance
103.30091
seq distance
604
chain
C
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
104.04583
seq distance
False
chain
H
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
104.04583
seq distance
False
chain
H
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
1560
score
50.0
distance
110.66222
seq distance
False
chain
A
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
1560
score
50.0
distance
110.66222
seq distance
False
chain
A
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
113.95088
seq distance
False
chain
H
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
113.95088
seq distance
False
chain
H
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
124.10994
seq distance
False
chain
I
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
124.10994
seq distance
False
chain
I
Factor I module (FIM) 2
begin
749
end
821
score
100.0
distance
126.49324
seq distance
680
chain
C
Factor I module (FIM) 2
begin
749
end
821
score
100.0
distance
126.49324
seq distance
680
chain
C
In C7D; dbSNP:rs369349760.
original residue
R
variation residue
Q
position
198
score
72.72727272727273
distance
127.936035
seq distance
129
chain
C
In C7D; dbSNP:rs369349760.
original residue
R
variation residue
Q
position
198
score
72.72727272727273
distance
127.936035
seq distance
129
chain
C
In dbSNP:rs75345202.
original residue
R
variation residue
H
position
200
score
72.72727272727273
distance
134.57964
seq distance
131
chain
C
In dbSNP:rs75345202.
original residue
R
variation residue
H
position
200
score
72.72727272727273
distance
134.57964
seq distance
131
chain
C

Details

Redox score
64.36
PDB code
7nyc
Structure name
cryoem structure of 3c9-smac
Structure deposition date
2021-03-22
Thiol separation (Å)
9.11
Half-sphere exposure sum
67
Minimum pKa
nan
% buried
nan
Peptide accession
P10643
Residue number A
85 (Residue 63 in this structure)
Residue number B
91 (Residue 69 in this structure)
Peptide name
Complement component C7
A redox-regulated disulphide may form within Complement component C7 at these cysteines. However, the redox score of this cysteine pair is lower than any known redox-active disulphide.

Relevent regions

LDL-receptor class A
begin
83
end
121
score
100.0
distance
2.8071914
seq distance
0
chain
D
LDL-receptor class A
begin
83
end
121
score
100.0
distance
2.8071914
seq distance
0
chain
D
Disordered
begin
108
end
143
score
100.0
distance
2.8195877
seq distance
0
chain
D
Disordered
begin
108
end
143
score
100.0
distance
2.8195877
seq distance
0
chain
D
MACPF
begin
124
end
456
score
98.9079989079989
distance
8.401839
seq distance
15
chain
D
MACPF
begin
124
end
456
score
98.9079989079989
distance
8.401839
seq distance
15
chain
D
LDL-receptor class A
begin
84
end
92
score
56.56565656565656
distance
13.921476
seq distance
False
chain
C
LDL-receptor class A
begin
84
end
92
score
56.56565656565656
distance
13.921476
seq distance
False
chain
C
TSP type-1 1
begin
27
end
80
score
99.83164983164983
distance
16.139687
seq distance
16
chain
D
TSP type-1 1
begin
27
end
80
score
99.83164983164983
distance
16.139687
seq distance
16
chain
D
Disordered
begin
91
end
92
score
68.18181818181817
distance
18.861853
seq distance
False
chain
C
Disordered
begin
91
end
92
score
68.18181818181817
distance
18.861853
seq distance
False
chain
C
In dbSNP:rs2271708.
original residue
C
variation residue
R
position
128
score
100.0
distance
21.112877
seq distance
19
chain
D
In dbSNP:rs2271708.
original residue
C
variation residue
R
position
128
score
100.0
distance
21.112877
seq distance
19
chain
D
CCP 1
begin
545
end
615
score
83.48271446862996
distance
21.4108
seq distance
436
chain
D
CCP 1
begin
545
end
615
score
83.48271446862996
distance
21.4108
seq distance
436
chain
D
TSP type-1 2
begin
500
end
549
score
100.0
distance
28.518593
seq distance
391
chain
D
TSP type-1 2
begin
500
end
549
score
100.0
distance
28.518593
seq distance
391
chain
D
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
412
score
63.63636363636363
distance
28.958422
seq distance
False
chain
C
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
412
score
63.63636363636363
distance
28.958422
seq distance
False
chain
C
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
420
score
100.0
distance
29.059496
seq distance
311
chain
D
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
420
score
100.0
distance
29.059496
seq distance
311
chain
D
Sushi 1
begin
572
end
628
score
99.04306220095694
distance
35.912273
seq distance
463
chain
D
Sushi 1
begin
572
end
628
score
99.04306220095694
distance
35.912273
seq distance
463
chain
D
EGF-like
begin
457
end
487
score
100.0
distance
36.09064
seq distance
348
chain
D
EGF-like
begin
457
end
487
score
100.0
distance
36.09064
seq distance
348
chain
D
LDL-receptor class A
begin
83
end
98
score
52.69886363636363
distance
37.05589
seq distance
False
chain
F
LDL-receptor class A
begin
83
end
98
score
52.69886363636363
distance
37.05589
seq distance
False
chain
F
Disordered
begin
516
end
538
score
100.0
distance
41.139782
seq distance
407
chain
D
Disordered
begin
516
end
538
score
100.0
distance
41.139782
seq distance
407
chain
D
Confirmed at protein level; dbSNP:rs1063499.
original residue
S
variation residue
T
position
389
score
100.0
distance
43.24064
seq distance
280
chain
D
Confirmed at protein level; dbSNP:rs1063499.
original residue
S
variation residue
T
position
389
score
100.0
distance
43.24064
seq distance
280
chain
D
CCP 2
begin
616
end
691
score
99.2822966507177
distance
44.521667
seq distance
507
chain
D
CCP 2
begin
616
end
691
score
99.2822966507177
distance
44.521667
seq distance
507
chain
D
Confirmed at protein level; dbSNP:rs13157656.
original residue
T
variation residue
P
position
587
score
100.0
distance
44.699226
seq distance
478
chain
D
Confirmed at protein level; dbSNP:rs13157656.
original residue
T
variation residue
P
position
587
score
100.0
distance
44.699226
seq distance
478
chain
D
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
521
score
100.0
distance
46.38438
seq distance
412
chain
D
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
521
score
100.0
distance
46.38438
seq distance
412
chain
D
In dbSNP:rs75345202.
original residue
R
variation residue
H
position
414
score
54.54545454545454
distance
48.144688
seq distance
False
chain
F
In dbSNP:rs75345202.
original residue
R
variation residue
H
position
414
score
54.54545454545454
distance
48.144688
seq distance
False
chain
F
Disordered
begin
585
end
589
score
50.90909090909091
distance
53.411446
seq distance
False
chain
B
Disordered
begin
585
end
589
score
50.90909090909091
distance
53.411446
seq distance
False
chain
B
EGF-like
begin
451
end
455
score
54.090909090909086
distance
53.99988
seq distance
False
chain
C
EGF-like
begin
451
end
455
score
54.090909090909086
distance
53.99988
seq distance
False
chain
C
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
587
score
68.18181818181817
distance
54.70882
seq distance
False
chain
B
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
587
score
68.18181818181817
distance
54.70882
seq distance
False
chain
B
Disordered
begin
504
end
504
score
68.18181818181817
distance
54.74447
seq distance
False
chain
C
Disordered
begin
504
end
504
score
68.18181818181817
distance
54.74447
seq distance
False
chain
C
Disordered
begin
138
end
138
score
50.0
distance
56.77306
seq distance
False
chain
E
Disordered
begin
138
end
138
score
50.0
distance
56.77306
seq distance
False
chain
E
Disordered
begin
41
end
41
score
70.45454545454545
distance
58.981544
seq distance
False
chain
B
Disordered
begin
41
end
41
score
70.45454545454545
distance
58.981544
seq distance
False
chain
B
Sushi 2
begin
629
end
690
score
99.56011730205279
distance
59.18024
seq distance
520
chain
D
Sushi 2
begin
629
end
690
score
99.56011730205279
distance
59.18024
seq distance
520
chain
D
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
65.7578
seq distance
False
chain
G
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
65.7578
seq distance
False
chain
G
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
68.8456
seq distance
False
chain
X
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
68.8456
seq distance
False
chain
X
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
69.67851
seq distance
False
chain
X
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
69.67851
seq distance
False
chain
X
In C7D; dbSNP:rs541873000.
original residue
E
variation residue
Q
position
682
score
100.0
distance
73.25477
seq distance
573
chain
D
In C7D; dbSNP:rs541873000.
original residue
E
variation residue
Q
position
682
score
100.0
distance
73.25477
seq distance
573
chain
D
TSP type-1 2
begin
512
end
517
score
80.30303030303031
distance
73.75797
seq distance
False
chain
F
TSP type-1 2
begin
512
end
517
score
80.30303030303031
distance
73.75797
seq distance
False
chain
F
Confirmed at protein level; dbSNP:rs1063499.
original residue
S
variation residue
T
position
1058
score
54.54545454545454
distance
75.26886
seq distance
False
chain
A
Confirmed at protein level; dbSNP:rs1063499.
original residue
S
variation residue
T
position
1058
score
54.54545454545454
distance
75.26886
seq distance
False
chain
A
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
31
score
50.0
distance
76.43301
seq distance
False
chain
F
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
31
score
50.0
distance
76.43301
seq distance
False
chain
F
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
82.77908
seq distance
False
chain
X
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
82.77908
seq distance
False
chain
X
In C7D; dbSNP:rs113187203.
original residue
R
variation residue
H
position
687
score
100.0
distance
83.138985
seq distance
578
chain
D
In C7D; dbSNP:rs113187203.
original residue
R
variation residue
H
position
687
score
100.0
distance
83.138985
seq distance
578
chain
D
Disordered
begin
219
end
240
score
100.0
distance
84.93689
seq distance
110
chain
D
Disordered
begin
219
end
240
score
100.0
distance
84.93689
seq distance
110
chain
D
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
85.76481
seq distance
False
chain
P
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
85.76481
seq distance
False
chain
P
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
86.2522
seq distance
False
chain
G
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
86.2522
seq distance
False
chain
G
Confirmed at protein level; dbSNP:rs13157656.
original residue
T
variation residue
P
position
714
score
50.0
distance
87.25461
seq distance
False
chain
B
Confirmed at protein level; dbSNP:rs13157656.
original residue
T
variation residue
P
position
714
score
50.0
distance
87.25461
seq distance
False
chain
B
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
92.11372
seq distance
False
chain
W
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
92.11372
seq distance
False
chain
W
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
92.65043
seq distance
False
chain
W
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
92.65043
seq distance
False
chain
W
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
98.00616
seq distance
False
chain
G
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
98.00616
seq distance
False
chain
G
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
101.44372
seq distance
False
chain
W
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
101.44372
seq distance
False
chain
W
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
105.17166
seq distance
False
chain
H
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
105.17166
seq distance
False
chain
H
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
107.9416
seq distance
False
chain
P
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
107.9416
seq distance
False
chain
P
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
114.48764
seq distance
False
chain
V
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
114.48764
seq distance
False
chain
V
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
115.90324
seq distance
False
chain
V
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
115.90324
seq distance
False
chain
V
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
119.425995
seq distance
False
chain
V
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
119.425995
seq distance
False
chain
V
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
119.62219
seq distance
False
chain
P
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
119.62219
seq distance
False
chain
P
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
122.954124
seq distance
False
chain
I
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
122.954124
seq distance
False
chain
I
In C7D; dbSNP:rs369349760.
original residue
R
variation residue
Q
position
220
score
100.0
distance
125.93419
seq distance
111
chain
D
In C7D; dbSNP:rs369349760.
original residue
R
variation residue
Q
position
220
score
100.0
distance
125.93419
seq distance
111
chain
D
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
128.27806
seq distance
False
chain
H
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
128.27806
seq distance
False
chain
H
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
130.01164
seq distance
False
chain
X
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
130.01164
seq distance
False
chain
X
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
131.19922
seq distance
False
chain
G
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
131.19922
seq distance
False
chain
G
In dbSNP:rs75345202.
original residue
R
variation residue
H
position
222
score
100.0
distance
132.50764
seq distance
113
chain
D
In dbSNP:rs75345202.
original residue
R
variation residue
H
position
222
score
100.0
distance
132.50764
seq distance
113
chain
D
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
134.56183
seq distance
False
chain
U
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
134.56183
seq distance
False
chain
U
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
135.88132
seq distance
False
chain
U
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
135.88132
seq distance
False
chain
U
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
136.96484
seq distance
False
chain
U
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
136.96484
seq distance
False
chain
U
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
137.44514
seq distance
False
chain
W
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
137.44514
seq distance
False
chain
W
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
138.78247
seq distance
False
chain
J
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
138.78247
seq distance
False
chain
J
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
139.97292
seq distance
False
chain
H
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
139.97292
seq distance
False
chain
H
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
142.32332
seq distance
False
chain
P
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
142.32332
seq distance
False
chain
P
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
146.47185
seq distance
False
chain
I
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
146.47185
seq distance
False
chain
I
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
146.82303
seq distance
False
chain
V
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
146.82303
seq distance
False
chain
V
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
150.08264
seq distance
False
chain
T
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
150.08264
seq distance
False
chain
T
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
152.26784
seq distance
False
chain
K
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
152.26784
seq distance
False
chain
K
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
152.57748
seq distance
False
chain
T
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
152.57748
seq distance
False
chain
T
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
153.84068
seq distance
False
chain
H
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
153.84068
seq distance
False
chain
H
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
156.14648
seq distance
False
chain
T
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
156.14648
seq distance
False
chain
T
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
157.20737
seq distance
False
chain
U
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
157.20737
seq distance
False
chain
U
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
158.09445
seq distance
False
chain
I
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
158.09445
seq distance
False
chain
I
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
161.52798
seq distance
False
chain
S
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
161.52798
seq distance
False
chain
S
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
162.20734
seq distance
False
chain
J
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
162.20734
seq distance
False
chain
J
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
163.09
seq distance
False
chain
L
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
163.09
seq distance
False
chain
L
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
164.61046
seq distance
False
chain
I
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
164.61046
seq distance
False
chain
I
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
167.30913
seq distance
False
chain
T
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
167.30913
seq distance
False
chain
T
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
167.69565
seq distance
False
chain
S
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
167.69565
seq distance
False
chain
S
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
169.96455
seq distance
False
chain
R
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
169.96455
seq distance
False
chain
R
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
170.9659
seq distance
False
chain
M
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
170.9659
seq distance
False
chain
M
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
172.55692
seq distance
False
chain
S
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
172.55692
seq distance
False
chain
S
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
173.68163
seq distance
False
chain
J
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
173.68163
seq distance
False
chain
J
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
174.10037
seq distance
False
chain
J
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
174.10037
seq distance
False
chain
J
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
175.0846
seq distance
False
chain
K
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
175.0846
seq distance
False
chain
K
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
175.24532
seq distance
False
chain
Q
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
175.24532
seq distance
False
chain
Q
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
175.70834
seq distance
False
chain
N
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
175.70834
seq distance
False
chain
N
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
176.35744
seq distance
False
chain
S
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
176.35744
seq distance
False
chain
S
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
177.1801
seq distance
False
chain
O
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
177.1801
seq distance
False
chain
O
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
179.62912
seq distance
False
chain
R
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
179.62912
seq distance
False
chain
R
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
182.15259
seq distance
False
chain
K
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
182.15259
seq distance
False
chain
K
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
183.86095
seq distance
False
chain
R
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
183.86095
seq distance
False
chain
R
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
184.84392
seq distance
False
chain
L
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
184.84392
seq distance
False
chain
L
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
185.80556
seq distance
False
chain
R
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
185.80556
seq distance
False
chain
R
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
186.29291
seq distance
False
chain
K
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
186.29291
seq distance
False
chain
K
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
188.06778
seq distance
False
chain
Q
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
188.06778
seq distance
False
chain
Q
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
188.3154
seq distance
False
chain
L
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
188.3154
seq distance
False
chain
L
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
189.49103
seq distance
False
chain
Q
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
189.49103
seq distance
False
chain
Q
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
191.12431
seq distance
False
chain
M
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
191.12431
seq distance
False
chain
M
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
192.22182
seq distance
False
chain
M
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
192.22182
seq distance
False
chain
M
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
192.85153
seq distance
False
chain
O
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
192.85153
seq distance
False
chain
O
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
192.90959
seq distance
False
chain
O
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
192.90959
seq distance
False
chain
O
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
193.58197
seq distance
False
chain
N
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
193.58197
seq distance
False
chain
N
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
193.82417
seq distance
False
chain
N
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
193.82417
seq distance
False
chain
N
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
195.56978
seq distance
False
chain
Q
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
195.56978
seq distance
False
chain
Q
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
195.65276
seq distance
False
chain
L
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
195.65276
seq distance
False
chain
L
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
201.4485
seq distance
False
chain
M
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
201.4485
seq distance
False
chain
M
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
201.6084
seq distance
False
chain
O
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
201.6084
seq distance
False
chain
O
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
203.50763
seq distance
False
chain
N
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
203.50763
seq distance
False
chain
N

Details

Redox score
64.24
PDB code
6h04
Structure name
closed conformation of the membrane attack complex
Structure deposition date
2018-07-06
Thiol separation (Å)
8.46
Half-sphere exposure sum
79
Minimum pKa
nan
% buried
nan
Peptide accession
P10643
Residue number A
96
Residue number B
109
Peptide name
Complement component C7
A redox-regulated disulphide may form within Complement component C7 at these cysteines. However, the redox score of this cysteine pair is lower than any known redox-active disulphide.

Relevent regions

TSP type-1 1
begin
5
end
58
score
99.83164983164983
distance
2.7930448
seq distance
0
chain
C
TSP type-1 1
begin
5
end
58
score
99.83164983164983
distance
2.7930448
seq distance
0
chain
C
MACPF
begin
102
end
434
score
94.85394485394487
distance
2.8307612
seq distance
0
chain
C
MACPF
begin
102
end
434
score
94.85394485394487
distance
2.8307612
seq distance
0
chain
C
CCP 1
begin
523
end
593
score
100.0
distance
3.6411123
seq distance
112
chain
C
CCP 1
begin
523
end
593
score
100.0
distance
3.6411123
seq distance
112
chain
C
LDL-receptor class A
begin
61
end
99
score
100.0
distance
10.901575
seq distance
41
chain
C
LDL-receptor class A
begin
61
end
99
score
100.0
distance
10.901575
seq distance
41
chain
C
TSP type-1 2
begin
478
end
527
score
100.0
distance
13.151399
seq distance
67
chain
C
TSP type-1 2
begin
478
end
527
score
100.0
distance
13.151399
seq distance
67
chain
C
Disordered
begin
86
end
121
score
100.0
distance
24.205952
seq distance
66
chain
C
Disordered
begin
86
end
121
score
100.0
distance
24.205952
seq distance
66
chain
C
Sushi 1
begin
547
end
606
score
100.0
distance
25.595417
seq distance
136
chain
C
Sushi 1
begin
547
end
606
score
100.0
distance
25.595417
seq distance
136
chain
C
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
412
score
63.63636363636363
distance
27.050196
seq distance
False
chain
D
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
412
score
63.63636363636363
distance
27.050196
seq distance
False
chain
D
Disordered
begin
494
end
516
score
100.0
distance
27.059101
seq distance
83
chain
C
Disordered
begin
494
end
516
score
100.0
distance
27.059101
seq distance
83
chain
C
EGF-like
begin
435
end
465
score
100.0
distance
27.234606
seq distance
24
chain
C
EGF-like
begin
435
end
465
score
100.0
distance
27.234606
seq distance
24
chain
C
LDL-receptor class A
begin
84
end
92
score
56.56565656565656
distance
28.995426
seq distance
False
chain
D
LDL-receptor class A
begin
84
end
92
score
56.56565656565656
distance
28.995426
seq distance
False
chain
D
Disordered
begin
91
end
92
score
68.18181818181817
distance
30.650164
seq distance
False
chain
D
Disordered
begin
91
end
92
score
68.18181818181817
distance
30.650164
seq distance
False
chain
D
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
398
score
100.0
distance
30.764166
seq distance
13
chain
C
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
398
score
100.0
distance
30.764166
seq distance
13
chain
C
CCP 2
begin
594
end
671
score
100.0
distance
31.546877
seq distance
183
chain
C
CCP 2
begin
594
end
671
score
100.0
distance
31.546877
seq distance
183
chain
C
Confirmed at protein level; dbSNP:rs13157656.
original residue
T
variation residue
P
position
565
score
100.0
distance
32.55497
seq distance
154
chain
C
Confirmed at protein level; dbSNP:rs13157656.
original residue
T
variation residue
P
position
565
score
100.0
distance
32.55497
seq distance
154
chain
C
Disordered
begin
504
end
504
score
68.18181818181817
distance
32.82318
seq distance
False
chain
D
Disordered
begin
504
end
504
score
68.18181818181817
distance
32.82318
seq distance
False
chain
D
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
499
score
100.0
distance
35.895897
seq distance
88
chain
C
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
499
score
100.0
distance
35.895897
seq distance
88
chain
C
In dbSNP:rs2271708.
original residue
C
variation residue
R
position
106
score
100.0
distance
39.38075
seq distance
86
chain
C
In dbSNP:rs2271708.
original residue
C
variation residue
R
position
106
score
100.0
distance
39.38075
seq distance
86
chain
C
In C7D; dbSNP:rs121964921.
original residue
G
variation residue
R
position
357
score
100.0
distance
41.965195
seq distance
54
chain
C
In C7D; dbSNP:rs121964921.
original residue
G
variation residue
R
position
357
score
100.0
distance
41.965195
seq distance
54
chain
C
Disordered
begin
510
end
522
score
53.67132867132868
distance
42.6399
seq distance
False
chain
D
Disordered
begin
510
end
522
score
53.67132867132868
distance
42.6399
seq distance
False
chain
D
LDL-receptor class A
begin
83
end
95
score
50.87412587412587
distance
45.101166
seq distance
False
chain
E
LDL-receptor class A
begin
83
end
95
score
50.87412587412587
distance
45.101166
seq distance
False
chain
E
EGF-like
begin
451
end
455
score
54.090909090909086
distance
46.868824
seq distance
False
chain
D
EGF-like
begin
451
end
455
score
54.090909090909086
distance
46.868824
seq distance
False
chain
D
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
512
score
81.81818181818183
distance
48.454334
seq distance
False
chain
D
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
512
score
81.81818181818183
distance
48.454334
seq distance
False
chain
D
Disordered
begin
564
end
573
score
62.272727272727266
distance
50.233944
seq distance
False
chain
B
Disordered
begin
564
end
573
score
62.272727272727266
distance
50.233944
seq distance
False
chain
B
Confirmed at protein level; dbSNP:rs1063499.
original residue
S
variation residue
T
position
367
score
100.0
distance
51.12728
seq distance
44
chain
C
Confirmed at protein level; dbSNP:rs1063499.
original residue
S
variation residue
T
position
367
score
100.0
distance
51.12728
seq distance
44
chain
C
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
566
score
86.36363636363636
distance
51.73646
seq distance
False
chain
B
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
566
score
86.36363636363636
distance
51.73646
seq distance
False
chain
B
Sushi 2
begin
607
end
668
score
100.0
distance
54.444492
seq distance
196
chain
C
Sushi 2
begin
607
end
668
score
100.0
distance
54.444492
seq distance
196
chain
C
In dbSNP:rs75345202.
original residue
R
variation residue
H
position
414
score
54.54545454545454
distance
59.410484
seq distance
False
chain
E
In dbSNP:rs75345202.
original residue
R
variation residue
H
position
414
score
54.54545454545454
distance
59.410484
seq distance
False
chain
E
In C7D; dbSNP:rs369349760.
original residue
R
variation residue
Q
position
25
score
54.54545454545454
distance
66.39899
seq distance
False
chain
B
In C7D; dbSNP:rs369349760.
original residue
R
variation residue
Q
position
25
score
54.54545454545454
distance
66.39899
seq distance
False
chain
B
In C7D; dbSNP:rs541873000.
original residue
E
variation residue
Q
position
660
score
100.0
distance
67.07609
seq distance
249
chain
C
In C7D; dbSNP:rs541873000.
original residue
E
variation residue
Q
position
660
score
100.0
distance
67.07609
seq distance
249
chain
C
MACPF
begin
324
end
332
score
83.08080808080808
distance
67.281494
seq distance
False
chain
G
MACPF
begin
324
end
332
score
83.08080808080808
distance
67.281494
seq distance
False
chain
G
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
530
score
54.54545454545454
distance
68.28101
seq distance
False
chain
E
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
530
score
54.54545454545454
distance
68.28101
seq distance
False
chain
E
Confirmed at protein level; dbSNP:rs1063499.
original residue
S
variation residue
T
position
1040
score
54.54545454545454
distance
69.04426
seq distance
False
chain
A
Confirmed at protein level; dbSNP:rs1063499.
original residue
S
variation residue
T
position
1040
score
54.54545454545454
distance
69.04426
seq distance
False
chain
A
In dbSNP:rs2271708.
original residue
C
variation residue
R
position
532
score
54.54545454545454
distance
69.712814
seq distance
False
chain
E
In dbSNP:rs2271708.
original residue
C
variation residue
R
position
532
score
54.54545454545454
distance
69.712814
seq distance
False
chain
E
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
70.44338
seq distance
False
chain
G
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
70.44338
seq distance
False
chain
G
Disordered
begin
138
end
138
score
50.0
distance
77.678276
seq distance
False
chain
F
Disordered
begin
138
end
138
score
50.0
distance
77.678276
seq distance
False
chain
F
In C7D; dbSNP:rs113187203.
original residue
R
variation residue
H
position
665
score
100.0
distance
79.96681
seq distance
254
chain
C
In C7D; dbSNP:rs113187203.
original residue
R
variation residue
H
position
665
score
100.0
distance
79.96681
seq distance
254
chain
C
Disordered
begin
197
end
218
score
76.85950413223141
distance
86.48026
seq distance
177
chain
C
Disordered
begin
197
end
218
score
76.85950413223141
distance
86.48026
seq distance
177
chain
C
MACPF
begin
324
end
332
score
83.08080808080808
distance
89.12244
seq distance
False
chain
H
MACPF
begin
324
end
332
score
83.08080808080808
distance
89.12244
seq distance
False
chain
H
Confirmed at protein level; dbSNP:rs13157656.
original residue
T
variation residue
P
position
693
score
50.0
distance
89.567245
seq distance
False
chain
B
Confirmed at protein level; dbSNP:rs13157656.
original residue
T
variation residue
P
position
693
score
50.0
distance
89.567245
seq distance
False
chain
B
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
90.81424
seq distance
False
chain
G
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
90.81424
seq distance
False
chain
G
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
93.92531
seq distance
False
chain
H
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
93.92531
seq distance
False
chain
H
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
100.09411
seq distance
False
chain
G
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
100.09411
seq distance
False
chain
G
Factor I module (FIM) 1
begin
673
end
748
score
100.0
distance
101.822426
seq distance
262
chain
C
Factor I module (FIM) 1
begin
673
end
748
score
100.0
distance
101.822426
seq distance
262
chain
C
MACPF
begin
324
end
333
score
84.54545454545456
distance
108.911804
seq distance
False
chain
I
MACPF
begin
324
end
333
score
84.54545454545456
distance
108.911804
seq distance
False
chain
I
Disordered
begin
327
end
328
score
61.36363636363637
distance
112.70558
seq distance
False
chain
I
Disordered
begin
327
end
328
score
61.36363636363637
distance
112.70558
seq distance
False
chain
I
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
1560
score
50.0
distance
114.47444
seq distance
False
chain
A
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
1560
score
50.0
distance
114.47444
seq distance
False
chain
A
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
116.21342
seq distance
False
chain
I
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
116.21342
seq distance
False
chain
I
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
116.7703
seq distance
False
chain
H
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
116.7703
seq distance
False
chain
H
Factor I module (FIM) 2
begin
749
end
821
score
100.0
distance
126.090164
seq distance
338
chain
C
Factor I module (FIM) 2
begin
749
end
821
score
100.0
distance
126.090164
seq distance
338
chain
C
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
126.40069
seq distance
False
chain
H
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
126.40069
seq distance
False
chain
H
In C7D; dbSNP:rs369349760.
original residue
R
variation residue
Q
position
198
score
72.72727272727273
distance
126.601295
seq distance
178
chain
C
In C7D; dbSNP:rs369349760.
original residue
R
variation residue
Q
position
198
score
72.72727272727273
distance
126.601295
seq distance
178
chain
C
In dbSNP:rs75345202.
original residue
R
variation residue
H
position
200
score
72.72727272727273
distance
132.8407
seq distance
180
chain
C
In dbSNP:rs75345202.
original residue
R
variation residue
H
position
200
score
72.72727272727273
distance
132.8407
seq distance
180
chain
C
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
139.6124
seq distance
False
chain
I
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
139.6124
seq distance
False
chain
I

Details

Redox score
63.26
PDB code
7nyc
Structure name
cryoem structure of 3c9-smac
Structure deposition date
2021-03-22
Thiol separation (Å)
9.48
Half-sphere exposure sum
68
Minimum pKa
nan
% buried
nan
Peptide accession
P10643
Residue number A
42 (Residue 20 in this structure)
Residue number B
433 (Residue 411 in this structure)
Peptide name
Complement component C7
A redox-regulated disulphide may form within Complement component C7 at these cysteines. However, the redox score of this cysteine pair is lower than any known redox-active disulphide.

Relevent regions

TSP type-1 1
begin
27
end
80
score
99.83164983164983
distance
2.8195474
seq distance
0
chain
D
TSP type-1 1
begin
27
end
80
score
99.83164983164983
distance
2.8195474
seq distance
0
chain
D
MACPF
begin
124
end
456
score
98.9079989079989
distance
9.205395
seq distance
82
chain
D
MACPF
begin
124
end
456
score
98.9079989079989
distance
9.205395
seq distance
82
chain
D
CCP 1
begin
545
end
615
score
83.48271446862996
distance
14.626666
seq distance
503
chain
D
CCP 1
begin
545
end
615
score
83.48271446862996
distance
14.626666
seq distance
503
chain
D
LDL-receptor class A
begin
83
end
121
score
100.0
distance
14.671783
seq distance
41
chain
D
LDL-receptor class A
begin
83
end
121
score
100.0
distance
14.671783
seq distance
41
chain
D
TSP type-1 2
begin
500
end
549
score
100.0
distance
20.527573
seq distance
458
chain
D
TSP type-1 2
begin
500
end
549
score
100.0
distance
20.527573
seq distance
458
chain
D
Disordered
begin
108
end
143
score
100.0
distance
26.29767
seq distance
66
chain
D
Disordered
begin
108
end
143
score
100.0
distance
26.29767
seq distance
66
chain
D
EGF-like
begin
457
end
487
score
100.0
distance
27.276064
seq distance
415
chain
D
EGF-like
begin
457
end
487
score
100.0
distance
27.276064
seq distance
415
chain
D
Sushi 1
begin
572
end
628
score
99.04306220095694
distance
28.835049
seq distance
530
chain
D
Sushi 1
begin
572
end
628
score
99.04306220095694
distance
28.835049
seq distance
530
chain
D
LDL-receptor class A
begin
84
end
92
score
56.56565656565656
distance
29.31418
seq distance
False
chain
C
LDL-receptor class A
begin
84
end
92
score
56.56565656565656
distance
29.31418
seq distance
False
chain
C
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
412
score
63.63636363636363
distance
29.937197
seq distance
False
chain
C
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
412
score
63.63636363636363
distance
29.937197
seq distance
False
chain
C
Disordered
begin
504
end
504
score
68.18181818181817
distance
30.599499
seq distance
False
chain
C
Disordered
begin
504
end
504
score
68.18181818181817
distance
30.599499
seq distance
False
chain
C
Disordered
begin
516
end
538
score
100.0
distance
31.363056
seq distance
474
chain
D
Disordered
begin
516
end
538
score
100.0
distance
31.363056
seq distance
474
chain
D
Disordered
begin
91
end
92
score
68.18181818181817
distance
31.397388
seq distance
False
chain
C
Disordered
begin
91
end
92
score
68.18181818181817
distance
31.397388
seq distance
False
chain
C
Confirmed at protein level; dbSNP:rs13157656.
original residue
T
variation residue
P
position
587
score
100.0
distance
33.982246
seq distance
545
chain
D
Confirmed at protein level; dbSNP:rs13157656.
original residue
T
variation residue
P
position
587
score
100.0
distance
33.982246
seq distance
545
chain
D
CCP 2
begin
616
end
691
score
99.2822966507177
distance
36.077198
seq distance
574
chain
D
CCP 2
begin
616
end
691
score
99.2822966507177
distance
36.077198
seq distance
574
chain
D
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
521
score
100.0
distance
36.429207
seq distance
479
chain
D
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
521
score
100.0
distance
36.429207
seq distance
479
chain
D
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
420
score
100.0
distance
39.178535
seq distance
378
chain
D
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
420
score
100.0
distance
39.178535
seq distance
378
chain
D
LDL-receptor class A
begin
83
end
98
score
52.69886363636363
distance
43.713997
seq distance
False
chain
F
LDL-receptor class A
begin
83
end
98
score
52.69886363636363
distance
43.713997
seq distance
False
chain
F
EGF-like
begin
451
end
455
score
54.090909090909086
distance
46.32755
seq distance
False
chain
C
EGF-like
begin
451
end
455
score
54.090909090909086
distance
46.32755
seq distance
False
chain
C
In dbSNP:rs2271708.
original residue
C
variation residue
R
position
128
score
100.0
distance
46.388264
seq distance
86
chain
D
In dbSNP:rs2271708.
original residue
C
variation residue
R
position
128
score
100.0
distance
46.388264
seq distance
86
chain
D
Confirmed at protein level; dbSNP:rs1063499.
original residue
S
variation residue
T
position
389
score
100.0
distance
54.999157
seq distance
347
chain
D
Confirmed at protein level; dbSNP:rs1063499.
original residue
S
variation residue
T
position
389
score
100.0
distance
54.999157
seq distance
347
chain
D
Sushi 2
begin
629
end
690
score
99.56011730205279
distance
57.597435
seq distance
587
chain
D
Sushi 2
begin
629
end
690
score
99.56011730205279
distance
57.597435
seq distance
587
chain
D
Disordered
begin
41
end
41
score
70.45454545454545
distance
59.07035
seq distance
False
chain
B
Disordered
begin
41
end
41
score
70.45454545454545
distance
59.07035
seq distance
False
chain
B
Disordered
begin
585
end
589
score
50.90909090909091
distance
61.196587
seq distance
False
chain
B
Disordered
begin
585
end
589
score
50.90909090909091
distance
61.196587
seq distance
False
chain
B
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
587
score
68.18181818181817
distance
61.863148
seq distance
False
chain
B
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
587
score
68.18181818181817
distance
61.863148
seq distance
False
chain
B
In dbSNP:rs75345202.
original residue
R
variation residue
H
position
414
score
54.54545454545454
distance
62.49491
seq distance
False
chain
F
In dbSNP:rs75345202.
original residue
R
variation residue
H
position
414
score
54.54545454545454
distance
62.49491
seq distance
False
chain
F
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
66.47826
seq distance
False
chain
X
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
66.47826
seq distance
False
chain
X
TSP type-1 2
begin
512
end
517
score
80.30303030303031
distance
69.81311
seq distance
False
chain
F
TSP type-1 2
begin
512
end
517
score
80.30303030303031
distance
69.81311
seq distance
False
chain
F
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
71.728546
seq distance
False
chain
X
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
71.728546
seq distance
False
chain
X
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
72.1767
seq distance
False
chain
G
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
72.1767
seq distance
False
chain
G
In C7D; dbSNP:rs541873000.
original residue
E
variation residue
Q
position
682
score
100.0
distance
73.98962
seq distance
640
chain
D
In C7D; dbSNP:rs541873000.
original residue
E
variation residue
Q
position
682
score
100.0
distance
73.98962
seq distance
640
chain
D
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
31
score
50.0
distance
76.113785
seq distance
False
chain
F
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
31
score
50.0
distance
76.113785
seq distance
False
chain
F
Disordered
begin
138
end
138
score
50.0
distance
80.63583
seq distance
False
chain
E
Disordered
begin
138
end
138
score
50.0
distance
80.63583
seq distance
False
chain
E
Confirmed at protein level; dbSNP:rs1063499.
original residue
S
variation residue
T
position
1058
score
54.54545454545454
distance
82.22271
seq distance
False
chain
A
Confirmed at protein level; dbSNP:rs1063499.
original residue
S
variation residue
T
position
1058
score
54.54545454545454
distance
82.22271
seq distance
False
chain
A
In C7D; dbSNP:rs113187203.
original residue
R
variation residue
H
position
687
score
100.0
distance
84.45639
seq distance
645
chain
D
In C7D; dbSNP:rs113187203.
original residue
R
variation residue
H
position
687
score
100.0
distance
84.45639
seq distance
645
chain
D
Disordered
begin
219
end
240
score
100.0
distance
86.517334
seq distance
177
chain
D
Disordered
begin
219
end
240
score
100.0
distance
86.517334
seq distance
177
chain
D
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
91.30125
seq distance
False
chain
G
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
91.30125
seq distance
False
chain
G
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
91.742
seq distance
False
chain
X
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
91.742
seq distance
False
chain
X
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
95.51307
seq distance
False
chain
P
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
95.51307
seq distance
False
chain
P
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
96.55723
seq distance
False
chain
W
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
96.55723
seq distance
False
chain
W
Confirmed at protein level; dbSNP:rs13157656.
original residue
T
variation residue
P
position
714
score
50.0
distance
99.92931
seq distance
False
chain
B
Confirmed at protein level; dbSNP:rs13157656.
original residue
T
variation residue
P
position
714
score
50.0
distance
99.92931
seq distance
False
chain
B
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
100.36115
seq distance
False
chain
W
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
100.36115
seq distance
False
chain
W
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
102.00084
seq distance
False
chain
G
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
102.00084
seq distance
False
chain
G
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
114.4846
seq distance
False
chain
W
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
114.4846
seq distance
False
chain
W
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
117.34743
seq distance
False
chain
P
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
117.34743
seq distance
False
chain
P
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
117.99135
seq distance
False
chain
H
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
117.99135
seq distance
False
chain
H
In C7D; dbSNP:rs369349760.
original residue
R
variation residue
Q
position
220
score
100.0
distance
123.53208
seq distance
178
chain
D
In C7D; dbSNP:rs369349760.
original residue
R
variation residue
Q
position
220
score
100.0
distance
123.53208
seq distance
178
chain
D
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
125.13518
seq distance
False
chain
V
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
125.13518
seq distance
False
chain
V
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
126.97246
seq distance
False
chain
V
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
126.97246
seq distance
False
chain
V
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
128.37503
seq distance
False
chain
P
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
128.37503
seq distance
False
chain
P
In dbSNP:rs75345202.
original residue
R
variation residue
H
position
222
score
100.0
distance
129.62904
seq distance
180
chain
D
In dbSNP:rs75345202.
original residue
R
variation residue
H
position
222
score
100.0
distance
129.62904
seq distance
180
chain
D
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
130.06062
seq distance
False
chain
X
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
130.06062
seq distance
False
chain
X
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
135.42274
seq distance
False
chain
V
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
135.42274
seq distance
False
chain
V
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
135.47398
seq distance
False
chain
G
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
135.47398
seq distance
False
chain
G
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
138.54741
seq distance
False
chain
I
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
138.54741
seq distance
False
chain
I
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
139.8049
seq distance
False
chain
W
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
139.8049
seq distance
False
chain
W
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
141.40938
seq distance
False
chain
H
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
141.40938
seq distance
False
chain
H
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
149.97208
seq distance
False
chain
P
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
149.97208
seq distance
False
chain
P
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
150.49947
seq distance
False
chain
U
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
150.49947
seq distance
False
chain
U
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
150.7638
seq distance
False
chain
U
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
150.7638
seq distance
False
chain
U
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
152.14948
seq distance
False
chain
V
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
152.14948
seq distance
False
chain
V
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
152.74318
seq distance
False
chain
H
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
152.74318
seq distance
False
chain
H
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
154.31435
seq distance
False
chain
U
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
154.31435
seq distance
False
chain
U
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
156.81152
seq distance
False
chain
J
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
156.81152
seq distance
False
chain
J
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
162.80011
seq distance
False
chain
I
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
162.80011
seq distance
False
chain
I
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
164.77808
seq distance
False
chain
H
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
164.77808
seq distance
False
chain
H
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
165.71075
seq distance
False
chain
U
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
165.71075
seq distance
False
chain
U
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
170.58029
seq distance
False
chain
T
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
170.58029
seq distance
False
chain
T
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
171.41669
seq distance
False
chain
T
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
171.41669
seq distance
False
chain
T
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
172.37593
seq distance
False
chain
K
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
172.37593
seq distance
False
chain
K
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
173.36047
seq distance
False
chain
T
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
173.36047
seq distance
False
chain
T
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
174.26021
seq distance
False
chain
I
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
174.26021
seq distance
False
chain
I
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
178.42587
seq distance
False
chain
I
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
178.42587
seq distance
False
chain
I
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
178.81737
seq distance
False
chain
T
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
178.81737
seq distance
False
chain
T
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
181.23854
seq distance
False
chain
J
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
181.23854
seq distance
False
chain
J
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
183.6457
seq distance
False
chain
S
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
183.6457
seq distance
False
chain
S
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
184.87796
seq distance
False
chain
L
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
184.87796
seq distance
False
chain
L
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
188.86093
seq distance
False
chain
S
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
188.86093
seq distance
False
chain
S
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
189.8907
seq distance
False
chain
J
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
189.8907
seq distance
False
chain
J
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
190.48793
seq distance
False
chain
S
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
190.48793
seq distance
False
chain
S
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
192.52003
seq distance
False
chain
S
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
192.52003
seq distance
False
chain
S
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
192.67854
seq distance
False
chain
J
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
192.67854
seq distance
False
chain
J
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
193.24158
seq distance
False
chain
R
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
193.24158
seq distance
False
chain
R
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
194.00024
seq distance
False
chain
M
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
194.00024
seq distance
False
chain
M
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
196.32521
seq distance
False
chain
K
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
196.32521
seq distance
False
chain
K
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
199.19818
seq distance
False
chain
Q
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
199.19818
seq distance
False
chain
Q
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
199.44087
seq distance
False
chain
K
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
199.44087
seq distance
False
chain
K
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
199.52974
seq distance
False
chain
N
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
199.52974
seq distance
False
chain
N
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
200.19261
seq distance
False
chain
R
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
200.19261
seq distance
False
chain
R
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
201.31256
seq distance
False
chain
O
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
201.31256
seq distance
False
chain
O
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
202.54616
seq distance
False
chain
R
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
202.54616
seq distance
False
chain
R
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
206.65755
seq distance
False
chain
L
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
206.65755
seq distance
False
chain
L
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
207.52794
seq distance
False
chain
Q
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
207.52794
seq distance
False
chain
Q
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
207.5736
seq distance
False
chain
K
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
207.5736
seq distance
False
chain
K
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
207.76852
seq distance
False
chain
L
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
207.76852
seq distance
False
chain
L
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
207.87053
seq distance
False
chain
R
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
207.87053
seq distance
False
chain
R
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
211.13304
seq distance
False
chain
M
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
211.13304
seq distance
False
chain
M
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
211.7077
seq distance
False
chain
O
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
211.7077
seq distance
False
chain
O
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
212.15472
seq distance
False
chain
Q
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
212.15472
seq distance
False
chain
Q
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
212.67522
seq distance
False
chain
N
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
212.67522
seq distance
False
chain
N
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
215.1952
seq distance
False
chain
M
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
215.1952
seq distance
False
chain
M
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
217.5155
seq distance
False
chain
O
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
217.5155
seq distance
False
chain
O
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
218.47813
seq distance
False
chain
N
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
218.47813
seq distance
False
chain
N
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
218.62561
seq distance
False
chain
L
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
218.62561
seq distance
False
chain
L
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
219.10179
seq distance
False
chain
Q
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
219.10179
seq distance
False
chain
Q
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
225.52138
seq distance
False
chain
M
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
225.52138
seq distance
False
chain
M
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
225.96284
seq distance
False
chain
O
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
225.96284
seq distance
False
chain
O
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
228.07895
seq distance
False
chain
N
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
228.07895
seq distance
False
chain
N

Details

Redox score
63.23
PDB code
6h04
Structure name
closed conformation of the membrane attack complex
Structure deposition date
2018-07-06
Thiol separation (Å)
9.74
Half-sphere exposure sum
57
Minimum pKa
nan
% buried
nan
Peptide accession
P10643
Residue number A
39
Residue number B
42
Peptide name
Complement component C7
A redox-regulated disulphide may form within Complement component C7 at these cysteines. However, the redox score of this cysteine pair is lower than any known redox-active disulphide.

Relevent regions

TSP type-1 2
begin
500
end
549
score
100.0
distance
2.7957351
seq distance
0
chain
D
TSP type-1 2
begin
500
end
549
score
100.0
distance
2.7957351
seq distance
0
chain
D
EGF-like
begin
457
end
487
score
100.0
distance
2.817923
seq distance
0
chain
D
EGF-like
begin
457
end
487
score
100.0
distance
2.817923
seq distance
0
chain
D
MACPF
begin
124
end
456
score
98.9079989079989
distance
3.7485821
seq distance
17
chain
D
MACPF
begin
124
end
456
score
98.9079989079989
distance
3.7485821
seq distance
17
chain
D
TSP type-1 1
begin
27
end
80
score
99.83164983164983
distance
4.9242854
seq distance
393
chain
D
TSP type-1 1
begin
27
end
80
score
99.83164983164983
distance
4.9242854
seq distance
393
chain
D
Disordered
begin
516
end
538
score
100.0
distance
9.583976
seq distance
11
chain
D
Disordered
begin
516
end
538
score
100.0
distance
9.583976
seq distance
11
chain
D
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
521
score
100.0
distance
9.633959
seq distance
16
chain
D
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
521
score
100.0
distance
9.633959
seq distance
16
chain
D
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
412
score
63.63636363636363
distance
21.075468
seq distance
False
chain
C
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
412
score
63.63636363636363
distance
21.075468
seq distance
False
chain
C
CCP 1
begin
545
end
615
score
83.48271446862996
distance
22.404346
seq distance
40
chain
D
CCP 1
begin
545
end
615
score
83.48271446862996
distance
22.404346
seq distance
40
chain
D
Disordered
begin
108
end
143
score
100.0
distance
25.213755
seq distance
330
chain
D
Disordered
begin
108
end
143
score
100.0
distance
25.213755
seq distance
330
chain
D
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
420
score
100.0
distance
26.21846
seq distance
53
chain
D
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
420
score
100.0
distance
26.21846
seq distance
53
chain
D
Disordered
begin
41
end
41
score
70.45454545454545
distance
29.831944
seq distance
False
chain
B
Disordered
begin
41
end
41
score
70.45454545454545
distance
29.831944
seq distance
False
chain
B
Disordered
begin
504
end
504
score
68.18181818181817
distance
30.151415
seq distance
False
chain
C
Disordered
begin
504
end
504
score
68.18181818181817
distance
30.151415
seq distance
False
chain
C
Confirmed at protein level; dbSNP:rs1063499.
original residue
S
variation residue
T
position
389
score
100.0
distance
31.95345
seq distance
84
chain
D
Confirmed at protein level; dbSNP:rs1063499.
original residue
S
variation residue
T
position
389
score
100.0
distance
31.95345
seq distance
84
chain
D
EGF-like
begin
451
end
455
score
54.090909090909086
distance
32.892204
seq distance
False
chain
C
EGF-like
begin
451
end
455
score
54.090909090909086
distance
32.892204
seq distance
False
chain
C
LDL-receptor class A
begin
83
end
121
score
100.0
distance
40.086674
seq distance
352
chain
D
LDL-receptor class A
begin
83
end
121
score
100.0
distance
40.086674
seq distance
352
chain
D
Disordered
begin
585
end
589
score
50.90909090909091
distance
45.068157
seq distance
False
chain
B
Disordered
begin
585
end
589
score
50.90909090909091
distance
45.068157
seq distance
False
chain
B
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
587
score
68.18181818181817
distance
45.245262
seq distance
False
chain
B
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
587
score
68.18181818181817
distance
45.245262
seq distance
False
chain
B
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
45.55111
seq distance
False
chain
X
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
45.55111
seq distance
False
chain
X
Disordered
begin
91
end
92
score
68.18181818181817
distance
48.76474
seq distance
False
chain
C
Disordered
begin
91
end
92
score
68.18181818181817
distance
48.76474
seq distance
False
chain
C
LDL-receptor class A
begin
84
end
92
score
56.56565656565656
distance
48.76474
seq distance
False
chain
C
LDL-receptor class A
begin
84
end
92
score
56.56565656565656
distance
48.76474
seq distance
False
chain
C
In dbSNP:rs75345202.
original residue
R
variation residue
H
position
414
score
54.54545454545454
distance
49.504467
seq distance
False
chain
F
In dbSNP:rs75345202.
original residue
R
variation residue
H
position
414
score
54.54545454545454
distance
49.504467
seq distance
False
chain
F
Sushi 1
begin
572
end
628
score
99.04306220095694
distance
50.857265
seq distance
67
chain
D
Sushi 1
begin
572
end
628
score
99.04306220095694
distance
50.857265
seq distance
67
chain
D
CCP 2
begin
616
end
691
score
99.2822966507177
distance
52.4999
seq distance
111
chain
D
CCP 2
begin
616
end
691
score
99.2822966507177
distance
52.4999
seq distance
111
chain
D
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
53.03058
seq distance
False
chain
X
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
53.03058
seq distance
False
chain
X
Disordered
begin
219
end
240
score
100.0
distance
53.23708
seq distance
233
chain
D
Disordered
begin
219
end
240
score
100.0
distance
53.23708
seq distance
233
chain
D
In dbSNP:rs2271708.
original residue
C
variation residue
R
position
128
score
100.0
distance
55.598724
seq distance
345
chain
D
In dbSNP:rs2271708.
original residue
C
variation residue
R
position
128
score
100.0
distance
55.598724
seq distance
345
chain
D
TSP type-1 2
begin
512
end
517
score
80.30303030303031
distance
58.81717
seq distance
False
chain
F
TSP type-1 2
begin
512
end
517
score
80.30303030303031
distance
58.81717
seq distance
False
chain
F
Confirmed at protein level; dbSNP:rs13157656.
original residue
T
variation residue
P
position
587
score
100.0
distance
59.036705
seq distance
82
chain
D
Confirmed at protein level; dbSNP:rs13157656.
original residue
T
variation residue
P
position
587
score
100.0
distance
59.036705
seq distance
82
chain
D
LDL-receptor class A
begin
83
end
98
score
52.69886363636363
distance
60.72509
seq distance
False
chain
F
LDL-receptor class A
begin
83
end
98
score
52.69886363636363
distance
60.72509
seq distance
False
chain
F
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
66.87364
seq distance
False
chain
G
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
66.87364
seq distance
False
chain
G
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
68.7685
seq distance
False
chain
X
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
68.7685
seq distance
False
chain
X
Disordered
begin
138
end
138
score
50.0
distance
73.378525
seq distance
False
chain
E
Disordered
begin
138
end
138
score
50.0
distance
73.378525
seq distance
False
chain
E
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
31
score
50.0
distance
74.43596
seq distance
False
chain
F
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
31
score
50.0
distance
74.43596
seq distance
False
chain
F
Confirmed at protein level; dbSNP:rs1063499.
original residue
S
variation residue
T
position
1058
score
54.54545454545454
distance
75.036575
seq distance
False
chain
A
Confirmed at protein level; dbSNP:rs1063499.
original residue
S
variation residue
T
position
1058
score
54.54545454545454
distance
75.036575
seq distance
False
chain
A
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
77.039696
seq distance
False
chain
W
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
77.039696
seq distance
False
chain
W
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
82.43329
seq distance
False
chain
W
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
82.43329
seq distance
False
chain
W
Sushi 2
begin
629
end
690
score
99.56011730205279
distance
84.32133
seq distance
124
chain
D
Sushi 2
begin
629
end
690
score
99.56011730205279
distance
84.32133
seq distance
124
chain
D
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
89.37201
seq distance
False
chain
P
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
89.37201
seq distance
False
chain
P
In C7D; dbSNP:rs369349760.
original residue
R
variation residue
Q
position
220
score
100.0
distance
90.31529
seq distance
253
chain
D
In C7D; dbSNP:rs369349760.
original residue
R
variation residue
Q
position
220
score
100.0
distance
90.31529
seq distance
253
chain
D
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
93.184616
seq distance
False
chain
W
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
93.184616
seq distance
False
chain
W
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
93.713486
seq distance
False
chain
G
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
93.713486
seq distance
False
chain
G
In dbSNP:rs75345202.
original residue
R
variation residue
H
position
222
score
100.0
distance
96.55792
seq distance
251
chain
D
In dbSNP:rs75345202.
original residue
R
variation residue
H
position
222
score
100.0
distance
96.55792
seq distance
251
chain
D
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
96.58512
seq distance
False
chain
X
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
96.58512
seq distance
False
chain
X
In C7D; dbSNP:rs541873000.
original residue
E
variation residue
Q
position
682
score
100.0
distance
97.601494
seq distance
177
chain
D
In C7D; dbSNP:rs541873000.
original residue
E
variation residue
Q
position
682
score
100.0
distance
97.601494
seq distance
177
chain
D
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
102.5465
seq distance
False
chain
G
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
102.5465
seq distance
False
chain
G
Confirmed at protein level; dbSNP:rs13157656.
original residue
T
variation residue
P
position
714
score
50.0
distance
102.585846
seq distance
False
chain
B
Confirmed at protein level; dbSNP:rs13157656.
original residue
T
variation residue
P
position
714
score
50.0
distance
102.585846
seq distance
False
chain
B
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
106.228424
seq distance
False
chain
V
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
106.228424
seq distance
False
chain
V
In C7D; dbSNP:rs113187203.
original residue
R
variation residue
H
position
687
score
100.0
distance
106.69588
seq distance
182
chain
D
In C7D; dbSNP:rs113187203.
original residue
R
variation residue
H
position
687
score
100.0
distance
106.69588
seq distance
182
chain
D
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
107.57266
seq distance
False
chain
W
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
107.57266
seq distance
False
chain
W
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
108.38462
seq distance
False
chain
G
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
108.38462
seq distance
False
chain
G
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
109.85549
seq distance
False
chain
V
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
109.85549
seq distance
False
chain
V
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
110.73897
seq distance
False
chain
H
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
110.73897
seq distance
False
chain
H
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
116.013374
seq distance
False
chain
V
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
116.013374
seq distance
False
chain
V
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
116.79785
seq distance
False
chain
P
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
116.79785
seq distance
False
chain
P
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
121.19922
seq distance
False
chain
V
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
121.19922
seq distance
False
chain
V
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
123.39246
seq distance
False
chain
P
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
123.39246
seq distance
False
chain
P
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
126.241745
seq distance
False
chain
P
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
126.241745
seq distance
False
chain
P
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
130.16975
seq distance
False
chain
I
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
130.16975
seq distance
False
chain
I
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
132.89888
seq distance
False
chain
U
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
132.89888
seq distance
False
chain
U
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
134.79509
seq distance
False
chain
U
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
134.79509
seq distance
False
chain
U
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
135.79005
seq distance
False
chain
U
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
135.79005
seq distance
False
chain
U
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
136.68352
seq distance
False
chain
U
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
136.68352
seq distance
False
chain
U
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
138.42477
seq distance
False
chain
H
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
138.42477
seq distance
False
chain
H
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
138.45222
seq distance
False
chain
H
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
138.45222
seq distance
False
chain
H
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
147.35358
seq distance
False
chain
J
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
147.35358
seq distance
False
chain
J
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
148.35895
seq distance
False
chain
H
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
148.35895
seq distance
False
chain
H
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
149.68738
seq distance
False
chain
T
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
149.68738
seq distance
False
chain
T
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
152.04884
seq distance
False
chain
I
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
152.04884
seq distance
False
chain
I
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
154.59692
seq distance
False
chain
T
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
154.59692
seq distance
False
chain
T
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
157.0376
seq distance
False
chain
T
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
157.0376
seq distance
False
chain
T
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
157.06711
seq distance
False
chain
T
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
157.06711
seq distance
False
chain
T
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
157.89745
seq distance
False
chain
I
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
157.89745
seq distance
False
chain
I
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
161.88602
seq distance
False
chain
S
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
161.88602
seq distance
False
chain
S
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
161.9015
seq distance
False
chain
K
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
161.9015
seq distance
False
chain
K
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
163.56448
seq distance
False
chain
J
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
163.56448
seq distance
False
chain
J
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
168.0299
seq distance
False
chain
I
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
168.0299
seq distance
False
chain
I
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
168.94228
seq distance
False
chain
S
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
168.94228
seq distance
False
chain
S
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
171.94391
seq distance
False
chain
R
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
171.94391
seq distance
False
chain
R
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
172.94446
seq distance
False
chain
K
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
172.94446
seq distance
False
chain
K
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
173.50114
seq distance
False
chain
L
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
173.50114
seq distance
False
chain
L
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
174.70148
seq distance
False
chain
J
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
174.70148
seq distance
False
chain
J
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
175.91513
seq distance
False
chain
S
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
175.91513
seq distance
False
chain
S
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
177.72557
seq distance
False
chain
S
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
177.72557
seq distance
False
chain
S
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
178.91396
seq distance
False
chain
R
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
178.91396
seq distance
False
chain
R
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
179.54594
seq distance
False
chain
Q
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
179.54594
seq distance
False
chain
Q
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
179.85728
seq distance
False
chain
L
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
179.85728
seq distance
False
chain
L
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
181.83339
seq distance
False
chain
M
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
181.83339
seq distance
False
chain
M
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
183.7754
seq distance
False
chain
O
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
183.7754
seq distance
False
chain
O
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
184.01813
seq distance
False
chain
M
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
184.01813
seq distance
False
chain
M
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
184.89218
seq distance
False
chain
J
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
184.89218
seq distance
False
chain
J
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
185.2887
seq distance
False
chain
Q
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
185.2887
seq distance
False
chain
Q
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
185.72789
seq distance
False
chain
N
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
185.72789
seq distance
False
chain
N
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
186.67207
seq distance
False
chain
N
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
186.67207
seq distance
False
chain
N
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
187.8813
seq distance
False
chain
O
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
187.8813
seq distance
False
chain
O
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
188.43977
seq distance
False
chain
K
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
188.43977
seq distance
False
chain
K
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
190.9667
seq distance
False
chain
R
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
190.9667
seq distance
False
chain
R
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
194.62607
seq distance
False
chain
R
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
194.62607
seq distance
False
chain
R
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
198.49411
seq distance
False
chain
K
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
198.49411
seq distance
False
chain
K
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
198.77237
seq distance
False
chain
L
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
198.77237
seq distance
False
chain
L
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
200.77069
seq distance
False
chain
Q
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
200.77069
seq distance
False
chain
Q
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
205.31784
seq distance
False
chain
M
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
205.31784
seq distance
False
chain
M
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
206.45123
seq distance
False
chain
Q
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
206.45123
seq distance
False
chain
Q
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
206.4612
seq distance
False
chain
O
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
206.4612
seq distance
False
chain
O
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
207.90753
seq distance
False
chain
N
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
207.90753
seq distance
False
chain
N
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
208.49446
seq distance
False
chain
L
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
208.49446
seq distance
False
chain
L
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
213.60805
seq distance
False
chain
O
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
213.60805
seq distance
False
chain
O
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
214.55997
seq distance
False
chain
M
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
214.55997
seq distance
False
chain
M
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
216.32889
seq distance
False
chain
N
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
216.32889
seq distance
False
chain
N

Details

Redox score
62.97
PDB code
6h04
Structure name
closed conformation of the membrane attack complex
Structure deposition date
2018-07-06
Thiol separation (Å)
9.96
Half-sphere exposure sum
63
Minimum pKa
nan
% buried
nan
Peptide accession
P10643
Residue number A
473
Residue number B
505
Peptide name
Complement component C7
A redox-regulated disulphide may form within Complement component C7 at these cysteines. However, the redox score of this cysteine pair is lower than any known redox-active disulphide.

Relevent regions

LDL-receptor class A
begin
61
end
99
score
100.0
distance
2.757768
seq distance
0
chain
C
LDL-receptor class A
begin
61
end
99
score
100.0
distance
2.757768
seq distance
0
chain
C
Disordered
begin
86
end
121
score
100.0
distance
4.3414235
seq distance
12
chain
C
Disordered
begin
86
end
121
score
100.0
distance
4.3414235
seq distance
12
chain
C
MACPF
begin
102
end
434
score
94.85394485394487
distance
7.3749647
seq distance
28
chain
C
MACPF
begin
102
end
434
score
94.85394485394487
distance
7.3749647
seq distance
28
chain
C
LDL-receptor class A
begin
84
end
92
score
56.56565656565656
distance
12.3690605
seq distance
False
chain
D
LDL-receptor class A
begin
84
end
92
score
56.56565656565656
distance
12.3690605
seq distance
False
chain
D
TSP type-1 1
begin
5
end
58
score
99.83164983164983
distance
16.078758
seq distance
11
chain
C
TSP type-1 1
begin
5
end
58
score
99.83164983164983
distance
16.078758
seq distance
11
chain
C
Disordered
begin
91
end
92
score
68.18181818181817
distance
16.726353
seq distance
False
chain
D
Disordered
begin
91
end
92
score
68.18181818181817
distance
16.726353
seq distance
False
chain
D
CCP 1
begin
523
end
593
score
100.0
distance
18.425951
seq distance
449
chain
C
CCP 1
begin
523
end
593
score
100.0
distance
18.425951
seq distance
449
chain
C
In dbSNP:rs2271708.
original residue
C
variation residue
R
position
106
score
100.0
distance
20.837814
seq distance
32
chain
C
In dbSNP:rs2271708.
original residue
C
variation residue
R
position
106
score
100.0
distance
20.837814
seq distance
32
chain
C
TSP type-1 2
begin
478
end
527
score
100.0
distance
26.017117
seq distance
404
chain
C
TSP type-1 2
begin
478
end
527
score
100.0
distance
26.017117
seq distance
404
chain
C
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
412
score
63.63636363636363
distance
27.608892
seq distance
False
chain
D
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
412
score
63.63636363636363
distance
27.608892
seq distance
False
chain
D
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
398
score
100.0
distance
29.757437
seq distance
324
chain
C
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
398
score
100.0
distance
29.757437
seq distance
324
chain
C
In C7D; dbSNP:rs121964921.
original residue
G
variation residue
R
position
357
score
100.0
distance
32.251713
seq distance
283
chain
C
In C7D; dbSNP:rs121964921.
original residue
G
variation residue
R
position
357
score
100.0
distance
32.251713
seq distance
283
chain
C
LDL-receptor class A
begin
83
end
95
score
50.87412587412587
distance
32.97331
seq distance
False
chain
E
LDL-receptor class A
begin
83
end
95
score
50.87412587412587
distance
32.97331
seq distance
False
chain
E
EGF-like
begin
435
end
465
score
100.0
distance
35.278004
seq distance
361
chain
C
EGF-like
begin
435
end
465
score
100.0
distance
35.278004
seq distance
361
chain
C
Sushi 1
begin
547
end
606
score
100.0
distance
35.87312
seq distance
473
chain
C
Sushi 1
begin
547
end
606
score
100.0
distance
35.87312
seq distance
473
chain
C
Disordered
begin
494
end
516
score
100.0
distance
38.71365
seq distance
420
chain
C
Disordered
begin
494
end
516
score
100.0
distance
38.71365
seq distance
420
chain
C
Confirmed at protein level; dbSNP:rs1063499.
original residue
S
variation residue
T
position
367
score
100.0
distance
42.668194
seq distance
293
chain
C
Confirmed at protein level; dbSNP:rs1063499.
original residue
S
variation residue
T
position
367
score
100.0
distance
42.668194
seq distance
293
chain
C
CCP 2
begin
594
end
671
score
100.0
distance
43.36116
seq distance
520
chain
C
CCP 2
begin
594
end
671
score
100.0
distance
43.36116
seq distance
520
chain
C
Confirmed at protein level; dbSNP:rs13157656.
original residue
T
variation residue
P
position
565
score
100.0
distance
43.439095
seq distance
491
chain
C
Confirmed at protein level; dbSNP:rs13157656.
original residue
T
variation residue
P
position
565
score
100.0
distance
43.439095
seq distance
491
chain
C
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
499
score
100.0
distance
45.584404
seq distance
425
chain
C
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
499
score
100.0
distance
45.584404
seq distance
425
chain
C
In dbSNP:rs75345202.
original residue
R
variation residue
H
position
414
score
54.54545454545454
distance
47.809998
seq distance
False
chain
E
In dbSNP:rs75345202.
original residue
R
variation residue
H
position
414
score
54.54545454545454
distance
47.809998
seq distance
False
chain
E
Disordered
begin
504
end
504
score
68.18181818181817
distance
49.90706
seq distance
False
chain
D
Disordered
begin
504
end
504
score
68.18181818181817
distance
49.90706
seq distance
False
chain
D
EGF-like
begin
451
end
455
score
54.090909090909086
distance
51.135777
seq distance
False
chain
D
EGF-like
begin
451
end
455
score
54.090909090909086
distance
51.135777
seq distance
False
chain
D
Disordered
begin
564
end
573
score
62.272727272727266
distance
52.288506
seq distance
False
chain
B
Disordered
begin
564
end
573
score
62.272727272727266
distance
52.288506
seq distance
False
chain
B
Disordered
begin
510
end
522
score
53.67132867132868
distance
52.387966
seq distance
False
chain
D
Disordered
begin
510
end
522
score
53.67132867132868
distance
52.387966
seq distance
False
chain
D
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
566
score
86.36363636363636
distance
53.5764
seq distance
False
chain
B
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
566
score
86.36363636363636
distance
53.5764
seq distance
False
chain
B
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
512
score
81.81818181818183
distance
55.985012
seq distance
False
chain
D
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
512
score
81.81818181818183
distance
55.985012
seq distance
False
chain
D
MACPF
begin
324
end
332
score
83.08080808080808
distance
57.742043
seq distance
False
chain
G
MACPF
begin
324
end
332
score
83.08080808080808
distance
57.742043
seq distance
False
chain
G
Sushi 2
begin
607
end
668
score
100.0
distance
58.726513
seq distance
533
chain
C
Sushi 2
begin
607
end
668
score
100.0
distance
58.726513
seq distance
533
chain
C
Disordered
begin
138
end
138
score
50.0
distance
60.148308
seq distance
False
chain
F
Disordered
begin
138
end
138
score
50.0
distance
60.148308
seq distance
False
chain
F
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
62.49762
seq distance
False
chain
G
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
62.49762
seq distance
False
chain
G
In C7D; dbSNP:rs541873000.
original residue
E
variation residue
Q
position
660
score
100.0
distance
69.03604
seq distance
586
chain
C
In C7D; dbSNP:rs541873000.
original residue
E
variation residue
Q
position
660
score
100.0
distance
69.03604
seq distance
586
chain
C
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
530
score
54.54545454545454
distance
69.36849
seq distance
False
chain
E
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
530
score
54.54545454545454
distance
69.36849
seq distance
False
chain
E
In C7D; dbSNP:rs369349760.
original residue
R
variation residue
Q
position
25
score
54.54545454545454
distance
69.71424
seq distance
False
chain
B
In C7D; dbSNP:rs369349760.
original residue
R
variation residue
Q
position
25
score
54.54545454545454
distance
69.71424
seq distance
False
chain
B
In dbSNP:rs2271708.
original residue
C
variation residue
R
position
532
score
54.54545454545454
distance
70.07314
seq distance
False
chain
E
In dbSNP:rs2271708.
original residue
C
variation residue
R
position
532
score
54.54545454545454
distance
70.07314
seq distance
False
chain
E
Confirmed at protein level; dbSNP:rs1063499.
original residue
S
variation residue
T
position
1040
score
54.54545454545454
distance
72.44719
seq distance
False
chain
A
Confirmed at protein level; dbSNP:rs1063499.
original residue
S
variation residue
T
position
1040
score
54.54545454545454
distance
72.44719
seq distance
False
chain
A
MACPF
begin
324
end
332
score
83.08080808080808
distance
76.23648
seq distance
False
chain
H
MACPF
begin
324
end
332
score
83.08080808080808
distance
76.23648
seq distance
False
chain
H
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
81.67362
seq distance
False
chain
G
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
81.67362
seq distance
False
chain
G
In C7D; dbSNP:rs113187203.
original residue
R
variation residue
H
position
665
score
100.0
distance
82.49403
seq distance
591
chain
C
In C7D; dbSNP:rs113187203.
original residue
R
variation residue
H
position
665
score
100.0
distance
82.49403
seq distance
591
chain
C
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
82.613235
seq distance
False
chain
H
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
82.613235
seq distance
False
chain
H
Confirmed at protein level; dbSNP:rs13157656.
original residue
T
variation residue
P
position
693
score
50.0
distance
85.422295
seq distance
False
chain
B
Confirmed at protein level; dbSNP:rs13157656.
original residue
T
variation residue
P
position
693
score
50.0
distance
85.422295
seq distance
False
chain
B
Disordered
begin
197
end
218
score
76.85950413223141
distance
85.66048
seq distance
123
chain
C
Disordered
begin
197
end
218
score
76.85950413223141
distance
85.66048
seq distance
123
chain
C
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
91.581696
seq distance
False
chain
G
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
91.581696
seq distance
False
chain
G
MACPF
begin
324
end
333
score
84.54545454545456
distance
93.642136
seq distance
False
chain
I
MACPF
begin
324
end
333
score
84.54545454545456
distance
93.642136
seq distance
False
chain
I
Disordered
begin
327
end
328
score
61.36363636363637
distance
98.3066
seq distance
False
chain
I
Disordered
begin
327
end
328
score
61.36363636363637
distance
98.3066
seq distance
False
chain
I
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
102.33391
seq distance
False
chain
I
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
102.33391
seq distance
False
chain
I
Factor I module (FIM) 1
begin
673
end
748
score
100.0
distance
103.35778
seq distance
599
chain
C
Factor I module (FIM) 1
begin
673
end
748
score
100.0
distance
103.35778
seq distance
599
chain
C
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
104.04583
seq distance
False
chain
H
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
104.04583
seq distance
False
chain
H
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
1560
score
50.0
distance
110.91369
seq distance
False
chain
A
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
1560
score
50.0
distance
110.91369
seq distance
False
chain
A
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
113.95088
seq distance
False
chain
H
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
113.95088
seq distance
False
chain
H
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
124.10994
seq distance
False
chain
I
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
124.10994
seq distance
False
chain
I
Factor I module (FIM) 2
begin
749
end
821
score
100.0
distance
126.79179
seq distance
675
chain
C
Factor I module (FIM) 2
begin
749
end
821
score
100.0
distance
126.79179
seq distance
675
chain
C
In C7D; dbSNP:rs369349760.
original residue
R
variation residue
Q
position
198
score
72.72727272727273
distance
127.936035
seq distance
124
chain
C
In C7D; dbSNP:rs369349760.
original residue
R
variation residue
Q
position
198
score
72.72727272727273
distance
127.936035
seq distance
124
chain
C
In dbSNP:rs75345202.
original residue
R
variation residue
H
position
200
score
72.72727272727273
distance
134.57964
seq distance
126
chain
C
In dbSNP:rs75345202.
original residue
R
variation residue
H
position
200
score
72.72727272727273
distance
134.57964
seq distance
126
chain
C

Details

Redox score
62.68
PDB code
7nyc
Structure name
cryoem structure of 3c9-smac
Structure deposition date
2021-03-22
Thiol separation (Å)
9.89
Half-sphere exposure sum
69
Minimum pKa
nan
% buried
nan
Peptide accession
P10643
Residue number A
91 (Residue 69 in this structure)
Residue number B
96 (Residue 74 in this structure)
Peptide name
Complement component C7
A redox-regulated disulphide may form within Complement component C7 at these cysteines. However, the redox score of this cysteine pair is lower than any known redox-active disulphide.

Relevent regions

LDL-receptor class A
begin
83
end
121
score
100.0
distance
2.8064141
seq distance
0
chain
D
LDL-receptor class A
begin
83
end
121
score
100.0
distance
2.8064141
seq distance
0
chain
D
Disordered
begin
108
end
143
score
100.0
distance
2.8195877
seq distance
0
chain
D
Disordered
begin
108
end
143
score
100.0
distance
2.8195877
seq distance
0
chain
D
MACPF
begin
124
end
456
score
98.9079989079989
distance
8.401839
seq distance
15
chain
D
MACPF
begin
124
end
456
score
98.9079989079989
distance
8.401839
seq distance
15
chain
D
LDL-receptor class A
begin
84
end
92
score
56.56565656565656
distance
13.921476
seq distance
False
chain
C
LDL-receptor class A
begin
84
end
92
score
56.56565656565656
distance
13.921476
seq distance
False
chain
C
TSP type-1 1
begin
27
end
80
score
99.83164983164983
distance
16.605398
seq distance
5
chain
D
TSP type-1 1
begin
27
end
80
score
99.83164983164983
distance
16.605398
seq distance
5
chain
D
Disordered
begin
91
end
92
score
68.18181818181817
distance
18.861853
seq distance
False
chain
C
Disordered
begin
91
end
92
score
68.18181818181817
distance
18.861853
seq distance
False
chain
C
In dbSNP:rs2271708.
original residue
C
variation residue
R
position
128
score
100.0
distance
21.112877
seq distance
19
chain
D
In dbSNP:rs2271708.
original residue
C
variation residue
R
position
128
score
100.0
distance
21.112877
seq distance
19
chain
D
CCP 1
begin
545
end
615
score
83.48271446862996
distance
21.555008
seq distance
436
chain
D
CCP 1
begin
545
end
615
score
83.48271446862996
distance
21.555008
seq distance
436
chain
D
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
412
score
63.63636363636363
distance
28.958422
seq distance
False
chain
C
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
412
score
63.63636363636363
distance
28.958422
seq distance
False
chain
C
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
420
score
100.0
distance
29.059496
seq distance
311
chain
D
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
420
score
100.0
distance
29.059496
seq distance
311
chain
D
TSP type-1 2
begin
500
end
549
score
100.0
distance
29.293835
seq distance
391
chain
D
TSP type-1 2
begin
500
end
549
score
100.0
distance
29.293835
seq distance
391
chain
D
Sushi 1
begin
572
end
628
score
99.04306220095694
distance
35.03134
seq distance
463
chain
D
Sushi 1
begin
572
end
628
score
99.04306220095694
distance
35.03134
seq distance
463
chain
D
EGF-like
begin
457
end
487
score
100.0
distance
36.09064
seq distance
348
chain
D
EGF-like
begin
457
end
487
score
100.0
distance
36.09064
seq distance
348
chain
D
LDL-receptor class A
begin
83
end
98
score
52.69886363636363
distance
37.05589
seq distance
False
chain
F
LDL-receptor class A
begin
83
end
98
score
52.69886363636363
distance
37.05589
seq distance
False
chain
F
Disordered
begin
516
end
538
score
100.0
distance
42.33582
seq distance
407
chain
D
Disordered
begin
516
end
538
score
100.0
distance
42.33582
seq distance
407
chain
D
Confirmed at protein level; dbSNP:rs1063499.
original residue
S
variation residue
T
position
389
score
100.0
distance
43.24064
seq distance
280
chain
D
Confirmed at protein level; dbSNP:rs1063499.
original residue
S
variation residue
T
position
389
score
100.0
distance
43.24064
seq distance
280
chain
D
Confirmed at protein level; dbSNP:rs13157656.
original residue
T
variation residue
P
position
587
score
100.0
distance
43.852665
seq distance
478
chain
D
Confirmed at protein level; dbSNP:rs13157656.
original residue
T
variation residue
P
position
587
score
100.0
distance
43.852665
seq distance
478
chain
D
CCP 2
begin
616
end
691
score
99.2822966507177
distance
43.966988
seq distance
507
chain
D
CCP 2
begin
616
end
691
score
99.2822966507177
distance
43.966988
seq distance
507
chain
D
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
521
score
100.0
distance
47.20476
seq distance
412
chain
D
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
521
score
100.0
distance
47.20476
seq distance
412
chain
D
In dbSNP:rs75345202.
original residue
R
variation residue
H
position
414
score
54.54545454545454
distance
48.144688
seq distance
False
chain
F
In dbSNP:rs75345202.
original residue
R
variation residue
H
position
414
score
54.54545454545454
distance
48.144688
seq distance
False
chain
F
EGF-like
begin
451
end
455
score
54.090909090909086
distance
53.99988
seq distance
False
chain
C
EGF-like
begin
451
end
455
score
54.090909090909086
distance
53.99988
seq distance
False
chain
C
Disordered
begin
585
end
589
score
50.90909090909091
distance
54.064705
seq distance
False
chain
B
Disordered
begin
585
end
589
score
50.90909090909091
distance
54.064705
seq distance
False
chain
B
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
587
score
68.18181818181817
distance
55.16839
seq distance
False
chain
B
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
587
score
68.18181818181817
distance
55.16839
seq distance
False
chain
B
Disordered
begin
504
end
504
score
68.18181818181817
distance
55.566906
seq distance
False
chain
C
Disordered
begin
504
end
504
score
68.18181818181817
distance
55.566906
seq distance
False
chain
C
Disordered
begin
138
end
138
score
50.0
distance
56.77306
seq distance
False
chain
E
Disordered
begin
138
end
138
score
50.0
distance
56.77306
seq distance
False
chain
E
Sushi 2
begin
629
end
690
score
99.56011730205279
distance
57.570892
seq distance
520
chain
D
Sushi 2
begin
629
end
690
score
99.56011730205279
distance
57.570892
seq distance
520
chain
D
Disordered
begin
41
end
41
score
70.45454545454545
distance
58.981544
seq distance
False
chain
B
Disordered
begin
41
end
41
score
70.45454545454545
distance
58.981544
seq distance
False
chain
B
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
65.7578
seq distance
False
chain
G
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
65.7578
seq distance
False
chain
G
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
69.64419
seq distance
False
chain
X
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
69.64419
seq distance
False
chain
X
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
70.63526
seq distance
False
chain
X
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
70.63526
seq distance
False
chain
X
In C7D; dbSNP:rs541873000.
original residue
E
variation residue
Q
position
682
score
100.0
distance
71.622986
seq distance
573
chain
D
In C7D; dbSNP:rs541873000.
original residue
E
variation residue
Q
position
682
score
100.0
distance
71.622986
seq distance
573
chain
D
TSP type-1 2
begin
512
end
517
score
80.30303030303031
distance
73.75797
seq distance
False
chain
F
TSP type-1 2
begin
512
end
517
score
80.30303030303031
distance
73.75797
seq distance
False
chain
F
Confirmed at protein level; dbSNP:rs1063499.
original residue
S
variation residue
T
position
1058
score
54.54545454545454
distance
75.183075
seq distance
False
chain
A
Confirmed at protein level; dbSNP:rs1063499.
original residue
S
variation residue
T
position
1058
score
54.54545454545454
distance
75.183075
seq distance
False
chain
A
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
31
score
50.0
distance
76.43301
seq distance
False
chain
F
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
31
score
50.0
distance
76.43301
seq distance
False
chain
F
In C7D; dbSNP:rs113187203.
original residue
R
variation residue
H
position
687
score
100.0
distance
81.514946
seq distance
578
chain
D
In C7D; dbSNP:rs113187203.
original residue
R
variation residue
H
position
687
score
100.0
distance
81.514946
seq distance
578
chain
D
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
82.77908
seq distance
False
chain
X
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
82.77908
seq distance
False
chain
X
Disordered
begin
219
end
240
score
100.0
distance
84.93689
seq distance
110
chain
D
Disordered
begin
219
end
240
score
100.0
distance
84.93689
seq distance
110
chain
D
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
85.76481
seq distance
False
chain
P
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
85.76481
seq distance
False
chain
P
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
86.2522
seq distance
False
chain
G
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
86.2522
seq distance
False
chain
G
Confirmed at protein level; dbSNP:rs13157656.
original residue
T
variation residue
P
position
714
score
50.0
distance
86.55658
seq distance
False
chain
B
Confirmed at protein level; dbSNP:rs13157656.
original residue
T
variation residue
P
position
714
score
50.0
distance
86.55658
seq distance
False
chain
B
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
92.67565
seq distance
False
chain
W
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
92.67565
seq distance
False
chain
W
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
93.31866
seq distance
False
chain
W
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
93.31866
seq distance
False
chain
W
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
98.00616
seq distance
False
chain
G
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
98.00616
seq distance
False
chain
G
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
101.44372
seq distance
False
chain
W
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
101.44372
seq distance
False
chain
W
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
105.17166
seq distance
False
chain
H
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
105.17166
seq distance
False
chain
H
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
107.9416
seq distance
False
chain
P
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
107.9416
seq distance
False
chain
P
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
114.48764
seq distance
False
chain
V
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
114.48764
seq distance
False
chain
V
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
116.073135
seq distance
False
chain
V
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
116.073135
seq distance
False
chain
V
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
119.425995
seq distance
False
chain
V
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
119.425995
seq distance
False
chain
V
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
119.62219
seq distance
False
chain
P
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
119.62219
seq distance
False
chain
P
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
122.954124
seq distance
False
chain
I
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
122.954124
seq distance
False
chain
I
In C7D; dbSNP:rs369349760.
original residue
R
variation residue
Q
position
220
score
100.0
distance
125.93419
seq distance
111
chain
D
In C7D; dbSNP:rs369349760.
original residue
R
variation residue
Q
position
220
score
100.0
distance
125.93419
seq distance
111
chain
D
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
128.27806
seq distance
False
chain
H
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
128.27806
seq distance
False
chain
H
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
130.01164
seq distance
False
chain
X
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
130.01164
seq distance
False
chain
X
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
131.19922
seq distance
False
chain
G
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
131.19922
seq distance
False
chain
G
In dbSNP:rs75345202.
original residue
R
variation residue
H
position
222
score
100.0
distance
132.50764
seq distance
113
chain
D
In dbSNP:rs75345202.
original residue
R
variation residue
H
position
222
score
100.0
distance
132.50764
seq distance
113
chain
D
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
134.56183
seq distance
False
chain
U
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
134.56183
seq distance
False
chain
U
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
135.88132
seq distance
False
chain
U
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
135.88132
seq distance
False
chain
U
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
136.96484
seq distance
False
chain
U
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
136.96484
seq distance
False
chain
U
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
137.44514
seq distance
False
chain
W
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
137.44514
seq distance
False
chain
W
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
138.78247
seq distance
False
chain
J
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
138.78247
seq distance
False
chain
J
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
139.97292
seq distance
False
chain
H
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
139.97292
seq distance
False
chain
H
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
142.32332
seq distance
False
chain
P
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
142.32332
seq distance
False
chain
P
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
146.47185
seq distance
False
chain
I
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
146.47185
seq distance
False
chain
I
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
146.82303
seq distance
False
chain
V
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
146.82303
seq distance
False
chain
V
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
150.08264
seq distance
False
chain
T
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
150.08264
seq distance
False
chain
T
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
152.26784
seq distance
False
chain
K
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
152.26784
seq distance
False
chain
K
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
152.57748
seq distance
False
chain
T
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
152.57748
seq distance
False
chain
T
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
153.84068
seq distance
False
chain
H
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
153.84068
seq distance
False
chain
H
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
156.14648
seq distance
False
chain
T
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
156.14648
seq distance
False
chain
T
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
157.20737
seq distance
False
chain
U
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
157.20737
seq distance
False
chain
U
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
158.09445
seq distance
False
chain
I
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
158.09445
seq distance
False
chain
I
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
161.52798
seq distance
False
chain
S
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
161.52798
seq distance
False
chain
S
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
162.20734
seq distance
False
chain
J
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
162.20734
seq distance
False
chain
J
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
163.09
seq distance
False
chain
L
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
163.09
seq distance
False
chain
L
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
164.61046
seq distance
False
chain
I
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
164.61046
seq distance
False
chain
I
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
167.30913
seq distance
False
chain
T
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
167.30913
seq distance
False
chain
T
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
167.69565
seq distance
False
chain
S
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
167.69565
seq distance
False
chain
S
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
169.96455
seq distance
False
chain
R
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
169.96455
seq distance
False
chain
R
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
170.9659
seq distance
False
chain
M
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
170.9659
seq distance
False
chain
M
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
172.55692
seq distance
False
chain
S
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
172.55692
seq distance
False
chain
S
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
173.68163
seq distance
False
chain
J
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
173.68163
seq distance
False
chain
J
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
174.10037
seq distance
False
chain
J
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
174.10037
seq distance
False
chain
J
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
175.0846
seq distance
False
chain
K
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
175.0846
seq distance
False
chain
K
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
175.24532
seq distance
False
chain
Q
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
175.24532
seq distance
False
chain
Q
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
175.70834
seq distance
False
chain
N
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
175.70834
seq distance
False
chain
N
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
176.35744
seq distance
False
chain
S
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
176.35744
seq distance
False
chain
S
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
177.1801
seq distance
False
chain
O
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
177.1801
seq distance
False
chain
O
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
179.62912
seq distance
False
chain
R
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
179.62912
seq distance
False
chain
R
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
182.15259
seq distance
False
chain
K
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
182.15259
seq distance
False
chain
K
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
183.86095
seq distance
False
chain
R
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
183.86095
seq distance
False
chain
R
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
184.84392
seq distance
False
chain
L
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
184.84392
seq distance
False
chain
L
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
185.80556
seq distance
False
chain
R
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
185.80556
seq distance
False
chain
R
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
186.29291
seq distance
False
chain
K
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
186.29291
seq distance
False
chain
K
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
188.06778
seq distance
False
chain
Q
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
188.06778
seq distance
False
chain
Q
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
188.3154
seq distance
False
chain
L
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
188.3154
seq distance
False
chain
L
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
189.49103
seq distance
False
chain
Q
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
189.49103
seq distance
False
chain
Q
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
191.12431
seq distance
False
chain
M
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
191.12431
seq distance
False
chain
M
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
192.22182
seq distance
False
chain
M
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
192.22182
seq distance
False
chain
M
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
192.85153
seq distance
False
chain
O
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
192.85153
seq distance
False
chain
O
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
192.90959
seq distance
False
chain
O
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
192.90959
seq distance
False
chain
O
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
193.58197
seq distance
False
chain
N
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
193.58197
seq distance
False
chain
N
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
193.82417
seq distance
False
chain
N
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
193.82417
seq distance
False
chain
N
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
195.56978
seq distance
False
chain
Q
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
195.56978
seq distance
False
chain
Q
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
195.65276
seq distance
False
chain
L
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
195.65276
seq distance
False
chain
L
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
201.4485
seq distance
False
chain
M
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
201.4485
seq distance
False
chain
M
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
201.6084
seq distance
False
chain
O
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
201.6084
seq distance
False
chain
O
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
203.50763
seq distance
False
chain
N
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
203.50763
seq distance
False
chain
N

Details

Redox score
62.65
PDB code
6h04
Structure name
closed conformation of the membrane attack complex
Structure deposition date
2018-07-06
Thiol separation (Å)
9.85
Half-sphere exposure sum
72
Minimum pKa
nan
% buried
nan
Peptide accession
P10643
Residue number A
85
Residue number B
109
Peptide name
Complement component C7
A redox-regulated disulphide may form within Complement component C7 at these cysteines. However, the redox score of this cysteine pair is lower than any known redox-active disulphide.

Relevent regions

TSP type-1 1
begin
5
end
58
score
99.83164983164983
distance
2.7431734
seq distance
0
chain
C
TSP type-1 1
begin
5
end
58
score
99.83164983164983
distance
2.7431734
seq distance
0
chain
C
MACPF
begin
102
end
434
score
94.85394485394487
distance
2.8307612
seq distance
0
chain
C
MACPF
begin
102
end
434
score
94.85394485394487
distance
2.8307612
seq distance
0
chain
C
CCP 1
begin
523
end
593
score
100.0
distance
3.6411123
seq distance
112
chain
C
CCP 1
begin
523
end
593
score
100.0
distance
3.6411123
seq distance
112
chain
C
LDL-receptor class A
begin
61
end
99
score
100.0
distance
10.901575
seq distance
4
chain
C
LDL-receptor class A
begin
61
end
99
score
100.0
distance
10.901575
seq distance
4
chain
C
TSP type-1 2
begin
478
end
527
score
100.0
distance
13.151399
seq distance
67
chain
C
TSP type-1 2
begin
478
end
527
score
100.0
distance
13.151399
seq distance
67
chain
C
Disordered
begin
86
end
121
score
100.0
distance
24.153767
seq distance
29
chain
C
Disordered
begin
86
end
121
score
100.0
distance
24.153767
seq distance
29
chain
C
Sushi 1
begin
547
end
606
score
100.0
distance
25.595417
seq distance
136
chain
C
Sushi 1
begin
547
end
606
score
100.0
distance
25.595417
seq distance
136
chain
C
Disordered
begin
494
end
516
score
100.0
distance
27.059101
seq distance
83
chain
C
Disordered
begin
494
end
516
score
100.0
distance
27.059101
seq distance
83
chain
C
LDL-receptor class A
begin
84
end
92
score
56.56565656565656
distance
28.246048
seq distance
False
chain
D
LDL-receptor class A
begin
84
end
92
score
56.56565656565656
distance
28.246048
seq distance
False
chain
D
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
412
score
63.63636363636363
distance
28.445395
seq distance
False
chain
D
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
412
score
63.63636363636363
distance
28.445395
seq distance
False
chain
D
EGF-like
begin
435
end
465
score
100.0
distance
29.122662
seq distance
24
chain
C
EGF-like
begin
435
end
465
score
100.0
distance
29.122662
seq distance
24
chain
C
Disordered
begin
91
end
92
score
68.18181818181817
distance
30.224298
seq distance
False
chain
D
Disordered
begin
91
end
92
score
68.18181818181817
distance
30.224298
seq distance
False
chain
D
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
398
score
100.0
distance
30.764166
seq distance
13
chain
C
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
398
score
100.0
distance
30.764166
seq distance
13
chain
C
CCP 2
begin
594
end
671
score
100.0
distance
31.546877
seq distance
183
chain
C
CCP 2
begin
594
end
671
score
100.0
distance
31.546877
seq distance
183
chain
C
Confirmed at protein level; dbSNP:rs13157656.
original residue
T
variation residue
P
position
565
score
100.0
distance
32.55497
seq distance
154
chain
C
Confirmed at protein level; dbSNP:rs13157656.
original residue
T
variation residue
P
position
565
score
100.0
distance
32.55497
seq distance
154
chain
C
Disordered
begin
504
end
504
score
68.18181818181817
distance
34.346737
seq distance
False
chain
D
Disordered
begin
504
end
504
score
68.18181818181817
distance
34.346737
seq distance
False
chain
D
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
499
score
100.0
distance
35.895897
seq distance
88
chain
C
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
499
score
100.0
distance
35.895897
seq distance
88
chain
C
In dbSNP:rs2271708.
original residue
C
variation residue
R
position
106
score
100.0
distance
39.38075
seq distance
49
chain
C
In dbSNP:rs2271708.
original residue
C
variation residue
R
position
106
score
100.0
distance
39.38075
seq distance
49
chain
C
In C7D; dbSNP:rs121964921.
original residue
G
variation residue
R
position
357
score
100.0
distance
41.965195
seq distance
54
chain
C
In C7D; dbSNP:rs121964921.
original residue
G
variation residue
R
position
357
score
100.0
distance
41.965195
seq distance
54
chain
C
Disordered
begin
510
end
522
score
53.67132867132868
distance
44.29556
seq distance
False
chain
D
Disordered
begin
510
end
522
score
53.67132867132868
distance
44.29556
seq distance
False
chain
D
LDL-receptor class A
begin
83
end
95
score
50.87412587412587
distance
44.568832
seq distance
False
chain
E
LDL-receptor class A
begin
83
end
95
score
50.87412587412587
distance
44.568832
seq distance
False
chain
E
EGF-like
begin
451
end
455
score
54.090909090909086
distance
48.19377
seq distance
False
chain
D
EGF-like
begin
451
end
455
score
54.090909090909086
distance
48.19377
seq distance
False
chain
D
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
512
score
81.81818181818183
distance
50.10141
seq distance
False
chain
D
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
512
score
81.81818181818183
distance
50.10141
seq distance
False
chain
D
Disordered
begin
564
end
573
score
62.272727272727266
distance
50.233944
seq distance
False
chain
B
Disordered
begin
564
end
573
score
62.272727272727266
distance
50.233944
seq distance
False
chain
B
Confirmed at protein level; dbSNP:rs1063499.
original residue
S
variation residue
T
position
367
score
100.0
distance
51.699936
seq distance
44
chain
C
Confirmed at protein level; dbSNP:rs1063499.
original residue
S
variation residue
T
position
367
score
100.0
distance
51.699936
seq distance
44
chain
C
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
566
score
86.36363636363636
distance
51.73646
seq distance
False
chain
B
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
566
score
86.36363636363636
distance
51.73646
seq distance
False
chain
B
Sushi 2
begin
607
end
668
score
100.0
distance
54.444492
seq distance
196
chain
C
Sushi 2
begin
607
end
668
score
100.0
distance
54.444492
seq distance
196
chain
C
In dbSNP:rs75345202.
original residue
R
variation residue
H
position
414
score
54.54545454545454
distance
60.28008
seq distance
False
chain
E
In dbSNP:rs75345202.
original residue
R
variation residue
H
position
414
score
54.54545454545454
distance
60.28008
seq distance
False
chain
E
In C7D; dbSNP:rs369349760.
original residue
R
variation residue
Q
position
25
score
54.54545454545454
distance
66.39899
seq distance
False
chain
B
In C7D; dbSNP:rs369349760.
original residue
R
variation residue
Q
position
25
score
54.54545454545454
distance
66.39899
seq distance
False
chain
B
In C7D; dbSNP:rs541873000.
original residue
E
variation residue
Q
position
660
score
100.0
distance
67.07609
seq distance
249
chain
C
In C7D; dbSNP:rs541873000.
original residue
E
variation residue
Q
position
660
score
100.0
distance
67.07609
seq distance
249
chain
C
MACPF
begin
324
end
332
score
83.08080808080808
distance
67.62763
seq distance
False
chain
G
MACPF
begin
324
end
332
score
83.08080808080808
distance
67.62763
seq distance
False
chain
G
Confirmed at protein level; dbSNP:rs1063499.
original residue
S
variation residue
T
position
1040
score
54.54545454545454
distance
69.04426
seq distance
False
chain
A
Confirmed at protein level; dbSNP:rs1063499.
original residue
S
variation residue
T
position
1040
score
54.54545454545454
distance
69.04426
seq distance
False
chain
A
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
530
score
54.54545454545454
distance
69.21565
seq distance
False
chain
E
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
530
score
54.54545454545454
distance
69.21565
seq distance
False
chain
E
In dbSNP:rs2271708.
original residue
C
variation residue
R
position
532
score
54.54545454545454
distance
70.76614
seq distance
False
chain
E
In dbSNP:rs2271708.
original residue
C
variation residue
R
position
532
score
54.54545454545454
distance
70.76614
seq distance
False
chain
E
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
70.87176
seq distance
False
chain
G
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
70.87176
seq distance
False
chain
G
Disordered
begin
138
end
138
score
50.0
distance
77.678276
seq distance
False
chain
F
Disordered
begin
138
end
138
score
50.0
distance
77.678276
seq distance
False
chain
F
In C7D; dbSNP:rs113187203.
original residue
R
variation residue
H
position
665
score
100.0
distance
79.96681
seq distance
254
chain
C
In C7D; dbSNP:rs113187203.
original residue
R
variation residue
H
position
665
score
100.0
distance
79.96681
seq distance
254
chain
C
Disordered
begin
197
end
218
score
76.85950413223141
distance
87.189514
seq distance
140
chain
C
Disordered
begin
197
end
218
score
76.85950413223141
distance
87.189514
seq distance
140
chain
C
MACPF
begin
324
end
332
score
83.08080808080808
distance
89.50906
seq distance
False
chain
H
MACPF
begin
324
end
332
score
83.08080808080808
distance
89.50906
seq distance
False
chain
H
Confirmed at protein level; dbSNP:rs13157656.
original residue
T
variation residue
P
position
693
score
50.0
distance
89.567245
seq distance
False
chain
B
Confirmed at protein level; dbSNP:rs13157656.
original residue
T
variation residue
P
position
693
score
50.0
distance
89.567245
seq distance
False
chain
B
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
90.75278
seq distance
False
chain
G
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
90.75278
seq distance
False
chain
G
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
94.245514
seq distance
False
chain
H
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
94.245514
seq distance
False
chain
H
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
100.075325
seq distance
False
chain
G
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
100.075325
seq distance
False
chain
G
Factor I module (FIM) 1
begin
673
end
748
score
100.0
distance
101.822426
seq distance
262
chain
C
Factor I module (FIM) 1
begin
673
end
748
score
100.0
distance
101.822426
seq distance
262
chain
C
MACPF
begin
324
end
333
score
84.54545454545456
distance
109.25619
seq distance
False
chain
I
MACPF
begin
324
end
333
score
84.54545454545456
distance
109.25619
seq distance
False
chain
I
Disordered
begin
327
end
328
score
61.36363636363637
distance
112.935936
seq distance
False
chain
I
Disordered
begin
327
end
328
score
61.36363636363637
distance
112.935936
seq distance
False
chain
I
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
1560
score
50.0
distance
114.47444
seq distance
False
chain
A
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
1560
score
50.0
distance
114.47444
seq distance
False
chain
A
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
116.506744
seq distance
False
chain
I
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
116.506744
seq distance
False
chain
I
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
116.74327
seq distance
False
chain
H
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
116.74327
seq distance
False
chain
H
Factor I module (FIM) 2
begin
749
end
821
score
100.0
distance
126.090164
seq distance
338
chain
C
Factor I module (FIM) 2
begin
749
end
821
score
100.0
distance
126.090164
seq distance
338
chain
C
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
126.39899
seq distance
False
chain
H
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
126.39899
seq distance
False
chain
H
In C7D; dbSNP:rs369349760.
original residue
R
variation residue
Q
position
198
score
72.72727272727273
distance
127.91915
seq distance
141
chain
C
In C7D; dbSNP:rs369349760.
original residue
R
variation residue
Q
position
198
score
72.72727272727273
distance
127.91915
seq distance
141
chain
C
In dbSNP:rs75345202.
original residue
R
variation residue
H
position
200
score
72.72727272727273
distance
134.30167
seq distance
143
chain
C
In dbSNP:rs75345202.
original residue
R
variation residue
H
position
200
score
72.72727272727273
distance
134.30167
seq distance
143
chain
C
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
139.60835
seq distance
False
chain
I
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
139.60835
seq distance
False
chain
I

Details

Redox score
62.63
PDB code
7nyc
Structure name
cryoem structure of 3c9-smac
Structure deposition date
2021-03-22
Thiol separation (Å)
9.68
Half-sphere exposure sum
78
Minimum pKa
nan
% buried
nan
Peptide accession
P10643
Residue number A
79 (Residue 57 in this structure)
Residue number B
433 (Residue 411 in this structure)
Peptide name
Complement component C7
A redox-regulated disulphide may form within Complement component C7 at these cysteines. However, the redox score of this cysteine pair is lower than any known redox-active disulphide.

Relevent regions

MACPF
begin
124
end
456
score
98.9079989079989
distance
2.8091636
seq distance
0
chain
D
MACPF
begin
124
end
456
score
98.9079989079989
distance
2.8091636
seq distance
0
chain
D
EGF-like
begin
457
end
487
score
100.0
distance
2.817923
seq distance
0
chain
D
EGF-like
begin
457
end
487
score
100.0
distance
2.817923
seq distance
0
chain
D
TSP type-1 2
begin
500
end
549
score
100.0
distance
3.1448064
seq distance
27
chain
D
TSP type-1 2
begin
500
end
549
score
100.0
distance
3.1448064
seq distance
27
chain
D
TSP type-1 1
begin
27
end
80
score
99.83164983164983
distance
4.9242854
seq distance
375
chain
D
TSP type-1 1
begin
27
end
80
score
99.83164983164983
distance
4.9242854
seq distance
375
chain
D
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
521
score
100.0
distance
9.381221
seq distance
48
chain
D
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
521
score
100.0
distance
9.381221
seq distance
48
chain
D
Disordered
begin
516
end
538
score
100.0
distance
9.381221
seq distance
43
chain
D
Disordered
begin
516
end
538
score
100.0
distance
9.381221
seq distance
43
chain
D
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
412
score
63.63636363636363
distance
21.075468
seq distance
False
chain
C
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
412
score
63.63636363636363
distance
21.075468
seq distance
False
chain
C
CCP 1
begin
545
end
615
score
83.48271446862996
distance
22.010685
seq distance
72
chain
D
CCP 1
begin
545
end
615
score
83.48271446862996
distance
22.010685
seq distance
72
chain
D
Disordered
begin
108
end
143
score
100.0
distance
24.192572
seq distance
312
chain
D
Disordered
begin
108
end
143
score
100.0
distance
24.192572
seq distance
312
chain
D
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
420
score
100.0
distance
24.206007
seq distance
35
chain
D
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
420
score
100.0
distance
24.206007
seq distance
35
chain
D
Disordered
begin
41
end
41
score
70.45454545454545
distance
28.814257
seq distance
False
chain
B
Disordered
begin
41
end
41
score
70.45454545454545
distance
28.814257
seq distance
False
chain
B
Disordered
begin
504
end
504
score
68.18181818181817
distance
30.151415
seq distance
False
chain
C
Disordered
begin
504
end
504
score
68.18181818181817
distance
30.151415
seq distance
False
chain
C
Confirmed at protein level; dbSNP:rs1063499.
original residue
S
variation residue
T
position
389
score
100.0
distance
31.95345
seq distance
66
chain
D
Confirmed at protein level; dbSNP:rs1063499.
original residue
S
variation residue
T
position
389
score
100.0
distance
31.95345
seq distance
66
chain
D
EGF-like
begin
451
end
455
score
54.090909090909086
distance
32.892204
seq distance
False
chain
C
EGF-like
begin
451
end
455
score
54.090909090909086
distance
32.892204
seq distance
False
chain
C
LDL-receptor class A
begin
83
end
121
score
100.0
distance
39.11544
seq distance
334
chain
D
LDL-receptor class A
begin
83
end
121
score
100.0
distance
39.11544
seq distance
334
chain
D
Disordered
begin
585
end
589
score
50.90909090909091
distance
43.671814
seq distance
False
chain
B
Disordered
begin
585
end
589
score
50.90909090909091
distance
43.671814
seq distance
False
chain
B
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
587
score
68.18181818181817
distance
43.83087
seq distance
False
chain
B
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
587
score
68.18181818181817
distance
43.83087
seq distance
False
chain
B
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
45.132664
seq distance
False
chain
X
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
45.132664
seq distance
False
chain
X
Disordered
begin
91
end
92
score
68.18181818181817
distance
48.76474
seq distance
False
chain
C
Disordered
begin
91
end
92
score
68.18181818181817
distance
48.76474
seq distance
False
chain
C
LDL-receptor class A
begin
84
end
92
score
56.56565656565656
distance
48.76474
seq distance
False
chain
C
LDL-receptor class A
begin
84
end
92
score
56.56565656565656
distance
48.76474
seq distance
False
chain
C
In dbSNP:rs75345202.
original residue
R
variation residue
H
position
414
score
54.54545454545454
distance
49.504467
seq distance
False
chain
F
In dbSNP:rs75345202.
original residue
R
variation residue
H
position
414
score
54.54545454545454
distance
49.504467
seq distance
False
chain
F
Sushi 1
begin
572
end
628
score
99.04306220095694
distance
50.78856
seq distance
99
chain
D
Sushi 1
begin
572
end
628
score
99.04306220095694
distance
50.78856
seq distance
99
chain
D
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
52.097977
seq distance
False
chain
X
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
52.097977
seq distance
False
chain
X
CCP 2
begin
616
end
691
score
99.2822966507177
distance
52.54426
seq distance
143
chain
D
CCP 2
begin
616
end
691
score
99.2822966507177
distance
52.54426
seq distance
143
chain
D
Disordered
begin
219
end
240
score
100.0
distance
53.23708
seq distance
215
chain
D
Disordered
begin
219
end
240
score
100.0
distance
53.23708
seq distance
215
chain
D
In dbSNP:rs2271708.
original residue
C
variation residue
R
position
128
score
100.0
distance
54.60566
seq distance
327
chain
D
In dbSNP:rs2271708.
original residue
C
variation residue
R
position
128
score
100.0
distance
54.60566
seq distance
327
chain
D
TSP type-1 2
begin
512
end
517
score
80.30303030303031
distance
58.81717
seq distance
False
chain
F
TSP type-1 2
begin
512
end
517
score
80.30303030303031
distance
58.81717
seq distance
False
chain
F
Confirmed at protein level; dbSNP:rs13157656.
original residue
T
variation residue
P
position
587
score
100.0
distance
59.230427
seq distance
114
chain
D
Confirmed at protein level; dbSNP:rs13157656.
original residue
T
variation residue
P
position
587
score
100.0
distance
59.230427
seq distance
114
chain
D
LDL-receptor class A
begin
83
end
98
score
52.69886363636363
distance
60.72509
seq distance
False
chain
F
LDL-receptor class A
begin
83
end
98
score
52.69886363636363
distance
60.72509
seq distance
False
chain
F
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
66.87364
seq distance
False
chain
G
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
66.87364
seq distance
False
chain
G
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
67.47657
seq distance
False
chain
X
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
67.47657
seq distance
False
chain
X
Disordered
begin
138
end
138
score
50.0
distance
73.378525
seq distance
False
chain
E
Disordered
begin
138
end
138
score
50.0
distance
73.378525
seq distance
False
chain
E
Confirmed at protein level; dbSNP:rs1063499.
original residue
S
variation residue
T
position
1058
score
54.54545454545454
distance
74.125046
seq distance
False
chain
A
Confirmed at protein level; dbSNP:rs1063499.
original residue
S
variation residue
T
position
1058
score
54.54545454545454
distance
74.125046
seq distance
False
chain
A
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
31
score
50.0
distance
74.43596
seq distance
False
chain
F
In C7D; dbSNP:rs121964920.
original residue
R
variation residue
S
position
31
score
50.0
distance
74.43596
seq distance
False
chain
F
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
76.20298
seq distance
False
chain
W
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
76.20298
seq distance
False
chain
W
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
81.28161
seq distance
False
chain
W
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
81.28161
seq distance
False
chain
W
Sushi 2
begin
629
end
690
score
99.56011730205279
distance
84.05372
seq distance
156
chain
D
Sushi 2
begin
629
end
690
score
99.56011730205279
distance
84.05372
seq distance
156
chain
D
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
89.37201
seq distance
False
chain
P
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
89.37201
seq distance
False
chain
P
In C7D; dbSNP:rs369349760.
original residue
R
variation residue
Q
position
220
score
100.0
distance
90.31529
seq distance
235
chain
D
In C7D; dbSNP:rs369349760.
original residue
R
variation residue
Q
position
220
score
100.0
distance
90.31529
seq distance
235
chain
D
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
91.77431
seq distance
False
chain
W
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
91.77431
seq distance
False
chain
W
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
93.713486
seq distance
False
chain
G
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
93.713486
seq distance
False
chain
G
In dbSNP:rs75345202.
original residue
R
variation residue
H
position
222
score
100.0
distance
96.55792
seq distance
233
chain
D
In dbSNP:rs75345202.
original residue
R
variation residue
H
position
222
score
100.0
distance
96.55792
seq distance
233
chain
D
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
96.58512
seq distance
False
chain
X
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
96.58512
seq distance
False
chain
X
In C7D; dbSNP:rs541873000.
original residue
E
variation residue
Q
position
682
score
100.0
distance
97.2397
seq distance
209
chain
D
In C7D; dbSNP:rs541873000.
original residue
E
variation residue
Q
position
682
score
100.0
distance
97.2397
seq distance
209
chain
D
Confirmed at protein level; dbSNP:rs13157656.
original residue
T
variation residue
P
position
714
score
50.0
distance
101.2665
seq distance
False
chain
B
Confirmed at protein level; dbSNP:rs13157656.
original residue
T
variation residue
P
position
714
score
50.0
distance
101.2665
seq distance
False
chain
B
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
102.5465
seq distance
False
chain
G
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
102.5465
seq distance
False
chain
G
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
105.08612
seq distance
False
chain
V
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
105.08612
seq distance
False
chain
V
In C7D; dbSNP:rs113187203.
original residue
R
variation residue
H
position
687
score
100.0
distance
106.321686
seq distance
214
chain
D
In C7D; dbSNP:rs113187203.
original residue
R
variation residue
H
position
687
score
100.0
distance
106.321686
seq distance
214
chain
D
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
107.57266
seq distance
False
chain
W
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
107.57266
seq distance
False
chain
W
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
108.38462
seq distance
False
chain
G
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
108.38462
seq distance
False
chain
G
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
108.49451
seq distance
False
chain
V
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
108.49451
seq distance
False
chain
V
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
110.73897
seq distance
False
chain
H
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
110.73897
seq distance
False
chain
H
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
114.47538
seq distance
False
chain
V
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
114.47538
seq distance
False
chain
V
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
116.79785
seq distance
False
chain
P
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
116.79785
seq distance
False
chain
P
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
120.811295
seq distance
False
chain
V
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
120.811295
seq distance
False
chain
V
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
123.39246
seq distance
False
chain
P
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
123.39246
seq distance
False
chain
P
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
126.241745
seq distance
False
chain
P
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
126.241745
seq distance
False
chain
P
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
130.16975
seq distance
False
chain
I
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
130.16975
seq distance
False
chain
I
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
131.5142
seq distance
False
chain
U
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
131.5142
seq distance
False
chain
U
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
133.25174
seq distance
False
chain
U
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
133.25174
seq distance
False
chain
U
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
135.02954
seq distance
False
chain
U
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
135.02954
seq distance
False
chain
U
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
135.13664
seq distance
False
chain
U
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
135.13664
seq distance
False
chain
U
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
138.42477
seq distance
False
chain
H
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
138.42477
seq distance
False
chain
H
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
138.45222
seq distance
False
chain
H
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
138.45222
seq distance
False
chain
H
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
147.35358
seq distance
False
chain
J
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
147.35358
seq distance
False
chain
J
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
148.35895
seq distance
False
chain
H
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
148.35895
seq distance
False
chain
H
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
149.1548
seq distance
False
chain
T
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
149.1548
seq distance
False
chain
T
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
152.04884
seq distance
False
chain
I
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
152.04884
seq distance
False
chain
I
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
152.84857
seq distance
False
chain
T
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
152.84857
seq distance
False
chain
T
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
155.3754
seq distance
False
chain
T
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
155.3754
seq distance
False
chain
T
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
155.46083
seq distance
False
chain
T
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
155.46083
seq distance
False
chain
T
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
157.89745
seq distance
False
chain
I
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
157.89745
seq distance
False
chain
I
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
161.77962
seq distance
False
chain
S
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
161.77962
seq distance
False
chain
S
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
161.9015
seq distance
False
chain
K
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
161.9015
seq distance
False
chain
K
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
163.56448
seq distance
False
chain
J
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
163.56448
seq distance
False
chain
J
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
167.43416
seq distance
False
chain
S
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
167.43416
seq distance
False
chain
S
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
168.0299
seq distance
False
chain
I
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
168.0299
seq distance
False
chain
I
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
171.94391
seq distance
False
chain
R
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
171.94391
seq distance
False
chain
R
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
172.94446
seq distance
False
chain
K
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
172.94446
seq distance
False
chain
K
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
173.50114
seq distance
False
chain
L
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
173.50114
seq distance
False
chain
L
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
174.11276
seq distance
False
chain
S
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
174.11276
seq distance
False
chain
S
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
174.70148
seq distance
False
chain
J
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
174.70148
seq distance
False
chain
J
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
176.00465
seq distance
False
chain
S
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
176.00465
seq distance
False
chain
S
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
178.59416
seq distance
False
chain
R
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
178.59416
seq distance
False
chain
R
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
179.54594
seq distance
False
chain
Q
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
179.54594
seq distance
False
chain
Q
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
179.85728
seq distance
False
chain
L
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
179.85728
seq distance
False
chain
L
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
181.83339
seq distance
False
chain
M
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
181.83339
seq distance
False
chain
M
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
183.7754
seq distance
False
chain
O
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
183.7754
seq distance
False
chain
O
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
184.01813
seq distance
False
chain
M
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
184.01813
seq distance
False
chain
M
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
184.89218
seq distance
False
chain
J
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
184.89218
seq distance
False
chain
J
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
185.2887
seq distance
False
chain
Q
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
185.2887
seq distance
False
chain
Q
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
185.72789
seq distance
False
chain
N
Sushi 1
begin
256
end
257
score
69.31818181818183
distance
185.72789
seq distance
False
chain
N
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
186.67207
seq distance
False
chain
N
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
186.67207
seq distance
False
chain
N
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
187.8813
seq distance
False
chain
O
In dbSNP:rs3792646.
original residue
K
variation residue
Q
position
451
score
68.18181818181817
distance
187.8813
seq distance
False
chain
O
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
188.43977
seq distance
False
chain
K
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
188.43977
seq distance
False
chain
K
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
189.20448
seq distance
False
chain
R
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
189.20448
seq distance
False
chain
R
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
192.80765
seq distance
False
chain
R
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
192.80765
seq distance
False
chain
R
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
198.49411
seq distance
False
chain
K
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
198.49411
seq distance
False
chain
K
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
198.77237
seq distance
False
chain
L
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
198.77237
seq distance
False
chain
L
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
200.376
seq distance
False
chain
Q
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
200.376
seq distance
False
chain
Q
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
205.31784
seq distance
False
chain
M
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
205.31784
seq distance
False
chain
M
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
205.63887
seq distance
False
chain
Q
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
205.63887
seq distance
False
chain
Q
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
206.4612
seq distance
False
chain
O
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
206.4612
seq distance
False
chain
O
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
207.90753
seq distance
False
chain
N
Factor I module (FIM) 1
begin
306
end
306
score
72.72727272727273
distance
207.90753
seq distance
False
chain
N
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
208.49446
seq distance
False
chain
L
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
208.49446
seq distance
False
chain
L
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
213.60805
seq distance
False
chain
O
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
213.60805
seq distance
False
chain
O
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
214.55997
seq distance
False
chain
M
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
214.55997
seq distance
False
chain
M
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
216.32889
seq distance
False
chain
N
TSP type-1 2
begin
30
end
31
score
77.27272727272727
distance
216.32889
seq distance
False
chain
N

Details

Redox score
62.57
PDB code
6h04
Structure name
closed conformation of the membrane attack complex
Structure deposition date
2018-07-06
Thiol separation (Å)
9.96
Half-sphere exposure sum
69
Minimum pKa
nan
% buried
nan
Peptide accession
P10643
Residue number A
455
Residue number B
473
Peptide name
Complement component C7
If this tool was useful for finding a disulphide, please cite: